S. Ito

发表

S. Ito, 2011, Paediatrics & child health.

Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Activated T Cells 5)

K. Ohashi, S. Ito, B. Ko, 2007, Molecular Pharmacology.

Predicting Escitalopram Exposure to Breastfeeding Infants: Integrating Analytical and In Silico Techniques

Cristiana Stefan, S. Ito, A. Edginton, 2018, Clinical Pharmacokinetics.

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.

U. Amstutz, B. Carleton, G. Koren, 2013, Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique.

Guidelines for maternal codeine use during breastfeeding.

G. Koren, S. Ito, P. Madadi, 2009, Canadian family physician Medecin de famille canadien.

Motherisk Update Guidelines for maternal codeine use during breastfeeding

G. Koren, S. Ito, P. Madadi, 2009 .

Acute liver failure after recommended doses of acetaminophen in patients with myopathies

D. Tibboel, G. Koren, R. Mathôt, 2011, Critical care medicine.

Inhibition of matrix metalloproteinase‐9 activity improves coronary outcome in an animal model of Kawasaki disease

R. Yeung, G. Wilson, S. Ito, 2009, Clinical and experimental immunology.

Brain structure, working memory and response inhibition in childhood leukemia survivors

R. Schachar, J. Crosbie, S. Ito, 2016, Brain and behavior.

Induction of Multidrug Resistance Transporter ABCG2 by Prolactin in Human Breast Cancer Cells

D. Ross, P. Harper, J. Matthews, 2013, Molecular Pharmacology.

Is use of nifurtimox for the treatment of Chagas disease compatible with breast feeding? A population pharmacokinetics analysis

J. Altcheh, F. Garcia-Bournissen, S. Ito, 2009, Archives of Disease in Childhood.

Ambient tonicity and intestinal cytochrome CYP3A

S. Ito, Andrew I. Chuang, 2010, Expert opinion on drug metabolism & toxicology.

Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial)

A. Kiss, E. Asztalos, S. Ito, 2012, BMC Pregnancy and Childbirth.

Lead exposure during breastfeeding.

G. Koren, Toshihiro Tanaka, S. Ito, 2008, Canadian family physician Medecin de famille canadien.

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

P. Boutros, D. Ross, P. Harper, 2010, Molecular Pharmacology.

Xenobiotic transporter expression and function in the human mammary gland.

S. Ito, J. Alcorn, 2003, Advanced drug delivery reviews.

Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women

G. Koren, Toshihiro Tanaka, F. Garcia-Bournissen, 2009, Canadian Medical Association Journal.

The Effect of Amitriptyline, Gabapentin, and Carbamazepine on Morphine-Induced Hypercarbia in Rabbits

G. Koren, B. Kapur, F. Garcia-Bournissen, 2008, Anesthesia and analgesia.

High prevalence and adverse effect of hepatitis C virus infection in type II diabetic-related nephropathy.

S. Ogawa, S. Ito, Y. Taguma, 2000, Journal of the American Society of Nephrology : JASN.

Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy

J. Beyene, C. Carew, S. Ito, 2016, The Pharmacogenomics Journal.

Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.

T. Einarson, G. Koren, J. Leeder, 1995, Reproductive toxicology.

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

J. Kigawa, Y. Kanamori, Masakuni Takahashi, 2001, The Journal of pharmacology and experimental therapeutics.

Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review

G. Koren, S. Ito, T. Adams-Webber, 2016, PLoS medicine.

Neonatal Pharmacology: Rational Therapeutics for the Most Vulnerable

S. Ito, L. James, 2009, Clinical pharmacology and therapeutics.

Examining the transplacental passage of apixaban using the dually perfused human placenta

G. Koren, S. Ito, K. Aleksa, 2016, Journal of thrombosis and haemostasis : JTH.

Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment

R. Weksberg, D. Butcher, R. Schachar, 2018, Clinical Cancer Research.

Estrogen therapy in a male patient with chronic hepatitis C and irradiation-induced testicular dysfunction.

S. Ito, H. Honda, Y. Kusaka, 2001, Internal medicine.

Energy-dependent transport of digoxin across renal tubular cell monolayers (LLC-PK1).

G. Koren, P. Harper, S. Ito, 1993, Canadian Journal of Physiology and Pharmacology.

Drugs in lactation

S. Ito, R. Verstegen, 2019, The journal of obstetrics and gynaecology research.

Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations

E. Neufeld, A. Iorio, J. Blatny, 2018, Research and practice in thrombosis and haemostasis.

Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial

S. Halperin, A. Taddio, S. Ito, 2019, Human vaccines & immunotherapeutics.

Drug excretion into breast milk--overview.

S. Ito, Amy Lee, A. Lee, 2003, Advanced drug delivery reviews.

Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases

G. Koren, C. Westall, C. Laskin, 2001, The Lancet.

Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication.

G. Koren, S. Ito, C. Eliopoulos, 1993, American journal of obstetrics and gynecology.

Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells.

Sarah E. Walker, G. Koren, B. Sarkadi, 1999, The American journal of physiology.

Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells.

G. Koren, B. Sarkadi, S. Ito, 1999, American journal of physiology. Renal physiology.

Discovery of Osmo-sensitive Transcriptional Regulation of Human Cytochrome P 450 3 As ( CYP 3 As ) by the Tonicity-Responsive Enhancer Binding Protein ( TonEBP / NFAT 5 )

K. Ohashi, S. Ito, B. Ko, 2007 .

Induction of cytochrome P450 1A by cow milk‐based formula: a comparative study between human milk and formula

P. Harper, Haibo Xu, S. Ito, 2005, British journal of pharmacology.

Renal ontogeny of ifosfamide nephrotoxicity.

G. Koren, N. Halachmi, S. Ito, 2004, The Journal of laboratory and clinical medicine.

Participation of nuclear factor (erythroid 2‐related), factor 2 in ameliorating lithocholic acid‐induced cholestatic liver injury in mice

S. Ito, K. P. Tan, G. Wood, 2010, British journal of pharmacology.

NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity.

S. Ito, K. Kosuge, K. P. Tan, 2008, Free radical biology & medicine.

From Bench to Bedside: Utilization of an In Vitro Model to Predict Potential Drug‐Drug Interactions in the Kidney: The Digoxin‐Mifepristone Example

G. Koren, S. Ito, C. Woodland, 2003, Journal of clinical pharmacology.

Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.

G. Koren, G. Batist, S. Ito, 2003, Canadian journal of physiology and pharmacology.

A model for the prediction of digoxin-drug interactions at the renal tubular cell level.

G. Koren, S. Ito, C. Woodland, 1998, Therapeutic drug monitoring.

Comment: Possible Mechanism of Digoxin–Itraconazole Interaction

G. Koren, S. Ito, C. Alderman, 1997, The Annals of pharmacotherapy.

The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers.

G. Koren, S. Ito, Z. Verjee, 1997, The Journal of pharmacology and experimental therapeutics.

Comment: Clarithromycin-Digoxin Interaction

D. Juurlink, S. Ito, 1999, The Annals of pharmacotherapy.

Novel influenza A/H1N1 during pregnancy and lactation: safety of vaccines and drug treatment

Toshihiro Tanaka, S. Ito, 2010 .

Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes.

G. Koren, A. Hosokawa, S. Ito, 2008, Reproductive toxicology.

Excretion of Fluoxetine and Its Metabolite, Norfluoxetine, in Human Breast Milk

G. Koren, A. Taddio, S. Ito, 1996, Journal of clinical pharmacology.

Quetiapine Excretion Into Human Breast Milk

Izhar Wallach, F. Garcia-Bournissen, S. Ito, 2018, Journal of clinical psychopharmacology.

Listeriosis during pregnancy

S. Ito, S. Chaudhry, M. Madjunkov, 2017, Archives of Gynecology and Obstetrics.

Towards therapeutic drug monitoring of TNF inhibitors for children with juvenile idiopathic arthritis: a scoping review.

B. Feldman, S. Ito, R. Laxer, 2019, Rheumatology.

Pregnancy outcome following in utero exposure to bisphosphonates.

G. Koren, S. Ito, D. Matsui, 2009, Bone.

alpha1-Proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial.

D. Cox, E. Kelly, S. Ito, 1998, Pediatrics.

β-Defensin Expression in Human Mammary Gland Epithelia

E. Valore, T. Ganz, P. Harper, 2000, Pediatric Research.

Eosinophilic Myocarditis Temporally Associated With Conjugate Meningococcal C and Hepatitis B Vaccines in Children

Y. Finkelstein, T. Ho, G. Taylor, 2008, The Pediatric infectious disease journal.

Drugs in pregnancy.

G. Koren, A. Pastuszak, S. Ito, 1998, The New England journal of medicine.

Paternal use of ribavirin-interferon alpha 2B combination therapy before conception.

S. Ito, Nobuko Taguchi, 2005, Canadian family physician Medecin de famille canadien.

Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model.

Y. Tanigawara, Izhar Wallach, A. Taddio, 2014, British journal of clinical pharmacology.

Prediction of Infant Drug Exposure Through Breastfeeding: Population PK Modeling and Simulation of Fluoxetine Exposure

C. Csajka, A. Taddio, F. Garcia-Bournissen, 2011, Clinical pharmacology and therapeutics.

Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation.

P. Harper, S. Ito, A. Wu, 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

Using Brexanolone for Postpartum Depression Must Account for Lactation

S. Ito, Casey B Rosen-Carole, 2021, Maternal and Child Health Journal.

Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary

C. Chambers, M. Tassinari, S. Ito, 2017, Clinical pharmacology and therapeutics.

Low Levels of Amlodipine in Breast Milk and Plasma.

A. Okamoto, Yoshiro Saito, S. Ito, 2018, Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.

Multiple leg ulcers in a patient with Fabry disease

K. Yoneda, K. Nakai, S. Ito, 2008, Journal of the European Academy of Dermatology and Venereology : JEADV.

Safety of Amlodipine in Early Pregnancy

Y. Wada, S. Ito, M. Mikami, 2019, Journal of the American Heart Association.

Professional opportunity for pharmacists to integrate pharmacogenomics in medication therapy

S. Ito, I. Cohn, R. D. Cohn, 2018, Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC.

Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?

G. Koren, S. Ito, I. Nulman, 2004, Canadian family physician Medecin de famille canadien.

Digoxin clearance and serum beta-2-microglobulin in neonates.

S. Ito, Y. Mori, R. Oka, 1989, The Journal of pediatrics.

Safety and efficacy of ketorolac in children after cardiac surgery

H. Frndova, A. Guerguerian, A. Taddio, 2009, Intensive Care Medicine.

Isoniazid toxicity in a 5-year-old boy

I. Kitai, S. Ito, M. Science, 2013, Canadian Medical Association Journal.

Morphine in kidney failure

G. Koren, M. Berkovitch, S. Ito, 1994, Clinical pharmacology and therapeutics.

Substance Use in Pregnancy Among Vulnerable Women Seeking Addiction and Parenting Support

D. Pepler, S. Ito, Naomi C. Z. Andrews, 2018, International Journal of Mental Health and Addiction.

Functional and Antigenic Concentrations of Alpha-1-Proteinase Inhibitor after Administration for the Prevention of Chronic Lung Disease of Prematurity

D. Cox, E. Kelly, S. Ito, 1999, Neonatology.

The kidney--the body's playground for drugs: an overview of renal drug handling with selected clinical correlates.

D. Perri, S. Ito, N. Shear, 2003, The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique.

Risks of congenital malformations in offspring exposed to valproic acid in utero: A systematic review and cumulative meta‐analysis

J. Beyene, G. Koren, T. Kobayashi, 2015, Clinical pharmacology and therapeutics.

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.

G. Koren, S. Ito, K. Kosuge, 2010, Canadian journal of physiology and pharmacology.

Neonatal paroxetine withdrawal syndrome

G. Koren, T. Ho, S. Ito, 2001, Archives of disease in childhood. Fetal and neonatal edition.

Hyperthyroidism during pregnancy.

G. Koren, S. Ito, N. Arata, 2009, Canadian family physician Medecin de famille canadien.

Motherisk Update Hyperthyroidism during pregnancy

G. Koren, S. Ito, N. Arata, 2009 .

Biotransformation

S. Ito, 2014, Clinical pharmacology and therapeutics.

Bupropion and Escitalopram During Lactation

S. Ito, D. Colantonio, S. Delaney, 2014, The Annals of pharmacotherapy.

Prediction of Milk/Plasma Concentration Ratio of Drugs

Shinya Ito, Gideon Koren, G. Koren, 2003, The Annals of pharmacotherapy.

Sclerodermalike esophageal disease in children of mothers with silicone breast implants.

G. Koren, S. Ito, M. Liau, 1994, JAMA.

BIOTRANSFORMATION

S. Ito, 1981 .

Choice of Breastfeeding and Physicians' Advice: A Cohort Study of Women Receiving Propylthiouracil

G. Koren, S. Ito, M. Moretti, 1999, Pediatrics.

The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics

S. Ito, K. Uhl, S. Neubauer, 2016, Pediatric Clinical Practice Guidelines & Policies.

Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature

S. Ito, S. Lavi, M. Weinstein, 2018, Pediatric dermatology.

Emerging Research Paradigm for Infant Drug Exposure Through Breast Milk.

S. Ito, 2019, Current pharmaceutical design.

Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications

S. Ito, 2018, Journal of clinical pharmacology.

A Cost-Effectiveness Analysis of Maternal Genotyping to Guide Treatment for Postpartum Pain and Avert Infant Adverse Events

G. Koren, S. Ito, W. Ungar, 2014 .

Chronic illness and the breastfeeding mother.

S. Ito, 2014, Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique.

Frequency of infant adverse events that are associated with citalopram use during breast-feeding.

S. Ito, Amy Lee, A. Lee, 2004, American journal of obstetrics and gynecology.

When breastfeeding mothers need CNS-acting drugs.

S. Ito, Amy Lee, Evelyn T Rubin, 2004, The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique.

Initiation and duration of breast-feeding in women receiving antiepileptics.

G. Koren, S. Ito, M. Liau, 1995, American journal of obstetrics and gynecology.

Developmental renal tubular toxicity: a hypothetical framework and experimental approaches☆

G. Koren, S. Ito, K. Aleksa, 2001 .

Fluconazole use during breastfeeding.

G. Koren, S. Ito, Y. Kaplan, 2015, Canadian family physician Medecin de famille canadien.

Recurrence and Outcomes of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children

G. Koren, Y. Finkelstein, F. Garcia-Bournissen, 2011, Pediatrics.

Relative bioequivalence of amoxicillin dissolved in breast milk

F. Garcia-Bournissen, S. Ito, R. Tanoshima, 2013, Archives of Disease in Childhood.

Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine.

S. Ito, A. Edginton, J. Autmizguine, 2021, The AAPS journal.

Anticonvulsants and Breast Feeding

G. Koren, S. Ito, I. Nulman, 2000 .

Perinatal exposure to maternal lamotrigine: clinical considerations for the mother and child.

S. Ito, P. Madadi, 2010, Canadian family physician Medecin de famille canadien.

Drug therapy for breast-feeding women.

S. Ito, 2000, The New England journal of medicine.

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein ( BCRP / ABCG 2 )

P. Boutros, D. Ross, P. Harper, 2010 .

Challenges for drug studies in children: CYP3A phenotyping as example.

Shinya Ito, Gideon Koren, G. Koren, 2009, Drug discovery today.

[6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation.

S. Ito, L. Houghton, R. Pawlosky, 2006, The American journal of clinical nutrition.

Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig.

S. Bryson, D. Young, S. Ito, 1992, Developmental pharmacology and therapeutics.

Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes

Smita H. Karande, P. Nathan, D. Johnston, 2018, Clinical pharmacology and therapeutics.

Hypothetical framework for enhanced renal tubular secretion of drugs in cystic fibrosis.

G. Koren, M. Spino, D. Blowey, 1998, Medical hypotheses.

Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate.

R. Weksberg, D. Butcher, R. Schachar, 2015, Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent.

Excretion of quetiapine in breast milk.

S. Ito, E. Giesbrecht, Amy Lee, 2004, The American journal of psychiatry.

Monitoring lithium in breast milk: an individualized approach for breast-feeding mothers.

G. Koren, S. Ito, Z. Verjee, 2003 .

Infant drug exposure via breast milk

S. Ito, R. Verstegen, P. Anderson, 2020, British journal of clinical pharmacology.

Disposition of maternal ketoconazole in breast milk.

G. Koren, S. Ito, M. Moretti, 1995, American journal of obstetrics and gynecology.

A novel index for expressing exposure of the infant to drugs in breast milk.

G. Koren, S. Ito, Gideon Koren, 1994, British journal of clinical pharmacology.

Perinatal outcome following third trimester exposure to paroxetine.

G. Koren, T. Ho, S. Ito, 2002, Archives of pediatrics & adolescent medicine.

Exposure to attention deficit hyperactivity disorder medications during pregnancy.

G. Koren, F. Garcia-Bournissen, S. Ito, 2007, Canadian family physician Medecin de famille canadien.

Inhibition of Multidrug Resistance by AdamantylGb3, a Globotriaosylceramide Analog*

C. Ackerley, C. Lingwood, S. Ito, 2008, Journal of Biological Chemistry.

Essay for the 2011 CIHR/CMAJ award: Motherisk — caring for mothers, protecting the unborn

G. Koren, S. Ito, Irena Nulman, 2012, Canadian Medical Association Journal.

Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland.

Andrei L. Turinsky, R. Weksberg, A. Turinsky, 2014, American journal of physiology. Endocrinology and metabolism.

Role of STAT 5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG 2 in the mammary gland

Andrei L. Turinsky, R. Weksberg, A. Turinsky, 2014 .

Carbamazepine interference with an immune assay for tricyclic antidepressants in plasma.

G. Koren, S. Ito, Z. Verjee, 1998, Journal of toxicology. Clinical toxicology.

Genome sequencing as a platform for pharmacogenetic genotyping: a pediatric cohort study

C. Marshall, T. Paton, S. Bowdin, 2017, npj Genomic Medicine.

Is CFTR Dysfunction in Cystic Fibrosis Compensated by MRPs?: Commentary on the article by Hurbain et al. on page 627

S. Ito, 2003, Pediatric Research.

Care and cost consequences of pediatric whole genome sequencing compared to chromosome microarray

Michael Brudno, Raveen Basran, Christian R Marshall, 2017, European Journal of Human Genetics.

In Vitro Effects of Paclitaxel and Cremophor EL on Human Riboflavin Transporter SLC52A2.

P. Harper, S. Ito, Pooja Dalvi, 2020, Biological & pharmaceutical bulletin.

Care and cost consequences of pediatric whole genome sequencing compared to chromosome microarray

S. Scherer, C. Marshall, M. Brudno, 2017, European Journal of Human Genetics.

Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care Setting

T. Paton, M. Reuter, A. Goldman, 2021, JAMA network open.

Drugs for Children

S. Ito, 2017, Clinical pharmacology and therapeutics.

Children: Are We Doing Enough?

S. Ito, Shinya Ito, 2015, Clinical pharmacology and therapeutics.

Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis.

T. Ishizaki, F. Sasaki, S. Ameshima, 1996, The European respiratory journal.

Transplacental treatment of fetal tachycardia: implications of drug transporting proteins in placenta.

S. Ito, 2001, Seminars in perinatology.

Paediatric clinical pharmacology training programmes in Canada and the UK: a comparison

G. Koren, M. Rieder, I. Choonara, 2007 .

Pediatric Pharmacology in Japan

Hidefumi Nakamura, S. Ito, Tohru Kobayashi, 2012, Pediatric Drugs.

Cost-effectiveness and Clinical Outcomes of Early Anti-Tumor Necrosis Factor-α Intervention in Pediatric Crohn's Disease.

A. Griffiths, T. Walters, S. Ito, 2019, Inflammatory bowel diseases.

Comment: Breast-feeding During Maternal Use of Azathioprine

G. Koren, S. Ito, Z. Verjee, 2007 .

Which drugs are contraindicated during breastfeeding? Practice guidelines.

S. Ito, M. Moretti, A. Lee, 2000, Canadian family physician Medecin de famille canadien.

Breast-Feeding During Maternal Use of Azathioprine

G. Koren, S. Ito, Z. Verjee, 2006, The Annals of pharmacotherapy.

Maternal Noncompliance with Antibiotics during Breastfeeding

S. Ito, T. Einarson, Gideon Koren, 1993, The Annals of pharmacotherapy.

Breast-feeding and maternal drug use.

S. Ito, B. Bailey, Benoit Bailey, 1997, Pediatric clinics of North America.

Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.

C. Carew, S. Ito, W. Ungar, 2015, Pharmacogenomics.

Methotrexate Use in a Breastfeeding Patient with Rheumatoid Arthritis

S. Ito, J. Thorne, M. Moretti, 2014, The Journal of Rheumatology.

A tubule cell model for ifosfamide nephrotoxicity.

G. Koren, N. Halachmi, S. Ito, 2005, Canadian journal of physiology and pharmacology.

Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels.

G. Koren, S. Ito, K. Aleksa, 2004, The Journal of laboratory and clinical medicine.

Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia

R. Weksberg, D. Butcher, R. Schachar, 2020, Pediatric Research.

Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress

S. Ito, K. P. Tan, Mingdong Yang, 2007, Molecular Pharmacology.

α1-Proteinase Inhibitor Therapy for the Prevention of Chronic Lung Disease of Prematurity: A Randomized, Controlled Trial

D. Cox, E. Kelly, S. Ito, 1998, Pediatrics.

Population pharmacokinetics of vancomycin in paediatric patients with febrile neutropenia and augmented renal clearance: development of new dosing recommendations.

S. Ito, T. Mizuno, R. Verstegen, 2021, The Journal of antimicrobial chemotherapy.

Toxic digoxin-drug interactions: the major role of renal P-glycoprotein.

G Koren, G. Koren, S. Ito, 1998, Veterinary and human toxicology.

Quantitative MRI outcomes in child and adolescent leukemia survivors: Evidence for global alterations in gray and white matter

R. Weksberg, D. Butcher, R. Schachar, 2020, NeuroImage: Clinical.

Risk Factors for Long‐Term Outcome of Ifosfamide‐Induced Nephrotoxicity in Children

G. Koren, J. Wolpin, S. Ito, 1999, Journal of clinical pharmacology.

Toxicity of long-term use of proton pump inhibitors in children

S. Ito, P. De Bruyne, 2017, Archives of Disease in Childhood.

Ceftriaxone-Induced Immune Hemolytic Anemia

G. Koren, S. Ito, M. Kirby-Allen, 2014, The Annals of pharmacotherapy.

Pharmacogenomic investigation of adverse drug reactions(ADRs): the ADR prioritization tool, APT.

Lucila I. Castro-Pastrana, M. Hayden, Kaitlyn Shaw, 2013, Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique.

Intravenous and Oral Propafenone for Treatment of Tachycardia in Infants and Children: Pharmacokinetics and Clinical Response

G. Koren, R. Freedom, S. Ito, 1998, Journal of clinical pharmacology.

The Future of Precision Medicine

S. Ito, R. Verstegen, 2019, Clinical pharmacology and therapeutics.

Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions

U. Amstutz, B. Carleton, M. Rieder, 2014, Epilepsia.

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy

Jacques Turgeon, Shinya Ito, Lawrence J Lesko, 2015, Therapeutic drug monitoring.

Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

J. Nezu, P. Harper, I. Tamai, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Exposure of pregnant women to ribavirin‐contaminated air: risk assessment and recommendations

G. Koren, S. Ito, 1993, The Pediatric infectious disease journal.

CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis

Kaitlyn Shaw, B. Carleton, M. Loriot, 2019, The Pharmacogenomics Journal.

Continuing drug therapy while breastfeeding. Part 2. Common misconceptions of physicians.

G. Koren, S. Ito, M. Moretti, 1999, Canadian family physician Medecin de famille canadien.

Continuing drug therapy while breastfeeding. Part 1. Common misconceptions of patients.

G. Koren, S. Ito, W. Chan, 1999, Canadian family physician Medecin de famille canadien.

A Coding Variant in RARG Confers Susceptibility to Anthracycline-Induced Cardiotoxicity in Childhood Cancer

Smita H. Karande, C. Portwine, D. Johnston, 2015, Nature Genetics.

Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants

A. Kiss, E. Asztalos, S. Ito, 2017, Journal of human lactation : official journal of International Lactation Consultant Association.

Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation

S. Ito, H. Goto, R. Tanoshima, 2017, Pediatric blood & cancer.

Maternal cocaine use during breastfeeding.

G. Koren, A. Cressman, S. Ito, 2012, Canadian family physician Medecin de famille canadien.

Reasons for substance use continuation and discontinuation during pregnancy: A qualitative study.

D. Pepler, Z. Austin, S. Ito, 2019, Women and birth : journal of the Australian College of Midwives.

Probability of Rash Related to Gabapentin Therapy in a Child

S. Ito, S. Wildt, V. Gijsen, 2009, The Annals of pharmacotherapy.

Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis

L. Brandão, S. Ito, Tohru Kobayashi, 2016, Systematic Reviews.

Re: use of contemporary antidepressants during breastfeeding: a proposal for a specific safety index.

S. Ito, A. Einarson, 2007, Drug safety.

Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial.

A. Kiss, E. Asztalos, S. Ito, 2019, Breastfeeding Medicine.

Role of days postdelivery on breast milk production: a secondary analysis from the EMPOWER trial

A. Kiss, E. Asztalos, S. Ito, 2019, International Breastfeeding Journal.

Unusual reactions to 5‐HT3 receptor antagonists in a child with rhabdomyosarcoma

P. Nathan, G. Koren, F. Garcia-Bournissen, 2009, The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique.

Beta-defensin expression in human mammary gland epithelia.

E. Valore, T. Ganz, P. Harper, 2000, Pediatric research.

BIOTRANSFORMATION

S. Ito, 1981 .

Genome sequencing as a platform for pharmacogenetic genotyping: a pediatric cohort study

S. Scherer, C. Marshall, T. Paton, 2017, npj Genomic Medicine.

Use of lipid-lowering agents (statins) during pregnancy.

A. Hosokawa, S. Ito, B. Bar‐Oz, 2003, Canadian family physician Medecin de famille canadien.

A Pitfall of Measuring Lithium Levels in Neonates

Toshihiro Tanaka, S. Ito, Z. Verjee, 2008, Therapeutic drug monitoring.

Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]?

G. Koren, S. Ito, P. Bozzo, 2012, Canadian family physician Medecin de famille canadien.

Drug therapy for fetal arrhythmias.

J. Smallhorn, S. Ito, L. Magee, 1994, Clinics of Perinatology.

Mother and Child: Medication Use in Pregnancy and Lactation

S. Ito, 2016, Clinical pharmacology and therapeutics.

Autism spectrum disorder and prenatal exposure to selective serotonin reuptake inhibitors: A systematic review and meta-analysis.

S. Ito, T. Matsuyama, Tohru Kobayashi, 2016, Reproductive toxicology.

Antenatal Use of Selective Serotonin-Reuptake Inhibitors and QT Interval Prolongation in Newborns

G. Koren, D. Juurlink, Y. Finkelstein, 2008, Pediatrics.

Prolongation in Newborns Antenatal Use of Selective Serotonin-Reuptake Inhibitors and QT Interval

G. Koren, D. Juurlink, S. Ito, 2008 .

Disposition of single-dose intravenous and oral aspirin in children.

S. Ito, R. Oka, A. Tsuchida, 1991, Developmental pharmacology and therapeutics.

Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents

S. Ito, P. Madadi, W. Ungar, 2014, The Pharmacogenomics Journal.

A critical review of the reproductive safety of Leflunomide

D. Aletaha, S. Ito, Anna Pupco, 2019, Clinical Rheumatology.

Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity

G. Koren, K. Krausz, S. Ito, 2005, Pediatric Nephrology.

Enantioselective metabolism of ifosfamide by the kidney.

G. Koren, S. Ito, K. Aleksa, 2006, Chirality.

Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures

R. Weksberg, D. Butcher, R. Schachar, 2018, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

P-glycoprotein-mediated renal tubular secretion of digoxin: the toxicological significance of the urine-blood barrier model.

G. Koren, P. Harper, S. Ito, 1993, Life sciences.

Imputing missing patient-level data and propensity score matching in cost-effectiveness analysis in Crohn's disease

A. Griffiths, T. Walters, S. Ito, 2021, Expert review of pharmacoeconomics & outcomes research.

The safety of St. John's wort (Hypericum perforatum) during breastfeeding.

S. Ito, N. Matsuda, Amy Lee, 2003, The Journal of clinical psychiatry.

Lack of cisplatin-ranitidine kinetic interactions: in vivo study in children, and in vitro study using dog renal brush border membrane vesicles.

G. Koren, S. Ito, R. Lau, 1998, Life Science.

The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1).

G. Koren, P. Harper, S. Ito, 1993, Life sciences.

Safety of medicines during breastfeeding – from case report to modeling: a contribution from the ConcePTION project

A. Smits, K. Allegaert, P. Annaert, 2023, Expert opinion on drug metabolism & toxicology.

Handling of digoxin and ouabain by renal tubular cells (LLC-PK1).

G. Koren, P. Harper, S. Ito, 1992, The Journal of pharmacology and experimental therapeutics.

Measurement of serum acetylsalicylic acid in a porcine model of aspirin overdose.

S. Ito, Z. Verjee, J. Eppler, 1996, Veterinary and human toxicology.

Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model.

S. Ito, Z. Verjee, T. Wiggins, 1995, Annals of emergency medicine.

Digoxin toxicity and ritonavir: a drug interaction mediated through p-glycoprotein?

E. Phillips, A. Rachlis, S. Ito, 2003, AIDS.

Authors' Reply

G. Koren, S. Ito, L. A. Larsen, 2004 .

A New Dimension of Clinical Pharmacology: Induced Pluripotent Stem Cells

S. Ito, 2011, Clinical pharmacology and therapeutics.

Drug and Chemical Contaminants in Breast Milk: Effects on Neurodevelopment of the Nursing Infant

S. Ito, Tom Leibson, P. Lala, 2018 .

Pharmacogenomic testing: Enhancing personalized medication use for patients.

C. Ross, B. Carleton, M. Rieder, 2020, Canadian family physician Medecin de famille canadien.

Pharmacogenomic testing

C. Ross, M. Rieder, D. Lebel, 2020 .