C. Aldrich

发表

Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol.

F. Liu, Xiao-Kang Zhang, William D. Fiers, 2017, The Journal of organic chemistry.

Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

Feng Liu, Dirk Schnappinger, Courtney C Aldrich, 2015, Journal of medicinal chemistry.

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

B. Finzel, C. Aldrich, Daniel J. Wilson, 2014, Chembiochem : a European journal of chemical biology.

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

D. Schnappinger, A. Blumenthal, K. Rhee, 2011, PLoS pathogens.

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Y. Sham, G. Magni, M. Di Stefano, 2009, Bioorganic & medicinal chemistry.

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

W. Gerwick, Janet L. Smith, D. Sherman, 2016, ACS chemical biology.

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

C. Aldrich, R. Remmel, Surendra Dawadi, 2016, Bioorganic & medicinal chemistry.

Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.

C. Aldrich, A. Baughn, Anthony D. Baughn, 2017, Organic letters.

Total synthesis and biological evaluation of transvalencin Z.

C. Salomon, C. Aldrich, Kathryn M. Nelson, 2012, Journal of natural products.

Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2012, ACS chemical biology.

Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides

Diego E. Escalante, D. Ferguson, C. Aldrich, 2022, Molecules.

Polyketide Intermediate Mimics as Probes for Revealing Cryptic Stereochemistry of Ketoreductase Domains

Janet L. Smith, S. Bernard, William D. Fiers, 2014, ACS chemical biology.

Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2013, Bioorganic & medicinal chemistry.

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Tory M. Schaaf, David D. Thomas, J. Sachs, 2019, Science Signaling.

Molecular Analysis of the Rebeccamycin l-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243

D. Sherman, C. Aldrich, T. Nishizawa, 2005, Journal of bacteriology.

Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular

M. Zimmerman, T. Dick, D. Negatu, 2017, Antimicrobial Agents and Chemotherapy.

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

M. Zimmerman, T. Dick, V. Dartois, 2021, Antimicrobial agents and chemotherapy.

Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates

Joseph A Buonomo, C. Aldrich, Yusuke Minato, 2016, Scientific Reports.

Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System

Joseph A Buonomo, C. Aldrich, J. Buonomo, 2015, Angewandte Chemie.

The Ecstasy and Agony of Assay Interference Compounds

K. Merz, C. Bertozzi, C. Lindsley, 2017, J. Chem. Inf. Model..

The Ecstasy and Agony of Assay Interference Compounds.

K. Merz, C. Bertozzi, C. Lindsley, 2017, ACS chemical biology.

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae

C. Aldrich, A. Gulick, E. Drake, 2018, The Journal of Biological Chemistry.

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.

G. Minasov, W. Anderson, L. Shuvalova, 2016, ACS infectious diseases.

Human Urinary Composition Controls Antibacterial Activity of Siderocalin* ♦

Robin R. Shields-Cutler, J. Crowley, J. Marschall, 2015, The Journal of Biological Chemistry.

Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis.

C. Aldrich, C. Shi, 2012, The Journal of organic chemistry.

Innovative Strategies for the Construction of Diverse 1'-Modified C-Nucleoside Derivatives.

C. Aldrich, Subhankar Panda, Tej Narayan Poudel, 2021, The Journal of organic chemistry.

Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.

Vivek T. Natarajan, R. Sankaranarayanan, C. Aldrich, 2015, Chemistry & biology.

Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

C. Aldrich, Kathryn M. Nelson, B. Duckworth, 2012, Current topics in medicinal chemistry.

Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP.

C. Aldrich, C. Shi, 2010, Organic letters.

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.

P. M. Pereira, H. Sahl, M. Zimmerman, 2022, Journal of medicinal chemistry.

Confronting Racism in Chemistry Journals

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, ACS Central Science.

Confronting Racism in Chemistry Journals

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, ACS Omega.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, ACS Applied Bio Materials.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, The Journal of organic chemistry.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, Journal of the American Chemical Society.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, ACS combinatorial science.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, Biomacromolecules.

Update to Our Reader, Reviewer, and Author Communities-April 2020.

Scott J. Miller, Thomas F. Hofmann, Bryan W. Brooks, 2020, Journal of proteome research.

Iterative chain elongation by a pikromycin monomodular polyketide synthase.

K. Reynolds, D. Sherman, C. Aldrich, 2003, Journal of the American Chemical Society.

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

C. Aldrich, C. Barry, H. Boshoff, 2006, Journal of medicinal chemistry.

Chemoenzymatic synthesis of cryptophycin/arenastatin natural products.

Zachary Q. Beck, D. Sherman, G. Georg, 2005, Biochemistry.

Design, Synthesis and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases.

C. Aldrich, C. Shi, A. Gulick, 2020, ACS chemical biology.

Methionine antagonizes para-aminosalicylic acid activity via affecting folate precursor biosynthesis pathway in Mycobacterium tuberculosis

C. Aldrich, Yusuke Minato, A. Baughn, 2018, bioRxiv.

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

D. Schnappinger, S. Chakraborty, K. Rhee, 2013, Proceedings of the National Academy of Sciences.

Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

B. Finzel, D. Schnappinger, F. Liu, 2017, Journal of medicinal chemistry.

2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2016, Bioorganic & medicinal chemistry.

Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis.

C. Aldrich, R. Remmel, A. Teitelbaum, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides.

C. Aldrich, Zhao-yong Yang, M. Cushman, 2020, European journal of medicinal chemistry.

Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor.

W. Saw, G. Grüber, Joon Shin, 2022, ACS infectious diseases.

1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides.

C. Aldrich, Subhankar Panda, Tej Narayan Poudel, 2022, The Journal of organic chemistry.

Structural Basis of Polyketide Synthase O-Methylation.

P. Wipf, W. Gerwick, Janet L. Smith, 2018, ACS chemical biology.

Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.

C. Aldrich, J. Neres, Daniel J. Wilson, 2008, Biochemistry.

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.

D. Schnappinger, S. W. Park, C. Aldrich, 2018, ACS medicinal chemistry letters.

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2015, Journal of medicinal chemistry.

Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.

C. Aldrich, C. Barry, H. Boshoff, 2015, The Journal of organic chemistry.

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.

C. Aldrich, C. Barry, H. Boshoff, 2006, Organic letters.

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2006, Journal of medicinal chemistry.

The Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum

C. Allen, P. Schneider, D. Hoffmeister, 2009, Chembiochem : a European journal of chemical biology.

Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.

Michael Schroeder, Feng Liu, Thierry Langer, 2016, Journal of medicinal chemistry.

Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral Entry

Alon Herschhorn, Shilei Ding, A. Finzi, 2022, ACS infectious diseases.

Drugging the microbiome: targeting small microbiome molecules.

C. Aldrich, Subhankar Panda, Sachin Sharma, 2022, Current opinion in microbiology.

Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates

G. Dodge, Janet L. Smith, William D. Fiers, 2015, Chemical science.

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase.

K. Reynolds, D. Sherman, C. Aldrich, 2003, Journal of the American Chemical Society.

Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance

Joel S. Freundlich, R. Ebright, M. Zimmerman, 2022, Angewandte Chemie.

Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.

G. Grüber, Joon Shin, S. Rishikesan, 2021, ACS chemical biology.

Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis.

C. Aldrich, Curtis A. Engelhart, 2013, The Journal of organic chemistry.

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

C. Aldrich, A. Gulick, 2018, Natural product reports.

PKS-NRPS Enzymology and Structural Biology: Considerations in Protein Production.

Janet L. Smith, W. C. Brown, C. Aldrich, 2018, Methods in enzymology.

Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase.

G. Dodge, Janet L. Smith, William D. Fiers, 2015, Journal of the American Chemical Society.

Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction.

Michael Olin, Courtney C Aldrich, D. Ferguson, 2014, Journal of medicinal chemistry.

Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.

D. Ferguson, C. Aldrich, J. Ohlfest, 2012, ACS medicinal chemistry letters.

Formal total synthesis of the polyketide macrolactone narbonolide.

D. Sherman, C. Aldrich, R. Fecik, 2005, The Journal of organic chemistry.

Development of a high-throughput fluorescence polarization assay for the discovery of phosphopantetheinyl transferase inhibitors.

C. Aldrich, B. Duckworth, 2010, Analytical biochemistry.

Development of an imidazole salt catalytic system for the preparation of bis(indolyl)methanes and bis(naphthyl)methane

C. Aldrich, Xu Wang, 2019, PloS one.

Copper(II)-Catalyzed Conversion of Aryl/Heteroaryl Boronic Acids, Boronates, and Trifluoroborates into the Corresponding Azides: Substrate Scope and Limitations.

C. Aldrich, A. Gupte, K. Grimes, 2010, Synthesis.

Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP.

C. Aldrich, C. Shi, 2010, Organic letters.

Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers.

A. Saghatelian, C. Aldrich, C. Merlic, 2001, The Journal of organic chemistry.

Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins.

A. Saghatelian, C. Aldrich, C. Merlic, 2000, Journal of the American Chemical Society.

Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

G. Dodge, Janet L. Smith, D. Sherman, 2016, Journal of the American Chemical Society.

Acylamino Chromium Carbene Complexes: Direct Carbonyl Insertion, Formation of Münchnones, and Trapping with Dipolarophiles.

C. Aldrich, C. Merlic, A. Baur, 2000, Journal of the American Chemical Society.

Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane.

Joseph A Buonomo, C. Aldrich, J. Buonomo, 2017, Chemistry.

Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme

L. Wackett, J. Richman, S. Robinson, 2019, Chembiochem : a European journal of chemical biology.

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

Courtney C Aldrich, C. Xing, C. Aldrich, 2008, Journal of medicinal chemistry.

β-Lactamase-Mediated Fragmentation: Historical Perspectives and Recent Advances in Diagnostics, Imaging, and Antibacterial Design.

C. Aldrich, M. Cole, P. Hegde, 2022, ACS infectious diseases.

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

A. Joachimiak, L. Hedstrom, Youngchang Kim, 2015, PloS one.

Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide.

D. Sherman, C. Aldrich, R. Fecik, 2005, Journal of the American Chemical Society.

Macozinone: revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis.

C. Aldrich, Gang Zhang, 2019, Acta crystallographica. Section C, Structural chemistry.

Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

V. Guidolin, P. Villalta, S. Balbo, 2020, ACS infectious diseases.

Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis.

F. Liu, Zheng Liu, C. Aldrich, 2015, The Journal of organic chemistry.

1,3-Diphenyldisiloxane Enables Additive-Free Redox Recycling Reactions and Catalysis with Triphenylphosphine

C. Aldrich, M. Cole, J. Buonomo, 2020 .

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

Joseph M. Muretta, Y. Sham, David D. Thomas, 2011, Analytical biochemistry.

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

C. Aldrich, C. Barry, H. Boshoff, 2008, Journal of medicinal chemistry.

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis.

C. Aldrich, H. Boshoff, Daniel J. Wilson, 2020, European journal of medicinal chemistry.

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.

B. Finzel, D. Schnappinger, F. Liu, 2015, Journal of medicinal chemistry.

Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.

D. Schnappinger, Christopher L. Seiler, C. Aldrich, 2013, ACS medicinal chemistry letters.

Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.

B. Finzel, D. Schnappinger, C. Aldrich, 2011, Chemistry & biology.

Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli.

J. Blanchard, C. Aldrich, Daniel J. Wilson, 2010, Biochemistry.

Reinvestigation of the structure-activity relationships of isoniazid.

T. Dick, C. Salomon, C. Aldrich, 2021, Tuberculosis.

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.

C. Aldrich, C. Barry, H. Boshoff, 2013, Journal of medicinal chemistry.

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.

Y. Sham, C. Aldrich, Daniel J. Wilson, 2010, Journal of medicinal chemistry.

The Biotin Biosynthetic Pathway in Mycobacterium tuberculosis is a Validated Target for the Development of Antibacterial Agents.

N. Mishra, C. Aldrich, M. Bockman, 2019, Current medicinal chemistry.

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

C. Aldrich, Yusuke Minato, A. Baughn, 2018, Nature Communications.

Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogues as Mechanism-Based Inhibitors of BioA, a Pyridoxal Phosphate-Dependent Enzyme.

C. Aldrich, C. Eiden, 2017, The Journal of organic chemistry.

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture*

Courtney C Aldrich, C. Aldrich, Andrew M Gulick, 2016, The Journal of Biological Chemistry.

Structure of PA1221, a nonribosomal peptide synthetase containing adenylation and peptidyl carrier protein domains.

C. Aldrich, C. Shi, C. Mitchell, 2012, Biochemistry.

Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains.

C. Aldrich, Daniel J. Wilson, C. Shi, 2012, Chemistry & biology.

A mechanism-based aryl carrier protein/thiolation domain affinity probe.

Courtney C Aldrich, C. Aldrich, Chunhua Qiao, 2007, Journal of the American Chemical Society.

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Leonardo K. Martinelli, V. Mizrahi, C. Aldrich, 2014, Bioorganic & medicinal chemistry.

Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates.

David H Sherman, Courtney C Aldrich, D. Sherman, 2005, Journal of the American Chemical Society.

Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS).

M. Zimmerman, V. Dartois, C. Aldrich, 2022, European journal of medicinal chemistry.

Parameterization and Application of the General Amber Force Field to Model Fluro Substituted Furanose Moieties and Nucleosides

Diego E. Escalante, D. Ferguson, C. Aldrich, 2022, bioRxiv.

The Ecstasy and Agony of Assay Interference Compounds.

Kenneth M Merz, Gunda I Georg, Carolyn Bertozzi, 2017, Journal of medicinal chemistry.

Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters.

I. Merfort, Kathrin Schmich, D. Hoffmeister, 2009, Journal of natural products.

Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillusanthracis

Brian F. Pfleger, Karla D. Passalacqua, N. Bergman, 2006, Journal of bacteriology.

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.

G. Grüber, A. Harikishore, T. Dick, 2022, Bioorganic & medicinal chemistry.

Targeting protein biotinylation enhances tuberculosis chemotherapy

J. Sacchettini, T. Ioerger, D. Schnappinger, 2018, Science Translational Medicine.

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Joshua A. Bittker, S. Schreiber, B. Finzel, 2015, Chemistry & biology.

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.

N. Mishra, D. Ferguson, D. Schnappinger, 2019, ACS infectious diseases.

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

C. Aldrich, Yusuke Minato, A. Baughn, 2018, Front. Cell. Infect. Microbiol..

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

B. Finzel, D. Schnappinger, Orishadipe Abayomi, 2011, Journal of the American Chemical Society.

The Ecstasy and Agony of Assay Interference Compounds.

K. Merz, C. Bertozzi, C. Lindsley, 2017, ACS infectious diseases.

The Ecstasy and Agony of Assay Interference Compounds.

Kenneth M Merz, Gunda I Georg, Carolyn Bertozzi, 2017, ACS medicinal chemistry letters.

The Ecstasy and Agony of Assay Interference Compounds.

Shaomeng Wang, Kenneth M. Merz, Carolyn Bertozzi, 2017, Journal of chemical information and modeling.

8-cyanobenzothiazinone analogs with potent antitubercular activity

C. Aldrich, Gang Zhang, Yan Li, 2021, Medicinal Chemistry Research.

Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties.

C. Aldrich, Gang Zhang, Michael D. Howe, 2019, ACS medicinal chemistry letters.

Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis.

C. Aldrich, J. Neres, A. Gulick, 2010, Biochemistry.

Mycobacterial MenG: Partial Purification, Characterization, and Inhibition.

D. Crick, C. Aldrich, Rakesh K. Dhiman, 2022, ACS infectious diseases.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS chemical biology.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS infectious diseases.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, Journal of medicinal chemistry.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS chemical neuroscience.

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.

C. Wagner, C. Aldrich, Mamta Gupta, 2017, Journal of medicinal chemistry.

Pyrazinamide: A Frontline Drug Used for Tuberculosis. Molecular Mechanism of Action Resolved after 50 Years?

C. Aldrich, Alvin S. Kalinda, 2012, ChemMedChem.

Antimetabolite poisoning of cofactor biosynthesis.

Leonardo K. Martinelli, C. Aldrich, 2012, Chemistry & biology.

Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Georgios Skiniotis, G. Skiniotis, Jeffrey Tarrasch, 2015, Nature.

Update to Our Reader, Reviewer, and Author Communities-April 2020.

Scott J. Miller, Thomas F. Hofmann, Bryan W. Brooks, 2020, ACS applied materials & interfaces.

A continuous kinetic assay for adenylation enzyme activity and inhibition.

C. Aldrich, Daniel J. Wilson, 2010, Analytical biochemistry.

Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches.

Vivek T. Natarajan, Anil Kumar Singh, D. Dash, 2015, Molecular cell.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

The Ecstasy and Agony of Assay Interference Compounds.

K. Merz, C. Bertozzi, C. Lindsley, 2017, Biochemistry.

Biotin-dependent cell envelope remodelling is required for Mycobacterium abscessus survival in lung infection

Sahadevan Raman, E. Rubin, C. Aldrich, 2023, Nature Microbiology.

Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis.

Brian F. Pfleger, D. Sherman, C. Aldrich, 2007, Biochemistry.

Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.

Courtney C Aldrich, Jun Yin, C. Aldrich, 2013, Chemistry & biology.

Synthesis of deuterium-labelled 5'-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d(4)) as an internal standard for quantitation of Sal-AMS.

C. Aldrich, R. Remmel, A. Gupte, 2008, Journal of labelled compounds & radiopharmaceuticals.

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

Andrew R. Thompson, R. Cornea, C. Aldrich, 2023, bioRxiv.

A Large-Scale High-Throughput Screen for Modulators of SERCA Activity

R. Cornea, C. Aldrich, Ji Li, 2022, Biomolecules.

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.

C. Aldrich, C. Barry, H. Boshoff, 2007, Journal of medicinal chemistry.

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

D. Bers, David D. Thomas, A. Zima, 2021, The Journal of biological chemistry.

Confronting Racism in Chemistry Journals.

Scott J. Miller, Thomas F. Hofmann, Sarah B. Tegen, 2020, ACS applied materials & interfaces.

Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome

C. Aldrich, S. Gobec, Izidor Sosič, 2020, Molecules.

A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae.

D. Ferguson, C. Aldrich, Xu Wang, 2019, Journal of medicinal chemistry.

Assigning enzyme function from the metabolic milieu.

C. Aldrich, B. Duckworth, 2010, Chemistry & biology.

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

David D. Thomas, F. van Petegem, B. Svensson, 2021, bioRxiv.

Structural and Functional Characterization of Mycobacterium tuberculosis Homoserine Transacetylase.

D. Ronning, C. Aldrich, J. Dalluge, 2023, ACS infectious diseases.

Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis.

D. Schnappinger, C. Aldrich, Curtis A. Engelhart, 2023, Tuberculosis.

Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.

D. Ferguson, C. Aldrich, E. Bennett, 2008, Journal of medicinal chemistry.

Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

Andrew R. Thompson, R. Cornea, C. Aldrich, 2023, Scientific reports.

New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping.

A. Zima, E. Bovo, R. Cornea, 2022, Biophysical journal.

Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay.

C. Aldrich, Daniel J. Wilson, B. Duckworth, 2016, Methods in molecular biology.

Siderophore Pathway from Bacillus anthracis

Brian F. Pfleger, Karla D. Passalacqua, N. Bergman, 2006 .

2nd SCI/RSC Symposium on Medicinal Chemistry for Global Health: A Unique Opportunity for the Field.

C. Aldrich, Félix Calderón, 2018, ACS Infectious Diseases.

A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.

C. Aldrich, K. Grimes, 2011, Analytical biochemistry.

PROTAC antibiotics: the time is now

T. Dick, C. Aldrich, M. Go, 2023, Expert opinion on drug discovery.

Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High‐Throughput Screening

C. Aldrich, J. Neres, R. Remmel, 2010, ChemMedChem.

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

Linnan Zhu, D. Schnappinger, S. Ehrt, 2023, mBio.

Gram Scale Synthesis of Membrane-Active Antibacterial 4-Quinolone Lead Compound.

C. Aldrich, Gorakhnath R. Jachak, Moyosore O Orimoloye, 2023, The Journal of organic chemistry.

Pyrazinamide: A Frontline Drug Used for Tuberculosis. Molecular Mechanism of Action Resolved after 50 Years?

C. Aldrich, Alvin S. Kalinda, 2012 .

Update to Our Reader, Reviewer, and Author Communities - April 2020

Sébastien Lecommandoux, Harry A. Atwater, Kenneth M. Merz, 2020, Journal of Chemical Information and Modeling.

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

B. Finzel, D. Schnappinger, S. W. Park, 2011, Journal of the American Chemical Society.

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Joshua A. Bittker, S. Schreiber, B. Finzel, 2015, Chemistry & biology.

Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane

Joseph A Buonomo, C. Aldrich, C. Eiden, 2017, Synthesis.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis.

Zheng Liu, C. Aldrich, Feng Liu, 2015, The Journal of organic chemistry.

Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.

B. Finzel, J. Lipscomb, C. Aldrich, 2017, Journal of the American Chemical Society.

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

B. Finzel, C. Aldrich, Daniel J. Wilson, 2014, Chembiochem : a European journal of chemical biology.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS medicinal chemistry letters.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS pharmacology & translational science.

The Ecstasy and Agony of Assay Interference Compounds.

Kenneth M Merz, Gunda I Georg, Carolyn Bertozzi, 2017, ACS chemical neuroscience.