U. Heiser

发表

Dipeptidyl Peptidase IV Inhibitors for Treatment of Diabetes

R. Pederson, C. Mcintosh, Su-jin Kim, 2011 .

Inhibition of Mammalian Legumain by Michael Acceptors and AzaAsn-Halomethylketones

A. Barrett, B. Gerhartz, K. Feussner, 2002, Biological chemistry.

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

A. Kehlen, A. Hellvard, N. Delaleu, 2016, Scientific Reports.

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

T. Hoffmann, T. Saido, S. Schilling, 2006, Biochimica et biophysica acta.

Inhibition of Glutaminyl Cyclases alleviates CCL2‐mediated inflammation of non‐alcoholic fatty liver disease in mice

T. Hoffmann, A. Kehlen, S. Schilling, 2013, International journal of experimental pathology.

Metabolism of glucagon by dipeptidyl peptidase IV (CD26)

R. Pederson, C. Mcintosh, T. Hoffmann, 2001, Regulatory Peptides.

Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY

C. Mcintosh, S. Unniappan, H. Demuth, 2006, Diabetologia.

Inhibition of glutaminyl cyclase prevents pGlu‐Aβ formation after intracortical/hippocampal microinjection in vivo/in situ

T. Hoffmann, W. Jagla, S. Schilling, 2008, Journal of neurochemistry.

Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation

T. Hoffmann, M. Rothermundt, J. Rahfeld, 2016, Neuropeptides.

Glutaminyl cyclases as novel targets for the treatment of septic arthritis.

R. Jonsson, A. Hellvard, J. Potempa, 2013, The Journal of infectious diseases.

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

C. Parthier, M. Stubbs, S. Schilling, 2011, Biochemistry.

Continuous spectrometric assays for glutaminyl cyclase activity.

T. Hoffmann, C. Wasternack, S. Schilling, 2002, Analytical biochemistry.

Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition.

B. Gerhartz, M. Hafner, H. Demuth, 2002, European journal of biochemistry.

Copper-catalysed coupling of undec-10-enylmagnesium bromide with ω-functionalised halogenoalkanes as a key reaction for the synthesis of novel bipolar phospholipids with different head groups and chain length

B. Dobner, U. Heiser, 1997 .

Temperature-dependent behavior of a symmetric long-chain bolaamphiphile with phosphocholine headgroups in water: from hydrogel to nanoparticles.

B. Dobner, A. Blume, W. Richter, 2004, Journal of the American Chemical Society.

Self-assembly in a bipolar phosphocholine-water system: the formation of nanofibers and hydrogels.

B. Dobner, A. Blume, W. Richter, 2004, Angewandte Chemie.

Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.

M. Werman, T. Hoffmann, B. Gerhartz, 2003, Advances in experimental medicine and biology.

Novel bipolar phospholipids with different headgroups

B. Dobner, U. Heiser, 1996 .

Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold.

T. Hoffmann, B. Koch, H. Demuth, 2013, Journal of medicinal chemistry.

Simple and high yield synthesis of (±)10,10′-dimethyl-dotriacontan-1,1′-diol as a building block for branched bola compounds. Preparation of (±)10,10′-dimethyl-dotriaconta-1,1′-diyl-bis[2-(trimethylammonio)ethyl phosphate] and the corresponding unbranched equivalent

B. Dobner, U. Heiser, R. Wolf, 1997 .

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

Robert Huber, Hans-Ulrich Demuth, Ulrich Heiser, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

P. Quax, T. Hoffmann, W. Jagla, 2011, EMBO molecular medicine.

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

R. Huber, T. Hoffmann, W. Bode, 2006, Journal of molecular biology.

Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4

T. Hoffmann, H. Naim, J. Rahfeld, 2007, Peptides.

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

Hans-Ulrich Demuth, Mike Francke, Ulrich Heiser, 2008, Nature Medicine.

Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy

T. Hoffmann, S. Schilling, H. Demuth, 2017, The Journal of Pharmacology and Experimental Therapeutics.

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects

F. Weber, T. Hoffmann, U. Heiser, 2015, Alzheimer's & dementia.

Probing Secondary Glutaminyl Cyclase (QC) Inhibitor Interactions Applying an in silico‐Modeling/Site‐Directed Mutagenesis Approach: Implications for Drug Development

S. Schilling, B. Koch, M. Wermann, 2012, Chemical biology & drug design.

Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.

Hans-Ulrich Demuth, Mirko Buchholz, Wolfgang Brandt, 2009, Journal of medicinal chemistry.

The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.

Hans-Ulrich Demuth, Mirko Buchholz, Ulrich Heiser, 2006, Journal of medicinal chemistry.

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Hans-Ulrich Demuth, Mirko Buchholz, Ulrich Heiser, 2005, Biochemistry.

Does human attractin have DP4 activity?

T. Hoffmann, M. Wermann, H. Demuth, 2007, Biological chemistry.

Phase transitions and hydrogen bonding in a bipolar phosphocholine evidenced by calorimetry and vibrational spectroscopy.

B. Dobner, S. Wartewig, W. Pohle, 2001, Archives of biochemistry and biophysics.

The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.

B. Klapp, T. Hoffmann, P. Arck, 2002, Cellular immunology.

Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.

T. Hoffmann, T. Yoshimoto, Yue Xu, 2008, Journal of molecular biology.

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

T. Hoffmann, W. Jagla, A. Kehlen, 2008, Nature Medicine.