R. Kettenhofen

发表

Dynamic monitoring of beating periodicity of stem cell‐derived cardiomyocytes as a predictive tool for preclinical safety assessment

M. Watzele, E. Kolossov, Xiao Xu, 2012, British journal of pharmacology.

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Daniel C Millard, G. Gintant, Jennifer B Pierson, 2018, Cell reports.

Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction

Ralf Kettenhofen, Heribert Bohlen, Michael George, 2011, Journal of biomolecular screening.

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system.

N. Fertig, M. George, D. Malan, 2013, Journal of pharmacological and toxicological methods.

Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation

T. Bruegmann, D. Malan, P. Sasse, 2017, International journal of molecular sciences.

Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

Ralf Kettenhofen, Heribert Bohlen, Martin Breitbach, 2006, The Journal of experimental medicine.

Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations.

G. Gintant, Jennifer B Pierson, S. Stoelzle-Feix, 2020, Regulatory toxicology and pharmacology : RTP.

HTS-Compatible Voltage- and Ca 2+ -Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems

R. Kettenhofen, 2017 .

Regulation of Gadd45a mRNA expression in vascular smooth muscle under growth and stress conditions.

A. Sachinidis, R. Kettenhofen, J. Hoppe, 2001, Cellular signalling.

Identification of a phosphodiesterase I/nucleotide pyrophosphatase-related gene mRNA in rat vascular smooth muscle cells by the differential display approach.

H. Vetter, A. Sachinidis, R. Kettenhofen, 1998, Journal of molecular biology.

An impedance‐based approach using human iPSC‐derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities

J. Woska, R. Kettenhofen, H. Bohlen, 2017, Toxicology and applied pharmacology.

Preclinical assessment of cardiac toxicity.

Ralf Kettenhofen, Heribert Bohlen, R. Kettenhofen, 2008, Drug discovery today.

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system.

Ralf Kettenhofen, Heribert Bohlen, Michael George, 2013, Journal of pharmacological and toxicological methods.

Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects.

R. Kettenhofen, S. Bedut, J. D'Angelo, 2020, Journal of pharmacological and toxicological methods.

Evidence that lipoproteins are carriers of bioactive factors.

H. Vetter, A. Sachinidis, I. Gouni-Berthold, 1999, Arteriosclerosis, Thrombosis and Vascular Biology.

Synchronized electromechanical integration recording of cardiomyocytes.

Liujing Zhuang, Ning Hu, Tianxing Wang, 2018, Biosensors & bioelectronics.

State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening

Ralf Kettenhofen, Michael George, Sonja Stoelzle, 2011, Front. Pharmacol..

Role of mitogen-activated protein kinase in the angiotensin II-induced DNA synthesis in vascular smooth muscle cells.

Y. Ko, H. Vetter, A. Sachinidis, 1998, Hypertension.

The role of platelet‐derived growth factor‐BB‐induced increase in cytosolic free Ca2+ in activation of mitogen‐ activated protein kinase and DNA synthesis in vascular smooth muscle cells

A. Sachinidis, R. Kettenhofen, Y. Ko, 1997, Journal of hypertension.

Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites.

Jennifer B Pierson, I. Kopljar, R. Kettenhofen, 2019, Toxicological sciences : an official journal of the Society of Toxicology.