M. Truppo

发表

Rapid screening and scale-up of transaminase catalysed reactions.

Jeffrey C. Moore, M. Truppo, J. Rozzell, 2009, Organic & biomolecular chemistry.

A generic platform for the immobilisation of engineered biocatalysts

Nicholas J. Turner, Paul N. Devine, Matthew D. Truppo, 2019, Tetrahedron.

Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases

Nicholas J. Turner, Matthew D. Truppo, J. David Rozzell, 2010 .

A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases.

M. Truppo, N. Turner, R. Lloyd, 2011, Chemical communications.

Micro-scale process development of transaminase catalysed reactions.

M. Truppo, N. Turner, 2010, Organic & biomolecular chemistry.

Rapid determination of both the activity and enantioselectivity of ketoreductases.

M. Truppo, N. Turner, F. Escalettes, 2008, Angewandte Chemie.

Production of (S)-γ-fluoroleucine ethyl ester by enzyme mediated dynamic kinetic resolution: Comparison of batch and fed batch stirred tank processes to a packed bed column reactor

Paul N. Devine, Jeffrey C. Moore, M. Truppo, 2008 .

An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme‐Mediated Dynamic Kinetic Resolution

M. Truppo, 2010 .

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Shane T. Grosser, Deeptak Verma, Edward C. Sherer, 2019, Science.

The importance of synthetic chemistry in the pharmaceutical industry

P. Coleman, J. Alvarez, M. Truppo, 2019, Science.

Biocatalysis in the Fine Chemical and Pharmaceutical Industries

Joseph P. Adams, Peter W. Sutton, Roger M. Howard, 2012 .

Industrial Hydrolases and Related Enzymes

Roger M. Howard, Gary Francis GlaxoSmithKline Breen, Rebecca E. Meadows, 2012 .

8.07 Reduction of C O to CHOH Using Enzymes and Microorganisms

M. Truppo, 2014 .

Effective synthesis of (S)-3,5-bistrifluoromethylphenyl ethanol by asymmetric enzymatic reduction

Jeffrey C. Moore, M. Truppo, D. Pollard, 2006 .

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

M. Truppo, J. Janey, J. Arredondo, 2014 .

A Biocatalytic/Reductive Etherification Approach to Substituted Piperidinyl Ethers.

M. Truppo, J. Janey, J. Arredondo, 2014 .

Enzyme-catalyzed enantioselective diaryl ketone reductions.

Paul N. Devine, M. Truppo, D. Pollard, 2007, Organic letters.

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

M. Truppo, T. Moody, Paul P. Kelly, 2016 .

Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir.

Rebecca T. Ruck, M. Truppo, Hongming Li, 2017, Organic letters.

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase.

Nicholas J Turner, Matthew D Truppo, M. Truppo, 2009, Chemical communications.

7.4 Cofactor Recycling for Enzyme Catalyzed Processes

M. Truppo, M. D. Truppo, 2012 .

2. Reductive Amination

G. Huisman, A. Chadha, Jeffrey C. Moore, 2012 .

Extending the application of biocatalysis to meet the challenges of drug development

Rajesh Kumar, Matthew P. Thompson, Paul N. Devine, 2018, Nature Reviews Chemistry.

Biocatalytic Routes to Nonracemic Chiral Amines

Nicholas J. Turner, Matthew D. Truppo, M. Truppo, 2010 .

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

Matthew D. Truppo, M. Truppo, Hongmei Li, 2015 .

Biocatalysis in the Pharmaceutical Industry: The Need for Speed.

Matthew D Truppo, M. Truppo, 2017, ACS medicinal chemistry letters.

Copper-catalyzed synthesis of enantioenriched tetraarylethanes.

Paul N. Devine, M. Truppo, Mirlinda Biba, 2008, Organic Letters.

A novel resolution of a pharmaceutically important bridged bicyclic ketone intermediate via selective enzymatic reduction with a commercially available ketoreductase

M. Sturr, M. Truppo, Mark Brower, 2006 .

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

Gregory Hughes, Matthew D. Truppo, M. Truppo, 2012 .

Optimization and Scale-Up of a Lipase-Catalyzed Enzymatic Resolution of an Indole Ester Intermediate for a Prostaglandin D2 (DP) Receptor Antagonist Targeting Allergic Rhinitis

M. Truppo, M. Journet, J. C. Moore, 2006 .

Copper‐Catalyzed Synthesis of Enantioenriched Tetraarylethanes.

Paul N. Devine, M. Truppo, Mirlinda Biba, 2008 .

Biocatalysis enters a new era.

Nicholas J Turner, Matthew D Truppo, M. Truppo, 2013, Current opinion in chemical biology.

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

Therapeutic antibody discovery

M. Truppo, J. M. Hoover, J. Teigler, 2021 .

"Site and Mutation"-Specific Predictions Enable Minimal Directed Evolution Libraries.

Katrina W. Lexa, S. Govindarajan, K. Hiraga, 2018, ACS synthetic biology.

Synthesis of Chiral Amines Using Transaminases

M. Truppo, N. Turner, 2013 .

Development of an Improved Immobilized CAL-B for the Enzymatic Resolution of a Key Intermediate to Odanacatib

Gregory Hughes, Matthew D. Truppo, M. Truppo, 2011 .

Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment

Brian J. Geist, M. Truppo, Q. Jiao, 2021, mAbs.

Enzymatic ketone reductions with co-factor recycling: Improved reactions with ionic liquid co-solvents

G. Lye, M. Truppo, D. Pollard, 2008 .

A highly efficient asymmetric synthesis of vernakalant.

M. Truppo, Eric Ashley, G. Beutner, 2014, Organic letters.

Asymmetric, biocatalytic labeled compound synthesis using transaminases

S. Pollack, I. Davies, M. Truppo, 2012 .

Biocatalysis enters a new era.

M. Truppo, N. Turner, 2013, Current opinion in chemical biology.