S. McLachlan

发表

The thyrotropin receptor in Graves' disease.

B. Rapoport, S. McLachlan, 2007, Thyroid : official journal of the American Thyroid Association.

Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.

R. Murali, P. Hubbard, B. Rapoport, 2015, Molecular endocrinology.

Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis.

V. Lagishetty, A. Misharin, S. McLachlan, 2010, Endocrinology.

D‐penicillamine‐associated myasthenia gravis: Immunological and electrophysiological studies

F. Mastaglia, S. McLachlan, P. Fawcett, 1982, Muscle & nerve.

Mechanisms of Autoantibody-Induced Pathology

A. Verkman, F. Leypoldt, J. Lindstrom, 2017, Front. Immunol..

Graves' hyperthyroidism and the hygiene hypothesis in a mouse model.

B. Rapoport, S. McLachlan, K. Oishi, 2004, Endocrinology.

Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells.

B. Rapoport, S. McLachlan, J. Jaume, 1994, Endocrinology.

The NOD Mouse Beyond Autoimmune Diabetes

S. McLachlan, Anne Aubin, S. Lesage, 2022, Frontiers in Immunology.

Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.

A. Misharin, B. Rapoport, S. McLachlan, 2009, Endocrinology.

The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease.

B. Rapoport, S. McLachlan, 1992, Endocrine reviews.

Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.

D. Russo, B. Rapoport, S. McLachlan, 1993, The Journal of clinical investigation.

The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors.

John C. Morris, B. Rapoport, S. McLachlan, 2003, Endocrinology.

Schistosoma mansoni and α-Galactosylceramide: Prophylactic Effect of Th1 Immune Suppression in a Mouse Model of Graves’ Hyperthyroidism

B. Rapoport, S. McLachlan, M. Niwa, 2004, The Journal of Immunology.

Combinatorial libraries: new insights into human organ-specific autoantibodies.

B. Rapoport, S. McLachlan, S. Portolano, 1995, Immunology today.

Thyrotropin Receptor Cleavage at Site 1 Does Not Involve a Specific Amino Acid Motif but Instead Depends on the Presence of the Unique, 50 Amino Acid Insertion*

K. Tanaka, B. Rapoport, S. McLachlan, 1998, The Journal of Biological Chemistry.

T Cells and the Autoimmune Response to the TSH Receptor

B. Rapoport, S. McLachlan, 2000 .

The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies

B. Rapoport, S. McLachlan, J. Jaume, 1998 .

Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fc epsilon receptor by a recombinant human autoantibody Fab converted to IgE.

S. Quaratino, M. Londei, B. Rapoport, 1996, Journal of immunological methods.

The greater glycan content of recombinant human thyroid peroxidase of mammalian than of insect cell origin facilitates purification to homogeneity of enzymatically protein remaining soluble at high concentration.

B. Rapoport, S. McLachlan, J. Guo, 1998, Endocrinology.

Update in thyroidology.

Y. Tomer, S. McLachlan, E. Ridgway, 2007, The Journal of clinical endocrinology and metabolism.

A Role for Satb1 in Thyroid Autoimmunity?

B. Rapoport, S. McLachlan, 2018, Thyroid : official journal of the American Thyroid Association.

High‐level intrathymic thyrotrophin receptor expression in thyroiditis‐prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies

B. Rapoport, S. McLachlan, S. Lesage, 2017, Clinical and experimental immunology.

Role of the transgenic human thyrotropin receptor A‐subunit in thyroiditis induced by A‐subunit immunization and regulatory T cell depletion

A. Misharin, B. Rapoport, S. McLachlan, 2008, Clinical and experimental immunology.

Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain*

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2010, The Journal of Biological Chemistry.

A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2009, Endocrinology.

The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2008, Molecular endocrinology.

Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2003, Endocrinology.

Is receptor cleavage into two subunits necessary for thyrotropin action?

B. Rapoport, S. McLachlan, Y. Nagayama, 1996, Biochemical and biophysical research communications.

Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease.

R. Alsabeh, B. Rapoport, S. McLachlan, 2000, Thyroid : official journal of the American Thyroid Association.

Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells.

B. Rapoport, S. McLachlan, J. Jaume, 1996, Endocrinology.

Variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2010, Thyroid : official journal of the American Thyroid Association.

Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity.

R. Murali, P. Hubbard, B. Rapoport, 2018, Thyroid : official journal of the American Thyroid Association.

A mouse TSH receptor A-subunit transgene expressed in thyroiditis-prone mice may provide insight into why Graves' disease only occurs in humans.

B. Rapoport, S. McLachlan, H. Aliesky, 2019, Thyroid : official journal of the American Thyroid Association.

Aberrant Iodine Autoregulation Induces Hypothyroidism in a Mouse Strain in the Absence of Thyroid Autoimmunity

B. Rapoport, S. McLachlan, H. Aliesky, 2017, Journal of the Endocrine Society.

The genetic basis of autoimmune thyroid disease: time to focus on chromosomal loci other than the major histocompatibility complex (HLA in man).

S. McLachlan, 1993, The Journal of clinical endocrinology and metabolism.

Discoveries in Thyroid Autoimmunity in the Past Century.

B. Rapoport, S. McLachlan, 2022, Thyroid : official journal of the American Thyroid Association.

To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex‐independent) NOD.H2h4 mice

B. Rapoport, S. McLachlan, H. Aliesky, 2019, Clinical and Experimental Immunology.

Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans

B. Rapoport, S. McLachlan, H. Aliesky, 2016, The Journal of Immunology.

Immunopathogenesis of Graves’ Disease

B. Rapoport, S. McLachlan, 2015 .

Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity.

C. Courtney, B. Rapoport, S. McLachlan, 2013, Endocrinology.

Review and hypothesis: does Graves' disease develop in non-human great apes?

K. Alpi, B. Rapoport, S. McLachlan, 2011, Thyroid : official journal of the American Thyroid Association.

Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2010, Endocrinology.

Autoimmune hypothyroidism: T cells caught in the act

B. Rapoport, S. McLachlan, 2004, Nature Medicine.

Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?

B. Rapoport, S. McLachlan, 2004, Thyroid : official journal of the American Thyroid Association.

Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

B. Rapoport, S. McLachlan, 2000, International reviews of immunology.

Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA.

B. Rapoport, S. McLachlan, H. Braley‐Mullen, 2002, Thyroid : official journal of the American Thyroid Association.

Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward

B. Rapoport, S. McLachlan, 2004, Clinical endocrinology.

Thyroid peroxidase as an autoantigen.

B. Rapoport, S. McLachlan, 2007, Thyroid : official journal of the American Thyroid Association.

Antibodies focused on the human autoantibody immunodominant region are induced by B lymphocytes that constitutively express thyroid peroxidase diverted to the major histocompatibility complex II pathway.

B. Rapoport, S. McLachlan, Jin Guo, 2006, Thyroid : official journal of the American Thyroid Association.

Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves’ hyperthyroidism in BALB/c mice

B. Rapoport, S. McLachlan, P. Pichurin, 2003, Clinical and experimental immunology.

Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen

B. Rapoport, S. McLachlan, P. Pichurin, 2003, Clinical and experimental immunology.

Thyroid Autoantibodies in Graves’ Disease

B. Rapoport, S. McLachlan, 2000 .

Autoimmune endocrinopathies 2 Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid disease

B. Rapoport, S. McLachlan, 1993 .

Progression of autoimmune damage in primary biliary cirrhosis: an immunohistochemical study.

A. Floreani, M. Bennett, S. McLachlan, 1989, Autoimmunity.

Thyrotropin Receptor Antibodies: Clinico‐Pathological Correlations

A. Weetman, S. McLachlan, B. Smith, 2008 .

An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2011, Thyroid : official journal of the American Thyroid Association.

Evidence that the complement control protein-epidermal growth factor-like domain of thyroid peroxidase lies on the fringe of the immunodominant region recognized by autoantibodies.

B. Rapoport, S. McLachlan, P. Carayon, 2002, Thyroid : official journal of the American Thyroid Association.

Human monoclonal autoantibodies to B-cell epitopes outside the thyroid peroxidase autoantibody immunodominant region.

B. Rapoport, S. McLachlan, P. Pichurin, 2001, Thyroid : official journal of the American Thyroid Association.

On the Functional Importance of Thyrotropin Receptor Intramolecular Cleavage1.

B. Rapoport, S. McLachlan, Kunihiko Tanaka, 1999, Endocrinology.

Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies.

B. Rapoport, S. McLachlan, J. Jaume, 1997, The Journal of clinical endocrinology and metabolism.

The epitopic "fingerprint" of thyroid peroxidase-specific Fab isolated from a patient's thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donor's serum.

B. Rapoport, S. McLachlan, J. Jaume, 1997, Clinical immunology and immunopathology.

Both the 5' and 3' noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells.

B. Rapoport, S. McLachlan, G. Chazenbalk, 1996, Endocrinology.

Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries.

B. Rapoport, S. McLachlan, J. Jaume, 1996, Autoimmunity.

Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type.

M. Prummel, B. Rapoport, S. McLachlan, 1995, Molecular immunology.

Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.

B. Rapoport, S. McLachlan, G. Chazenbalk, 1992, The Journal of clinical investigation.

A human-mouse hybridoma which secretes monoclonal thyroglobulin autoantibody with properties similar to those of the donor patient's serum autoantibody.

M. Devey, S. McLachlan, D. Phillips, 1989, Autoimmunity.

Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase.

S. McLachlan, D. Phillips, B. Smith, 1989, Clinical chemistry.

Severe combined immunodeficient (SCID) mice: a model for investigating human thyroid autoantibody synthesis

S. McLachlan, D. Phillips, C. Elson, 1991, Clinical and experimental immunology.

Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2012, PloS one.

Enhanced Response to Mouse Thyrotropin (TSH) Receptor Immunization in TSH Receptor Knockout Mice Short title: anti-mouse TSHR immune response in TSHR KO mice

B. Rapoport, S. McLachlan, N. Mitsutake, 2018 .

Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2010, Endocrinology.

TSH receptor‐adenovirus‐induced Graves’ hyperthyroidism is attenuated in both interferon‐γ and interleukin‐4 knockout mice; implications for the Th1/Th2 paradigm

Y. Kumazawa, B. Rapoport, S. McLachlan, 2004, Clinical and experimental immunology.

Thyrotrophin receptor‐specific memory T cell responses require normal B cells in a murine model of Graves’ disease

B. Rapoport, S. McLachlan, P. Pichurin, 2003, Clinical and experimental immunology.

A powerful role for B cells and autoantibodies in disease.

B. Rapoport, S. McLachlan, 2000, Immunology today.

Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites.

K. Tanaka, B. Rapoport, S. McLachlan, 1997, Endocrinology.

Carbimazole and the autoimmune response in Graves' disease.

A. McGregor, S. McLachlan, B. Smith, 1980, The New England journal of medicine.

Peri-tumor administration of controlled release anti-CTLA-4 synergizes with systemic anti-PD-1 to induce systemic antitumor immunity while sparing autoimmune toxicity

M. Roth, T. Zarembinski, B. Rapoport, 2020, Cancer Immunology, Immunotherapy.

Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.

A. Misharin, B. Rapoport, S. McLachlan, 2009, Endocrinology.

Thyroid peroxidase autoantibody epitopic ‘fingerprints’ in juvenile Hashimoto's thyroiditis: evidence for conservation over time and in families

B. Rapoport, N. Rose, S. McLachlan, 1996, Clinical and experimental immunology.

Does the autoantibody immunodominant region on thyroid peroxidase include amino acid residues 742-771?

B. Rapoport, S. McLachlan, Zhenggang Xiong, 2001, Thyroid : official journal of the American Thyroid Association.

Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies

B. Rapoport, S. McLachlan, S. Hee, 2017, Endocrinology.

Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice.

A. Misharin, B. Rapoport, S. McLachlan, 2009, Thyroid : official journal of the American Thyroid Association.

Immune Deviation Away from Th1 in Interferon-γ Knockout Mice Does Not Enhance TSH Receptor Antibody Production after Naked DNA Vaccination.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2002, Endocrinology.

Presence of Interleukin 4 or Interleukin 10, but Not Both Cytokines, in Pancreatic Tissue of Two Patients with Recently Diagnosed Diabetes Mellitus Type I

B. Rapoport, S. McLachlan, F. Dotta, 2000, Autoimmunity.

Prevention of Autoantibody-Mediated Graves’-Like Hyperthyroidism in Mice with IL-4, a Th2 Cytokine

H. Mizuguchi, T. Hayakawa, B. Rapoport, 2003, The Journal of Immunology.

Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2004, The Journal of clinical endocrinology and metabolism.

Does thyrotropin cleave its cognate receptor?

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2004, Endocrinology.

Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2003, Endocrinology.

Evidence for a simplified view of autoantibody interactions with the thyrotropin receptor.

B. Rapoport, S. McLachlan, Y. Nagayama, 2002, Thyroid : official journal of the American Thyroid Association.

Subunit Structure of Thyrotropin Receptors Expressed on the Cell Surface*

K. Tanaka, B. Rapoport, S. McLachlan, 1999, The Journal of Biological Chemistry.

Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites.

K. Tanaka, B. Rapoport, S. McLachlan, 1997, Endocrinology.

Monoclonal, human autoantibodies to the TSH receptor--the Holy Grail and why are we looking for it?

B. Rapoport, S. McLachlan, 1996, The Journal of clinical endocrinology and metabolism.

High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies.

B. Rapoport, S. McLachlan, S. Portolano, 1993, Journal of immunology.

"Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism.

B. Rapoport, S. McLachlan, P. Pichurin, 2004, Endocrinology.

Naked TSH Receptor DNA Vaccination: A TH1 T Cell Response in Which Interferon-γ Production, Rather than Antibody, Dominates the Immune Response in Mice.

B. Rapoport, S. McLachlan, P. Pichurin, 2001, Endocrinology.

Thyroid-stimulating autoantibody production in vitro

T. Davies, S. McLachlan, B. Smith, 1977, Nature.

Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes

T. Davies, S. McLachlan, B. Smith, 1978, Molecular and Cellular Endocrinology.

T cell regulation of thyroglobulin autoantibody IgG subclasses in Hashimoto's thyroiditis.

N. Forouhi, S. McLachlan, F. Clark, 1987, Clinical and experimental immunology.

Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.

S. McLachlan, F. Clark, G. Proud, 1985, Clinical and experimental immunology.

Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitogen.

J. Farndon, E. Young, S. McLachlan, 1983, Clinical and experimental immunology.

TSH RECEPTOR ANTIBODY SYNTHESIS BY THYROID LYMPHOCYTES

S. McLachlan, F. Clark, B. Smith, 1986, Clinical endocrinology.

Whither TSH receptor blocking antibodies in the treatment of Graves' disease?

B. Rapoport, S. McLachlan, 2008, Thyroid : official journal of the American Thyroid Association.

Human Autoantibodies Modulate the T Cell Epitope Repertoire but Fail to Unmask a Pathogenic Cryptic Epitope1

S. Quaratino, M. Londei, B. Rapoport, 2005, The Journal of Immunology.

This information is current as Pathogenic Cryptic Epitope Epitope Repertoire but Fail to Unmask a Human Autoantibodies Modulate the T Cell

S. Quaratino, M. Londei, B. Rapoport, 2004 .

Surrogate thyroglobulin receptors and T cell proliferation in Hashimoto's thyroiditis.

S. McLachlan, D. Phillips, T. Hoy, 1992, Thyroid : official journal of the American Thyroid Association.

T Cell Epitopes and Thyroid Peroxidase

B. Rapoport, S. McLachlan, D. Phillips, 1991 .

Thyroid autoantigens and human T cell responses

B. Rapoport, S. McLachlan, J. Goodacre, 1990, Clinical and experimental immunology.

Thyroid autoantigens andhumanT cell responses

B. Rapoport, S. McLachlan, D. Phillips, 1990 .

Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen.

T. Davies, R. Marians, B. Rapoport, 2004, Endocrinology.

Atypical T lymphoproliferative disorder demonstrating in vitro suppressor and helper characteristics

Jennifer Hayes Clark, A. McGregor, S. McLachlan, 1982, British journal of haematology.

Evidence that the thyrotropin receptor protease is membrane-associated and is not within lipid rafts.

B. Rapoport, S. McLachlan, F. Latrofa, 2004, Thyroid : official journal of the American Thyroid Association.

Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2015, Endocrinology.

Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2011, Molecular endocrinology.

Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2007, Endocrinology.

Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies.

B. Rapoport, S. McLachlan, P. Pichurin, 2003, The Journal of clinical endocrinology and metabolism.

Insight into screening immunoglobulin gene combinatorial libraries in a phage display vector: a tale of two antibodies.

B. Rapoport, S. McLachlan, G. Chazenbalk, 1997, Autoimmunity.

Gene expression profiles differ markedly in mouse strains that are (or are not) susceptible to hyperthyroidism induced using thyrotropin receptor-expressing adenovirus.

Charles Wang, B. Rapoport, S. McLachlan, 2005, Thyroid : official journal of the American Thyroid Association.

Interactions between the mannose receptor and thyroid autoantigens

B. Rapoport, S. McLachlan, P. Pichurin, 2005, Clinical and experimental immunology.

Role of self-tolerance and chronic stimulation in the long-term persistence of adenovirus-induced thyrotropin receptor antibodies in wild-type and transgenic mice.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2012, Thyroid : official journal of the American Thyroid Association.

Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue.

M. Prummel, B. Rapoport, S. McLachlan, 1994, The Journal of clinical endocrinology and metabolism.

Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2009, The Journal of clinical endocrinology and metabolism.

Reflections on Thyroid Autoimmunity: A Personal Overview from the Past into the Future

B. Rapoport, S. McLachlan, 2018, Hormone and Metabolic Research.

The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells.

A. Misharin, B. Rapoport, S. McLachlan, 2007, Endocrinology.

Cytokine profiles of in vivo activated thyroid-infiltrating T cells cloned in the presence or absence of interleukin 4.

B. Rapoport, S. McLachlan, J. Guo, 1997, Autoimmunity.

On the functional importance of thyrotropin receptor intramolecular cleavage.

K. Tanaka, B. Rapoport, S. McLachlan, 1999, Endocrinology.

Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves' ophthalmopathy.

M. Prummel, B. Rapoport, S. McLachlan, 1994, The Journal of clinical endocrinology and metabolism.

Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co‐expressing MHC class II and thyroid autoantigens

K. Tanaka, B. Rapoport, S. McLachlan, 2000, Clinical and experimental immunology.

Autoantibodies to the thyrotropin receptor.

S. McLachlan, B. Rees Smith, J. Furmaniak, 1988, Endocrine reviews.

TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.

B. Rapoport, S. McLachlan, 2016, Endocrine reviews.

Graves'-Like Hyperthyroidism in Mice with Prevention of Autoantibody-Mediated

H. Mizuguchi, T. Hayakawa, B. Rapoport, 2003 .

The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit

B. Rapoport, S. McLachlan, Kunihiko Tanaka, 1999, Molecular and Cellular Endocrinology.

Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro.

B. Rapoport, S. McLachlan, J. Guo, 1999, Autoimmunity.

Engineering the Human Thyrotropin Receptor Ectodomain from a Non-secreted Form to a Secreted, Highly Immunoreactive Glycoprotein That Neutralizes Autoantibodies in Graves’ Patients’ Sera*

B. Rapoport, S. McLachlan, J. Jaume, 1997, The Journal of Biological Chemistry.

Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: analysis by flow cytometry.

B. Rapoport, S. McLachlan, J. Jaume, 1997, The Journal of clinical endocrinology and metabolism.

Critical relationship between autoantibody recognition and thyrotropin receptor maturation as reflected in the acquisition of complex carbohydrate.

B. Rapoport, S. McLachlan, G. Chazenbalk, 1996, The Journal of clinical endocrinology and metabolism.

Heterogeneity of organ-specific autoimmune diseases.

B. Rapoport, S. McLachlan, 1995, Immunology today.

Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response

B. Rapoport, S. McLachlan, 1995, Clinical and experimental immunology.

Profile of lambda light chain variable region genes in Graves' orbital tissue.

M. Prummel, B. Rapoport, S. McLachlan, 1994, Molecular immunology.

Human monoclonal thyroglobulin autoantibodies of high affinity. I. Production, characterisation and interaction with murine monoclonal thyroglobulin antibodies.

S. McLachlan, B. Rees Smith, N. Fukuma, 1991, Autoimmunity.

Cytokines, thyroid autoantibody synthesis and thyroid cell survival in culture

A. Cooke, S. McLachlan, F. Clark, 1990, Clinical and experimental immunology.

The TSH receptor: structure and interaction with autoantibodies in thyroid disease.

S. McLachlan, B. Rees Smith, J. Furmaniak, 1987, Acta endocrinologica. Supplementum.

IgG SUBCLASS DISTRIBUTION OF THYROID AUTOANTIBODIES: A ‘FINGERPRINT’ OF AN INDIVIDUAL'S RESPONSE TO THYROGLOBULIN AND THYROID MICROSOMAL ANTIGEN

E. Young, S. McLachlan, U. Feldt-Rasmussen, 1987, Clinical endocrinology.

Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto thyroid glands.

S. McLachlan, F. Clark, A. Dickinson, 1986, Clinical and experimental immunology.

The effect of carbimazole on thyroid autoantibody synthesis by thyroid lymphocytes.

E. Young, S. McLachlan, F. Clark, 1985, The Journal of clinical endocrinology and metabolism.

EFFECT OF IRRADIATION ON THYROID-AUTOANTIBODY PRODUCTION

A. McGregor, S. McLachlan, R. Hall, 1979, The Lancet.

THYROID-AUTOANTIBODY SYNTHESIS BY HASHIMOTO THYROID LYMPHOCYTES

A. McGregor, S. McLachlan, B. Smith, 1979, The Lancet.

A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies.

B. Rapoport, S. McLachlan, P. Pichurin, 2001, The Journal of clinical endocrinology and metabolism.

Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves’ disease

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2004, Clinical and experimental immunology.

HLA-DR3 transgenic mice immunized with adenovirus encoding the thyrotropin receptor: T cell epitopes and functional analysis of the CD40 Graves' polymorphism.

B. Rapoport, S. McLachlan, C. David, 2006, Thyroid : official journal of the American Thyroid Association.

Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2006, Thyroid : official journal of the American Thyroid Association.

Human thyroperoxidase folds in one complex B-cell immunodominant region.

B. Rapoport, S. McLachlan, P. Carayon, 2002, Biochemical and biophysical research communications.

Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease

H. Chapman, B. Rapoport, S. McLachlan, 2005, Immunology.

Naked deoxyribonucleic acid vaccination induces recognition of diverse thyroid peroxidase T cell epitopes.

B. Rapoport, S. McLachlan, P. Pichurin, 2004, Endocrinology.

Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa.

B. Rapoport, S. McLachlan, 2013, Thyroid : official journal of the American Thyroid Association.

Studies of thyroglobulin autoantibody synthesis using a micro-ELISA assay.

S. Clark, S. McLachlan, F. Clark, 1982, Immunology letters.

Use of Plaque Assays to Study Thyroglobulin Autoantibody Synthesis by Human Peripheral Blood Lymphocytes

A. Weetman, S. McLachlan, R. Hall, 1981, Scandinavian journal of immunology.

In vitro studies on the control of thyroid autoantibody synthesis.

A. McGregor, S. McLachlan, B. Smith, 1980, Journal of clinical & laboratory immunology.

Thyroglobulin and microsomal autoantibody production by cultures of Hashimoto peripheral blood lymphocytes.

A. McGregor, S. McLachlan, F. Clark, 1979, Immunology.

Thyroid autoimmunity.

B. Rapoport, S. McLachlan, 2001, The Journal of clinical investigation.

Graves' Disease

B. Rapoport, S. McLachlan, 1895, Endocrine Updates.

CYCLOSPORIN A AND EPSTEIN-BARR VIRUS

S. McLachlan, A. Bird, 1980, The Lancet.

Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.

B. Rapoport, S. McLachlan, 2014, Endocrine reviews.

Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase.

E. Young, S. McLachlan, D. Phillips, 1990, The Journal of clinical endocrinology and metabolism.

Autoantibodies in the sera of patients with autoimmune thyroid disease recognize a secreted form of human thyroid peroxidase generated in a baculovirus system

D. Foti, B. Rapoport, S. McLachlan, 1993, Molecular and Cellular Endocrinology.

Thyroid peroxidase autoantibody fingerprints. II. A longitudinal study in postpartum thyroiditis.

B. Rapoport, S. McLachlan, J. Jaume, 1995, The Journal of clinical endocrinology and metabolism.

Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein–Barr virus-induced B-cell lines

S. McLachlan, S. Britton, A. Bird, 1981, Nature.

Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice

B. Rapoport, S. McLachlan, H. Aliesky, 2019, The Journal of Immunology.

Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice

B. Rapoport, S. McLachlan, S. Lesage, 2017, Endocrinology.

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-Ak NOD mice

B. Rapoport, S. McLachlan, G. Chabot-Roy, 2015, Genes and Immunity.

A transgenic mouse that spontaneously develops pathogenic TSH receptor antibodies will facilitate study of antigen-specific immunotherapy for human Graves’ disease

B. Rapoport, S. McLachlan, 2019, Endocrine.

A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves’ Disease Only Occurs in Humans

B. Rapoport, S. McLachlan, H. Aliesky, 2019 .

Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

B. Rapoport, S. McLachlan, 2017, Front. Immunol..

TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.

B. Rapoport, S. McLachlan, 2016, Endocrine reviews.

A Unique Mouse Strain That Develops Spontaneous, Iodine-Accelerated, Pathogenic Antibodies to the Human Thyrotrophin Receptor

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2015, The Journal of Immunology.

The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.

Yuji Nagayama, B. Rapoport, S. McLachlan, 2003, The Journal of clinical investigation.

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2002, The Journal of clinical investigation.

A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies.

B. Rapoport, S. McLachlan, J. Jaume, 1999, The Journal of clinical endocrinology and metabolism.

Immunoglobujin A in Graves’ orbital tissue: Deoxyribonucleic acid amplification by polymerase chain reaction

M. Prummel, B. Rapoport, S. McLachlan, 1994 .

LATERAL ROOT ELONGATION IN VICIA FABA L.: CHANGES IN LABELLING INDEX IN THE CAP, EPIDERMIS, CORTEX AND STELE

R. Macleod, S. McLachlan, 1974 .

Lateral root elongation inVicia faba L.

R. Macleod, S. McLachlan, 2005, Protoplasma.

LATERAL ROOT ELONGATION IN VICIA FABA L: THE PLANES OF CELL DIVISION IN THE EPIDERMIS, CORTEX AND STELE

R. Macleod, S. McLachlan, 1975 .

Lateral root elongation in Vicia faba L. Changes in mitotic index in the cap, epidermis, cortex, and stele.

R. Macleod, S. McLachlan, 1974, Protoplasma.

The development of large primordia inVicia faba L.: Some cytological and anatomical changes

R. Macleod, S. McLachlan, 1975, Protoplasma.

Geographical distribution of subclinical autoimmune thyroid disease in Britain: a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase.

S. McLachlan, D. Phillips, B. Smith, 1990, Acta endocrinologica.

Thyroid peroxidase and the induction of autoimmune thyroid disease

R. K. Jordan, S. McLachlan, F. Clark, 1990, Clinical and experimental immunology.

Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice.

Robert W. Williams, B. Rapoport, S. McLachlan, 2006, Endocrinology.

Targeted Expression of the Human Thyrotropin Receptor A-Subunit to the Mouse Thyroid: Insight into Overcoming the Lack of Response to A-Subunit Adenovirus Immunization1

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2006, Journal of Immunology.

Immunization Lack of Response to A-Subunit Adenovirus Mouse Thyroid : Insight into Overcoming the Thyrotropin Receptor A-Subunit to the Targeted Expression of the Human and

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2005 .

Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease.

B. Rapoport, S. McLachlan, J. Jaume, 1999, The Journal of clinical endocrinology and metabolism.

Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes.

M. Phillips, B. Rapoport, S. McLachlan, 2004, The Journal of clinical endocrinology and metabolism.

Insight into Graves' hyperthyroidism from animal models.

B. Rapoport, S. McLachlan, Y. Nagayama, 2005, Endocrine reviews.

Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2003, Thyroid : official journal of the American Thyroid Association.

A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves' hyperthyroidism.

B. Rapoport, S. McLachlan, M. Niwa, 2003, Thyroid : official journal of the American Thyroid Association.

The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies.

B. Rapoport, S. McLachlan, J. Jaume, 1998, Endocrine reviews.

Thyroid Peroxidase Autoantibodies

B. Rapoport, S. McLachlan, 1996 .

Human monoclonal autoantibodies against the immunodominant region on thyroid peroxidase: lack of cross-reactivity with related peroxidases or thyroglobulin and inability to inhibit thyroid peroxidase enzymatic activity.

T. Nishikawa, B. Rapoport, S. McLachlan, 1995, The Journal of clinical endocrinology and metabolism.

Evidence for a potential common T-cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease.

B. Rapoport, S. McLachlan, Basil Rapoport, 1989, Autoimmunity.

Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease.

Yuji Nagayama, B. Rapoport, S. McLachlan, 2004, Endocrinology.

Enrichment and depletion of thyroglobulin autoantibody synthesizing lymphocytes.

S. McLachlan, A. Dickinson, B. Rees Smith, 1983, Clinical and experimental immunology.

Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. II. Effect of thyroglobulin on thyroglobulin antibody synthesis.

J. Fawcett, S. McLachlan, B. Smith, 1983, Clinical and experimental immunology.

An enzyme-linked immunoassay for thyroid microsomal antibodies.

S. McLachlan, B. Smith, J. Matheson, 1982, Journal of immunological methods.

The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses.

S. McLachlan, A. Parkes, B. Rees Smith, 1984, Clinical and experimental immunology.

The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three-dimensional model.

T. Nishikawa, B. Rapoport, S. McLachlan, 1996, Endocrinology.

Human monoclonal thyroglobulin autoantibodies of high affinity. II. Interaction between thyroglobulin and thyroglobulin autoantibodies of different IgG subclasses.

S. McLachlan, B. Rees Smith, N. Fukuma, 1991, Autoimmunity.

Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2004, Endocrinology.

Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain

B. Rapoport, S. McLachlan, H. Aliesky, 2018, European Thyroid Journal.

Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization.

V. Lagishetty, A. Misharin, B. Rapoport, 2009, Endocrinology.

Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library.

A. Vincent, J. Newsom-Davis, B. Rapoport, 1997, International immunology.

Graves' hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease.

B. Rapoport, S. McLachlan, 2014, The Journal of clinical endocrinology and metabolism.

IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION GENES CONTRIBUTE TO THE INDUCTION OF THYROID STIMULATING ANTIBODIES IN RECOMBINANT INBRED MICE

Robert W. Williams, B. Rapoport, S. McLachlan, 2010, Genes and Immunity.

Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".

D. Pauls, B. Rapoport, J. Mckenzie, 1999, The Journal of clinical endocrinology and metabolism.

HLA CLASS II DNA GENOTYPES IN GRAVES' DISEASE: CLUES TO INHERITANCE OF THE HLA‐LINKED COMPONENT OF SUSCEPTIBILITY

E. Young, S. McLachlan, J. A. Franklyn, 1988, Clinical endocrinology.

Endocrine ophthalmopathy: a re-evaluation of the association with thyroid autoantibodies.

B. Rapoport, S. McLachlan, R. Bahn, 1992, Autoimmunity.

WHY THYROID IS MAJOR SITE OF THYROID AUTOANTIBODY SYNTHESIS IN AUTOIMMUNE THYROID DISEASE

G. Canonica, S. McLachlan, B. Smith, 1983, The Lancet.

Evidence that Cleavage of the Thyrotropin Receptor Involves a" Molecular Ruler" Mechanism: Deletion of Amino Acid Residues 305-320 Causes a Spatial Shift in Cleavage Site 1 Independent of Amino Acid Motif.

B. Rapoport, S. McLachlan, Kunihiko Tanaka, 2000, Endocrinology.

Thyroid peroxidase autoantibodies of IgE class in thyroid autoimmunity.

B. Rapoport, S. McLachlan, J. Guo, 1997, Clinical immunology and immunopathology.

Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2005, Endocrinology.

Recombinant thyroid peroxidase autoantibodies can be used for epitopic "fingerprinting" of thyroid peroxidase autoantibodies in the sera of individual patients.

M. Prummel, T. Nishikawa, B. Rapoport, 1994, The Journal of clinical endocrinology and metabolism.

The thyroid microenvironment in autoimmune thyroid disease: effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells.

S. McLachlan, F. Clark, B. Smith, 1987, Acta endocrinologica. Supplementum.

Association between thyroid microsomal antibodies of subclass IgG-1 and hypothyroidism in autoimmune postpartum thyroiditis.

P. M. Thompson, S. McLachlan, R. Jansson, 1986, Clinical and experimental immunology.

Structural Studies of Human Autoantibodies

E. Padlan, B. Rapoport, S. McLachlan, 1996, The Journal of Biological Chemistry.

Isolation and characterization of a monoclonal human thyroidperoxidase autoantibody of lambda light chain type

M. Prummel, B. Rapoport, S. McLachlan, 1994, Molecular and Cellular Endocrinology.

A Full Biological Response to Autoantibodies in Graves' Disease Requires a Disulfide-bonded Loop in the Thyrotropin Receptor N Terminus Homologous to a Laminin Epidermal Growth Factor-like Domain*

Kunihiko Tanaka, B. Rapoport, S. McLachlan, 2001, The Journal of Biological Chemistry.

A direct binding assay for thyrotropin receptor autoantibodies.

B. Rapoport, S. McLachlan, P. Pichurin, 1999, Thyroid : official journal of the American Thyroid Association.

The human thyrotropin (TSH) receptor in a TSH binding inhibition assay for TSH receptor autoantibodies.

B. Rapoport, S. McLachlan, J. Jaume, 1997, The Journal of clinical endocrinology and metabolism.

Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women.

T. Nishikawa, B. Rapoport, S. McLachlan, 1995, The Journal of clinical endocrinology and metabolism.

Comparison of recombinant human thyrotropin receptors versus porcine thyrotropin receptors in the thyrotropin binding inhibition assay for thyrotropin receptor autoantibodies.

B. Rapoport, S. McLachlan, I. Morimoto, 1999, Thyroid : official journal of the American Thyroid Association.

Thyroid peroxidase autoantibody epitopes revisited *

B. Rapoport, S. McLachlan, 2008, Clinical Endocrinology.

The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope.

B. Rapoport, S. McLachlan, G. Chazenbalk, 1993, The Journal of clinical endocrinology and metabolism.

Thyrotropin receptor autoantibodies recognizing two different epitopes on the TSH receptor: lack of relationship to patient age, sex, and ophthalmopathy.

M. Prummel, W. Wiersinga, B. Rapoport, 1993, Thyroid : official journal of the American Thyroid Association.

Recommendations for a Revised Nomenclature of Thyroid Autoantigens and Autoantibodies

S. McLachlan, 1991, Clinical Endocrinology.

Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms.

R. Murali, B. Rapoport, S. McLachlan, 2013, Endocrinology.

The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2012, Endocrinology.

Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2012, PloS one.

Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2011, Thyroid : official journal of the American Thyroid Association.

Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2008, Endocrinology.

Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2010, Endocrinology.

Exclusion of two major areas on thyroid peroxidase from the immunodominant region containing the conformational epitopes recognized by human autoantibodies.

T. Nishikawa, B. Rapoport, S. McLachlan, 1994, The Journal of clinical endocrinology and metabolism.

An N-Linked Glycosylation Motif from the Noncleaving Luteinizing Hormone Receptor Substituted for the Homologous Region (Gly367 to Glu369) of the Thyrotropin Receptor Prevents Cleavage at Its Second, Downstream Site*

B. Rapoport, S. McLachlan, Kunihiko Tanaka, 1997, The Journal of Biological Chemistry.

Search for the Autoantibody Immunodominant Region on Thyroid Peroxidase: Epitopic Footprinting with a Human Monoclonal Autoantibody Locates a Facet on the Native Antigen Containing a Highly Conformational Epitope1

B. Rapoport, S. McLachlan, Jin Guo, 2001, The Journal of Immunology.

A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library.

B. Rapoport, S. McLachlan, Y. Nagayama, 1991, Biochemical and biophysical research communications.

Graves' disease: the T(H)1/T(H)2 paradigm versus the "hygiene" hypothesis and defective immune regulation.

S. McLachlan, 2003, Thyroid : official journal of the American Thyroid Association.

Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function.

Robert W. Williams, B. Rapoport, S. McLachlan, 2013, Thyroid : official journal of the American Thyroid Association.

Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface.

K. Wawrowsky, B. Rapoport, S. McLachlan, 2006, Endocrinology.

Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit.

B. Rapoport, S. McLachlan, F. Latrofa, 2004, The Journal of clinical endocrinology and metabolism.

Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2005, Endocrinology.

Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves' disease model.

B. Rapoport, S. McLachlan, Chun-Rong Chen, 2012, Thyroid : official journal of the American Thyroid Association.

Kinetics of immunoglobulin production by cultured human peripheral blood lymphocytes.

S. McLachlan, R. Hall, B. Smith, 1978, Journal of immunological methods.

Defective in vitro immunoglobulin production in response to pokeweed mitogen in patients with Hodgkin's disease pretreatment and in remission.

S. McLachlan, A. Dickinson, S. Proctor, 1986, Clinical immunology and immunopathology.

A technique for the isolation and mitogenic activation of thyroglobulin-specific human B lymphocytes.

S. McLachlan, F. Clark, B. Rees Smith, 1986, Immunology letters.

Immunoglobulins in CAPD

D. Kerr, S. McLachlan, T. Goodship, 1986 .

CHARACTERISATION OF THYROID AUTOANTIBODY SYNTHESIZING CELLS IN GRAVES' & HASHIMOTO'S DISEASES

E. Young, S. McLachlan, F. Clark, 1985 .

Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan

S. Melmed, D. Hasselschwert, S. McLachlan, 2021, Journal of the Endocrine Society.

Reassessment of the location of the thyrotropin receptor 50 amino acid "insertion" provides evidence in favor of a second downstream cleavage site.

K. Tanaka, B. Rapoport, S. McLachlan, 2001, Thyroid : official journal of the American Thyroid Association.

Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor.

B. Rapoport, S. McLachlan, G. Chazenbalk, 2001, European journal of biochemistry.

Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin.

M. Devey, E. Young, S. McLachlan, 1989, Clinical and experimental immunology.

Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease.

M. Upadhyaya, S. McLachlan, D. Phillips, 1991, The Journal of clinical endocrinology and metabolism.

Sex, genetics, and the control of thyroxine and thyrotropin in mice.

Robert W. Williams, B. Rapoport, S. McLachlan, 2014, Thyroid : official journal of the American Thyroid Association.

The influence of propranolol on the thyrotropin receptor.

T. Davies, S. McLachlan, B. Smith, 1977, Endocrinology.

A Search for Linkage Between Phenylthiocarbamide Tasting, the Kell Blood Group Locus and Autoantibodies to Thyroglobulin and Thyroid Peroxidase

S. McLachlan, D. Phillips, B. Smith, 1991 .

Thyroid autoantibody synthesis by lymphocytes from different lymphoid organs: fractionation of B cells on density gradients.

E. Young, S. McLachlan, A. Dickinson, 1985, Immunology.

Prescience of a surgeon in 1980.

S. McLachlan, 2013, Thyroid : official journal of the American Thyroid Association.

Potential role of PHA in producing human monoclonal thyroid autoantibodies of different subclasses.

S. McLachlan, D. Phillips, B. Smith, 1990, Human antibodies and hybridomas.

Exceptional Hyperthyroidism and a Role for both Major Histocompatibility Class I and Class II Genes in a Murine Model of Graves' Disease

Robert W. Williams, B. Rapoport, S. McLachlan, 2011, PloS one.

Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin.

M. Devey, S. McLachlan, B. Smith, 1989, Immunology.

Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice.

Robert W. Williams, B. Rapoport, S. McLachlan, 2008, Endocrinology.

IgA class thyroid peroxidase and thyroglobulin autoantibodies in Graves' disease: association with the male sex.

M. Prummel, W. Wiersinga, B. Rapoport, 1993, Autoimmunity.

Role of MHC class I expression and CD8+ T cells in the evolution of iodine‐induced thyroiditis in NOD‐H2h4 and NOD mice

A. Cooke, B. Rapoport, S. McLachlan, 2000, European journal of immunology.

Production of Fab Fragments against the Human Acetylcholine Receptor from Myasthenia Gravis Thymus Lambda and Kappa Phage Libraries a

A. Vincent, J. Newsom-Davis, B. Rapoport, 1998, Annals of the New York Academy of Sciences.

Immunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred mice.

Robert W. Williams, B. Rapoport, S. McLachlan, 2014, Endocrinology.

Intrathyroidal Lymphocytes, Thyroid Autoantibodies and Thyroid Destruction

E. Young, S. McLachlan, P. Clark, 1987 .

Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.

Robert W. Williams, Lu Lu, B. Rapoport, 2011, Endocrinology.

Directed Mutagenesis in Region 713-720 of Human Thyroperoxidase Assigns 713KFPED717 Residues as Being Involved in the B Domain of the Discontinuous Immunodominant Region Recognized by Human Autoantibodies*

Jin Guo, F. Roquet, B. Rapoport, 2004, Journal of Biological Chemistry.

The IgG Subclass Distribution of Thyroglobulin Antibody Synthesized in Culture

P. M. Thompson, S. McLachlan, A. Parkes, 1983, Scandinavian journal of immunology.

Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)‐specific B cells in mice injected with fibroblasts co‐expressing TPO and MHC class II

B. Rapoport, S. McLachlan, Yan Wang, 2000, Clinical and experimental immunology.

Localization of the Thyroid Peroxidase Autoantibody Immunodominant Region to a Junctional Region Containing Portions of the Domains Homologous to Complement Control Protein and Myeloperoxidase*

B. Rapoport, S. McLachlan, Jin Guo, 2002, Journal of Biological Chemistry.

Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region

Rapoport, B. Rapoport, S. McLachlan, 1999, Clinical and experimental immunology.

Recombinant thyroid peroxidase-specific autoantibodies. II. Role of individual heavy and light chains in determining epitope recognition.

T. Nishikawa, B. Rapoport, S. McLachlan, 1994, Endocrinology.

Acetylcholine receptor antibody synthesis in lymphocyte cultures.

S. McLachlan, G. Venables, B. Smith, 1981, Journal of clinical & laboratory immunology.

Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity.

C. Courtney, B. Rapoport, S. McLachlan, 2013, Endocrinology.

Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease.

B. Rapoport, S. McLachlan, H. Aliesky, 2015, The Journal of clinical endocrinology and metabolism.

This information is current as Receptor Antibodies to the Human Thyrotrophin Spontaneous , Iodine-Accelerated , Pathogenic A Unique Mouse Strain That Develops

B. Rapoport, S. McLachlan, H. Aliesky, 2015 .

Reflections on Thyroid Autoimmunity: A Personal Overview from the Past into the Future

B. Rapoport, S. McLachlan, 2018, Hormone and Metabolic Research.

IgG antibody and delayed-type hypersensitivity responses in nude mice grafted with thymic epithelium.

R. K. Jordan, C. Chapman, B. Loveland, 1990, Immunology.

IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION GENES CONTRIBUTE TO THE INDUCTION OF THYROID STIMULATING ANTIBODIES IN RECOMBINANT INBRED MICE

Robert W. Williams, B. Rapoport, S. McLachlan, 2010, Genes and Immunity.

Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.

Robert W. Williams, Lu Lu, B. Rapoport, 2011, Endocrinology.

Relationship between autoantibody epitopic recognition and immunoglobulin gene usage

Rapoport, B. Rapoport, B. Czarnocka, 1998, Clinical and experimental immunology.

Lack of female bias in a mouse model of autoimmune hyperthyroidism (Graves' disease).

B. Rapoport, S. McLachlan, J. Jaume, 1999, Autoimmunity.