K. Isozaki

发表

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.

S. Hirota, Y. Matsuzawa, T. Nishida, 1998, Science.

Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction.

K Isozaki, S. Hirota, Y. Matsuzawa, 1997, The American journal of gastroenterology.

Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factor.

Y. Matsuzawa, S. Hirota, Y. Kitamura, 2002, Life sciences.

c‐kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors

Y. Matsuzawa, T. Nishida, S. Hirota, 2003, Journal of gastroenterology and hepatology.

Over‐expression of bcl‐xL gene in human gastric adenomas and carcinomas

Y. Shinomura, K. Isozaki, J. Miyagawa, 1996, International journal of cancer.

Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.

E. Morii, Y. Kitamura, S. Nomura, 1994, The American journal of pathology.

and a normal c-kit coding region deficient Wsh/Wsh mice that have a normal number of erythrocytes c-kit Gene was not transcribed in cultured mast cells of mast cell-

S. Nishikawa, M. Morimoto, K. Isozaki, 2010 .

Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours

Y. Matsuzawa, T. Nishida, S. Hirota, 2003, European journal of gastroenterology & hepatology.

Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats.

S. Hirota, Y. Kitamura, Y. Shinomura, 1995, Gastroenterology.

Deficient differentiation of mast cells in the skin of mi/mi mice. Usefulness of in situ hybridization for evaluation of mast cell phenotype.

M. Morimoto, K. Isozaki, K. Yoshida, 1993, The American journal of pathology.

Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries.

Y. Matsuzawa, N. Taniguchi, S. Higashiyama, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa.

Y. Shinomura, N. Taniguchi, S. Higashiyama, 1995, Gastroenterology.

A mouse model of a human multiple GIST family with KIT‐Asp820Tyr mutation generated by a knock‐in strategy

S. Hirota, T. Nishida, J. Fujimoto, 2008, The Journal of pathology.

Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor.

S. Hirota, N. Hayashi, T. Nishida, 2007, The American journal of gastroenterology.

Significance of the association between heparin‐binding epidermal growth factor‐like growth factor and CD9 in human gastric cancer

Y. Matsuzawa, S. Ishiguro, Y. Shinomura, 2002, International journal of cancer.

CADM1 promotes adhesion to vascular endothelial cells and transendothelial migration in cultured GIST cells

S. Hirota, K. Isozaki, Takashi Yamasaki, 2022, Oncology letters.

A decreased number of c-kit-expressing cells in a patient with afferent loop syndrome

Y. Matsuzawa, Y. Shinomura, K. Isozaki, 2003, Journal of Gastroenterology.

Gain-of-Function Mutations of Receptor Tyrosine Kinases in Gastrointestinal Stromal Tumors.

S. Hirota, K. Isozaki, Seiichi Hirota, 2006, Current genomics.

Inhibition of attachment between cultured mast cells and fibroblasts by phorbol 12-myristate 13-acetate and stem cell factor.

Y. Kitamura, M. Morimoto, S. Nomura, 1995, Experimental hematology.

Wn mutation of c-kit receptor affects its post-translational processing and extracellular expression.

Y. Kitamura, S. Nomura, Y. Nishimune, 1994, Oncogene.

Deficiency of KIT‐positive cells in the colon of patients with diabetes mellitus

Y. Matsuzawa, S. Hirota, Y. Shinomura, 2002, Journal of gastroenterology and hepatology.

Absence of c‐kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients

S. Hirota, Y. Matsuzawa, T. Nishida, 2004, The Journal of pathology.

Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

S. Hirota, T. Nishida, Y. Kitamura, 2003, Gastroenterology.

Familial gastrointestinal stromal tumours with germline mutation of the KIT gene

S. Hirota, T. Nishida, Y. Kitamura, 1998, Nature Genetics.

Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation

Y. Matsuzawa, Y. Kitamura, M. Morimoto, 1994 .

Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation.

Y. Nishimune, Y. Kanakura, K. Isozaki, 1993, Blood.

c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region.

S. Nishikawa, M. Morimoto, S. Nomura, 1992, Blood.

A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors.

S. Hirota, Y. Matsuzawa, T. Nishida, 1998, Gastroenterology.

Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours

Y. Matsuzawa, S. Hirota, Y. Kitamura, 2002, Gut.

Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation.

Y. Matsuzawa, Y. Kitamura, M. Morimoto, 1994, Blood.

Peliosis of the spleen with intraperitoneal hemorrhage

T. Murakami, Hironobu Nakamura, T. Kozuka, 1993, Abdominal Radiology.

Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.

S. Hirota, T. Nishida, Y. Kitamura, 2002, Gastroenterology.

Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors.

S. Hirota, T. Nishida, S. Hirota, 1999, Cancer research.

Effects of loss-of-function and gain-of-function mutations of c-kit on the gastrointestinal tract.

S. Hirota, T. Nishida, Y. Kitamura, 2000, Journal of gastroenterology.

Gastrointestinal stromal tumors with exon 8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature.

S. Hirota, T. Kanda, M. Yamamura, 2014, International journal of clinical and experimental pathology.

Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor tyrosine kinase KIT.

C. Erneux, J. Vanderwinden, K. Isozaki, 2006, Cellular signalling.

Pathology of gastrointestinal stromal tumors

S. Hirota, K. Isozaki, 2006, Pathology international.

Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors

Y. Matsuzawa, S. Hirota, Y. Kitamura, 2003, International journal of cancer.

Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors.

S. Hirota, S. Schiffmann, S. Hirota, 2000, The American journal of pathology.

Differential expression of connexin 43 in gastrointestinal stromal tumours of gastric and small intestinal origin

S. Hirota, T. Nishida, H. Matsuda, 2005, The Journal of pathology.

Different inhibitory effect of imatinib on phosphorylation of mitogen‐activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet‐derived growth factor receptor‐α

T. Nishida, S. Hirota, Y. Kitamura, 2004, International journal of cancer.

THE BASIS AND CLINIC OF GASTROINTESTINAL STROMAL TUMOR(GIST)

T. Nishida, S. Hirota, Y. Shinomura, 2003 .

C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression.

E. Morii, Y. Kitamura, S. Nomura, 1994, Blood.

Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation.

S. Hirota, K. Isozaki, Noriko Kajimoto, 2015, International journal of clinical and experimental pathology.

Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors

S. Hirota, M. Yamamura, K. Isozaki, 2012, Laboratory Investigation.

In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice

S. Hirota, K. Hatakeyama, J. Fujimoto, 2009, Laboratory Investigation.

Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503

S. Hirota, T. Nishida, Tsuyoshi Takahashi, 2013, Laboratory Investigation.

Gain‐of‐function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours

T. Nishida, S. Hirota, K. Isozaki, 2001, The Journal of pathology.

Differential Expression of CADM1 in Gastrointestinal Stromal Tumors of Different Sites and with Different Gene Abnormalities

S. Hirota, T. Nishida, Tsuyoshi Takahashi, 2021, Pathology & Oncology Research.

Molecular Mechanism and Morphology in Cancer

Mitsutoshi Nakamura, H. Nakase, S. Hirota, 2012 .

Anti-tumor effect of antibody-drug conjugate targeting cell adhesion molecule 1 on GIST cells representing small intestinal GIST.

K. Isozaki, M. Hagiyama, Mizuka Ohkouchi, 2024, Experimental and molecular pathology (Print).