Joanne Natale

发表

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease

J. Corradi, A. Cacace, C. Albright, 2014, PloS one.

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides

Brian R. Anderson, A. Cacace, J. Thompson, 2020, Molecular therapy. Nucleic acids.

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

A. Cacace, J. Macor, Tai-Hsien Ou Yang, 2022, Molecular therapy. Nucleic acids.

(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.

S. Dworetzky, Ronald J. Knox, Joanne Natale, 2005, Bioorganic & medicinal chemistry letters.

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.

Astrid A. Ortiz, V. Gribkoff, J. Starrett, 2007, Journal of medicinal chemistry.

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.

V. Gribkoff, S. Dworetzky, Ronald J. Knox, 2003, Journal of medicinal chemistry.

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

V. Gribkoff, Ping Chen, S. Dworetzky, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.

Qi Gao, Nicholas A Meanwell, Yi Li, 2002, Journal of medicinal chemistry.

Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004 .

Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists.

Ping Chen, J. Macor, Yulia Benitex, 2017, Bioorganic & medicinal chemistry letters.