P. Desai

发表

Mining Relational Paths in Integrated Biomedical Data

J. Qiu, Jie Tang, Ying Ding, 2011, PloS one.

Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights

P. Desai, Priyanka Arora, Gary Gudelsky, 2021, PloS one.

Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors

J. Unadkat, P. Desai, Anshul Gupta, 2008, Drug Metabolism and Disposition.

Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions

N. Hariparsad, J. Unadkat, P. Desai, 2007, Drug Metabolism and Disposition.

In vitro and in vivo percutaneous absorption of catechol.

R. Bronaugh, P. Desai, R. Wickett, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis

P. Desai, G. Gudelsky, Nimita Dave, 2013, Cancer Chemotherapy and Pharmacology.

Erratum for Mor et al., “Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids”

Patrick Flaherty, G. Giaever, Xuewen Pan, 2018, mBio.

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Patrick Flaherty, G. Giaever, Xuewen Pan, 2015, mBio.

Development of a Local Perivascular Paclitaxel Delivery System for Hemodialysis Vascular Access Dysfunction: Polymer Preparation and in vitroActivity

S. Heffelfinger, G. Kasting, P. Desai, 2006, Blood Purification.

Steady‐State Pharmacokinetic Interactions of Darunavir/Ritonavir With Lipid‐Lowering Agent Rosuvastatin

C. Fichtenbaum, P. Desai, L. Sallans, 2012, Journal of clinical pharmacology.

Renal Function Descriptors in Neonates: Which Creatinine‐Based Formula Best Describes Vancomycin Clearance?

P. Desai, C. Stockmann, Catherine M Sherwin, 2016, Journal of clinical pharmacology.

Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor &bgr;-agonist being developed for the treatment of menopausal symptoms

P. Desai, R. Jackson, J. S. Greiwe, 2010, Menopause.

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats

B. Dasgupta, P. Desai, Priyanka Arora, 2018, Cancer Chemotherapy and Pharmacology.

Pre-clinical Pharmacological Evaluation of Letrozole as a Novel Treatment for Gliomas AUTHORS:

P. Desai, K. LaSance, X. Qi, 2015 .

Preclinical Pharmacological Evaluation of Letrozole as a Novel Treatment for Gliomas

P. Desai, K. LaSance, X. Qi, 2015, Molecular Cancer Therapeutics.

Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes.

K. Setchell, P. Desai, N. Brown, 2003, The Journal of nutrition.

Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.

K. Setchell, P. Desai, A. Cassidy, 2001, The Journal of nutrition.

Dipyridamole modulates multidrug resistance and intracellular as well as nuclear levels of doxorubicin in B16 melanoma cells

P. Desai, B. Damle, R. Sridhar, 2007, International journal of cancer.

Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes

D. Buckley, A. Buckley, P. Desai, 2004, Cancer Chemotherapy and Pharmacology.

Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis

P. Desai, G. Gudelsky, S. Apparaju, 2007, Cancer Chemotherapy and Pharmacology.

Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine.

G. Rosenthal, P. Desai, D. S. Swaffar, 1994, Cancer research.

Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.

K. Setchell, P. Desai, A. Brzezinski, 2005, Journal of agricultural and food chemistry.

Accelerated Communication INDUCTION OF CYTOCHROME P 450 3 A BY PACLITAXEL IN MICE : PIVOTAL ROLE OF THE NUCLEAR XENOBIOTIC RECEPTOR , PREGNANE X RECEPTOR

D. Buckley, A. Buckley, P. Desai, 2003 .

Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.

D. Buckley, A. Buckley, P. Desai, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Assessment of the Impact of CYP3A Polymorphisms on the Formation of α-Hydroxytamoxifen and N-Desmethyltamoxifen in Human Liver Microsomes

P. Desai, L. Sallans, Yingying Guo, 2012, Drug Metabolism and Disposition.

Assessment of the Impact of CYP 3 A Polymorphisms on the Formation of-Hydroxytamoxifen and N-Desmethyltamoxifen in Human Liver Microsomes

P. Desai, L. Sallans, Yingying Guo, 2012 .

Preparation, characterization, and preliminary application of fibrinogen-coated olive oil droplets for the targeted delivery of docetaxel to solid malignancies.

P. Desai, G. Retzinger, Abhijeet S Jakate, 2003, Cancer research.

Preparation, characterization, and preliminary application of fibrinogen-coated olive oil droplets for the targeted delivery of docetaxel to solid malignancies.

P. Desai, G. Retzinger, Abhijeet S Jakate, 2003, Cancer research.

Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma

B. Dasgupta, P. Desai, L. Sallans, 2022, Investigational New Drugs.

Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole

D. Plas, T. Wise-Draper, B. Dasgupta, 2022, Cancer Chemotherapy and Pharmacology.

Cytochrome P450 Enzymes And Transporters Induced By Anti-HIV Protease Inhibitors In Human Hepatocytes: Implications For Predicting Clinical Drug Interactions

N. Hariparsad, J. Unadkat, P. Desai, 2007 .

Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells

D. Buckley, A. Buckley, R. Sane, 2008, Drug Metabolism and Disposition.

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.

M. Tschöp, M. Thorner, B. Gaylinn, 2013, European journal of endocrinology.

Title: The Pharmacokinetics of Acyl, Desacyl and Total Ghrelin in Healthy Human

M. Tschöp, M. Thorner, B. Gaylinn, 2013 .

Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

V. Takiar, J. S. Gutkind, A. Molinolo, 2020, Cancer.

Effect of tamoxifen on mitoxantrone cytotoxicity in drug-sensitive and multidrug-resistant MCF-7 cells

R. Bhardwaj, P. Desai, B. Damle, 2004, Cancer Chemotherapy and Pharmacology.

Bioavailability of Nutrients and Other Bioactive Components from Dietary Supplements Bioavailability of Pure Isoﬂavones in Healthy Humans and Analysis of Commercial Soy Isoﬂavone Supplements 1,2

P. Desai, A. Cassidy, N. Brown, 2001 .

Fibrinogen-Coated Droplets of Olive Oil for Delivery of Docetaxel to a Fibrin(ogen)-Rich Ascites Form of a Murine Mammary Tumor

P. Desai, G. Retzinger, A. C. Retzinger, 2004, Clinical Cancer Research.

P1.14A Dose Escalation Single Arm Phase Ib Combination Study of BEZ235 with Everolimus in Patients with Advanced Solid Malignancies

G. Thomas, S. Kozma, T. Wise-Draper, 2015 .

Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration–Time Curve to the Minimum Inhibitory Concentration ≥400 Target

P. Desai, C. Stockmann, Catherine M Sherwin, 2015, Therapeutic drug monitoring.

Vascular access in hemodialysis: issues, management, and emerging concepts.

Prabir Roy-Chaudhury, S. Heffelfinger, P. Desai, 2005, Cardiology clinics.

Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain

P. Desai, M. Genter, G. Gudelsky, 2014, Drug delivery.

Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies.

P. Crooks, G. Rosenthal, W. John, 1995, Anti-cancer drugs.

Bioavailability Study of a 1200 mg Miconazole Nitrate Vaginal Ovule in Healthy Female Adults

P. Desai, R. E. Stevens, J. Konsil, 2002, Journal of clinical pharmacology.

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

M. Del Poeta, J. Haley, M. Cushion, 2018, Antimicrobial Agents and Chemotherapy.

Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC‐MS/MS cocktail assays and RT‐PCR

J. Unadkat, P. Desai, B. Kirby, 2012, Biopharmaceutics & drug disposition.

Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

D. Kalman, R. Buller, I. Damon, 2018, BMC Pharmacology and Toxicology.

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

A. Collier, E. Kharasch, D. Whittington, 2011, Drug Metabolism and Disposition.

Induction of CYP3A4 by Efavirenz in Primary Human Hepatocytes: Comparison With Rifampin and Phenobarbital

N. Hariparsad, D. Buckley, A. Buckley, 2004, Journal of clinical pharmacology.

Dose‐dependent Induction of Cytochrome P450 (CYP) 3A4 and Activation of Pregnane X Receptor by Topiramate

N. Hariparsad, D. Buckley, A. Buckley, 2003, Epilepsia.

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

M. Weirauch, C. Brennan, K. Komurov, 2021, Science Advances.

Methylphenidate and cocaine: A placebo-controlled drug interaction study

J. Harrer, P. Horn, B. Singal, 2006, Pharmacology Biochemistry and Behavior.

Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL). Lederle Cooperative Group.

P. Desai, E. Feldman, J. Moore, 1990, Leukemia.

In vitro methods in human drug biotransformation research: implications for cancer chemotherapy.

N. Hariparsad, S. Strom, R. Sane, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Tina N. Davis, Forrest M Kievit, Atique U. Ahmed, 2013 .

Novel Therapies for Hemodialysis Vascular Access Dysfunction: Fact or Fiction!

S. Heffelfinger, P. Desai, B. Kelly, 2004, Blood Purification.

Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery

P. Desai, M. Genter, C. Jung, 1999, European Journal of Drug Metabolism and Pharmacokinetics.

Pulsatile Cardiopulmonary Bypass: Failure to Influence Hemodynamics or Hormones

M. Blaufox, R. Frater, P. Desai, 1980, Circulation.

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

A. Collier, E. Kharasch, D. Whittington, 2011, Drug Metabolism And Disposition.

In vitro LC‐MS cocktail assays to simultaneously determine human cytochrome P450 activities

N. Hariparsad, J. Unadkat, P. Desai, 2007, Biopharmaceutics & drug disposition.

Reuse of Molecules for Glioblastoma Therapy

D. P. Pomeranz Krummel, J. Arbiser, Debanjan Bhattacharya, 2021, Pharmaceuticals.

Human liver microsomal metabolism of paclitaxel and drug interactions

P. Desai, S. Kouzi, J. Duan, 1998, European Journal of Drug Metabolism and Pharmacokinetics.

Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice.

P. Succop, G. Talaska, M. Al-Zoughool, 2006, Environmental toxicology and pharmacology.

Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles

B. Gray, H. Davis, P. Desai, 2020, Cells.

Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

P. Desai, S. Apparaju, Mary Beth Genter, 2002, Journal of biochemical and molecular toxicology.

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

George Thomas, Carol A. Mercer, John C. Morris, 2017, Targeted Oncology.

Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth

Haizhou Zhu, Aaron White, P. Desai, 2021, International journal of molecular sciences.

Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen.

L. Moore, D. Buckley, A. Buckley, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Safety, tolerability and pharmacokinetics of 2‐pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD

F. Sallee, P. Desai, L. Sallans, 2015, Biopharmaceutics & drug disposition.

Reversal of doxorubicin resistance in multidrug resistant melanoma cells in vitro and in vivo by dipyridamole.

P. Desai, B. Damle, J. Duan, 1997, Methods and findings in experimental and clinical pharmacology.

Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model.

S. Heffelfinger, G. Kasting, P. Desai, 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Hemodialysis Vascular Access Dysfunction: From Pathophysiology to Novel Therapies

A. Narayana, S. Heffelfinger, P. Desai, 2003, Blood Purification.

In vitro Paclitaxel and Radiation Effects on the Cell Types Responsible for Vascular Stenosis: A Preliminary Analysis

S. Heffelfinger, P. Desai, J. Zhang, 2006, Blood Purification.

The 12th International Conference on Continuous Renal Replacement Therapies (CRRT). March 7–10, 2007, San Diego, Calif.

S. Heffelfinger, P. Stenvinkel, Sawako Kato, 2007, Blood Purification.

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

B. Aronow, Jordon K. Wang, H. Versteeg, 2021, Frontiers in Oncology.

Hemodialysis vascular access dysfunction from basic biology to clinical intervention.

A. Narayana, S. Heffelfinger, P. Desai, 2002, Advances in renal replacement therapy.

Increased activity of CYP3A enzyme in primary cultures of rat hepatocytes treated with docetaxel: comparative evaluation with paclitaxel

P. Desai, M. Genter, S. Nallani, 2001, Cancer Chemotherapy and Pharmacology.