G. Rajaraman

发表

Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria

M. Jamei, X. Chu, K. Hillgren, 2013, Drug Metabolism and Disposition.

Membrane Binding Proteins are the Major Determinants for the Hepatocellular Transmembrane Flux of Long-Chain Fatty Acids Bound to Albumin

M. Roberts, F. Burczynski, G. Rajaraman, 2005, Pharmaceutical Research.

Assessment of P‐Glycoprotein Substrate and Inhibition Potential of Test Compounds in MDR1‐Transfected MDCK Cells

G. Rajaraman, Kevin C L Lam, 2012, Current protocols in pharmacology.

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo

V. Shanmugasundaram, L. Hamann, A. Shakya, 2021, bioRxiv.

Assessment of the Time‐Dependent Inhibition (TDI) Potential of Test Compounds with Human Liver Microsomes by IC50 Shift Method Using a Nondilution Approach

G. Rajaraman, Liang Ron, 2012, Current protocols in pharmacology.

Effect of dexamethasone, 2‐bromopalmitate and clofibrate on L‐FABP mediated hepatoma proliferation

F. Burczynski, G. Rajaraman, 2004, The Journal of pharmacy and pharmacology.

Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment

F. Burczynski, G. Rajaraman, G. Q. Wang, 2006, Molecular and Cellular Biochemistry.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Discovery of N-ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET bromodomain inhibitor with selectivity for the second bromodomain.

K. Longenecker, P. Kovar, L. Hasvold, 2020, Journal of medicinal chemistry.

A High-Throughput (HTS) Assay for Enzyme Reaction Phenotyping in Human Recombinant P450 Enzymes Using LC-MS/MS.

G. Rajaraman, T. Suhar, Xiaofeng Li, 2014, Current protocols in pharmacology.

Expression and antioxidant function of liver fatty acid binding protein in normal and bile-duct ligated rats.

M. Roberts, F. Burczynski, G. Rajaraman, 2007, European journal of pharmacology.

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, Chaohong Sun, P. Kovar, 2017, Journal of medicinal chemistry.

Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions

Sophie P. Chung, Shibing Deng, M. Jamei, 2013, Drug Metabolism and Disposition.

DMD050542 1367..1374

Sophie P. Chung, Shibing Deng, M. Jamei, 2013 .

Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.

G. Rajaraman, A. Lau, Thomas K. H. Chang, 2013, Journal of ethnopharmacology.

Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor

G. Rajaraman, A. Lau, Thomas K. H. Chang, 2012, Drug Metabolism and Disposition.

Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor

G. Rajaraman, A. Lau, Thomas K. H. Chang, 2011, Journal of Pharmacology and Experimental Therapeutics.

Human Pregnane X Receptor Agonism by Ginkgo biloba Extract: Assessment of the Role of Individual Ginkgolides

G. Rajaraman, A. Lau, Thomas K. H. Chang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Assessing the cellular transmembrane electrical potential difference on the hepatic uptake of palmitate

M. Roberts, F. Burczynski, G. Rajaraman, 2005, Molecular and Cellular Biochemistry.

Effect of diltiazem isomers and thiamine on piglet liver microsomal peroxidation using dichlorofluorescein.

F. Burczynski, G. Rajaraman, Guqi Wang, 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.

G. Rajaraman, Thomas K. H. Chang, Jie Chen, 2006, Toxicology and Applied Pharmacology.

Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.

G. Rajaraman, Thomas K. H. Chang, Jie Chen, 2009, Canadian journal of physiology and pharmacology.

Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor

G. Rajaraman, A. Lau, C. Baucom, 2011 .

Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor

G. Rajaraman, A. Lau, C. Baucom, 2011 .

Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor

G. Rajaraman, A. Lau, C. Baucom, 2011 .

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, P. Kovar, Chang H. Park, 2017, Journal of medicinal chemistry.

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.

Ana L. Aguirre, A. Bogdan, Justin D Dietrich, 2018, Bioorganic & medicinal chemistry letters.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chang H. Park, D. Albert, Emily J. Faivre, 2017, Journal of medicinal chemistry.