Dierk Thomas

发表

Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy

J. Utikal, T. Wieland, M. Borggrefe, 2018, Circulation. Genomic and precision medicine.

Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams

K. D. Parker, M. Durante, J. Debus, 2016, Scientific Reports.

Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone

H. Katus, Dierk Thomas, E. Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone

H. Katus, Dierk Thomas, E. Ficker, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post‐transplant mortality

H. Katus, Dierk Thomas, Ann-Kathrin Rahm, 2020, ESC heart failure.

Cardiac K2P13.1 (THIK-1) two-pore-domain K+ channels: Pharmacological regulation and remodeling in atrial fibrillation.

H. Katus, Dierk Thomas, P. Lugenbiel, 2019, Progress in biophysics and molecular biology.

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

C. Gleissner, H. Katus, L. Frankenstein, 2016, Drug design, development and therapy.

Inhibition of cardiac two-pore-domain K+ (K2P) channels--an emerging antiarrhythmic concept.

H. Katus, Dierk Thomas, C. Schmidt, 2014, European journal of pharmacology.

Channelopathies in Heart Disease

Dierk Thomas, C. Remme, 2018, Cardiac and Vascular Biology.

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

H. Katus, Dierk Thomas, E. Zitron, 2015, Drug design, development and therapy.

Herg K+ Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells

H. Katus, Dierk Thomas, P. Schweizer, 2014, PloS one.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

H. Katus, Dierk Thomas, E. Ficker, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine

W. Wenzel, H. Katus, Dierk Thomas, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin

H. Katus, Dierk Thomas, A. Bauer, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656

G. Seemann, H. Katus, F. Konrad, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels

H. Katus, Dierk Thomas, A. Bauer, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation

H. Katus, Dierk Thomas, E. Zitron, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action

Hugo A. Katus, Eberhard P. Scholz, Edgar Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of human ether-a-go-go-related gene potassium channels by α1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

Hugo A. Katus, Y. Kuryshev, H. Katus, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.

H. Katus, Dierk Thomas, J. Kiehn, 2003, Cardiovascular research.

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine

H. Katus, Dierk Thomas, E. Zitron, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.

M. Völkers, H. Katus, Dierk Thomas, 2011, Journal of molecular and cellular cardiology.

Post-Transcriptional Control of Human Ether-a-go-go-Related Gene Potassium Channel Protein by α-Adrenergic Receptor Stimulation

T. McDonald, J. Bian, Dierk Thomas, 2010, Molecular Pharmacology.

Post-transcriptional control of HERG potassium channel protein by α -adrenergic receptor stimulation.

T. McDonald, Dierk Thomas, Jian Chen, 2010 .

Deletion of Protein Kinase A Phosphorylation Sites in the HERG Potassium Channel Inhibits Activation Shift by Protein Kinase A*

W. Kübler, Dierk Thomas, W. Schöls, 1999, The Journal of Biological Chemistry.

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Cardiovascular research.

In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts

H. Katus, U. Leimer, Dierk Thomas, 2020, World journal of stem cells.

Differential regulation of KCa2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure

P. Most, H. Katus, Dierk Thomas, 2021, Physiological reports.

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease.

A. Draguhn, C. Bruehl, F. Sedaghat-Hamedani, 2019, Biochemical and biophysical research communications.

Human Cardiac Inwardly-Rectifying K+ Channel Kir2.1b Is Inhibited by Direct Protein Kinase C-Dependent Regulation in Human Isolated Cardiomyocytes and in an Expression System

C. Vahl, H. Katus, Dierk Thomas, 2002, Circulation.

PGPM_A_290291 579..590

P. Most, H. Katus, T. Korff, 2021 .

Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation

P. Most, H. Katus, T. Korff, 2021, Pharmacogenomics and personalized medicine.

HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3 (KCNN3) K+ channels in atrial fibrillation with concomitant heart failure.

P. Most, H. Katus, Dierk Thomas, 2020, Life sciences.

The influence of endoscopic vein harvesting on outcomes after coronary bypass grafting: a meta-analysis of 267,525 patients.

Dierk Thomas, Ann-Kathrin Rahm, R. Rivinius, 2013, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference

H. Katus, Dierk Thomas, E. Zitron, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Activation of inwardly rectifying Kir2.x potassium channels by β3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2

H. Katus, Dierk Thomas, A. Bauer, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1

H. Katus, Dierk Thomas, E. Zitron, 2005, Journal of Molecular Medicine.

Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.

H. Katus, Dierk Thomas, E. Zitron, 2004, Cardiovascular research.

Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels.

H. Katus, Dierk Thomas, C. Schmidt, 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block

H. Katus, Dierk Thomas, P. Lugenbiel, 2018, Journal of Interventional Cardiac Electrophysiology.

Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center

L. Uhlmann, H. Katus, Dierk Thomas, 2017, European Journal of Medical Research.

Inhibition of hK2P3.1 (TASK-1) Potassium Channels by the Tyrosine Kinase Inhibitor Genistein

H. Katus, Dierk Thomas, E. Ficker, 2009 .

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.

S. Heinemann, J. Haas, H. Katus, 2019, Biochemical and biophysical research communications.

Atrioventricular delay programming in cardiac resynchronization therapy devices: fixed or adaptive? A randomized monocenter trial.

H. Katus, Dierk Thomas, A. Bauer, 2012, Journal of electrocardiology.

Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation

H. Katus, Dierk Thomas, Ann-Kathrin Rahm, 2020, Clinical Research in Cardiology.

Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart

H. Katus, Dierk Thomas, Ann-Kathrin Rahm, 2018, Clinical Research in Cardiology.

Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation

R. Eils, R. Wachter, H. Katus, 2020, Clinical Research in Cardiology.

J. Brachmann, L. Eckardt, K. Kuck, 2016, Heart rhythm.

QTc Prolongation by Grapefruit Juice and Its Potential Pharmacological Basis: HERG Channel Blockade by Flavonoids

R. Owen, H. Katus, F. Niroomand, 2005, Circulation.

Bertosamil blocks HERG potassium channels in their open and inactivated states

Dierk Thomas, E. Zitron, S. Kathöfer, 2002, British journal of pharmacology.

Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels

H. Katus, Dierk Thomas, E. Zitron, 2003, British journal of pharmacology.

Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry

P. Kirchhof, J. Brachmann, H. Ince, 2021, Clinical Research in Cardiology.

Biophysical properties of mutant KCNQ1 S277L channels linked to hereditary long QT syndrome with phenotypic variability.

H. Katus, Dierk Thomas, P. Schweizer, 2011, Biochimica et biophysica acta.

Rescue renal sympathetic denervation in a patient with ventricular electrical storm refractory to endo- and epicardial catheter ablation

H. Katus, E. Blessing, B. Vogel, 2014, Clinical Research in Cardiology.

Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels.

H. Katus, Dierk Thomas, J. Gierten, 2019, Journal of molecular and cellular cardiology.

Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.

H. Katus, Dierk Thomas, E. Zitron, 2012, Biochemical and biophysical research communications.

Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents

W. Rottbauer, G. Seemann, H. Katus, 2009, British journal of pharmacology.

Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.

A. Remppis, H. Katus, J. Greten, 2007, Biochemical and biophysical research communications.

In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.

H. Katus, J. Greten, Dierk Thomas, 2006, Toxicology letters.

Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, IKr, and the underlying hERG ion channel

H. Katus, Dierk Thomas, J. Kiehn, 2004, Basic Research in Cardiology.

Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: potential significance in arrhythmogenesis and antiarrhythmic therapy.

James Elber Duverger, S. Nattel, J. Tardif, 2014, Heart Rhythm.

Human β3-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling

A. Draguhn, C. Bruehl, R. Fink, 2019, Nature Communications.

Alternative splicing determines mRNA translation initiation and function of human K2P10.1 K+ channels

H. Katus, Dierk Thomas, Ann-Kathrin Rahm, 2011, The Journal of physiology.

Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure.

M. Karck, H. Katus, F. Müller, 2017, Progress in biophysics and molecular biology.

Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

H. Katus, Dierk Thomas, C. Schmidt, 2016, Clinical science.

Inhibition of cardiac two-pore-domain K+ (K2P) channels by the antiarrhythmic drug vernakalant--comparison with flecainide.

H. Katus, Dierk Thomas, P. Schweizer, 2014, European journal of pharmacology.

Enhancement of K2P2.1 (TREK1) background currents expressed in Xenopus oocytes by voltage-gated K+ channel β subunits.

H. Katus, Dierk Thomas, P. Schweizer, 2012, Life sciences.

Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels

H. Katus, Dierk Thomas, C. Schmidt, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development

H. Katus, Dierk Thomas, P. Schweizer, 2009, Basic Research in Cardiology.

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

H. Katus, Dierk Thomas, E. Ficker, 2008, European journal of pharmacology.

HERG Potassium Channel Activation Is Shifted by Phorbol Esters via Protein Kinase A-dependent Pathways*

W. Kübler, Dierk Thomas, J. Kiehn, 1998, The Journal of Biological Chemistry.

Biological Heart Rate Reduction Through Genetic Suppression of Gαs Protein in the Sinoatrial Node

H. Katus, Dierk Thomas, P. Lugenbiel, 2012, Journal of the American Heart Association.

Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature

H. Katus, B. Meder, Dierk Thomas, 2020, Clinical Research in Cardiology.

Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1

H. Katus, F. Müller, N. Voigt, 2018, Basic Research in Cardiology.

Digitalis therapy is associated with higher comorbidities and poorer prognosis in patients undergoing ablation of atrial arrhythmias: data from the German Ablation Registry

J. Brachmann, L. Eckardt, H. Ince, 2019, Clinical Research in Cardiology.

Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel-Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling.

M. Borggrefe, G. Seemann, M. Karck, 2019, Circulation. Arrhythmia and electrophysiology.

New Targets for Old Drugs: Cardiac Glycosides Inhibit Atrial-Specific K2P3.1 (TASK-1) Channels

H. Katus, A. Ratte, Dierk Thomas, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis

A. Fürnkranz, J. Bauersachs, R. Wakili, 2017, Clinical Research in Cardiology.

Identification and functional characterization of zebrafish K(2P)10.1 (TREK2) two-pore-domain K(+) channels.

H. Katus, Dierk Thomas, J. Gierten, 2012, Biochimica et biophysica acta.

Identification and functional characterization of zebrafish K2P17.1 (TASK‐4, TALK‐2) two‐pore‐domain K+ channels

H. Katus, Dierk Thomas, J. Gierten, 2018, European journal of pharmacology.

Vernakalant activates human cardiac K(2P)17.1 background K(+) channels.

H. Katus, Dierk Thomas, E. Zitron, 2014, Biochemical and biophysical research communications.

Cloning, functional characterization, and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure.

W. Wenzel, H. Katus, Dierk Thomas, 2014, Heart rhythm.

Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2 ₂p) channels.

H. Katus, Dierk Thomas, C. Schmidt, 2013, European journal of pharmacology.

Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels

H. Katus, Dierk Thomas, C. Schmidt, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

PKC‐dependent activation of human K2P18.1 K+ channels

H. Katus, Dierk Thomas, Ann-Kathrin Rahm, 2012, British journal of pharmacology.

The novel antiarrhythmic drug dronedarone: comparison with amiodarone.

Dierk Thomas, C. Karle, S. Kathofer, 2006, Cardiovascular drug reviews.

Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action

H. Katus, Dierk Thomas, E. Zitron, 2014, Drug design, development and therapy.

The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

A. Draguhn, C. Bruehl, J. Haas, 2014, Journal of the American College of Cardiology.

Electrophysiological fi ndings in Fabry cardiomyopathy: mapping the maze of risk stratifi cation

A. Warth, P. Schnabel, H. Katus, 2012 .

Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction

M. Kieser, H. Katus, N. Frey, 2022, Circulation. Heart failure.

Obesity Cardiovascular Disease and the Failure of Public Health Education

S. Boekholdt, H. Katus, C. Bezzina, 2022 .

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

A. Draguhn, C. Bruehl, H. Katus, 2010, Circulation. Arrhythmia and electrophysiology.

Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference

H. Katus, Dierk Thomas, E. Zitron, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations.

A. Wilde, S. Boekholdt, H. Katus, 2016, Journal of the American College of Cardiology.

A Distinct Cardiomyopathy: HCN4 Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation.

H. Katus, Dierk Thomas, P. Schweizer, 2017, Journal of the American College of Cardiology.

Inherited Arrhythmias: Of Channels, Currents, and Swimming.

Dierk Thomas, Maura M. Zylla, Maura M Zylla, 2016, Biophysical journal.

Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2.

H. Katus, Dierk Thomas, P. Schweizer, 2012, Biochemical and biophysical research communications.

Reduced Na+ Current in Native Cardiomyocytes of a Brugada Syndrome Patient Associated With &bgr;-2-Syntrophin Mutation

M. Borggrefe, M. Karck, H. Katus, 2018, Circulation. Genomic and precision medicine.

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by α1A-adrenoceptors

H. Katus, Dierk Thomas, E. Zitron, 2004, Journal of Molecular Medicine.

Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation.

A. Draguhn, C. Bruehl, I. Schlichting, 2013, European heart journal.

Skipping of Exon 1 in the KCNQ1 Gene Causes Jervell and Lange-Nielsen Syndrome*

H. Katus, Dierk Thomas, K. Brockmeier, 2006, Journal of Biological Chemistry.

The antiarrhythmic drug BRL-32872.

Dierk Thomas, J. Kiehn, C. Karle, 2006, Cardiovascular drug reviews.

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Sudden cardiac death while waiting: do we need the wearable cardioverter-defibrillator?

C. Israel, C. Leclercq, D. Scherr, 2022, Clinical Research in Cardiology.

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

R. D. Jenkins, Andreas Wilke, A. Capucci, 2022, Clinical Research in Cardiology.

Anticoagulant Selection in Relation to SAMe-TT2R2 Score in Patients with Atrial Fibrillation: The GLORIA-AF Registry.

R. D. Jenkins, A. Capucci, G. Lip, 2020, Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.

H. Katus, Dierk Thomas, S. Kathöfer, 2005, Cardiovascular research.

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

Hugo A Katus, H. Katus, Dierk Thomas, 2003, British journal of pharmacology.

Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality

H. Katus, Dierk Thomas, R. Rivinius, 2017, Therapeutics and clinical risk management.

Isoenzyme-specific regulation of cardiac Kv1.5/Kvβ1.2 ion channel complex by protein kinase C: central role of PKCβII

H. Katus, Dierk Thomas, E. Zitron, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

B. Wible, H. Katus, Dierk Thomas, 2004, British journal of pharmacology.

Atrial myofibroblast activation and connective tissue formation in a porcine model of atrial fibrillation and reduced left ventricular function

H. Katus, Dierk Thomas, P. Lugenbiel, 2017, Life sciences.

Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy

C. Gleissner, H. Katus, L. Frankenstein, 2014, Drug design, development and therapy.

Sudden cardiac death while waiting: do we need the wearable cardioverter-defibrillator?

C. Israel, C. Leclercq, D. Scherr, 2022, Clinical Research in Cardiology.

Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system

S. Meuth, K. Klingel, T. Budde, 2022, Cellular and Molecular Life Sciences.

Quantitative Efficacy and Fate of Mesenchymal Stromal Cells Targeted to Cardiac Sites by Radiofrequency Catheter Ablation

H. Katus, A. Seckinger, Dierk Thomas, 2020, Cell transplantation.

Frequency, Risk Factors, and Clinical Outcomes of Late-Onset Atrial Flutter in Patients after Heart Transplantation

Dierk Thomas, P. Lugenbiel, R. Rivinius, 2022, Journal of cardiovascular development and disease.

Immobilization for carbon ion beam ablation of cardiac structures in a porcine model.

M. Durante, D. Packer, C. Bert, 2017, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

The influence of surgical technique on early posttransplant atrial fibrillation – comparison of biatrial, bicaval, and total orthotopic heart transplantation

C. Gleissner, H. Katus, Dierk Thomas, 2017, Therapeutics and clinical risk management.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels

H. Katus, S. Chai, Christina Mayer, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation

X. Wehrens, J. Noebels, D. Dobrev, 2015, Basic Research in Cardiology.

Study Design of the Man and Machine Trial: A Prospective International Controlled Noninferiority Trial Comparing Manual with Robotic Catheter Ablation for Treatment of Atrial Fibrillation

K. Kuck, A. Natale, L. Di Biase, 2013, Journal of cardiovascular electrophysiology.

Asymptomatic pulmonary vein stenosis after cryoballoon catheter ablation of paroxysmal atrial fibrillation.

H. Katus, Dierk Thomas, F. Voss, 2011, Journal of electrocardiology.

Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium

Dierk Thomas, S. Goldstein, Zoe A. McCrossan, 2008, Neuron.

Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19

F. Herth, M. Kieser, H. Katus, 2021, Journal of clinical medicine.

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.

A. Draguhn, C. Bruehl, D. Hose, 2019, Life Science.

Electrical Ventricular Remodeling in Dilated Cardiomyopathy

N. Frey, F. André, Dierk Thomas, 2021, Cells.

Antidepressant-induced Ubiquitination and Degradation of the Cardiac Potassium Channel hERG*

D. Nassal, Dierk Thomas, I. Deschênes, 2011, The Journal of Biological Chemistry.

Butterfly and reverse butterfly: usefulness of a resistance band to provoke exercise-induced arrhythmias during catheter ablation in a patient refractory to pharmacological stimulation

H. Katus, Dierk Thomas, P. Lugenbiel, 2018, Clinical Research in Cardiology.

Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

M. Borggrefe, G. Seemann, A. Loewe, 2020, Journal of the American Heart Association.

Cryoballoon pulmonary vein isolation-mediated rise of sinus rate in patients with paroxysmal atrial fibrillation

H. Katus, Dierk Thomas, P. Lugenbiel, 2020, Clinical Research in Cardiology.

Remote vs. conventional navigation for catheter ablation of atrial fibrillation: insights from prospective registry data

J. Brachmann, K. Kuck, S. Willems, 2018, Clinical Research in Cardiology.

Updated Survey on Interventional Electrophysiology: 5-Year Follow-Up of Infrastructure, Procedures, and Training Positions in Germany.

L. Eckardt, R. Tilz, D. Steven, 2018, JACC. Clinical electrophysiology.

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research.

D. Dobrev, L. Sacconi, J. Heijman, 2021, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation

H. Katus, Dierk Thomas, R. Rivinius, 2017, Drug design, development and therapy.

Safety and patient-reported outcomes in index ablation versus repeat ablation in atrial fibrillation: insights from the German Ablation Registry

J. Brachmann, L. Eckardt, K. Kuck, 2020, Clinical Research in Cardiology.

The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation

H. Katus, Dierk Thomas, C. Schmidt, 2011, Vascular health and risk management.

Dronedarone: current evidence for its safety and efficacy in the management of atrial fibrillation

H. Katus, Dierk Thomas, P. Schweizer, 2011, Drug design, development and therapy.

Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter.

M. Kieser, H. Katus, D. Mereles, 2015, The American journal of cardiology.

Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study.

H. Katus, Dierk Thomas, P. Lugenbiel, 2013, European heart journal.

Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model.

M. Koch, H. Katus, Dierk Thomas, 2011, Cardiovascular research.

Anti-KCNQ1 K⁺ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy.

H. Katus, Dierk Thomas, C. Schmidt, 2013, Cardiovascular research.

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

U. Schotten, I. V. Van Gelder, G. Hindricks, 2022, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Ablation of Atrial Fibrillation in Patients with Hypertension—An Analysis from the German Ablation Registry

J. Brachmann, L. Eckardt, K. Kuck, 2020, Journal of clinical medicine.

Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224

H. Katus, Dierk Thomas, E. Zitron, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels

H. Katus, Dierk Thomas, C. Schmidt, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.

H. Katus, Dierk Thomas, A. Bauer, 2008, Journal of molecular and cellular cardiology.

Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry

J. Brachmann, L. Eckardt, K. Kuck, 2017, European heart journal.

Novel ion channel targets in atrial fibrillation

J. Hancox, N. Marrion, Henggui Zhang, 2016, Expert opinion on therapeutic targets.

I Ks current and are associated with QT interval shortening in dilated cardiomyopathy

H. Katus, Dierk Thomas, C. Schmidt, 2013 .

Atrial Fibrillation Complicated by Heart Failure Induces Distinct Remodeling of Calcium Cycling Proteins

H. Katus, Dierk Thomas, P. Lugenbiel, 2015, PloS one.

Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference.

A. Camm, P. Kirchhof, G. Lip, 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation

M. Borggrefe, M. Karck, H. Katus, 2015, Circulation.

Upregulation of K 2 P 3 . 1 K + Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation

M. Borggrefe, M. Karck, H. Katus, 2015 .

German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management

A. Goette, R. Wakili, J. Heijman, 2018, Clinical Research in Cardiology.

University of Birmingham German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper

A. Goette, R. Wakili, J. Heijman, 2018 .

Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction

H. Katus, B. Meder, D. Mereles, 2015, Clinical Research in Cardiology.

Aquaporin-1 Channel Function Is Positively Regulated by Protein Kinase C*

H. Katus, M. Zeier, Dierk Thomas, 2007, Journal of Biological Chemistry.

Genetic suppression of Gαs protein provides rate control in atrial fibrillation

H. Katus, Dierk Thomas, P. Lugenbiel, 2012, Basic Research in Cardiology.

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1.

H. Katus, Dierk Thomas, P. Schweizer, 2012, Gene.

Atrial fibrillation before heart transplantation is a risk factor for post‐transplant atrial fibrillation and mortality

N. Frey, Dierk Thomas, R. Rivinius, 2021, ESC heart failure.

Antiarrhythmic gene therapy - will biologics replace catheters, drugs and devices?

H. Katus, Dierk Thomas, P. Lugenbiel, 2016, European journal of pharmacology.

Cardioverter defibrillator therapy in the primary and secondary prevention of sudden cardiac death

H. Katus, Dierk Thomas, R. Becker, 2012 .

Catheter ablation of atrial fibrillation in patients with concomitant sinus bradycardia-Insights from the German Ablation Registry.

J. Brachmann, K. Kuck, S. Willems, 2016, Journal of electrocardiology.

Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study

M. Borggrefe, M. Hochadel, C. Celano, 2022, Journal of clinical medicine.

A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation

H. Katus, D. Mereles, Dierk Thomas, 2016, PloS one.

Report on the Ion Channel Symposium

F. Mason, N. Voigt, Dierk Thomas, 2018, Herzschrittmachertherapie + Elektrophysiologie.

Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes

H. Katus, Dierk Thomas, P. Lugenbiel, 2018, Cellular Physiology and Biochemistry.

[Typical atrial flutter: Diagnosis and therapy].

L. Eckardt, D. Steven, H. Neuberger, 2016, Herzschrittmachertherapie & Elektrophysiologie.

Successful acute and long-term management of electrical storm in Brugada syndrome using orciprenaline and quinine/quinidine

H. Katus, Dierk Thomas, P. Schweizer, 2010, Clinical Research in Cardiology.

Efficacy, High Procedural Safety And Rapid Optimization Of Cryoballoon Atrial Fibrillation Ablation In The Hands Of A New Operator.

H. Katus, Dierk Thomas, P. Lugenbiel, 2016, Journal of atrial fibrillation.

TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control

C. Bruehl, M. Karck, H. Katus, 2016, Basic Research in Cardiology.

Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable

Mathias Wilhelms, Olaf Dössel, Gunnar Seemann, 2016, Front. Bioeng. Biotechnol..

Radiation therapy-induced electrical reset of an implantable cardioverter defibrillator device located outside the irradiation field.

Hugo A Katus, H. Katus, Dierk Thomas, 2004, Journal of electrocardiology.

hERG: protein trafficking and potential for therapy and drug side effects.

Hugo A Katus, H. Katus, Dierk Thomas, 2010, Current opinion in drug discovery & development.

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels.

Dierk Thomas, J. Kiehn, G. Wendt-Nordahl, 2002, The Journal of pharmacology and experimental therapeutics.

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

W. Kübler, Dierk Thomas, W. Schöls, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry.

J. Brachmann, L. Eckardt, K. Kuck, 2016, International journal of cardiology.

Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

M. Borggrefe, M. Karck, R. de Simone, 2017, European heart journal.

Symptomatic arrhythmias after catheter ablation of atrioventricular nodal reentrant tachycardia (AVNRT): results from the German Ablation Registry

J. Brachmann, L. Eckardt, K. Kuck, 2019, Clinical Research in Cardiology.

[Premature ventricular contractions and tachycardia in a structurally normal heart : Idiopathic PVC and VT].

L. Eckardt, R. Tilz, D. Steven, 2019, Herzschrittmachertherapie & Elektrophysiologie.

Renal denervation for treatment of ventricular arrhythmias: data from an International Multicenter Registry

G. Hindricks, A. Bollmann, M. Böhm, 2016, Clinical Research in Cardiology.

Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival

N. Frey, Dierk Thomas, Ann-Kathrin Rahm, 2021, ESC heart failure.

Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.

Daniel Scherer, Hugo A Katus, Edgar Zitron, 2009, Biochemical and biophysical research communications.

Role of ion channels in heart failure and channelopathies

H. Katus, Dierk Thomas, P. Lugenbiel, 2018, Biophysical Reviews.

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells

J. Utikal, A. Draguhn, H. Katus, 2017, Stem Cell Research & Therapy.

Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation.

H. Katus, Dierk Thomas, R. Rivinius, 2019, Journal of thoracic disease.

COPD in patients after heart transplantation is associated with a prolonged hospital stay, early posttransplant atrial fibrillation, and impaired posttransplant survival

H. Katus, Dierk Thomas, R. Rivinius, 2018, Clinical epidemiology.

Elevated pre‐transplant pulmonary vascular resistance is associated with early post‐transplant atrial fibrillation and mortality

H. Katus, Dierk Thomas, R. Rivinius, 2020, ESC heart failure.

Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation".

M. Borggrefe, M. Karck, H. Katus, 2016, Circulation.

ECG-based 4D-dose reconstruction of cardiac arrhythmia ablation with carbon ion beams: application in a porcine model

Marco Durante, Daniel Richter, Christoph Bert, 2017, Physics in medicine and biology.

Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant.

H. Katus, Dierk Thomas, A. Bauer, 2012, Heart rhythm.

Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels

H. Katus, Dierk Thomas, C. Schmidt, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A

H. Katus, J. Backs, Dierk Thomas, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Use of the wearable cardioverter-defibrillator (WCD) and WCD-based remote rhythm monitoring in a real-life patient cohort

M. Kieser, H. Katus, Dierk Thomas, 2018, Heart and Vessels.

Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.

H. Katus, Dierk Thomas, C. Karle, 2010, Journal of molecular and cellular cardiology.

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

M. Andrassy, M. Völkers, H. Katus, 2016, PloS one.

Rescue renal sympathetic denervation in a patient with ventricular electrical storm refractory to endo- and epicardial catheter ablation: response to comments by Huang et al.

H. Katus, E. Blessing, B. Vogel, 2015, Clinical Research in Cardiology.

Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine.

M. Karck, H. Katus, Dierk Thomas, 2020, European journal of pharmacology.

Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

A. Remppis, H. Katus, J. Greten, 2007, Nutrition, metabolism, and cardiovascular diseases : NMCD.

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells

J. Utikal, A. Draguhn, H. Katus, 2017, Stem Cell Research & Therapy.

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes

C. Bruehl, P. Most, M. Karck, 2021, Basic Research in Cardiology.

Cardiac expression and atrial fibrillation-associated remodeling of K₂p2.1 (TREK-1) K⁺ channels in a porcine model.

W. Wenzel, H. Katus, Dierk Thomas, 2014, Life sciences.

Constrictive Pericarditis in the Presence of Remaining Remnants of a Left Ventricular Assist Device in a Heart Transplanted Patient

C. Gleissner, M. Karck, F. Sedaghat-Hamedani, 2015, Case reports in transplantation.

N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels

H. Katus, A. Ratte, Dierk Thomas, 2019, International journal of molecular sciences.

Ventrikuläre Extrasystolen und Tachykardien bei strukturell normalem Herz

L. Eckardt, R. Tilz, D. Steven, 2019, Herzschrittmachertherapie + Elektrophysiologie.

Antidepressant-induced Ubiquitination and Degradation of the Cardiac Potassium Channel hERG*

D. Nassal, Dierk Thomas, I. Deschênes, 2011, The Journal of Biological Chemistry.

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

Daniel Scherer, Hugo A Katus, Y. Kuryshev, 2004, Cardiovascular research.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels

H. Katus, Christina Mayer, Dierk Thomas, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure.

M. Karck, H. Katus, F. Müller, 2017, Progress in biophysics and molecular biology.

Enhancement of K2P2.1 (TREK1) background currents expressed in Xenopus oocytes by voltage-gated K+ channel β subunits.

H. Katus, Dierk Thomas, P. Schweizer, 2012, Life sciences.

Anti-KCNQ1 K⁺ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy.

H. Katus, Dierk Thomas, C. Schmidt, 2013, Cardiovascular research.

Chest pain, shortness of breath, and palpitations unmask an unexpected diagnosis.

A. Remppis, H. Katus, S. Aulmann, 2012, Circulation.

Isoenzyme-specific regulation of cardiac Kv1.5/Kvβ1.2 ion channel complex by protein kinase C: central role of PKCβII

H. Katus, Dierk Thomas, E. Zitron, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Role of ion channels in heart failure and channelopathies

H. Katus, Dierk Thomas, P. Lugenbiel, 2018, Biophysical Reviews.

Title: Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and Pip 2 -interference Jpet #238287 4 Block and an Impaired Channel Stabilization via Interference with Pip 2

Germany, H. Katus, Dierk Thomas, 2022 .

Initial experience with robotic navigation for catheter ablation of paroxysmal and persistent atrial fibrillation.

Hugo A Katus, H. Katus, Dierk Thomas, 2012, Journal of electrocardiology.

Modulation of HERG potassium channel function by drug action

Dierk Thomas, J. Kiehn, C. Karle, 2004, Annals of medicine.