A. Cochran

发表

Turn stability in β‐hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns

N. Skelton, T. Blandl, A. Cochran, 2003, Protein science : a publication of the Protein Society.

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

Y. Leblanc, H. Jayaram, R. Sims, 2016, ACS medicinal chemistry letters.

Protein-protein interfaces: mimics and inhibitors.

A. Cochran, 2001, Current opinion in chemical biology.

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.

R. Kelley, V. Dixit, S. Hymowitz, 2003, Biochemistry.

Antagonists of protein-protein interactions.

A G Cochran, A. Cochran, 2000, Chemistry & biology.

Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair.

N. Skelton, T. Blandl, A. Cochran, 2003, Journal of the American Chemical Society.

Tryptophan zippers: stable, monomeric beta -hairpins.

A G Cochran, N. Skelton, M. Starovasnik, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists.

Sachdev S Sidhu, Bing Li, S. Sidhu, 2006, Journal of molecular biology.

Imitation of Escherichia coli Aspartate Receptor Signaling in Engineered Dimers of the Cytoplasmic Domain

P. S. Kim, A. Cochran, Andrea G. Cochran, 1996, Science.

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.

H. Jayaram, F. A. Romero, R. Cummings, 2018, Journal of medicinal chemistry.

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

D. Stokoe, P. Sandy, Steffan Vartanian, 2017, Bioorganic & medicinal chemistry letters.

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.

Andrew C Good, Vickie Tsui, Jian Wang, 2016, Journal of medicinal chemistry.

Crystal structure of the complex between VEGF and a receptor-blocking peptide.

A. D. de Vos, B. Cunningham, H. Christinger, 1998, Biochemistry.

Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.

N. Skelton, K. Deshayes, A. Cochran, 2001, Biochemistry.

Antibody-catalyzed porphyrin metallation.

Peter G. Schultz, P. Schultz, A. Cochran, 1990, Science.

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.

Jennafer Dotson, Christian Wiesmann, Jason Drummond, 2009, Journal of medicinal chemistry.

Regulation of deubiquitinase proteolytic activity.

A. Cochran, Oscar W. Huang, 2013, Current opinion in structural biology.

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

E. Bourhis, R. Hannoush, J. Ernst, 2010, The Journal of Biological Chemistry.

Phosphorylation-dependent activity of the deubiquitinase DUBA

V. Dixit, D. Arnott, S. Hymowitz, 2012, Nature Structural &Molecular Biology.

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.

A. Good, P. Sandy, Y. Leblanc, 2022, Journal of medicinal chemistry.

Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation.

G. Miller, A. Cochran, E. M. Flynn, 2022, ACS chemical biology.

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).

P. Sandy, H. Jayaram, R. Sims, 2017, ACS medicinal chemistry letters.

The Mitotic Regulator Survivin Binds as a Monomer to Its Functional Interactor Borealin*

E. Bourhis, S. Hymowitz, A. Cochran, 2007, Journal of Biological Chemistry.

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.

D. Seshasayee, V. Dixit, Minhong Yan, 2002, Immunity.

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Karen E Gascoigne, Fei Wang, S. Kharbanda, 2016, Journal of medicinal chemistry.

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

E. Bourhis, R. Hannoush, A. Estevez, 2011, Structure.

MECHANISTIC STUDIES OF ANTIBODY-CATALYZED PYRIMIDINE DIMER PHOTOCLEAVAGE

P. Schultz, D. King, A. Cochran, 1995 .

Photosensitized cleavage of a thymine dimer by an antibody

P. Schultz, A. Cochran, R. Sugasawara, 1988 .

A minimal peptide scaffold for beta-turn display: optimizing a strand position in disulfide-cyclized beta-hairpins.

N. Skelton, M. Starovasnik, J. Theaker, 2001, Journal of the American Chemical Society.

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.

Guy Georges, Elizabeth Blackwood, Christian Wiesmann, 2008, Journal of medicinal chemistry.

Computational learning reveals coiled coil-like motifs in histidine kinase linker domains

M Singh, B Berger, P S Kim, 1998, Proc. Natl. Acad. Sci. USA.

Designing Stable β-Hairpins: Energetic Contributions from Cross-Strand Residues

A. Cochran, Stephen J. Russell and, 2000 .

A Minimal Peptide Scaffold for β-Turn Display: Optimizing a Strand Position in Disulfide-Cyclized β-Hairpins

Robert S. McDowell, N. Skelton, M. Starovasnik, 2001 .

Short constrained peptides that inhibit HIV-1 entry

Samuel K Sia, Peter A Carr, P. S. Kim, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Tryptophan zippers: Stable, monomeric β-hairpins

N. Skelton, M. Starovasnik, A. Cochran, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Non-canonical reader modules of BAZ1A promote recovery from DNA damage

S. Kummerfeld, C. Ciferri, Jennifer Zhang, 2017, Nature Communications.

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

P. Trojer, E. Jackson, D. Arnott, 2016, Nature chemical biology.

Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module

A. Cochran, 2017 .

BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase

A. Taherbhoy, A. Cochran, Oscar W. Huang, 2015, Nature Communications.

Expansion of the ISWI chromatin remodeler family with new active complexes

W. Sandoval, C. Ciferri, B. Haley, 2017, EMBO reports.

Bromodomains: a new target class for drug development

R. Sims, A. Cochran, A. Conery, 2019, Nature Reviews Drug Discovery.

Substrate capacity considerations in developing kinase assays.

A. Cochran, W. Wong, L. Deforge, 2004, Assay and drug development technologies.

Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor.

B. Pan, W. Fairbrother, A. Cochran, 2002, Journal of molecular biology.

Bromodomains: a new target class for drug development

R. Sims, A. Cochran, A. Conery, 2019, Nature Reviews Drug Discovery.

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

J. Corn, A. Cochran, Q. Phung, 2011, The EMBO journal.

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.

M. Oppikofer, A. Cochran, E. M. Flynn, 2015, Structure.

Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library.

N. Skelton, F. D. de Sauvage, A. Cochran, 2002, Journal of molecular biology.

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition*

G. Hatzivassiliou, P. Sandy, H. Jayaram, 2016, The Journal of Biological Chemistry.

Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site.

A G Cochran, B. Cunningham, H. Christinger, 1998, Biochemistry.

Phage-display as a tool for quantifying protein stability determinants.

C. J. Bond, J. Kotz, A. Cochran, 2004, European journal of biochemistry.

Antibody-catalyzed bimolecular imine formation

P. Schultz, Tony Pham, A. Cochran, 1991 .

Peroxidase activity of an antibody-heme complex

Peter G. Schultz, P. Schultz, A. Cochran, 1990 .

β‐hairpin polypeptides by design and selection

N. Skelton, M. Starovasnik, T. Blandl, 2003 .

Quantifying β-Sheet Stability by Phage Display

A. Zhong, M. Distefano, A. Cochran, 2002 .

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

S. Rutz, Z. Modrušan, W. Ouyang, 2014, Nature.

NMR STRUCTURE OF TRYPTOPHAN ZIPPER 2: A STABLE, MONOMERIC BETA-HAIRPIN WITH A TYPE I' TURN

N. Skelton, M. Starovasnik, A. Cochran, 2001 .

Non-canonical reader modules of BAZ1A promote recovery from DNA damage

S. Kummerfeld, C. Ciferri, Jennifer Zhang, 2017, Nature Communications.

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

E. Bourhis, W. Fairbrother, Andreas Lingel, 2009, Biochemistry.

Aurora A: target invalidated?

A. Cochran, 2008, Chemistry & biology.