C. Hughesman

发表

Calorimetric and Spectroscopic Analysis of the Thermal Stability of Short Duplex DNA-Containing Sugar and Base-Modified Nucleotides.

Kareem Fakhfakh, C. Hughesman, A. Louise Creagh, 2016, Methods in enzymology.

A new general model for predicting melting thermodynamics of complementary and mismatched B-form duplexes containing locked nucleic acids: application to probe design for digital PCR detection of somatic mutations.

Kareem Fakhfakh, C. Hughesman, C. Haynes, 2015, Biochemistry.

Molecular thermodynamics of the stability of natural, sugar and base-modified DNA duplexes and its application to the design of probes and primers for sensitive detection of somatic point mutations

C. Hughesman, 2012 .

Megapixel digital PCR

Anupam Singhal, Kaston Leung, Michael VanInsberghe, 2011, Nature Methods.

EGFR circulating tumour DNA testing: identification of predictors of ctDNA detection and implications for survival outcomes

S. Yip, A. Karsan, I. Bosdet, 2020, Translational lung cancer research.

The Clinically Actionable Molecular Profile of Early versus Late-Stage Non-Small Cell Lung Cancer, an Individual Age and Sex Propensity-Matched Pair Analysis

M. McConechy, S. Yip, J. Yee, 2022, Current oncology.

Detection of clinically relevant copy number alterations in oral cancer progression using multiplexed droplet digital PCR

C. Hughesman, C. Haynes, C. Poh, 2017, Scientific Reports.

Role of the heat capacity change in understanding and modeling melting thermodynamics of complementary duplexes containing standard and nucleobase-modified LNA.

R. Turner, C. Haynes, C. Hughesman, 2011, Biochemistry.

EGFR Point of Care Clinical Testing using Idylla Platform Decreases Laboratory Turnaround Time in Advanced Stage Non-Small Cell Lung Cancer, as Compared to New Generation Sequencing

C. Hughesman, D. Ionescu, B. Melosky, 2021, Journal of Medical and Radiation Oncology.

Improving Time-to-Treatment for Advanced Non-Small Cell Lung Cancer Patients through Faster Single Gene EGFR Testing Using the Idylla™ EGFR Testing Platform

S. Yip, C. Hughesman, B. Melosky, 2022, Current oncology.

Stability and mismatch discrimination of DNA duplexes containing 2,6-diaminopurine and 2-thiothymidine locked nucleic acid bases.

R. Turner, C. Haynes, C. Hughesman, 2008, Nucleic acids symposium series.

Quantitative Detection and Resolution of BRAF V600 Status in Colorectal Cancer Using Droplet Digital PCR and a Novel Wild-Type Negative Assay.

A. Karsan, J. Bryan, Kareem Fakhfakh, 2016, The Journal of molecular diagnostics : JMD.

Initial Diagnosis of ALK-Positive Non-Small-Cell Lung Cancer Based on Analysis of ALK Status Utilizing Droplet Digital PCR.

L. Foster, A. Karsan, Kareem Fakhfakh, 2016, Analytical chemistry.

Optimizing molecular residual disease detection using liquid biopsy postoperatively in early stage lung cancer

S. Lam, M. McConechy, S. Yip, 2020, Lung cancer management.

A Robust Protocol for Using Multiplexed Droplet Digital PCR to Quantify Somatic Copy Number Alterations in Clinical Tissue Specimens

C. Hughesman, C. Haynes, C. Poh, 2016, PloS one.

Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR

L. Foster, A. Karsan, C. Hughesman, 2016, Analytical and Bioanalytical Chemistry.

Molecular thermodynamics of LNA:LNA base pairs and the hyperstabilizing effect of 5′‐proximal LNA:DNA base pairs

Kareem Fakhfakh, C. Hughesman, C. Haynes, 2015 .

Metastatic Small Bowel Adenocarcinoma Mimicking a Primary Ovarian Mucinous Tumour – Clinical, Radiologic, Pathologic and Molecular Correlation

G. Wang, C. Hughesman, U. Lee, 2022, International journal of surgical pathology.

MET exon 14 skipping mutation positive non-small cell lung cancer: Response to systemic therapy.

S. Yip, A. Karsan, I. Bosdet, 2021, Lung cancer.

Discrimination between UV radiation‐induced and thermally induced spectral changes in AT‐paired DNA oligomers using UV resonance Raman spectroscopy

H. G. Schulze, M. Blades, R. Turner, 2006 .

Detection of clinically relevant copy number alterations in oral cancer progression using multiplexed droplet digital PCR

C. Hughesman, C. Haynes, C. Poh, 2017, Scientific Reports.

Exploring the potential of Raman and resonance Raman spectroscopy for quantitative analysis of duplex DNA

Michael W. Blades, Robin F. B. Turner, Charles A. Haynes, 2005, Photonics North.

No Differences in Outcomes Between JAK2 V617F-Positive Patients with Variant Allele Fraction < 2% Versus 2-10%: A 6-Year Province-wide Retrospective Analysis.

A. Karsan, J. Parker, C. Hughesman, 2020, Clinical lymphoma, myeloma & leukemia.

Initial Diagnosis of ALK-Positive Non-Small-Cell Lung Cancer Based on Analysis of ALK Status Utilizing Droplet Digital PCR.

A. Karsan, Kareem Fakhfakh, C. Hughesman, 2016, Analytical chemistry.

Megapixel digital PCR

C. Tropini, M. VanInsberghe, C. Hughesman, 2011, Nature Methods.