J. Knudsen

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Acyl-CoA binding proteins inhibit the nonenzymic S-acylation of cysteinyl-containing peptide sequences by long-chain acyl-CoAs.

R. Leventis, G. Juel, J. Knudsen, 1997, Biochemistry.

Differential effects of acyl-CoA binding protein on enzymatic and non-enzymatic thioacylation of protein and peptide substrates.

R. Leventis, J. Knudsen, J. Silvius, 2000, Biochimica et biophysica acta.

Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.

Christer S. Ejsing, C. Ejsing, J. Knudsen, 2014, FEMS yeast research.

Mapping the lifetimes of local opening events in a native state protein

B. Kragelund, F. Poulsen, J. Knudsen, 1998, Protein science : a publication of the Protein Society.

A new family of H3 receptor antagonists based on the natural product Conessine.

V. Santora, J. Knudsen, C. Sage, 2008, Bioorganic & medicinal chemistry letters.

Probing the Nature of Noncovalent Interactions by Mass Spectrometry. A Study of Protein−CoA Ligand Binding and Assembly

C. Dobson, C. Robinson, B. Kragelund, 1996 .

Yeast sphingolipids do not need to contain very long chain fatty acids.

Olivier F. Aebischer, J. Knudsen, V. Cerantola, 2007, The Biochemical journal.

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

D. Connolly, J. Knudsen, C. Sage, 2012, Journal of medicinal chemistry.

The Acyl-CoA Synthetases Encoded within FAA1 andFAA4 in Saccharomyces cerevisiaeFunction as Components of the Fatty Acid Transport System Linking Import, Activation, and Intracellular Utilization*

P. Black, N. Færgeman, J. Knudsen, 2001, The Journal of Biological Chemistry.

Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae.

S. Feddersen, J. Knudsen, N. J. Faergeman, 2007, The Biochemical journal.

Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat.

G. Cooney, J. Knudsen, P. K. Pedersen, 2002, Diabetes.

Evolution of the acyl-CoA binding protein (ACBP).

Timothy M Rose, T. Rose, J. Knudsen, 2005, The Biochemical journal.

The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1.

C. A. Masuda, N. Færgeman, J. Knudsen, 2016, Insect biochemistry and molecular biology.

Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells.

B. Kragelund, J. Knudsen, N. J. Faergeman, 2008, The Biochemical journal.

MAA-1, a novel acyl-CoA-binding protein involved in endosomal vesicle transport in Caenorhabditis elegans.

J. Knudsen, N. J. Faergeman, S. Tuck, 2006, Molecular biology of the cell.

The secondary structure in solution of acyl-coenzyme A binding protein from bovine liver using 1H nuclear magnetic resonance spectroscopy.

S. Mandrup, F. Poulsen, J. Knudsen, 1991, Biochemistry.

Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family.

K. Kristiansen, S. Mandrup, R. Hummel, 1992, Journal of molecular biology.

Yeast acyl-CoA-binding protein: acyl-CoA-binding affinity and effect on intracellular acyl-CoA pool size.

K. Kristiansen, P. Højrup, P. Roepstorff, 1994, The Biochemical journal.

Saccharomyces carlsbergensis contains two functional genes encoding the Acyl‐CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis

K. Kristiansen, R. Hummel, T. Rose, 1997, Yeast.

The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I.

J. Knudsen, M. Cake, M. Lukas, 2001, The international journal of biochemistry & cell biology.

Structure, Function, and Phylogeny of Acyl‐CoA Binding Protein

S. Mandrup, N. Færgeman, J. Knudsen, 2004 .

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.

R. Schneiter, P. Roepstorff, C. Ungermann, 2004, The Biochemical journal.

Detection of acyl-CoA-binding protein in human red blood cells and investigation of its role in membrane phospholipid renewal.

H. Fyrst, J. Knudsen, F. Kuypers, 1995, The Biochemical journal.

The acyl-CoA binding protein is required for normal epidermal barrier function in mice[S]

S. Mandrup, L. Bagatolli, B. Finsen, 2012, Journal of Lipid Research.

Structure and function of normal and transformed murine acyl-CoA binding proteins.

F. Schroeder, A. Kier, R. Edmondson, 1998, Archives of biochemistry and biophysics.

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

A. R. Kim, Christer S. Ejsing, C. Ejsing, 2012, Molecular microbiology.

Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes.

M. Prentki, J. Deeney, B. Corkey, 2005, American journal of physiology. Endocrinology and metabolism.

Induction of hepatic acyl-CoA-binding protein and liver fatty acid-binding protein by perfluorodecanoic acid in rats. Lack of correlation with hepatic long-chain acyl-CoA levels.

J. Davis, J. V. Vanden Heuvel, R. Peterson, 1994, Biochemical pharmacology.

Evaluation of mass spectrometric techniques for charaterization of engineered proteins

K. Kristiansen, P. Roepstorff, J. Andersen, 1995, Molecular biotechnology.

Profiling of lipid species by normal-phase liquid chromatography, nanoelectrospray ionization, and ion trap-orbitrap mass spectrometry.

Christer S. Ejsing, K. Kristiansen, Jan Baumgart, 2013, Analytical biochemistry.

Regulatory elements in the promoter region of the rat gene encoding the acyl-CoA-binding protein.

K. Kristiansen, S. Mandrup, J. Knudsen, 1996, Gene.

Fatty Acyl-CoA Binding Domain of the Transcription Factor FadR

P. Højrup, V. Tsvetnitsky, J. Knudsen, 1998, The Journal of Biological Chemistry.

Long-chain Acyl-CoA is not primarily increased in myotubes established from type 2 diabetic subjects.

H. Beck-Nielsen, J. Knudsen, M. Gaster, 2006, Biochimica et biophysica acta.

Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

M. Jensen, J. Knudsen, T. B. Neergaard, 1999, Molecular and Cellular Biochemistry.

Purification and characterization of a cadmium-induced metallothionein from the shore crab Carcinus maenas (L.).

M. Depledge, P. Højrup, P. Roepstorff, 1994, The Biochemical journal.

Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference

N. Færgeman, J. Knudsen, K. Gondim, 2020, PloS one.

Opposing Effects of Fatty Acids and Acyl‐CoA Esters on Conformation and Cofactor Recruitment of Peroxisome Proliferator‐Activated Receptors

K. Kristiansen, T. Willson, I. Kratchmarova, 2002, Annals of the New York Academy of Sciences.

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).

J. Knudsen, C. Sage, E. Carballo-Jane, 2010, Bioorganic & medicinal chemistry letters.

Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains.

P. Black, J. Knudsen, N. J. Faergeman, 2000, European journal of biochemistry.

The amino acid sequence of a major protein component in the light harvesting complex of the green photosynthetic bacterium Chlorobium limicola f. thiosulfatophilum.

P. Højrup, J. Olson, P. Roepstorff, 1991, Biochimica et biophysica acta.

Acyl-CoA-binding protein (ACBP) and its relation to fatty acid-binding protein (FABP): an overview

J. Knudsen, 2004, Molecular and Cellular Biochemistry.

Yeast Cells Lacking All Known Ceramide Synthases Continue to Make Complex Sphingolipids and to Incorporate Ceramides into Glycosylphosphatidylinositol (GPI) Anchors*

Christer S. Ejsing, J. Knudsen, A. Conzelmann, 2010, The Journal of Biological Chemistry.

Thermodynamics of ligand binding to acyl-coenzyme A binding protein studied by titration calorimetry.

B. Kragelund, J. Knudsen, N. J. Faergeman, 1996, Biochemistry.

Characterization of ligand binding to acyl-CoA-binding protein.

J. Knudsen, P. Ertbjerg, J. Rosendal, 1993, The Biochemical journal.

Acyl-coenzyme A binding protein expression is fibre-type specific in rat skeletal muscle but not affected by moderate endurance training

J. Andersen, J. Knudsen, P. K. Pedersen, 2001, Pflügers Archiv.

Fluorescently labelled bovine acyl-CoA-binding protein acting as an acyl-CoA sensor: interaction with CoA and acyl-CoA esters and its use in measuring free acyl-CoA esters and non-esterified fatty acids.

P. Højrup, R. Møller, B. Kragelund, 2002, The Biochemical journal.

Induction of acyl-CoA-binding protein and its mRNA in 3T3-L1 cells by insulin during preadipocyte-to-adipocyte differentiation.

K. Kristiansen, S. Mandrup, J. Knudsen, 1991, The Biochemical journal.

Compositional and structural characterization of monolayers and bilayers composed of native pulmonary surfactant from wild type mice.

Christer S. Ejsing, L. Bagatolli, J. Knudsen, 2013, Biochimica et biophysica acta.

Genome organization and expression of the rat ACBP gene family

K. Kristiansen, S. Mandrup, J. Knudsen, 1993, Molecular and Cellular Biochemistry.

Fatty acyl-CoA oxidase activity is induced before long-chain acyl-CoA hydrolase activity and acyl-CoA binding protein in liver of rat treated with peroxisome proliferating 3-thia fatty acids.

J. Lillehaug, R. Berge, J. Knudsen, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Cardiac fatty acid-binding proteins. Isolation and characterization of the mitochondrial fatty acid-binding protein and its structural relationship with the cytosolic isoforms.

P. Højrup, P. Roepstorff, F. Spener, 1990, The Journal of biological chemistry.

Rapamycin inhibits activation of ryanodine receptors from skeletal muscle by the fatty acyl CoA-acyl CoA binding protein complex.

A. Benedetti, J. Knudsen, R. Fulceri, 1999, Biochemical and biophysical research communications.

Revision of the amino acid sequence of human heart fatty acid-binding protein

P. Højrup, P. Roepstorff, F. Spener, 2004, Molecular and Cellular Biochemistry.

Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence.

P. Højrup, P. Roepstorff, J. Knudsen, 1989, The Biochemical journal.

Acyl-CoA-binding protein in the armadillo Harderian gland: its primary structure and possible role in lipid secretion.

N. Sterin-Speziale, J. Knudsen, J. Affanni, 2001, Biochimica et biophysica acta.

Structure and expression of the mouse gene encoding the endozepine-like peptide from haploid male germ cells.

R. Ivell, J. Knudsen, G. Weinbauer, 2000, European journal of biochemistry.

Adipocyte Differentiation is Dependent on the Induction of the Acyl-CoA Binding Protein

K. Kristiansen, S. Mandrup, J. Knudsen, 1995 .

Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species.

M. Depledge, P. Højrup, K. Pedersen, 1996, The Biochemical journal.

Induction and identification of cadmium-, zinc- and copper-metallothioneins in the shore crab Carcinus maenas (L.).

M. Depledge, P. Højrup, K. Pedersen, 1998, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Unsaturated Glycerophospholipids Mediate Heme Crystallization: Biological Implications for Hemozoin Formation in the Kissing Bug Rhodnius prolixus

T. Egan, D. Wright, J. Knudsen, 2014, PloS one.

Analysis of the ligand binding properties of recombinant bovine liver-type fatty acid binding protein.

F. Spener, N. Færgeman, J. Knudsen, 1995, Biochimica et biophysica acta.

High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl‐CoA ligand

D. V. van Aalten, R. Wierenga, J. Knudsen, 2006, Proteins.

Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA

B. Kragelund, N. Færgeman, S. Feddersen, 2007, Molecular and Cellular Biochemistry.

Different secondary structure elements as scaffolds for protein folding transition states of two homologous four‐helix bundles

K. Teilum, B. Kragelund, F. Poulsen, 2005, Proteins.

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.

G J Kleywegt, T A Jones, G. Kleywegt, 2001, Journal of molecular biology.

Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes.

G. Schmitz, F. Spener, C. Kerkhoff, 1997, Biochimica et biophysica acta.

Possible roles of long-chain fatty Acyl-CoA esters in the fusion of biomembranes.

P. Black, J. Knudsen, C. DiRusso, 2000, Sub-cellular biochemistry.

A Role for Interferon‐Gamma in Focal Cerebral Ischemia in Mice

K. Lambertsen, R. Gregersen, B. Clausen, 2004, Journal of neuropathology and experimental neurology.

Comparison of the binding affinities of acyl-CoA-binding protein and fatty-acid-binding protein for long-chain acyl-CoA esters.

J. Knudsen, J. Rasmussen, T. Börchers, 1990, The Biochemical journal.

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

A. Zylicz, J. Nylandsted, M. Jäättelä, 2010, Nature.

Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity.

C. Jolly, J. Knudsen, Latha S. Kannan, 2003, Biochimica et biophysica acta.

Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor.

J. Knudsen, J. Rasmussen, J. Rosendal, 1993, The Biochemical journal.

Effect of heterologous expression of acyl-CoA-binding protein on acyl-CoA level and composition in yeast.

K. Kristiansen, P. Højrup, S. Mandrup, 1993, The Biochemical journal.

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.

N. Færgeman, J. Knudsen, N. Faergeman, 1997, The Biochemical journal.

Acyl-CoA binding protein is an essential protein in mammalian cell lines.

J. Knudsen, N. Faergeman, 2002, The Biochemical journal.

Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling.

M. Jensen, J. Knudsen, T. B. Neergaard, 2000, The Journal of nutrition.

Disruption of the Gene Encoding the Acyl-CoA-binding Protein (ACB1) Perturbs Acyl-CoA Metabolism in Saccharomyces cerevisiae*

K. Kristiansen, J. Knudsen, C. K. Schjerling, 1996, The Journal of Biological Chemistry.

Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis.

K. Kristiansen, J. Knudsen, J. Rasmussen, 1994, The Biochemical journal.

Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae.

J. Andersen, R. Schneiter, R. Sandhoff, 2001, Molecular biology of the cell.

Inhibition of 3T3-L1 Adipocyte Differentiation by Expression of Acyl-CoA-binding Protein Antisense RNA*

S. Mandrup, J. Knudsen, K. Kristiansen, 1998, The Journal of Biological Chemistry.

Acyl-coenzyme A binding protein (ACBP).

B. Kragelund, F. Poulsen, J. Knudsen, 1999, Biochimica et biophysica acta.

Diazepam-binding inhibitor: a neuropeptide and/or an acyl-CoA ester binding protein?

J. Knudsen, M. Nielsen, 1990, Biochemical Journal.

The function of acyl-CoA-binding protein (ACBP)/Diazepam binding inhibitor (DBI)

K. Kristiansen, S. Mandrup, F. Poulsen, 1993, Molecular and Cellular Biochemistry.

Long chain acyl-CoA esters and acyl-CoA binding protein (ACBP) in cell function

N. Færgeman, J. Knudsen, M. Burton, 2003 .

Acyl-CoA-binding and transport, an alternative function for diazepam binding inhibitor (DBI), which is identical with acyl-CoA-binding protein

J. Knudsen, 1991, Neuropharmacology.

Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides

J. Knudsen, V. Cerantola, A. Conzelmann, 2009, Molecular microbiology.

SLC1 and SLC4 Encode Partially Redundant Acyl-Coenzyme A 1-Acylglycerol-3-phosphate O-Acyltransferases of Budding Yeast*

J. Knudsen, A. Conzelmann, C. Roubaty, 2007, Journal of Biological Chemistry.

Chapter 4 – ANALYSIS OF LONG-CHAIN ACYL-COENZYME A ESTERS

J. Knudsen, T. Bækdal, C. K. Schjerling, 1996 .

A fast and versatile method for extraction and quantitation of long-chain acyl-CoA esters from tissue: content of individual long-chain acyl-CoA esters in various tissues from fed rat.

J. Knudsen, J. Rosendal, 1992, Analytical biochemistry.

The Role of Acylcoa Binding Protein (ACBP) and Long-Chain Acylcoa Esters in Cell Regulation and Function

J. Knudsen, 1996 .

Amino acid sequence of acyl-CoA-binding protein from cow liver.

P. Højrup, P. Roepstorff, J. Knudsen, 1987, The Biochemical journal.

Gene synthesis, expression in Escherichia coli, purification and characterization of the recombinant bovine acyl-CoA-binding protein.

K. Kristiansen, P. Højrup, S. Mandrup, 1991, The Biochemical journal.

Crystal structure of FadR, a fatty acid‐responsive transcription factor with a novel acyl coenzyme A‐binding fold

D. V. van Aalten, R. Wierenga, J. Knudsen, 2000, The EMBO journal.

Purification of goats' milk casein by reversed-phase high-performance liquid chromatography and identification of αs1-casein

P. Højrup, J. Knudsen, J. Mikkelsen, 1987, Journal of Dairy Research.

Affinity Labeling Fatty Acyl-CoA Synthetase with 9-p-Azidophenoxy Nonanoic Acid and the Identification of the Fatty Acid-binding Site*

P. Black, R. Maccoll, J. Knudsen, 2000, The Journal of Biological Chemistry.

Disruption of the Saccharomyces cerevisiae Homologue to the Murine Fatty Acid Transport Protein Impairs Uptake and Growth on Long-chain Fatty Acids*

P. Black, N. Færgeman, J. Knudsen, 1997, The Journal of Biological Chemistry.

Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium

Y. Yoshinaga, S. Griffey, S. Young, 2012, PloS one.

Determination by photoaffinity labelling of the hydrophobic part of the binding site for acyl-CoA esters on acyl-CoA-binding protein from bovine liver.

P. Højrup, J. Knudsen, S. N. Pedersen, 1990, The Biochemical journal.

Conserved residues and their role in the structure, function, and stability of acyl-coenzyme A binding protein.

K. Kristiansen, P. Roepstorff, B. Kragelund, 1999, Biochemistry.

Amino acid sequence around the active-site serine residue in the acyltransferase domain of goat mammary fatty acid synthetase.

P. Højrup, P. Roepstorff, J. Knudsen, 1985, The Biochemical journal.

Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A.

F M Poulsen, B. Kragelund, F. Poulsen, 1993, Journal of molecular biology.

Acyl-CoA Esters Antagonize the Effects of Ligands on Peroxisome Proliferator-activated Receptor α Conformation, DNA Binding, and Interaction with Co-factors*

K. Kristiansen, I. Kratchmarova, S. Mandrup, 2001, The Journal of Biological Chemistry.

Amino acid sequences of three acyl-binding/lipid-transfer proteins from rape seedlings.

P. Højrup, J. Knudsen, J. Ostergaard, 1995, Biochimica et biophysica acta.

Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP.

F M Poulsen, K. Teilum, B. Kragelund, 2000, Journal of molecular biology.

The formation of a native-like structure containing eight conserved hydrophobic residues is rate limiting in two-state protein folding of ACBP

Karsten Kristiansen, Birthe B. Kragelund, Flemming M. Poulsen, 1999, Nature Structural Biology.

Fast and one-step folding of closely and distantly related homologous proteins of a four-helix bundle family.

F M Poulsen, P. Højrup, B. Kragelund, 1996, Journal of molecular biology.

Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP).

F M Poulsen, B. Kragelund, F. Poulsen, 1995, Journal of molecular biology.

Fatty acyl-CoA-acyl-CoA-binding protein complexes activate the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum.

A. Benedetti, J. Knudsen, P. Volpe, 1997, The Biochemical journal.

Evaluation of the affinity and turnover number of both hepatic mitochondrial and microsomal carnitine acyltransferases: relevance to intracellular partitioning of acyl-CoAs.

J. Knudsen, M. Cake, M. Lukas, 1999, Biochemistry.

Acyl‐coenzyme A organizes laterally in membranes and is recognized specifically by acyl‐coenzyme A binding protein

J. Knudsen, A. Cohen Simonsen, O. Mouritsen, 2003, FEBS letters.

The structural basis of acyl coenzyme A‐dependent regulation of the transcription factor FadR

D. V. van Aalten, J. Knudsen, C. DiRusso, 2001, The EMBO journal.

Folding of a four-helix bundle: studies of acyl-coenzyme A binding protein.

F M Poulsen, C M Dobson, C. Dobson, 1995, Biochemistry.

Micro method for determination of nonesterified fatty acid in whole blood obtained by fingertip puncture.

J. Knudsen, M. Gaster, J. Hansen, 2006, Analytical biochemistry.

Aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes.

D. Haldar, C. Jolly, J. Knudsen, 2005, Biochimica et biophysica acta.

K. Kristiansen, T. Rose, J. Knudsen, 1997, Yeast.

Inhibition by rat diazepam-binding inhibitor/acyl-CoA-binding protein of glucose-induced insulin secretion in the rat.

B. Ahrén, J. Knudsen, C. Ostenson, 1994, European Journal of Endocrinology.

The acyl-CoA binding protein is required for normal epidermal barrier function in mice[S]

S. Mandrup, L. Bagatolli, B. Finsen, 2012, Journal of Lipid Research.

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

A. R. Kim, Christer S. Ejsing, Jeong-Yoon Kim, 2012, Molecular microbiology.

Profiling of lipid species by normal-phase liquid chromatography, nanoelectrospray ionization, and ion trap-orbitrap mass spectrometry.

Christer S. Ejsing, K. Kristiansen, Jan Baumgart, 2013, Analytical biochemistry.