M. Toney

发表

Conversion of aminodeoxychorismate synthase into anthranilate synthase with Janus mutations: mechanism of pyruvate elimination catalyzed by chorismate enzymes.

Justin E Culbertson, D. Chung, Kristin T Ziebart, 2015, Biochemistry.

Expression and characterization of PhzE from P. aeruginosa PAO1: aminodeoxyisochorismate synthase involved in pyocyanin and phenazine-1-carboxylate production.

Justin E Culbertson, M. Toney, Justin E. Culbertson, 2013, Biochimica et biophysica acta.

Nucleophile specificity in anthranilate synthase, aminodeoxychorismate synthase, isochorismate synthase, and salicylate synthase.

Kristin T Ziebart, M. Toney, 2010, Biochemistry.

Common enzymological experiments allow free energy profile determination.

M. Toney, 2013, Biochemistry.

Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase.

D. Larsen, M. Toney, E. C. Carroll, 2010, Journal of the American Chemical Society.

Molecular characterization of novel pyridoxal‐5′‐phosphate‐dependent enzymes from the human microbiome

Mitchell D. Miller, A. Godzik, A. Deacon, 2014, Protein science : a publication of the Protein Society.

Engineering amyloid fibrils from β-solenoid proteins for biomaterials applications.

Xi Chen, Gang-yu Liu, Natha Robert Hayre, 2015, ACS nano.

Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins

D. Cox, M. Toney, Maria D R Peralta, 2020, PloS one.

Extraordinarily Stable Amyloid Fibrils Engineered from Structurally Defined β-Solenoid Proteins.

M. Toney, Maria D R Peralta, Zeyu Peng, 2017, Biochemistry.

The K258R mutant of aspartate aminotransferase stabilizes the quinonoid intermediate.

J. Kirsch, M. Toney, 1991, The Journal of biological chemistry.

1,4,7-Trimethyloxatriquinane: S(N)2 reaction at tertiary carbon.

M. Mascal, M. Toney, N. Hafezi, 2010, Journal of the American Chemical Society.

Evidence for a two-base mechanism involving tyrosine-265 from arginine-219 mutants of alanine racemase.

M. Toney, S. Sun, Shaoxian Sun, 1999, Biochemistry.

Nitrate reductase (15)N discrimination in Arabidopsis thaliana,

A. Bloom, E. Carlisle, M. Toney, 2014 .

Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design.

Kristin T Ziebart, M. Toney, M. Kurth, 2010, Journal of medicinal chemistry.

A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, Wen Liu, M. Toney, 2003, Journal of the American Chemical Society.

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells

M. Toney, P. Beal, Yuru Wang, 2019, Nucleic acids research.

Crystallization and preliminary X-ray diffraction studies of dialkylglycine decarboxylase, a decarboxylating transaminase.

R. Pauptit, J. Jansonius, U. Sauder, 1991, Journal of molecular biology.

Analysis of catalytic determinants of diaminopimelate and ornithine decarboxylases using alternate substrates.

M. Toney, E. Fogle, 2011, Biochimica et biophysica acta.

Conservation of mechanism in three chorismate-utilizing enzymes.

P. Bartlett, M. Toney, Ze He, 2004, Journal of the American Chemical Society.

Crystallographic studies on the vitamin B6-assisted enzymic transamination reaction

B. Shen, V. Malashkevich, M. Hennig, 1994 .

Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, M. Spies, Weiming Wu, 2003, Biochemistry.

Serine Racemase Modulates Intracellular D-Serine Levels through an α,β-Elimination Activity*

R. Panizzutti, Elena Kartvelishvily, M. Toney, 2005, Journal of Biological Chemistry.

Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils.

Gang-yu Liu, Wei-feng Lin, M. Toney, 2016, Small.

NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5'-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine.

M. Toney, P. Tolstoy, H. Limbach, 2013, Journal of the American Chemical Society.

NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: toward a distinction of geometric and equilibrium H-bond isotope effects.

M. Toney, H. Limbach, G. Denisov, 2006, Journal of the American Chemical Society.

Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition.

A. Fisher, M. Toney, W. Liu, 2002, Biochemistry.

pH studies on the mechanism of the pyridoxal phosphate-dependent dialkylglycine decarboxylase.

M. Toney, X. Zhou, 1999, Biochemistry.

Observation by NMR of the tautomerism of an intramolecular OHOHN-charge relay chain in a model Schiff base

M. Toney, S. Smirnov, P. Tolstoy, 2007 .

Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

M. Toney, W. R. Griswold, 2010, Bioorganic & medicinal chemistry letters.

NMR studies of the protonation states of pyridoxal-5′-phosphate in water

M. Toney, P. Tolstoy, H. Limbach, 2010 .

Controlling reaction specificity in pyridoxal phosphate enzymes.

M. Toney, 2011, Biochimica et biophysica acta.

NMR studies of the stability, protonation States, and tautomerism of (13)C- AND (15)N-labeled aldimines of the coenzyme pyridoxal 5'-phosphate in water.

M. Toney, P. Tolstoy, H. Limbach, 2010, Biochemistry.

Aspartate aminotransferase: an old dog teaches new tricks.

M. Toney, 2014, Archives of biochemistry and biophysics.

Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate.

M. Toney, W. R. Griswold, 2011, Journal of the American Chemical Society.

Rapid photodynamics of vitamin B6 coenzyme pyridoxal 5'-phosphate and its Schiff bases in solution.

D. Larsen, M. Toney, E. C. Carroll, 2008, The journal of physical chemistry. B.

Pre-steady-state kinetic analysis of the reactions of alternate substrates with dialkylglycine decarboxylase.

M. Toney, C. Bagdassarian, S. Sun, 1998, Biochemistry.

Reaction specificity in pyridoxal phosphate enzymes.

M. Toney, Michael D Toney, 2005, Archives of biochemistry and biophysics.

Crystal structures of aspartate aminotransferase reconstituted with 1-deazapyridoxal 5'-phosphate: internal aldimine and stable L-aspartate external aldimine.

A. Fisher, M. Toney, W. R. Griswold, 2011, Biochemistry.

Critical hydrogen bonds and protonation states of pyridoxal 5'-phosphate revealed by NMR.

M. Toney, P. Tolstoy, H. Limbach, 2011, Biochimica et biophysica acta.

Studies of the Stability , Protonation States , and Tautomerism of 13 Cand 15 N-Labeled Aldimines of the Coenzyme Pyridoxal 5 0-Phosphate in Water †

M. Toney, P. Tolstoy, H. Limbach, 2010 .

X-ray crystallographic structures of enamine and amine Schiff bases of pyridoxal and its 1:1 hydrogen-bonded complexes with benzoic acid derivatives: evidence for coupled inter- and intramolecular proton transfer.

D. Powell, T. Steiner, M. Toney, 2006, Acta crystallographica. Section B, Structural science.

Tyrosine 70 fine-tunes the catalytic efficiency of aspartate aminotransferase.

J. Kirsch, M. Toney, 1991, Biochemistry.

Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy.

R. Phillips, M. Toney, K. Schnackerz, 2006, Biochimica et biophysica acta.

Kinetics and equilibria for the reactions of coenzymes with wild type and the Y70F mutant of Escherichia coli aspartate aminotransferase.

J. Kirsch, M. Toney, 1991, Biochemistry.

2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli.

D. Ringe, S. Almo, M. Toney, 1989, Biochemistry.

Tyrosine 70 increases the coenzyme affinity of aspartate aminotransferase. A site-directed mutagenesis study.

J. Kirsch, M. Toney, 1987, Journal of Biological Chemistry.

Broønsted analysis of aspartate aminotransferase via exogenous catalysis of reactions of an inactive mutant

J. Kirsch, M. Toney, 1992, Protein science : a publication of the Protein Society.

Alanine racemase free energy profiles from global analyses of progress curves.

M. Spies, M. Toney, M. Watnik, 2004, Journal of the American Chemical Society.

PLP‐Dependent Enzymes, Chemistry of

M. Toney, 2008 .

Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase.

M. Toney, T. Addington, J. N. Castro, 2013, Journal of the American Chemical Society.

Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites.

S. Cowan, J. Jansonius, E. Hohenester, 1994, Science.

Lysine 258 in aspartate aminotransferase: enforcer of the Circe effect for amino acid substrates and general-base catalyst for the 1,3-prototropic shift.

J. Kirsch, M. Toney, 1993, Biochemistry.

Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase.

J. Jansonius, E. Hohenester, M. Toney, 1995, Journal of molecular biology.

Estimation of free energy barriers in the cytoplasmic and mitochondrial aspartate aminotransferase reactions probed by hydrogen-exchange kinetics of C alpha-labeled amino acids with solvent.

J. Kirsch, M. Toney, H. Wiesinger, 1989, Biochemistry.

Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase.

V. Malashkevich, J. Jansonius, M. Toney, 1994, Biochemistry.

Brønsted Analysis of Enzymatic Proton Transfer Reactions through Site‐Directed Mutagenesis

J. Kirsch, M. Toney, 1990, Annals of the New York Academy of Sciences.

Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines.

J. Kirsch, M. Toney, J F Kirsch, 1989, Science.

Active site model for γ‐aminobutyrate aminotransferase explains substrate specificity and inhibitor reactivities

S. Pascarella, D. De Biase, M. Toney, 1995, Protein science : a publication of the Protein Society.

A simple method for site-directed mutagenesis using the polymerase chain reaction.

D. Galas, N. Arnheim, G. Cortopassi, 1989, Nucleic acids research.

NMR localization of protons in critical enzyme hydrogen bonds.

G. Buntkowsky, M. Toney, P. Tolstoy, 2007, Journal of the American Chemical Society.

Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase.

See-Tarn Woon, M. Toney, W. Liu, 2005, Biochemistry.

"On-the-fly" kinetics of enzymatic racemization using deuterium NMR in DNA-based chiral oriented media.

P. Pelupessy, G. Bodenhausen, L. Duma, 2013, Analytical chemistry.

Crystal structures of dialkylglycine decarboxylase inhibitor complexes.

V. Malashkevich, J. Jansonius, P. Strop, 1999, Journal of molecular biology.

Directed evolution of the substrate specificity of dialkylglycine decarboxylase.

M. Toney, Jared L. Taylor, Joseph E Price, 2015, Biochimica et biophysica acta.

A Novel Glutathione S-Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS Vibrio parahaemolyticus Shrimp Pathogen

R. Sotelo-Mundo, A. Ochoa‐Leyva, M. Toney, 2021, Toxins.

Coupling of functional hydrogen bonds in pyridoxal-5'-phosphate-enzyme model systems observed by solid-state NMR spectroscopy.

M. Toney, H. Limbach, Shasad Sharif, 2007, Journal of the American Chemical Society.

In silico stress-strain measurements on self-assembled protein lattices.

D. Cox, M. Toney, R. Baarda, 2018, Soft matter.

High Tensile Strength of Engineered β-Solenoid Fibrils via Sonication and Pulling.

Krishnakumar M. Ravikumar, D. Cox, M. Toney, 2017, Biophysical journal.

Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates.

R. D. Britt, M. Toney, J. Lagarias, 2004, Journal of the American Chemical Society.

Mechanistic Analysis of Dialkylglycine Decarboxylase

M. Toney, Shaoxian Sun, Xianzhi Zhou, 2000 .

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.

B. Shen, L. Du, M. Toney, 2001, Chemistry & biology.

Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase.

M. Spies, M. Toney, M. A. Spies, 2003, Biochemistry.

Nitrate reductase 15N discrimination in Arabidopsis thaliana, Zea mays, Aspergillus niger, Pichea angusta, and Escherichia coli

A. Bloom, E. Carlisle, M. Toney, 2014, Front. Plant Sci..

Genetic Engineering and Chemical Modification at the Position of Lysine 258 in Aspartate Aminotransferase

J. Kirsch, M. Toney, A. Planas, 1991 .

Mechanistic Analysis of the Aspartate Aminotransferase Active Site Mutants—Y70F, K258A, and R292D

J. Kirsch, M. Toney, C. Cronin, 1987 .

Janus: prediction and ranking of mutations required for functional interconversion of enzymes.

Vladimir Filkov, Justin B Siegel, James M Thompson, 2013, Journal of molecular biology.

Carbon Acidity in Enzyme Active Sites

M. Toney, 2019, Front. Bioeng. Biotechnol..

NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5'-phosphate model systems in polar solution.

M. Toney, H. Limbach, G. Denisov, 2007, Journal of the American Chemical Society.

Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.

M. Toney, M. Kurth, J. Butler, 2010, Chemistry.

Pyridoxal phosphate enzymology.

M. Toney, 2011, Biochimica et biophysica acta.

Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design.

Melissa R. Jeddeloh, K. Lam, Kristin T Ziebart, 2006, Journal of medicinal chemistry.

Metal ion inhibition of nonenzymatic pyridoxal phosphate catalyzed decarboxylation and transamination.

M. Toney, R. Zabinski, 2001, Journal of the American Chemical Society.

Biological conversion of gaseous alkenes to liquid chemicals.

Shuchi H. Desai, S. Atsumi, M. Toney, 2016, Metabolic engineering.

15N nuclear magnetic resonance studies of acid-base properties of pyridoxal-5'-phosphate aldimines in aqueous solution.

M. Toney, P. Tolstoy, H. Limbach, 2007, The journal of physical chemistry. B.

Analysis of catalytic determinants of diaminopimelate and ornithine decarboxylases using alternate substrates.

M. Toney, E. Fogle, 2011, Biochimica et Biophysica Acta.

Mutational analysis of substrate interactions with the active site of dialkylglycine decarboxylase.

M. Toney, E. Fogle, 2010, Biochemistry.

Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate.

M. Toney, W. R. Griswold, 2011, Journal of the American Chemical Society.

Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase.

A. Fisher, R. Carter, M. Toney, 2004, Biochemistry.

Highly Regioselective One‐Pot Synthesis of 7‐Hydroxy‐6‐methylphthalide from 3‐Hydroxy‐4‐methylbenzylalcohol

M. Toney, Meili Duan, 2005 .