P. De Meyts

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Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I.

J. Pitts, S. Wood, A. Wollmer, 2001, Protein Engineering.

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

V. Kiselyov, P. De Meyts, Soetkin Versteyhe, 2009, Molecular systems biology.

Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis.

M. Horne, P. De Meyts, S. B. Winge, 2014, The Biochemical journal.

Cooperativity in ligand binding: a new graphic analysis.

J. Roth, P. De Meyts, P. Meyts, 1975, Biochemical and biophysical research communications.

In Vitro Studies on Biosynthetic Human Insulin: an Overview

P. Halban, K. Hepp, P. De Meyts, 1981, Diabetes Care.

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)*

F. Metzger, A. Hoeflich, H. Schoenfeld, 2011, The Journal of Biological Chemistry.

Insulin receptor‐deficient cells as a new tool for dissecting complex interplay in insulin and insulin‐like growth factors

C. Christoffersen, A. Baudry, B. Lamothe, 1998, FEBS letters.

Structural biology of insulin and IGF-1 receptors.

P. De Meyts, Waseem Sajid, Jane Palsgaard, 2004, Novartis Foundation symposium.

Pancreatic hormone receptors on islet cells.

V. Rogiers, E. Hooghe-Peters, D. Pipeleers, 1985, Endocrinology.

The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate

C. Kahn, E. Van Obberghen, S. Emdin, 1979, Diabetes.

Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity.

C. Kahn, J. Roth, P. De Meyts, 1976, The Journal of biological chemistry.

Insulin: a hundred year-old discovery with a fascinating history.

W. Rostène, P. De Meyts, 2021, Endocrine reviews.

Regulation of receptor by homologous hormone enhances sensitivity and broadens scope of radioreceptor assay for human growth hormone.

P. Gorden, R. Eastman, P. De Meyts, 1979, The Journal of clinical endocrinology and metabolism.

Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture.

M. Wabitsch, H. Hauner, P. De Meyts, 1996, Metabolism: clinical and experimental.

Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition.

C. Christoffersen, C. Vlahos, R. Joshi, 1998, Biochemical and biophysical research communications.

Structural Basis of Allosteric Ligand–Receptor Interactions in the Insulin/Relaxin Peptide Family

V. Kiselyov, J. Nøhr, P. De Meyts, 2009, Annals of the New York Academy of Sciences.

The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

B. Ursø, C. Christoffersen, P. De Meyts, 1994, Hormone research.

A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II*

J. Wallace, B. Forbes, E. Jones, 2007, Journal of Biological Chemistry.

Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man.

C. Kahn, D. Neville, I. Goldfine, 1975, Recent progress in hormone research.

Comparison of the effects of hypertonic sucrose and intracellular potassium depletion on growth hormone receptor binding kinetics and down-regulation in IM-9 cells: evidence for a sequential block of receptor--mediated endocytosis.

P. Courtoy, P. De Meyts, M. Ilondo, 1991, Endocrinology.

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

C. Kahn, R. DiMarchi, Weikang Cai, 2018, Proceedings of the National Academy of Sciences.

Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses*

B. Ursø, L. Schäffer, P. De Meyts, 2007, Journal of Biological Chemistry.

Cooperative properties of hormone receptors in cell membranes.

P. De Meyts, 1976, Journal of supramolecular structure.

Carbohydrate metabolism in women who used oral contraceptives containing levonorgestrel or desogestrel: a 6-month prospective study.

F. Grigorescu, P. De Meyts, U. Gaspard, 1986, Fertility and sterility.

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

D. Neville, J. Roth, P. De Meyts, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Receptor Binding Properties and Biologic Activity In Vitro of Biosynthetic Human Insulin

P. De Meyts, L. Keefer, M. Piron, 1981, Diabetes Care.

Mitogenic Potential of Insulin on Lymphoma Cells Lacking IGF‐1 Receptor a

C. Christoffersen, G. Tzivion, P. De Meyts, 1995, Annals of the New York Academy of Sciences.

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.

V. Kiselyov, P. De Meyts, Louise Knudsen, 2011, The Biochemical journal.

Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.

J. Gu, I. Goldfine, P. De Meyts, 1988, Biochemical and biophysical research communications.

IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors.

B. Ursø, E. Van Obberghen, C. Christoffersen, 2003, Cellular signalling.

Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation

J. Holst, O. D. Madsen, J. Capeau, 2016, Endocrinology, diabetes & metabolism case reports.

Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors.

P. De Meyts, L. Keefer, M. Piron, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A rapid method for the preparation of 125I-labelled human growth hormone for receptor studies, using reverse-phase high performance liquid chromatography.

P. De Meyts, M. Ilondo, I. Dehart, 1986, Biochemical and biophysical research communications.

Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins.

P. De Meyts, D. Saunders, H. Gattner, 1981, Biochemical and biophysical research communications.

Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene.

J. Wade, C. Ruivenkamp, H. V. van Duyvenvoorde, 2010, The Journal of clinical endocrinology and metabolism.

Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF‐I and endogenous IGFBP‐3

W. Kiess, P. De Meyts, E. Brommer, 2002, Clinical endocrinology.

Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant.

M. White, J. Backer, P. De Meyts, 1989, Biochemical and biophysical research communications.

Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

P. De Meyts, J. Smal, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes.

M. Walker, P. De Meyts, R. Borup, 2009, Growth Hormone & IGF Research.

Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding.

J. Dumont, P. De Meyts, R. Shymko, 1999, The Biochemical journal.

Insulin and insulin-like growth factors: the paradox of signaling specificity.

P. De Meyts, 2002, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Serum growth hormone levels measured by radioimmunoassay and radioreceptor assay: a useful diagnostic tool in children with growth disorders?

P. De Meyts, E. Eggermont, M. Ilondo, 1990, The Journal of clinical endocrinology and metabolism.

Structure-function relationships of shortened [LeuB25]insulins, semisynthetic analogues of a mutant human insulin.

W. Fischer, A. Wollmer, G. Dodson, 1986, Biological Chemistry Hoppe-Seyler.

A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum.

H. Orskov, J. Frystyk, J. Christiansen, 2003, American journal of physiology. Endocrinology and metabolism.

Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.

P. De Meyts, 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

Genetic engineering in mice: impact on insulin signalling and action.

A. Baudry, B. Lamothe, R. Joshi, 1998, The Biochemical journal.

Identification of determinants that confer ligand specificity on the insulin receptor.

N. Møłler, L. Schäffer, P. De Meyts, 1992, The Journal of biological chemistry.

Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2.

J. Wade, J. Nøhr, M. Vrecl, 2008, Endocrinology.

Glycosylation of cell surface receptors: tunicamycin treatment decreases insulin and growth hormone binding to different levels in cultured lymphocytes.

P. De Meyts, L. Keefer, 1981, Biochemical and biophysical research communications.

In Memoriam: Guy Dodson (1937–2012)

P. De Meyts, 2013, Front. Endocrinol..

Insulin and its receptor: structure, function and evolution.

P. De Meyts, 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.

The diabetogenes concept of NIDDM.

P. De Meyts, 1993, Advances in experimental medicine and biology.

Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone.

C. Kahn, D. Neville, I. Goldfine, 1978, Endocrinology.

Cellular processing of growth hormone in IM-9 cells: evidence for exocytosis of internalized hormone.

P. Courtoy, P. De Meyts, M. Ilondo, 1992, Endocrinology.

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

P. De Meyts, 1994, Diabetologia.

Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth Factor-binding Protein-3*

R. Gill, P. De Meyts, A. Heding, 1996, The Journal of Biological Chemistry.

Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes.

P. De Meyts, R. Shymko, M. Ilondo, 1994, Endocrinology.

How ligand binds to the type 1 insulin-like growth factor receptor

J. Menting, M. Lawrence, V. Kiselyov, 2018, Nature Communications.

How ligand binds to the type 1 insulin-like growth factor receptor

J. Menting, M. Lawrence, V. Kiselyov, 2018, Nature Communications.

Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I*

J. Wallace, B. Forbes, P. De Meyts, 2008, Journal of Biological Chemistry.

Inhibition of insulin receptor binding by dimethyl sulfoxide.

E. Van Obberghen, J. Roth, P. De Meyts, 1979, Biochimica et biophysica acta.

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

D. Neville, J. Roth, P. De Meyts, 1973, Biochemical and biophysical research communications.

Thermodynamics of the interaction of insulin with its receptor.

E. Van Obberghen, P. De Meyts, M. Waelbroeck, 1979, The Journal of biological chemistry.

Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity.

C. Kahn, J. Roth, B. Ginsberg, 1976, Biochemical and biophysical research communications.

Alternative Splicing of Exon 17 and a Missense Mutation in Exon 20 of the Insulin Receptor Gene in Two Brothers with a Novel Syndrome of Insulin Resistance (Congenital Fiber-Type Disproportion Myopathy)

O. Pedersen, C. Christoffersen, H. Vestergaard, 1999, Hormone Research in Paediatrics.

Pancreatic Hormones

P. De Meyts, P. Lefèbvre, 2020, Hormonal Signaling in Biology and Medicine.

Molecular mechanisms of differential intracellular signaling from the insulin receptor.

P. De Meyts, M. Jensen, 2009, Vitamins and hormones.

An arginine to cysteine252 mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events

M. Foti, C. Kahn, J. Carpentier, 2002, Diabetologia.

Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

J. Wade, A. Brzozowski, J. Turkenburg, 2018, Nature Communications.

Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases.

B. Ursø, C. Christoffersen, P. De Meyts, 1995, Metabolism: clinical and experimental.

Role of histone and transcription factor acetylation in diabetes pathogenesis

P. De Meyts, S. Gray, 2005, Diabetes/metabolism research and reviews.

Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins.

A. Yoshimura, B. Herman, P. De Meyts, 2002, Protein expression and purification.

The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself.

C. Kahn, D. Neville, M. Muggeo, 1979, Endocrinology.

Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.

P De Meyts, B. Ursø, G. Rousseau, 1998, Molecular endocrinology.

Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes.

P. De Meyts, G. Hennen, J. Closset, 1987, The Journal of biological chemistry.

Structural Basis of the Aberrant Receptor Binding Properties of Hagfish and Lamprey Insulins

V. Kiselyov, P. Holst, P. De Meyts, 2009, Biochemistry.

Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers.

E. Van Obberghen, J. Roth, P. De Meyts, 1976, The Journal of biological chemistry.

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor

P. De Meyts, S. Gray, Soetkin Versteyhe, 2013, Front. Endocrinol..

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

M. Tatar, J. Wade, Stephanie Post, 2018, Front. Endocrinol..

Structural Conservation of Insulin/IGF Signalling Axis at the Insulin Receptors Level in Drosophila and Humans

A. Brzozowski, Talha Shafi, P. De Meyts, 2023, bioRxiv.

DOK4/IRS‐5 expression is altered in clear cell renal cell carcinoma

B. Teh, K. O'Byrne, P. De Meyts, 2007, International journal of cancer.

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

C. Kahn, J. Roth, P. Gorden, 1976, The Journal of clinical investigation.

Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes.

P. De Meyts, G. Hennen, J. Closset, 1985, The Biochemical journal.

Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytes.

P. De Meyts, J. Smal, 1987, Biochemical and biophysical research communications.

The receptor binding properties of the 20K variant of human growth hormone explain its discrepant insulin-like and growth promoting activities.

P. De Meyts, G. Hennen, J. Closset, 1986, Biochemical and biophysical research communications.

The same region of human growth hormone is involved in its binding to various receptors.

P. De Meyts, P. Masson, L. Retegui, 1982, Endocrinology.

Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation*

M. Tatar, V. Kiselyov, U. Ribel, 2010, The Journal of Biological Chemistry.

Crystal Structure of a “Nonfoldable” Insulin

P. Arvan, M. Weiss, Ming Liu, 2009, The Journal of Biological Chemistry.

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

P. De Meyts, 2008, Trends in biochemical sciences.

Mechanism of Insulin and IGF‐I

B. Ursø, C. Christoffersen, P. De Meyts, 1995 .

The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor

D. Steiner, M. Weiss, P. De Meyts, 2007, Journal of Biological Chemistry.

p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.

P. De Meyts, D. Gunn, P. Avery, 2015, American journal of physiology. Endocrinology and metabolism.

Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene.

G. Bell, J. Gu, P. De Meyts, 1990, Molecular endocrinology.

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor.

C. Christoffersen, N. Heisterkamp, J. Groffen, 1994, Endocrinology.

The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein.

J. Wade, C. Ruivenkamp, H. V. van Duyvenvoorde, 2011, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways

A. Vaag, C. Torp-Pedersen, H. Storgaard, 2009, PloS one.

Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors

J. Wade, J. Nøhr, M. Vrecl, 2009, Annals of the New York Academy of Sciences.

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

M. Weiss, Biaoru Li, P. De Meyts, 2004, Journal of molecular biology.

Structural Basis for the Lower Affinity of the Insulin-like Growth Factors for the Insulin Receptor*

B. Forbes, P. De Meyts, L. Gauguin, 2008, Journal of Biological Chemistry.

Identification and characterization of insulin receptors on foetal-mouse brain-cortical cells.

E. Hooghe-Peters, D. Pipeleers, P. De Meyts, 1984, The Biochemical journal.

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2).

M. Tatar, J. Wade, Stephanie Post, 2017, Australian journal of chemistry.