Hongqiang Cheng

发表

Kinetic cellular phenotypic profiling: prediction, identification, and analysis of bioactive natural products.

Li Teng, Wenqing Fu, G. Lv, 2011, Analytical chemistry.

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.

G. Wang, John M Westlund, M. Nóbrega, 2011, The Journal of clinical investigation.

A dynamic real-time method for monitoring epithelial barrier function in vitro.

Yuan Zhao, Xiuhua Liu, Xiuhua Liu, 2012, Analytical biochemistry.

Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5.

J. Yuan, Haiyang Tang, J. Raj, 2015, American journal of respiratory and critical care medicine.

Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy

Yusu Gu, N. Dalton, K. Peterson, 2010, Circulation research.

Isoform 1 Protein Directly Activated by Cyclic AMP Homeostasis in Mice Lacking Exchange Adiposity, and Improved Glucose Enhanced Leptin Sensitivity, Reduced

M. Motamedi, Xiaodong Cheng, K. Dineley, 2014 .

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

M. Motamedi, Xiaodong Cheng, K. Dineley, 2012, Molecular and Cellular Biology.

Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin)

J. M. Schilling, D. Sahoo, G. van den Bogaart, 2021, Hypertension.

Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway

Hongqiang Cheng, Xue Zhang, Y. Ke, 2021, Frontiers in Molecular Biosciences.

Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress.

Yang Ruan, Jian Li, Hongqiang Cheng, 2013, International journal of cardiology.

aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1

K. Limesand, Hongqiang Cheng, Ju Chen, 2018, Scientific Reports.

GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.

Ping Song, Hongqiang Cheng, Xue Zhang, 2022, Biochemical and biophysical research communications.

A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries

Yiming Xu, Hongqiang Cheng, Xue Zhang, 2020, Experimental Cell Research.

Shp2 in myocytes is essential for cardiovascular and neointima development.

Hongqiang Cheng, Xue Zhang, Y. Ke, 2019, Journal of molecular and cellular cardiology.

Epac 2 Mediates Cardiac β 1-Adrenergic – Dependent Sarcoplasmic Reticulum Ca 2 + Leak and Arrhythmia

D. Bers, X. Wehrens, J. Brown, 2013 .

Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

Tong Zhang, Ju Chen, Yusu Gu, 2009, The Journal of clinical investigation.

Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function

A. McCulloch, Yusu Gu, N. Dalton, 2020, Circulation research.

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

Li Teng, M. Lai, G. Feng, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

cardiomyopathy with premature death

M. Bang, Yusu Gu, N. Dalton, 2008 .

Normalization of Naxos plakoglobin levels restores cardiac function in mice.

Yusu Gu, N. Dalton, K. Peterson, 2015, The Journal of clinical investigation.

Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

Yun Xu, Hongqiang Cheng, Xue Zhang, 2017, The Journal of Biological Chemistry.

Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z‐line proteins increase risk of idiopathic dilated cardiomyopathy

Xiao-gang Guo, Hongqiang Cheng, Juan Fang, 2019, Journal of cellular and molecular medicine.

Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling*

Hongli Jiao, H. Im, Di Chen, 2012, The Journal of Biological Chemistry.

Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis

W. Jin, Hongqiang Cheng, Xue Zhang, 2014, The Journal of Immunology.

Mice to Pulmonary Fibrosis Activation of Macrophages and Predisposes Phosphatase Shp2 Promotes Alternative Myeloid-Specific Disruption of Tyrosine

W. Jin, Hongqiang Cheng, Xue Zhang, 2014 .

Manipulating the air-filled zebrafish swim bladder as a neutrophilic inflammation model for acute lung injury

Hongqiang Cheng, Shu Wan, Xue Zhang, 2016, Cell Death & Disease.

Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway

Xiao-gang Guo, Hongqiang Cheng, Juan Fang, 2020, International journal of medical sciences.

Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality

G. Wang, K. Peterson, Yunfu Sun, 2009, Circulation.

Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin

Hongqiang Cheng, Xue Zhang, Y. Ke, 2021, Journal of extracellular vesicles.

Epac2 Mediates Cardiac (cid:533) 1 -Adrenergic Dependent SR Ca 2+ Leak and Arrhythmia

D. Bers, X. Wehrens, J. Brown, 2013 .

Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation

Hongqiang Cheng, Xue Zhang, Y. Ke, 2016, Scientific Reports.

The alteration of left ventricular strain in later-onset spinal muscular atrophy children

Hongqiang Cheng, Jingjing Qian, Jingjing Ye, 2022, Frontiers in Cellular Neuroscience.

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Hongqiang Cheng, Xue Zhang, Y. Ke, 2021, Nature Communications.

Migfilin supports hemostasis and thrombosis through regulating platelet αIIbβ3 outside-in signaling.

Hongqiang Cheng, Hu Hu, Xiaoyan Chen, 2019, Haematologica.

Epithelial disruption of Gab1 perturbs surfactant homeostasis and predisposes mice to lung injuries.

Hongqiang Cheng, Xue Zhang, Y. Ke, 2016, American journal of physiology. Lung cellular and molecular physiology.

Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Epithelial disruption of Gab 1 perturbs surfactant homeostasis and predisposes mice to lung injuries

Hongqiang Cheng, Xue Zhang, Y. Ke, 2016 .

Catestatin (CST) is a key mediator of the immunoendocrine regulation of cardiovascular function

D. Sahoo, N. Webster, K. Tang, 2020, bioRxiv.

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

Hongqiang Cheng, Y. Ke, Yuxian Guo, 2021, Nature Communications.

Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription

M. Lai, Fengyan Han, Honghe Zhang, 2023, Angiogenesis.

SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis

Hongqiang Cheng, Xue Zhang, K. Ying, 2023, The Journal of clinical investigation.

aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1

K. Limesand, Hongqiang Cheng, Ju Chen, 2018, Scientific Reports.

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes*

Xianhua Wang, Heping Cheng, Quan Chen, 2012, The Journal of Biological Chemistry.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

D. Tieleman, Qiang Zhou, H. Duff, 2014, Nature Medicine.

SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1

Li Teng, Qingwei Zhao, Hongqiang Cheng, 2014, The Journal of Biological Chemistry.

PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells

Hongqiang Cheng, Xue Zhang, Y. Ke, 2020, The Journal of Biological Chemistry.

The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer

Hongqiang Cheng, Y. Ke, Yinyan Li, 2019, OncoTargets and therapy.

Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma

Huahao Shen, Yun Xu, Linrong Lu, 2016, Cell Research.

Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway

Hongqiang Cheng, Xue Zhang, Y. Ke, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum

R. Lieber, Hongqiang Cheng, Ju Chen, 2009, Journal of Cell Science.

ALP/Enigma PDZ-LIM domain proteins in the heart.

Hongqiang Cheng, Ju Chen, M. Zheng, 2010, Journal of molecular cell biology.

The Inhibition of Mast Cell Activation of Radix Paeoniae alba Extraction Identified by TCRP Based and Conventional Cell Function Assay Systems

Huiying Fu, Mingjiao Sun, Qiyang Shou, 2016, PloS one.

Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling

J Zhang, Yun Xu, Hongqiang Cheng, 2022, iScience.

Cypher/ZASP Is a Novel A-kinase Anchoring Protein*

Stephan Lange, Ju Chen, Xiaogang Guo, 2013, The Journal of Biological Chemistry.

Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.

Kensuke Kimura, Ju Chen, Norbert Frey, 2011, Human molecular genetics.

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.

Ju Chen, M. Bang, Yusu Gu, 2009, Human molecular genetics.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

D. Sahoo, G. Ghosh, N. Webster, 2020 .

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

O. Klezovitch, V. Vasioukhin, Y. Zou, 2019, iScience.

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

Andrew D McCulloch, Richard L Moss, Ju Chen, 2012, The Journal of clinical investigation.

Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling

Xinyan Wu, C. Xiao, Wen-Hsien Liu, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10

Hongqiang Cheng, Xue Zhang, Y. Ke, 2019, The Journal of experimental medicine.

Tyrosine phosphatase Shp2 regulates p115RhoGEF/Rho-dependent dendritic cell migration

Yun Xu, Hongqiang Cheng, Xue Zhang, 2020, Cellular & Molecular Immunology.

Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice

Hongqiang Cheng, Xue Zhang, Y. Ke, 2017, The Journal of Immunology.

Requirement for Ca 2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice (Journal of Clinical Investigation (2009) 119, 5, (1230-1240) doi: 10.1172/JCI38022)

Donald M. Bers, Tong Zhang, Ju Chen, 2012 .

Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit

Hongqiang Cheng, Xue Zhang, Y. Ke, 2022, Cellular & Molecular Immunology.

Compatibility principle in the Tanyu Tongzhi Formula revealed by a cell-based analysis.

Wei Mao, Xiao-ming Xu, Hongqiang Cheng, 2019, Journal of ethnopharmacology.

Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy

Xiao-gang Guo, Hongqiang Cheng, Dong-fei Wang, 2021, Frontiers in Cardiovascular Medicine.

SHP2 protects endothelial cell barrier through suppressing VE‐cadherin internalization regulated by MET‐ARF1

Luyang Yu, Hongqiang Cheng, Xue Zhang, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pinch1 Is Required for Normal Development of Cranial and Cardiac Neural Crest–Derived Structures

S. Bhattacharya, Yunfu Sun, Hongqiang Cheng, 2007, Circulation research.

Epac2 Mediates Cardiac &bgr;1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca2+ Leak and Arrhythmia

D. Bers, X. Wehrens, J. Brown, 2013, Circulation.

Epac 2 Mediates Cardiac 1-Adrenergic Dependent SR Ca 2 + Leak and Arrhythmia Running title :

D. Bers, X. Wehrens, J. Brown, 2013 .

Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes*

H. T. ter Keurs, Hongqiang Cheng, Ju Chen, 2015, The Journal of Biological Chemistry.

SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in KRAS-mutant gastric cancer through the suppression of KSR1 activity.

Hongqiang Cheng, Xue Zhang, Y. Ke, 2022, Cancer letters.

Cellular Phenotypic Analysis of Macrophage Activation Unveils Kinetic Responses of Agents Targeting Phosphorylation

Hongqiang Cheng, Y. Ke, Q. Cao, 2017, SLAS discovery : advancing life sciences R & D.

Epac2 Mediates Cardiac &bgr;1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca2+ Leak and Arrhythmia

D. Bers, X. Wehrens, J. Brown, 2013, Circulation.

Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.

Yusu Gu, N. Dalton, K. Peterson, 2011, Human molecular genetics.

ALP/Enigma PDZ-LIM domain proteins in the heart.

Hongqiang Cheng, Ju Chen, M. Zheng, 2010, Journal of molecular cell biology.

Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality

G. Wang, K. Peterson, Yunfu Sun, 2009, Circulation.

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

A. McCulloch, Yusu Gu, N. Dalton, 2012, The Journal of clinical investigation.

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.

G. Wang, John M Westlund, Yusu Gu, 2011, The Journal of clinical investigation.

Cypher and Enigma Homolog Protein Are Essential for Cardiac Development and Embryonic Survival

R. Jing, Hongqiang Cheng, Ju Chen, 2015, Journal of the American Heart Association.

Results Cypher and ENH Are Highly Expressed in the Myocardium During Early Heart Development

R. Jing, Hongqiang Cheng, Ju Chen, 2015 .

Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation

Hongqiang Cheng, Wei Jin, Jiaqi Xu, 2023, JCI insight.

Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment

X. Zhang, Honghe Zhang, Hongqiang Cheng, 2018, Oncogene.

NanoSHP099‐Targeted SHP2 Inhibition Boosts Ly6Clow Monocytes/Macrophages Differentiation to Accelerate Thrombolysis

Yiming Xu, Hongqiang Cheng, Dan Lv, 2024, Advanced science.