Liping Wang

发表

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2005, Journal of medicinal chemistry.

Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

P. A. Harris, J. Veal, Liping Wang, 2005, Journal of medicinal chemistry.

Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.

P. A. Harris, J. Veal, Rakesh Kumar, 2008, Journal of medicinal chemistry.

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.

P. A. Harris, J. Veal, Megumi Shibahara, 2007, Journal of medicinal chemistry.

Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles.

Kaili Hu, Liping Wang, Jianfang Feng, 2019, Nanomedicine.

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion

X. Xie, T. Mcguire, T. Cheng, 2015, Scientific Reports.

Molecularly Imprinted Polymers for Selective Extraction of Oblongifolin C from Garcinia yunnanensis Hu

Liping Wang, Hongxi Xu, Wen-wei Fu, 2017, Molecules.

Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury.

Xuesong Tian, Wei Sun, Liping Wang, 2017, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.

T. Willson, W. Zuercher, J. Collins, 2006, Bioorganic & medicinal chemistry letters.

p-Terphenyl alcohols from a marine sponge-derived fungus, Aspergillus candidus OUCMDZ-1051

Weiming Zhu, Liping Wang, Yi Wang, 2020, Marine Life Science & Technology.

Allosteric Inhibition of Human Immunodeficiency Virus Integrase

F. Bushman, Nirav Malani, Kushol Gupta, 2014, The Journal of Biological Chemistry.

A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia.

Xiao-nian Li, Liping Wang, X. Hao, 2015, Fitoterapia.

New alkaloids from the diversity-enhanced extracts of an endophytic fungus Aspergillus flavus GZWMJZ-288.

Weiming Zhu, Liping Wang, Dan Wu, 2021, Bioorganic chemistry.

Discovery of phenyl acetamides as potent and selective GPR119 agonists.

V. Hornak, A. Woods, A. Stamford, 2017, Bioorganic & Medicinal Chemistry Letters.

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site.

Ramona N Plant, K. Brown, J. Briand, 2014, Nature chemical biology.

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Liping Wang, R. Nolte, E. Stewart, 2012, Journal of medicinal chemistry.

Biomimetic semi-synthesis of fradcarbazole A and its analogues

Weiming Zhu, Liping Wang, Xiangui Mei, 2015 .

Semisynthetic Derivatives of Fradcarbazole A and Their Cytotoxicity against Acute Myeloid Leukemia Cell Lines.

Weiming Zhu, Liping Wang, Yanchao Xu, 2019, Journal of natural products.

Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity

Weiming Zhu, Liping Wang, Peng Fu, 2018, Marine drugs.

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups.

J. Weiel, Liping Wang, F. Tavares, 2009, Bioorganic & medicinal chemistry letters.

Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

M. Struthers, R. Berger, S. Feighner, 2010, Bioorganic & medicinal chemistry letters.

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

R. Annan, A. P. Graves, D. Mcnulty, 2018, SLAS discovery : advancing life sciences R & D.

Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258 Endophytic with the Medicinal and Edible Plant, Garcinia multiflora.

Weiming Zhu, Liping Wang, Peng Fu, 2019, Journal of Agricultural and Food Chemistry.

Kojic Acid Derivatives and Sesquiterpenes from the Aspergillus flavus GZWMJZ-288, A Fungal Endophyte of Garcinia multiflora

Weiming Zhu, Liping Wang, Xiao-jiang Hao, 2018, Natural Product Communications.

Phenolic polyketides from the marine alga-derived Streptomyces sp. OUCMDZ-3434

Weiming Zhu, Liping Wang, Yi Wang, 2017 .

Sulfur-Containing Phenolic Compounds from the Cave Soil-Derived Aspergillus fumigatus GZWMJZ-152.

Weiming Zhu, Liping Wang, Peng Fu, 2022, Journal of natural products.

Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora

Liping Wang, X. Hao, Yan-Hui Fu, 2017 .

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2014, Journal of medicinal chemistry.

Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.

J. Luengo, A. P. Graves, M. Pappalardi, 2019, ACS medicinal chemistry letters.

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Liping Wang, Yasheng Zhu, Kai Yuan, 2021, European journal of medicinal chemistry.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & medicinal chemistry letters.

Potent antibacterial and antibiofilm activities of TICbf-14, a peptide with increased stability against trypsin

Changlin Zhou, Liping Wang, Lingman Ma, 2021, Journal of Microbiology.

Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase **

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, Chembiochem : a European journal of chemical biology.

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, bioRxiv.

Characterization of novel inhibition of indoleamine 2,3-dioxygenase by targeting its apo form.

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2018 .

Strategies towards endo-type B polycyclic polyprenylated acylphloroglucinols: total synthesis of regio-hyperibone L and (+)-epi-clusianone

Liping Wang, Hong Zhang, Hongxi Xu, 2021 .

MSI-1 combats drug-resistant S. aureus by affecting bacterial viability and inhibiting carotenoid pigment production.

Xiaoyun Liu, Changlin Zhou, Liping Wang, 2021, Microbiological research.

PCL-1, a Trypsin-Resistant Peptide, Exerts Potent Activity Against Drug-Resistant Bacteria

Changlin Zhou, Liping Wang, Haomin Wu, 2021, Probiotics and Antimicrobial Proteins.

Targeting ADAR1 with a Novel Small-Molecule for the Treatment of Prostate Cancer

T. Zeng, Liping Wang, Yuzhang Jiang, 2021 .

New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313, a fungal endophyte of Garcinia multiflora

Weiming Zhu, Liping Wang, Xiao-jiang Hao, 2019, Chinese Chemical Letters.

Diketopiperazine and Diphenylether Derivatives from Marine Algae-Derived Aspergillus versicolor OUCMDZ-2738 by Epigenetic Activation

Weiming Zhu, Liping Wang, Bin Wang, 2018, Marine drugs.

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Weiming Zhu, Liping Wang, Peng Fu, 2018, Marine drugs.

Ophiobolins from the Mangrove Fungus Aspergillus ustus.

Tonghan Zhu, K. Hong, Weiming Zhu, 2017, Journal of natural products.

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).

D. Holt, A. P. Graves, L. Shewchuk, 2015, Journal of medicinal chemistry.

Identi fi cation of Purines and 7 ‐ Deazapurines as Potent and Selective Type I Inhibitors of Troponin I ‐ Interacting Kinase ( TNNI 3 K )

D. Holt, A. P. Graves, L. Shewchuk, 2015 .

Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

Weiming Zhu, Liping Wang, Yi Wang, 2018, Front. Chem..

Versicolactones A and B: total synthesis and structure revision

Weiming Zhu, Liping Wang, 2013 .

Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.

Joseph Kessler, Anthony Carella, D. Hazuda, 2005, Bioorganic & medicinal chemistry letters.

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

Weiming Zhu, Liping Wang, Yaqin Fan, 2018, Marine drugs.

Me2AlSEt-Promoted Domino Dieckmann Cyclization Enables the Total Synthesis of Polycyclic Polyprenylated Acylphloroglucinols.

Liping Wang, Rong Wu, Hua Zhou, 2019, Organic letters.

Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.

Qin Tong, Xiang-Qun Xie, Lirong Wang, 2013, Journal of medicinal chemistry.

New α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434

J. Hao, Weiming Zhu, Liping Wang, 2016, Scientific Reports.

Synthesis and biological activities of two camptothecin derivatives against Spodoptera exigua

Liping Wang, L. Mao, Yanning Zhang, 2019, Scientific Reports.

Synthesis, insecticidal activity and inhibition on topoisomerase I of 20(S)-t-Boc-amino acid derivatives of camptothecin.

Liping Wang, L. Mao, Yanning Zhang, 2017, Pesticide biochemistry and physiology.

Insecticidal, cytotoxic and anti-phytopathogenic fungal activities of chemical constituents from the aerial parts of Ferula sinkiangensis

Liping Wang, Tingting Liu, L. Mao, 2018, Natural product research.

Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.

Yutaka Maeda, Wei Liu, Megumi Shibahara, 2005, Bioorganic & medicinal chemistry letters.

α-Glucosidase Inhibitors from the Marine-Derived Fungus Aspergillus flavipes HN4-13.

J. Hao, Weiming Zhu, Lei Guo, 2016, Journal of natural products.

p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities

Weiming Zhu, Yong Wang, Liping Wang, 2021, Frontiers in Microbiology.

Improving the yield of (+)-terrein from the salt-tolerant Aspergillus terreus PT06-2

Weiming Zhu, Liping Wang, Guoliang Zhu, 2016, World Journal of Microbiology and Biotechnology.

Improving the yield of (+)-terrein from the salt-tolerant Aspergillus terreus PT06-2

Weiming Zhu, Chengying Zhao, Lei Guo, 2016, World journal of microbiology & biotechnology.

Liglaurates A-E, cytotoxic bis(lauric acid-12yl)lignanoates from the rhizomes of Drynaria roosii Nakaike.

Weiming Zhu, Liping Wang, Dongyang Wang, 2022, Phytochemistry.

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.

J. Weiel, Liping Wang, F. Tavares, 2009, Bioorganic & medicinal chemistry letters.

Prenylated benzoylphloroglucinols and biphenyl derivatives from the leaves of Garcinia multiflora Champ

Y. Lao, Liping Wang, H. Tan, 2015 .

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Liping Wang, Meiling Lu, Yuzhang Jiang, 2021, Nature Communications.

Targeting dual-speci city tyrosine phosphorylation- regulated kinase 2 (DYRK2) with a highly selective inhibitor for the treatment of prostate cancer

Liping Wang, Yibei Xiao, Z. Li, 2021 .

Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.

C. Chiu, J. Metzger, Liming Yang, 2018, ACS medicinal chemistry letters.

Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on erythromycin-resistant Streptococcus suis

Liping Wang, Yuan-shu Zhang, 2009, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase.

J. Veal, Liping Wang, R. Nolte, 2005, Bioorganic & medicinal chemistry letters.

X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation*

Timothy M Willson, William J Zuercher, T. Willson, 2006, Journal of Biological Chemistry.

Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.

Y. Lao, Liping Wang, Rong Wu, 2016, Bioorganic & medicinal chemistry.

The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors*

Cecil E. Rise, B. Wisely, T. Sheahan, 2015, The Journal of Biological Chemistry.

Crystallization of protein–ligand complexes

Lisa M. Shewchuk, L. Shewchuk, W. Rocque, 2006, Acta crystallographica. Section D, Biological crystallography.

Two New 4-Hydroxy-2-pyridone Alkaloids with Antimicrobial and Cytotoxic Activities from Arthrinium sp. GZWMJZ-606 Endophytic with Houttuynia cordata Thunb

Weiming Zhu, Liping Wang, Dongyang Wang, 2023, Molecules.

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Liping Wang, G. Xin, Hao Cheng, 2021, Journal of medicinal chemistry.

Chromanopyrones and a flavone from Hypericum monogynum.

Liping Wang, X. Hao, Yanrong Zeng, 2018, Fitoterapia.

Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.

Liping Wang, R. Nolte, A. Truesdale, 2007, Bioorganic & medicinal chemistry letters.

DNA Encoded Library Technology-based discovery, lead optimization and prodrug strategy toward structurally-unique indoleamine 2,3-dioxygenase (IDO1) inhibitors.

Zhengrong Zhu, John Miller, N. Prabhu, 2020, Journal of medicinal chemistry.

Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007

Weiming Zhu, Liping Wang, Yi Wang, 2014, Marine drugs.

Structure-Guided Synthesis of Tamoxifen Analogues with Improved Selectivity for the Orphan ERRγ.

T. Willson, W. Zuercher, J. Collins, 2006 .

Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7.

C. Luo, H. Ding, Liping Wang, 2020, Bioorganic & medicinal chemistry.

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf.

D. Holt, A. P. Graves, L. Shewchuk, 2021, Journal of medicinal chemistry.

Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption

Changlin Zhou, Liping Wang, Lingman Ma, 2020, EBioMedicine.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & Medicinal Chemistry Letters.

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site.

Ramona N Plant, K. Brown, J. Briand, 2014, Nature chemical biology.

Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury.

Wei Sun, Liping Wang, Lingyong Li, 2017, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.