H. Funke

G. Assmann, H. Schulte, H. Funke, 1986, Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.

Molecular genetics approach to lipoprotein metabolism disorders

G. Assmann, H. Wiebusch, H. Funke, 1995 .

Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I.

A. von Eckardstein, A. Benninghoven, G. Assmann, 1989, The Journal of clinical investigation.

A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities.

A. von Eckardstein, G. Assmann, M. Karas, 1991, The Journal of clinical investigation.

The Relationship of HDL-Apolipoprotein A-I and HDL-Cholesterol to Risk Factors of Coronary Heart Disease: Initial Results of the Prospective Epidemiological Study in Company Employees in Westfalia

G. Assmann, H. Funke, H. Schriewer, 1982, Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.

Molecular impact of ion channel mutations for the pathogenesis of long-QT (LQT) syndromes

G. Breithardt, W. Haverkamp, M. Borggrefe, 2000 .

The emergence of triglycerides as a significant independent risk factor in coronary artery disease.

A. von Eckardstein, G. Assmann, H. Schulte, 1998, European heart journal.

Lipoproteins and Cardiovascular Risk: From Genetics to Prevention of Coronary Heart Disease

G. Assmann, P. Cullen, H. Schulte, 1998 .

SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes

I. Runnebaum, H. Funke, M. Dürst, 2013, BMC Cancer.

Detection of apolipoprotein E variants by an oligonucleotide "melting" procedure.

G. Assmann, H. Funke, S. Rust, 1986, Clinical chemistry.

Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.

A. von Eckardstein, G. Assmann, H. Schulte, 1992, American journal of human genetics.

Compound heterozygosity for a known (D250N) and a novel (E410K) missense mutation in the C‐terminal domain of lipoprotein lipase causes familial chylomicronemia

A. von Eckardstein, G. Assmann, H. Wiebusch, 1996, Human mutation.

Lipoproteins and cardiovascular risk-from genetics to CHD prevention.

G. Assmann, P. Cullen, H. Schulte, 1997, Journal of atherosclerosis and thrombosis.

Lecithin: cholesterol acyltransferase deficiency and fish-eye disease

A. von Eckardstein, G. Assmann, H. Funke, 1991 .

Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure.

A. von Eckardstein, A. Benninghoven, G. Assmann, 1990, The Journal of biological chemistry.

A new molecular defect in the lecithin: cholesterol acyltransferase (LCAT) gene associated with fish eye disease.

G. Assmann, K. Rye, D. Sullivan, 1996, Journal of lipid research.

[Prediction and early diagnosis of coronary disease. Prospective epidemiologic study of industrial workers in Westphalia].

G. Assmann, H. Schulte, H. Funke, 1980, Der Internist.

Impact of polymorphisms in the alpha- and beta-fibrinogen gene on plasma fibrinogen concentrations of coronary heart disease patients.

G. Assmann, H. Schulte, H. Funke, 1995, Thrombosis research.

Sex-Specific Effects of the Glutamine / Histidine Polymorphism in Apo AIV on HDL Metabolism

G. Assmann, H. Schulte, S. Schwarz, 2005 .

Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency.

A. von Eckardstein, G. Assmann, G. Noseda, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Sex-specific effects of the glutamine/histidine polymorphism in apo A-IV on HDL metabolism.

A. von Eckardstein, G. Assmann, H. Schulte, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Uptake of Apolipoprotein E‐Containing High Density Lipoproteins by Hepatic Parenchymal Cells

R. Mahley, K. Weisgraber, J. Boyles, 1984, Arteriosclerosis.

Structure-Function Relationships of Apolipoprotein A-I Variants

A. Jonas, J. Fruchart, H. Funke, 1993 .

Metabolism of Canine β‐Very Low Density Lipoproteins in Normal and Cholesterol‐Fed Dogs

R. Mahley, T. Innerarity, J. Boyles, 1988, Arteriosclerosis.

HDL and Reverse Transport of Cholesterol: Insights from Mutants

G. Assmann, H. Funke, A. Eckardstein, 1991 .

Electrophoretic screening for human apolipoprotein C-II variants: repeated identification of apolipoprotein C-II(K19T)

G. Assmann, H. Wiebusch, J. Nofer, 1995, Journal of Molecular Medicine.

Pst I RFLP close to the LDL receptor gene.

G. Assmann, J. Klug, P. Frossard, 1986, Nucleic acids research.

The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction.

M. Hersberger, A. von Eckardstein, T. Lüscher, 2005, Clinical chemistry.

Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency.

M. Hayden, J. Kastelein, G. Assmann, 1996, The Netherlands journal of medicine.

Characterization ofFiveNew Mutants intheCarboxyl- terminal DomainofHumanApolipoprotein E: NoCosegregation withSevereHyperlipidemia

H. Funke, Peter deKnijfft, 1993 .

Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.

P. de Knijff, F. V. van’t Hooft, G. Assmann, 1993, American journal of human genetics.

De Novo Mutation in the SCN5A Gene Associated With Early Onset of Sudden Infant Death

G. Breithardt, W. Haverkamp, M. Borggrefe, 2001, Circulation.

240 Glutamine / Histidine Polymorphism in Apo AIV Affects Plasma Concentrations of Lipoprotein ( a ) and Fibrin Split Products in Coronary Heart Disease Patients

G. Assmann, H. Schulte, H. Funke, 2005 .

Glutamine/histidine polymorphism in apo A-IV affects plasma concentrations of lipoprotein(a) and fibrin split products in coronary heart disease patients.

A. von Eckardstein, G. Assmann, H. Schulte, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

Molecular Genetics Approach to Polygenic Disease—Initial Results from Atherosclerosis Research

G. Assmann, H. Funke, A. Eckardstein, 1991 .

Acquired abnormal QT prolongation and torsade de pointes — clinical significance of genetic information from congenital long QT syndrome

G. Breithardt, P. Kirchhof, G. Mönnig, 2000 .

A novel frameshift mutation in PMP22 accounts for hereditary neuropathy with liability to pressure palsies

G. Assmann, H. Wiebusch, H. Funke, 1997, Neurology.

PMP22 Thr118Met is not a clinically relevant CMT1 marker

C. van Broeckhoven, B. Rautenstrauss, V. Timmerman, 2000, Journal of Neurology.

PCR-based strategy for the diagnosis of hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease type 1A

E. Ringelstein, C. van Broeckhoven, G. Assmann, 1998, Neurology.

Absence of mutations in peripheral myelin protein-22, myelin protein zero, and connexin 32 in autosomal recessive Dejerine-Sottas syndrome

C. Broeckhoven, G. Assmann, H. Wiebusch, 1998, Neuroscience Letters.

Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine.

S. Lorkowski, A. Mosig, H. Funke, 2016, Cytokine.

Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).

G. Assmann, H. Funke, K. Ehlenz, 1990, Journal of lipid research.

Mutation analysis in Charcot-Marie Tooth disease type 1: point mutations in the MPZ gene and the GJB1 gene cause comparable phenotypic heterogeneity

G. Kuhlenbäumer, H. Funke, O. Debus, 2001, Journal of Neurology.

Clinical Value of Electrocardiographic Parameters in Genotyped Individuals with Familial Long QT Syndrome

G. Breithardt, P. Kirchhof, W. Haverkamp, 2001, Pacing and clinical electrophysiology : PACE.

Autosomal recessive long-QT syndrome (Jervell Lange-Nielsen syndrome) is genetically heterogeneous

G. Breithardt, W. Haverkamp, M. Borggrefe, 1997, Human Genetics.

Two newly identified SNPs in the APO AI‐CIII intergenic region are strongly associated with familial combined hyperlipidaemia

R. Cantor, G. Dallinga-Thie, H. Funke, 2001, European journal of clinical investigation.

Molecular analysis at the Harvey Ras-1 gene in patients with long QT syndrome

G. Breithardt, W. Haverkamp, M. Borggrefe, 1995, Journal of Molecular Medicine.

ECG repolarization patterns in chromosome 7-linked QT syndrome (LQTS 2)

G. Breithardt, W. Haverkamp, E. Schulze-Bahr, 1996, Circulation.

Apolipoproteins, Reverse Cholesterol Transport and Coronary Heart Disease

G. Assmann, H. Funke, A. Eckardstein, 1992 .

Homozygosity for a splice junction mutation in exon 8 of the gene encoding lysosomal acid lipase in a Spanish kindred with cholesterol ester storage disease (CESD)

G. Assmann, H. Wiebusch, U. Seedorf, 1995, Human Genetics.

Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease.

A. von Eckardstein, M. Hayden, H. Wiebusch, 1993, The Journal of clinical investigation.

Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro.

S. Lorkowski, G. Cruciani, M. Ristow, 2014, Free radical biology & medicine.

HDL Metabolism and Atherosclerosis

G. Assmann, H. Funke, 1990, Journal of cardiovascular pharmacology.

Mutational analysis of two frequently observed lipoprotein lipase gene variants in the Japanese population

G. Assmann, H. Wiebusch, K. Arakawa, 1997, Journal of Inherited Metabolic Disease.

Marked changes of lipid levels during puberty in a patient with lipoprotein lipase deficiency

G. Assmann, H. Wiebusch, H. Funke, 1997, European Journal of Pediatrics.

Genetic determinants of high density lipoprotein levels.

H. Funke, 1997, Current opinion in lipidology.

Phenotypic variation of mutations in the human lipoprotein-lipase gene.

M. Hayden, J. Kastelein, J. Brunzell, 1993, Biochemical Society transactions.

An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease).

G. Assmann, J. Kastelein, R. Benne, 1996, The Journal of clinical investigation.

A novel missense (E163G) mutation in the catalytic subunit of lipoprotein lipase causes familial chylomicronemia

G. Assmann, H. Wiebusch, R. Santer, 1996, Human mutation.

Analytical procedures for the detection and characterization of apolipoprotein E mutants.

G. Assmann, H. Funke, H. Jabs, 1987, American heart journal.

A novel variant of lysosomal acid lipase (Leu336-->Pro) associated with acid lipase deficiency and cholesterol ester storage disease.

G. Assmann, H. Wiebusch, U. Seedorf, 1995, Arteriosclerosis, thrombosis, and vascular biology.

A nonsense mutation in the apolipoprotein A-I gene is associated with high-density lipoprotein deficiency and periorbital xanthelasmas.

A. von Eckardstein, G. Assmann, G. Noseda, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient.

A. von Eckardstein, R. Mahley, G. Assmann, 1994, Journal of lipid research.

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

J. Piette, G. Assmann, P. Denéfle, 1999, Nature Genetics.

Prevalence of cholesteryl ester storage disease.

G. Assmann, H. Schulte, K. Berger, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Heterozygosity for lysosomal acid lipase E8SJM mutation and serum lipid concentrations.

G. Assmann, H. Schulte, H. Wiebusch, 2013, Nutrition, metabolism, and cardiovascular diseases : NMCD.

A novel missense mutation (Gly2Arg) in the human lysosomal acid lipase gene is found in individuals with and without cholesterol ester storage disease (CESD).

G. Assmann, H. Wiebusch, U. Seedorf, 2008, Clinical genetics.

Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia.

A. von Eckardstein, G. Assmann, H. Funke, 1991, The Journal of clinical investigation.

Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy

G. Assmann, P. Cullen, H. Hahmann, 1998, Nature Genetics.

Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort

U. John, C. Kessler, E. Ringelstein, 2006, Journal of Neurology, Neurosurgery & Psychiatry.

Gene expression profiles of T lymphocytes are sensitive to the influence of heavy smoking: a pilot study

H. Funke, P. Büttner, S. Mosig, 2006, Immunogenetics.

Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

Michael Bauer, Frank T. Peters, Michael Kiehntopf, 2016, Scientific Reports.

Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age.

G. Assmann, H. Schulte, H. Funke, 1990, Clinical chemistry.

Molecular genetics of arrhythmias – a new paradigm

W. Haverkamp, G. Breithardt, M. Borggrefe, 2000, Zeitschrift für Kardiologie.

The LQT syndromes – current status of molecular mechanisms

W. Haverkamp, G. Breithardt, M. Borggrefe, 1999, Zeitschrift für Kardiologie.

Exercise affects the gene expression profiles of human white blood cells.

A. Lechtermann, H. Funke, P. Büttner, 2007, Journal of applied physiology.

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred.

P. Denéfle, H. Brewer, M. Dinger, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Strategies for the assessment of genetic coronary artery disease risk.

G. Assmann, H. Funke, Gerd Assmann, 1999, Current opinion in lipidology.

Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and & epsilon;1/lsquo;null genotype‡

G. Assmann, K. Lackner, R. Ziegler, 1992, European journal of clinical investigation.

Molecular basis of lipoprotein lipase deficiency in two Austrian families with type I hyperlipoproteinemia.

M. Sippl, B. Paulweber, G. Assmann, 1991, Atherosclerosis.

A unique genetic and biochemical presentation of fish-eye disease.

G. Assmann, H. Wiebusch, J. Kastelein, 1995, The Journal of clinical investigation.

Complete deficiency of plasma lecithin‐cholesterol acyltransferase (LCAT) activity due to a novel homozygous mutation (Gly‐30‐Ser) in the LCAT gene

G. Watts, G. Assmann, P. Cullen, 1996, Human mutation.

Screening for naturally occurring apolipoprotein A-I variants: apo A-I(ΔK107) is associated with low HDL-cholesterol levels in men but not in women

G. Assmann, H. Schulte, H. Wiebusch, 1995, Human Genetics.

The replacement of arginine by cysteine at residue 151 in apolipoprotein A-I produces a phenotype similar to that of apolipoprotein A-IMilano.

A. von Eckardstein, G. Assmann, H. Wiebusch, 1997, Atherosclerosis.

Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease.

G. Assmann, H. Wiebusch, H. Funke, 1996, Circulation.

The low down on lipoprotein lipase

G. Assmann, H. Funke, 1995, Nature Genetics.

Apolipoprotein A-I and HDL deficiency

G. Assmann, G. Schmitz, H. Funke, 1990 .

Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study.

Olaf Riess, Klaus Berger, Bernhard T Baune, 2008, Psychoneuroendocrinology.

Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene.

M. Taskinen, G. Assmann, H. Wiebusch, 1997, Atherosclerosis.

Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism

Regine Heller, Siegfried Krause, R. Heller, 2008, BMC Medical Genomics.

Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites.

R. Mahley, G. Assmann, K. Weisgraber, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics

G. Breithardt, W. Haverkamp, M. Borggrefe, 2002, Journal of Molecular Medicine.

Next-generation Sequencing und hochparallele Genexpressionsanalyse in der klinischen Diagnostik / Next-generation sequencing and massively parallel analysis of gene expression: uses in clinical diagnostics

P. Cullen, H. Klein, H. Funke, 2010 .

Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene.

G. Assmann, P. Cullen, H. Wiebusch, 1995, Human molecular genetics.

High Density Lipoproteins, Reverse Transport of Cholesterol, and Coronary Artery Disease Insights From Mutations

G. Assmann, H. Funke, A. Eckardstein, 1993, Circulation.

Analysis of genetically determined structural polymorphisms in apolipoproteins E, B and (a)

G. Assmann, H. Funke, S. Rust, 1991 .

The contribution of candidate genes to the response of plasma lipids and lipoproteins to dietary challenge.

Y. Friedlander, J. Kark, H. Funke, 2000, Atherosclerosis.

Recurrent brachial plexus palsies as the only clinical expression of hereditary neuropathy with liability to pressure palsies associated with a de novo deletion of the peripheral myelin protein‐22 gene

G. Assmann, H. Funke, M. Kerschensteiner, 1998, Muscle & nerve.

Gene expression in the detection of autologous blood transfusion in sports – a pilot study

M. Baumstark, H. Funke, K. Rennert, 2009, Vox sanguinis.

Association between genetic variants of IL-1β, IL-6 and TNF-α cytokines and cognitive performance in the elderly general population of the MEMO-study

Bernhard T. Baune, Olaf Riess, Klaus Berger, 2008, Psychoneuroendocrinology.

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case–control studies

U. John, C. Kessler, Suzanne Cheng, 2007, Human Genetics.

white blood cells Exercise affects the gene expression profiles of human

A. Pereira, Y. Pitsiladis, E. Krieger, 2015 .

DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex.

D. W. Lim, G. Assmann, M. Malloy, 1986, Nucleic acids research.

PMP22 frameshift mutation and hereditary neuropathy with liability to pressure palsies

G. Assmann, H. Wiebusch, H. Funke, 1997, Neurology.

Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke

C. Kessler, E. Ringelstein, K. Berger, 2010, Cerebrovascular Diseases.

SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes

I. Runnebaum, H. Funke, M. Dürst, 2013, BMC Cancer.

A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica

A. Mosig, H. Funke, O. Huber, 2016, BMC Microbiology.

The importance of triglycerides as a significant risk factor

G. Assmann, P. Cullen, H. Schulte, 1999 .

Recurrent missense mutations at the first and second base of codon Arg243 in human lipoprotein lipase in patients of different ancestries

M. Hayden, J. Kastelein, D. Chitayat, 1994, Human mutation.

Dimorphic markers for the human apolipoprotein CII gene locus.

G. Assmann, P. Frossard, H. Funke, 1987, Gene.

HDL metabolism and atherosclerosis. Discussion

G. Assmann, H. Funke, 1990 .

A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica

Herbert Tomaso, A. Mosig, H. Funke, 2016, BMC Microbiology.

Bst NI (Eco RII) RFLP in the lipoprotein lipase gene (LPL).

G. Assmann, H. Funke, A. Reckwerth, 1988, Nucleic acids research.

Polymorphic site study at codon 347 of apolipoprotein A-IV in a Japanese population.

A. von Eckardstein, K. Arakawa, K. Saku, 1993, Biochimica et biophysica acta.

Multiparametrische Gendiagnostik in der Medizin: Indikation und Qualitätssicherung / Mulitparametric genetic diagnostics in medicine: indications and quality assurance

H. Funke, P. Cullen, T. Langmann, 2004 .

Heterozygosity for lysosomal acid lipase E8SJM mutation and serum lipid concentrations.

G. Assmann, H. Schulte, H. Wiebusch, 2013, Nutrition, metabolism, and cardiovascular diseases : NMCD.

Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine.

S. Lorkowski, A. Mosig, H. Funke, 2016, Cytokine.

Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

M. Bauer, M. Kiehntopf, A. Mosig, 2018, Scientific Reports.

The rapid molecular diagnosis of genetic cardiovascular risk factors

G. Assmann, H. Funke, 1993 .