Reshma A. Patel

发表

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2005, Journal of medicinal chemistry.

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

You-Jung Park, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.

Joseph L Duffy, Aleksandr Petrov, N. Thornberry, 2005, Bioorganic & medicinal chemistry letters.

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2008, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & medicinal chemistry letters.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2006, Journal of medicinal chemistry.

Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.

N. Thornberry, B. Leiting, Huaibing He, 2005, Bioorganic & medicinal chemistry letters.

Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).

N. Thornberry, B. Leiting, Dooseop Kim, 2007, Bioorganic & medicinal chemistry letters.

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, F. Marsilio, 2004, Bioorganic & medicinal chemistry letters.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Ping Chen, N. Thornberry, B. Leiting, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, S. Xu, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2007, Bioorganic & medicinal chemistry letters.

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

A. Woods, D. Zaller, N. Thornberry, 2005, Diabetes.

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.

C. Craik, N. Thornberry, R. Cummings, 2003, The Biochemical journal.

Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Huaibing He, 2004, Bioorganic & medicinal chemistry letters.

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

G. Scapin, Suresh B. Singh, N. Thornberry, 2008, Bioorganic & medicinal chemistry letters.

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.

G. Scapin, N. Thornberry, R. S. Roy, 2009, Bioorganic & medicinal chemistry letters.

4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & Medicinal Chemistry Letters.