C. Levy

发表

Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance.

J. Derrick, C. Levy, D. Minnis, 2008, The Biochemical journal.

Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor

J. Derrick, C. Levy, M. Z. Salleh, 2019, mBio.

Molecular basis of triclosan activity

Antoni R. Slabas, David W. Rice, D. Rice, 1999, Nature.

Discovery, characterization and engineering of ligases for amide synthesis

J. Micklefield, M. Rowlinson, C. Levy, 2021, Nature.

The crystal structure of P 450-TT heme-domain provides the first structural insights into the versatile class VII P 450 s

N. Turner, S. Flitsch, C. Levy, 2018 .

A Structure‐Guided Switch in the Regioselectivity of a Tryptophan Halogenase

Anna-Winona Struck, J. Micklefield, D. Leys, 2016, Chembiochem : a European journal of chemical biology.

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

K. Fisher, A. Green, J. L. Anderson, 2020, ACS catalysis.

Nonequivalence of Second Sphere “Noncatalytic” Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes

N. Scrutton, N. J. Baxter, J. Waltho, 2018, ACS catalysis.

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Journal of the American Chemical Society.

Structural and biochemical characterisation of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase.

K. Fisher, M. Cliff, D. Leys, 2022, The Journal of biological chemistry.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

A. Mould, T. Jowitt, Michael P. Lockhart-Cairns, 2017, Nucleic acids research.

The road to fully programmable protein catalysis

D. Hilvert, A. Green, C. Levy, 2022, Nature.

The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand

J. Chipperfield, L. Bird, Michael P. Lockhart-Cairns, 2020, Biophysical journal.

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

G. Peters, C. Levy, A. Golovanov, 2019, Scientific Reports.

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

T. Jowitt, K. Hayes, R. Grencis, 2019, Nature Communications.

The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer

T. Jowitt, R. Sandri-Goldin, C. Levy, 2015, Scientific Reports.

Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.

A. Munro, C. Simons, C. Levy, 2018, Bioorganic & medicinal chemistry.

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

L. D. de Carvalho, A. Munro, C. Simons, 2019, ChemistryOpen.

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

D. Nelson, K. Hollywood, A. Munro, 2018, Journal of inorganic biochemistry.

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00913h

Anna-Winona Struck, J. Micklefield, D. Leys, 2015, Chemical science.

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

Aiwu Zhou, N. Scrutton, L. Johannissen, 2019, Nature.

How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity

E. Takano, N. Scrutton, C. Levy, 2022, ACS catalysis.

Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation

K. Fisher, M. Dunstan, D. Leys, 2014, Nature.

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1

L. Tabernero, J. Bella, P. Woodman, 2016, Structure.

Structures of the Arabidopsis thaliana Oxygen-Sensing Plant Cysteine Oxidases PCO4 and PCO5 enable targeted manipulation of their activity

C. Levy, E. Flashman, Elisabete Pires, 2020 .

Crystal Structure of a Soluble Form of Human CD73 with Ecto‐5′‐Nucleotidase Activity

N. Scrutton, C. Levy, A. M. Shaw, 2012, Chembiochem : a European journal of chemical biology.

UbiD domain dynamics underpins aromatic decarboxylation

K. Fisher, D. Leys, C. Levy, 2021, Nature Communications.

Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).

M. Dunstan, I. Stratford, D. Ross, 2009, Journal of medicinal chemistry.

Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases.

Bernhard Hauer, Jason Micklefield, David Leys, 2009, Angewandte Chemie.

Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum

N. Scrutton, J. Gardiner, H. Toogood, 2013, ACS catalysis.

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

N. Scrutton, L. Johannissen, C. Schofield, 2015, Biochemistry.

Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase

M. Bennett, J. Micklefield, M. Dunstan, 2018, Angewandte Chemie.

A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.

D W Rice, D. Rice, J. Rafferty, 2001, Journal of molecular biology.

Crystallographic analysis of triclosan bound to enoyl reductase.

D. Rice, P. Baker, J. Rafferty, 1999, Journal of molecular biology.

Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction

L. Johannissen, A. Green, C. Levy, 2021, Nature Chemistry.

Relating localized protein motions to the reaction coordinate in coenzyme B12‐dependent enzymes

Nigel S Scrutton, N. Scrutton, Alex R. Jones, 2013, The FEBS journal.

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA*

A. Munro, D. Leys, C. Levy, 2012, The Journal of Biological Chemistry.

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

A. Munro, D. Leys, C. Levy, 2019, Scientific Reports.

Structural basis of terephthalate recognition by solute binding protein TphC

K. Fisher, L. Johannissen, N. Dixon, 2021, Nature Communications.

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

D. Chan, A. Munro, C. Abell, 2016, Journal of medicinal chemistry.

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

S. de Vries, N. Scrutton, F. Hollmann, 2016, Journal of the American Chemical Society.

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

D. Kell, K. Read, R. Schwarcz, 2019, Communications Biology.

Structure-activity relationships of cyclo(L-tyrosyl-L-tyrosine) derivatives binding to Mycobacterium tuberculosis CYP121: iodinated analogues promote shift to high-spin adduct.

A. Munro, C. Levy, K. J. McLean, 2019, Journal of medicinal chemistry.

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s.

N. Turner, S. Flitsch, C. Levy, 2018, Biochemical and biophysical research communications.

Structure-based Mechanism of CMP-2-keto-3-deoxymanno-octulonic Acid Synthetase

Steven B. Rossington, N. Scrutton, M. Goldrick, 2009, The Journal of Biological Chemistry.

Structure and Biocatalytic Scope of Coclaurine N ‐Methyltransferase

J. Micklefield, M. Dunstan, C. Levy, 2018, Angewandte Chemie.

Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

M. Bennett, Brian J. C. Law, J. Micklefield, 2016, Angewandte Chemie.

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

M. Wigglesworth, Mark Cockerill, T. Somervaille, 2016, Journal of medicinal chemistry.

Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator

H. Smidt, M. Joyce, J. van der Oost, 2008, Molecular microbiology.

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

R. Sandri-Goldin, C. Levy, A. Golovanov, 2018, Nucleic acids research.

Structure and mechanism of imidazoleglycerol-phosphate dehydratase.

S. Glynn, D. Rice, T. Hawkes, 2005, Structure.

Insights into enzyme evolution revealed by the structure of methylaspartate ammonia lyase.

D. Rice, P. Baker, Y. Asano, 2002, Structure.

Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme

L. Tabernero, C. Levy, E. Egbe, 2020, PloS one.

Directed evolution of an efficient and thermostable PET depolymerase

S. Haigh, P. Day, S. Ramachandran, 2021, Nature Catalysis.

Crystal structure of the bifunctional dihydroneopterin aldolase/6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Streptococcus pneumoniae.

J. Derrick, C. Levy, A. Garçon, 2006, Journal of molecular biology.

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

A. Mould, R. Sandri-Goldin, C. Levy, 2019, mBio.

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE*

A. Munro, D. Parker, D. Leys, 2017, The Journal of Biological Chemistry.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP

L. Tabernero, A. Mould, P. Woodman, 2017, Structure.

Structural basis of kynurenine 3-monooxygenase inhibition

F. Giorgini, N. Scrutton, T. Outeiro, 2013, Nature.

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142

A. Munro, D. Leys, C. Levy, 2010, The Journal of Biological Chemistry.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

A. Munro, C. Abell, D. Leys, 2016, The Journal of Biological Chemistry.

The Structure of Mycobacterium tuberculosis CYP125

A. Munro, D. Leys, C. Levy, 2009, The Journal of Biological Chemistry.

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

A. Munro, D. Leys, C. Levy, 2019, Scientific Reports.

Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: Evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen

A. Munro, D. Leys, C. Levy, 2010 .

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

A. Munro, C. Abell, D. Leys, 2022, European journal of medicinal chemistry.

Large-scale Domain Dynamics and Adenosylcobalamin Reorientation Orchestrate Radical Catalysis in Ornithine 4,5-Aminomutase

N. Scrutton, D. Leys, K. Wolthers, 2010, The Journal of Biological Chemistry.

An Internal Reaction Chamber in Dimethylglycine Oxidase Provides Efficient Protection from Exposure to Toxic Formaldehyde*

N. Scrutton, D. Leys, C. Levy, 2009, The Journal of Biological Chemistry.

Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?

N. Scrutton, D. Leys, C. Levy, 2009, Chembiochem : a European journal of chemical biology.

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Nigel S Scrutton, David Leys, N. Scrutton, 2013, Chembiochem : a European journal of chemical biology.

Updated structure of Drosophila cryptochrome

J. Widom, M. W. Young, B. Zoltowski, 2013, Nature.

How the dual PDZ domain from Postsynaptic density protein 95 clusters ion channels and receptors

J. Chipperfield, L. Bird, Michael P. Lockhart-Cairns, 2019, bioRxiv.

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

Francesco Licausi, C. Levy, E. Flashman, 2020, Proceedings of the National Academy of Sciences.

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

N. Scrutton, L. Johannissen, N. J. Baxter, 2019, ACS catalysis.

Crystallization of PTP Domains.

L. Tabernero, C. Levy, J. Adams, 2016, Methods in molecular biology.

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase

K. Fisher, C. Catlow, S. D. de Visser, 2021, JACS Au.

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Colin Levy, Mark Dunstan, Ashleigh J Burke, 2019, Nature.

Utilization of dietary mixed-linkage β-glucans by the Firmicute Blautia producta

T. Miyazaki, C. Levy, R. Singh, 2023, The Journal of biological chemistry.

CprK Crystal Structures Reveal Mechanism for Transcriptional Control of Halorespiration*

J. Oost, H. Smidt, M. Joyce, 2006, Journal of Biological Chemistry.

A Twin-track Approach Has Optimized Proton and Hydride Transfer by Dynamically Coupled Tunneling during the Evolution of Protochlorophyllide Oxidoreductase*

D. Robertson, N. Scrutton, C. Levy, 2011, The Journal of Biological Chemistry.

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

T. Jowitt, K. Hayes, R. Grencis, 2019, Nature Communications.

Structure and Function of Amino Acid Ammonia-lyases

D. Rice, P. Baker, Y. Asano, 2004 .

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

Aiwu Zhou, N. Scrutton, L. Johannissen, 2019, Nature.

Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

K. Fisher, P. Williams, A. Munro, 2010, The Biochemical journal.

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

A. Munro, C. Simons, C. Levy, 2017, Journal of medicinal chemistry.

Molecular architecture of the tyrosine phosphatase HD-PTP and the structural basis for its specific interaction with UBAP1

Bella, L. Tabernero, T. Jowitt, 2018 .

Structure and mechanism of an unusual malonate decarboxylase and related racemases.

Bernhard Hauer, Jason Micklefield, David Leys, 2008, Chemistry.

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

D. Kell, K. Read, R. Schwarcz, 2019, Communications Biology.

Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

A. Munro, C. Abell, D. Matak-Vinkovic, 2016, Scientific Reports.

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

S. de Vries, N. Scrutton, F. Hollmann, 2016, Journal of the American Chemical Society.

A designed photoenzyme for enantioselective [2+2] cycloadditions

A. Green, C. Levy, Murray J. B. Brown, 2022, Nature.

Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site

A. Green, C. Levy, Indrek Kalvet, 2023, Journal of the American Chemical Society.

Crystal structure of the cystatin-based engineered protein scaffold SQT-1C

C. Levy, A. Golovanov, Matja Zalar, 2019 .

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

M. Dunstan, A. Green, C. Levy, 2019, Nature.

Redox driven B12-ligand switch drives CarH photoresponse

N. Scrutton, L. Johannissen, G. Schirò, 2023, Nature communications.

Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases.

B. Hauer, Nina Baudendistel, D. Leys, 2009, Angewandte Chemie.