J. C. Borges

发表

Structure of chorismate synthase from Mycobacterium tuberculosis.

J. H. Pereira, W. F. de Azevedo, D. Santos, 2006, Journal of structural biology.

Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima.

W. F. de Azevedo, F. Canduri, D. Criddle, 2005, Journal of structural biology.

Spectroscopic and thermodynamic measurements of nucleotide-induced changes in the human 70-kDa heat shock cognate protein.

C. Ramos, J. C. Borges, 2006, Archives of biochemistry and biophysics.

EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells.

J. M. Marchetti, M. Chorilli, Amalia Ruiz, 2020, Colloids and surfaces. B, Biointerfaces.

Characterization of nucleotide-induced changes on the quaternary structure of human 70 kDa heat shock protein Hsp70.1 by analytical ultracentrifugation.

C. Ramos, J. C. Borges, 2009, BMB reports.

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.

H. Castro, C. R. Rodrigues, J. C. Borges, 2008, Bioorganic & medicinal chemistry.

The Interaction Networks of Hsp70 and Hsp90 in the Plasmodium and Leishmania Parasites

C. Ramos, J. C. Borges, T. V. Seraphim, 2014 .

Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies.

J. C. Borges, A. De Maio, P. R. Dores-Silva, 2019, International journal of biological macromolecules.

A review of multi-domain and flexible molecular chaperones studies by small-angle X-ray scattering

Leandro R. S. Barbosa, J. C. Borges, T. V. Seraphim, 2016, Biophysical Reviews.

Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1

Júlio C. Silva, I. Torriani, C. Ramos, 2011, BMC Structural Biology.

Identification of Regions Involved in Substrate Binding and Dimer Stabilization within the Central Domains of Yeast Hsp40 Sis1

C. Ramos, D. Cyr, F. Almeida, 2012, PloS one.

Anti-EGFR liquid crystalline nanodispersions for docetaxel delivery: Formulation, characterization and cytotoxicity in cancer cells

J. M. Marchetti, M. T. Luiz, M. Chorilli, 2021 .

Conformation differences in N-[2-(1-arenesulfonyl-1H-pyrazol-3-yl)-6-methyl-phenyl]-arenesulfonamides, (arene = benzene and 4-toluene)

J. C. Borges, J. Wardell, S. Wardell, 2014 .

Structural, thermodynamic and functional studies of human 71 kDa heat shock cognate protein (HSPA8/hHsc70).

C. Ramos, Leandro R. S. Barbosa, J. C. Borges, 2021, Biochimica et biophysica acta. Proteins and proteomics.

Insights into the full-length SRPK2 structure and its hydrodynamic behavior.

K. Massirer, G. Bressan, J. Kobarg, 2019, International journal of biological macromolecules.

Human HSPA9 (mtHsp70, mortalin) interacts with lipid bilayers containing cardiolipin, a major component of the inner mitochondrial membrane.

J. C. Borges, A. De Maio, P. R. Dores-Silva, 2020, Biochimica et biophysica acta. Biomembranes.

Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain

J. C. Borges, A. De Maio, P. R. Dores-Silva, 2020, Cell Stress and Chaperones.

New insights on human Hsp70-escort protein 1: Chaperone activity, interaction with liposomes, cellular localizations and HSPA's self-assemblies remodeling.

L. M. Gava, C. Ramos, J. C. Borges, 2021, International journal of biological macromolecules.

Possible Involvement of Hsp90 in the Regulation of Telomere Length and Telomerase Activity During the Leishmania amazonensis Developmental Cycle and Population Proliferation

R. Calado, J. C. Borges, M. Cano, 2021, Frontiers in Cell and Developmental Biology.

Structural and functional studies of Leishmania braziliensis Hsp90.

J. C. Borges, T. V. Seraphim, K. Silva, 2013, Biochimica et biophysica acta.

Molecular Chaperones Involved in Protein Recovery from Aggregates are Present in Protozoa Causative of Malaria and Leishmaniasis

J. C. Borges, F. A. Batista, P. R. Dores-Silva, 2018, Current Proteomics.

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

C. Ramos, Leandro R. S. Barbosa, J. C. Borges, 2015, PloS one.

Solution structure of Plasmodium falciparum Hsp90 indicates a high flexible dimer.

Leandro R. S. Barbosa, J. C. Borges, T. V. Seraphim, 2020, Archives of biochemistry and biophysics.

Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities

J. C. Borges, F. A. Batista, S. Murta, 2015, The FEBS journal.

The C-terminal region of the human p23 chaperone modulates its structure and function.

L. M. Gava, C. Ramos, Leandro R. S. Barbosa, 2015, Archives of biochemistry and biophysics.

Deactivation of ferrylmyoglobin by vanillin as affected by vanillin binding to β-lactoglobulin.

L. Skibsted, J. C. Borges, D. R. Cardoso, 2011, Journal of agricultural and food chemistry.

Heat Shock Proteins Revisited: Using a Mutasynthetically Generated Reblastatin Library to Compare the Inhibition of Human and Leishmania Hsp90s

T. Scheper, C. Herrmann, A. Kirschning, 2018, Chembiochem : a European journal of chemical biology.

Low sequence identity but high structural and functional conservation: The case of Hsp70/Hsp90 organizing protein (Hop/Sti1) of Leishmania braziliensis.

C. Ramos, Leandro R. S. Barbosa, J. C. Borges, 2016, Archives of biochemistry and biophysics.

Human heat shock cognate protein (HSC70/HSPA8) interacts with negatively charged phospholipids by a different mechanism than other HSP70s and brings HSP90 into membranes

J. C. Borges, A. De Maio, P. R. Dores-Silva, 2021, Cell Stress and Chaperones.

Structural and functional studies of the Leishmania braziliensis mitochondrial Hsp70: Similarities and dissimilarities to human orthologues.

J. C. Borges, Letícia S Nishimura, P. R. Dores-Silva, 2017, Archives of biochemistry and biophysics.

Exploiting supramolecular interactions to produce bevacizumab-loaded nanoparticles for potential mucosal delivery

Leonardo M. B. Ferreira, O. Assis, N. N. Ferreira, 2018, European Polymer Journal.

A Sporothrix spp enolase derived multi-epitope vaccine confers protective response in BALB/c mice challenged with Sporothrix brasiliensis.

A. Batista-Duharte, L. Mercado, J. C. Borges, 2022, Microbial pathogenesis.

Structural studies of Old Yellow Enzyme of Leishmania braziliensis in solution.

J. C. Borges, P. R. Dores-Silva, S. H. Libardi, 2019, Archives of biochemistry and biophysics.

Synthesis and antiviral activity of new 4-(phenylamino)/4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids derivatives

D. Ferreira, J. C. Borges, A. Bernardino, 2007, Medicinal Chemistry Research.

Rational design of nanocarriers based on gellan gum/retrograded starch exploiting polyelectrolyte complexation and ionic cross-linking processes: A potential technological platform for oral delivery of bevacizumab

Leonardo M. B. Ferreira, Valéria Maria de Oliveira Cardoso, F. I. Boni, 2021 .

Multimeric species in equilibrium in detergent-solubilized Na,K-ATPase.

P. Ciancaglini, Leandro R. S. Barbosa, R. Itri, 2016, International journal of biological macromolecules.

Structural and functional studies of Hsp70-escort protein--Hep1--of Leishmania braziliensis.

Leandro R. S. Barbosa, J. C. Borges, L. Beloti, 2015, International journal of biological macromolecules.

Sugarcane Hsp101 is a hexameric chaperone that binds nucleotides.

C. Ramos, J. C. Borges, V. C. D. da Silva, 2011, International journal of biological macromolecules.

Protein folding assisted by chaperones.

C. Ramos, J. C. Borges, 2005, Protein and peptide letters.

Plasmatic membrane of bovine spermatozoa: effect of the species oxygen reactive, antioxidant and cryopreservation

J. C. Borges, J. Guimarães, M. R. Silva, 2011 .

Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines

J. C. Borges, M. S. Dos Santos, Alice M. R. Bernardino, 2012, Organic and medicinal chemistry letters.

Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives.

H. Castro, C. R. Rodrigues, J. C. Borges, 2006, Bioorganic & medicinal chemistry.

Synthesis and in vitro evaluation of new benzenesulfonamides as antileishmanial agents

H. Castro, J. C. Borges, L. Leon, 2014 .

4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease

H. Castro, C. R. Rodrigues, J. C. Borges, 2012, Molecules.

An unexpected formation of pyrazolopyrimidines during the attempted to obtain 5-substituted tetrazoles from carbonitriles

J. C. Borges, Alice M. R. Bernardino, P. F. Vegi, 2013 .

PtII, PdII and AuIII complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the antiparasitic mechanism of action.

R. J. Oliveira, J. C. Borges, F. B. Ferreira, 2017, European journal of medicinal chemistry.

Identification of a Potential Lead Structure for Designing New Antimicrobials to Treat Infections Caused by Staphylococcus epidermidis-Resistant Strains

A. Lourenço, H. Castro, C. R. Rodrigues, 2008, Current Microbiology.

Searching for new antileishmanial lead drug candidates: Synthesis, biological and theoretical evaluations of promising thieno[2,3-b]pyridine derivatives

Es, H. Castro, C. R. Rodrigues, 2012 .

Immunization with recombinant enolase of Sporothrix spp. (rSsEno) confers effective protection against sporotrichosis in mice

L. M. Gava, A. Batista-Duharte, J. C. Borges, 2019, Scientific Reports.

Immunization with recombinant enolase of Sporothrix spp. (rSsEno) confers effective protection against sporotrichosis in mice

A. Batista-Duharte, J. C. Borges, F. Gúzman, 2019, Scientific Reports.

The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs

R. Owens, L. Bird, J. Brandão-Neto, 2018, bioRxiv.

Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi

J. C. Borges, C. M. Calvet, A. Bernardino, 2016, International journal for parasitology. Drugs and drug resistance.

Alginate hydrogel improves anti‐angiogenic bevacizumab activity in cancer therapy

Leonardo M. B. Ferreira, R. Reis, N. N. Ferreira, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes.

S. Phanse, M. Babu, W. Houry, 2021, Structure.

Molecular masses and sedimentation coefficients of extracellular hemoglobin of Glossoscolex paulistus: alkaline oligomeric dissociation.

M. Tabak, J. C. Borges, P. S. Santiago, 2011, International journal of biological macromolecules.

On the molecular mass of the extracellular hemoglobin of Glossoscolex paulistus: analytical ultracentrifugation reexamination.

M. Tabak, J. C. Borges, P. S. Santiago, 2009, Analytical biochemistry.

Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase

S. Valentini, J. C. Borges, O. Thiemann, 2020, bioRxiv.

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

M. Botta, M. Mori, J. C. Borges, 2020, Journal of enzyme inhibition and medicinal chemistry.

Low resolution structural characterization of the Hsp70-interacting protein - Hip - from Leishmania braziliensis emphasizes its high asymmetry.

Leandro R. S. Barbosa, J. C. Borges, P. R. Dores-Silva, 2012, Archives of biochemistry and biophysics.

Human regulatory protein Ki-1/57 has characteristics of an intrinsically unstructured protein.

Júlio C. Silva, G. Bressan, I. Torriani, 2008, Journal of proteome research.

Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation

J. C. Borges, I. Malavazi, A. D. da Cunha, 2020, Cellular microbiology.

Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases.

L. A. Basso, D. Santos, F. Canduri, 2007, Current drug targets.

Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

M. D. Polêto, G. Bressan, J. Kobarg, 2015, PloS one.

Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus

H. Castro, D. Ferreira, I. Bergmann, 2017, Archives of Virology.

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

E. Bilsland, L. Tilley, C. Andrade, 2021, ACS infectious diseases.

A review of multi-domain and flexible molecular chaperones studies by small-angle X-ray scattering

Leandro R. S. Barbosa, J. C. Borges, T. V. Seraphim, 2016, Biophysical Reviews.

Structural studies of the Trypanosoma cruzi Old Yellow Enzyme: insights into enzyme dynamics and specificity.

G. Oliva, M. Murakami, F. Canduri, 2013, Biophysical chemistry.

Heterotypic Coiled-Coil Formation is Essential for the Correct Assembly of the Septin Heterofilament.

J. C. Borges, R. Garratt, J. N. Macêdo, 2016, Biophysical journal.

Limited proteolysis of myoglobin opens channel in ferrochelatase-globin complex for iron to zinc transmetallation.

L. Skibsted, J. C. Borges, P. R. Dores-Silva, 2016, Food chemistry.

Molecular chaperone genes in the sugarcane expressed sequence database (SUCEST)

C. Ramos, J. C. Borges, M. C. Peroto, 2001 .

Free Human Mitochondrial GrpE Is a Symmetric Dimer in Solution*

L. Hansen, H. Fischer, A. Craievich, 2003, Journal of Biological Chemistry.

Identification and in silico expression pattern analysis of Eucalyptus expressed sequencing tags (ESTs) encoding molecular chaperones

C. Ramos, J. C. Borges, Ana O. Tiroli, 2005 .

Studies on the effect of the J-domain on the substrate binding domain (SBD) of Hsp70 using a chimeric human J-SBD polypeptide.

C. Ramos, L. Kubota, D. Souto, 2019, International journal of biological macromolecules.

Insights into the effect of the J-domain on the substrate binding domain (SBD) of the 70 kDa heat shock protein, Hsp70, from a chimeric human J-SBD polypeptide

C. Ramos, J. C. Borges, Ana O Tiroli-Cepeda, 2018, bioRxiv.

Expression and variability of molecular chaperones in the sugarcane expressome.

C. Ramos, J. C. Borges, Carlos H I Ramos, 2007, Journal of plant physiology.

Low resolution structure and stability studies of human GrpE#2, a mitochondrial nucleotide exchange factor.

C. L. Oliveira, I. Torriani, C. Ramos, 2006, Archives of biochemistry and biophysics.

Low Resolution Structural Study of Two Human HSP40 Chaperones in Solution

H. Fischer, A. Craievich, C. Ramos, 2005, Journal of Biological Chemistry.

Insights on the structural dynamics of Leishmania braziliensis Hsp90 molecular chaperone by small angle X-ray scattering.

J. C. Borges, T. V. Seraphim, P. R. Dores-Silva, 2017, International journal of biological macromolecules.

Transferrin-functionalized liposomes for docetaxel delivery to prostate cancer cells

M. Chorilli, M. Santos-Martinez, J. C. Borges, 2020 .

Synthesis and characterization of new 1 H-pyrazolo(3,4-b)pyridine phosphoramidate derivatives

J. C. Borges, J. Resende, G. Guedes, 2014 .

Solution structure of the human signaling protein RACK1

Júlio C. Silva, G. Bressan, I. Torriani, 2010, BMC Structural Biology.

Low Resolution Structural Studies Indicate that the Activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis Has an Elongated Shape Which Allows Its Interaction with Both N- and M-Domains of Hsp90

Leandro R. S. Barbosa, J. C. Borges, S. Murta, 2013, PloS one.

Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone.

C. Ramos, Leandro R. S. Barbosa, J. C. Borges, 2013, International journal of biological macromolecules.

Heterobimetallic nickel(II) and palladium(II) complexes derived from S-benzyl-N- (ferrocenyl)methylenedithiocarbazate: Trypanocidal activity and interaction with Trypanosoma cruzi Old Yellow Enzyme (TcOYE).

R. J. Oliveira, J. C. Borges, V. Deflon, 2019, European journal of medicinal chemistry.

Comparative studies of the low-resolution structure of two p23 co-chaperones for Hsp90 identified in Plasmodium falciparum genome.

Leandro R. S. Barbosa, J. C. Borges, T. V. Seraphim, 2018, International journal of biological macromolecules.

Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70.

C. Ramos, J. C. Borges, D. Gonçalves, 2011, Archives of biochemistry and biophysics.

Structural studies of shikimate 5‐dehydrogenase from Mycobacterium tuberculosis

J. H. Pereira, W. F. de Azevedo, L. A. Basso, 2008, Proteins.

Purification and characterization of a novel and conserved TPR-domain protein that binds both Hsp90 and Hsp70 and is expressed in all developmental stages of Leishmania major.

W. Houry, C. Ramos, J. C. Borges, 2021, Biochimie.

Structural and functional studies of the Leishmania braziliensis SGT co-chaperone indicate that it shares structural features with HIP and can interact with both Hsp90 and Hsp70 with similar affinities.

J. C. Borges, F. R. Teixeira, F. A. Batista, 2018, International journal of biological macromolecules.

Thermodynamic analysis of interactions of the Hsp90 with adenosine nucleotides: A comparative perspective.

F. R. de Moraes, A. S. Nascimento, C. Ramos, 2019, International journal of biological macromolecules.

Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities.

Leandro R. S. Barbosa, J. C. Borges, T. V. Seraphim, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis

W. F. de Azevedo, L. A. Basso, D. Santos, 2008, Proteins.

Sugarcane Hsp101 is a hexameric chaperone that binds nucleotides.

C. Ramos, J. C. Borges, Alessandra Prando, 2011, International journal of biological macromolecules.

Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis.

J. H. Pereira, W. F. de Azevedo, L. A. Basso, 2006, Archives of biochemistry and biophysics.

Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives.

H. Castro, C. R. Rodrigues, J. C. Borges, 2006, Bioorganic & Medicinal Chemistry.

Novel 4‐arylaminoquinoline‐3‐carbonitriles as Inhibitors of HIV‐1 Reverse Transcriptase

J. C. Borges, H. Pereira, I. Paixão, 2017 .

Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities

J. C. Borges, F. A. Batista, T. V. Seraphim, 2015, The FEBS journal.

Low resolution structural characterization of the Hsp70-interacting protein - Hip - from Leishmania braziliensis emphasizes its high asymmetry.

Leandro R. S. Barbosa, J. C. Borges, P. R. Dores-Silva, 2012, Archives of biochemistry and biophysics.

Structural characterization of the human DjC20/HscB cochaperone in solution

J. C. Borges, P. R. Dores-Silva, Ana Rita de Araujo Nogueira, 2023, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

Insights on the structural dynamics of Leishmania braziliensis Hsp90 molecular chaperone by small angle X-ray scattering.

J. C. Borges, T. V. Seraphim, P. R. Dores-Silva, 2017, International journal of biological macromolecules.

Conformational changes in human Hsp70 induced by high hydrostatic pressure produce oligomers with ATPase activity but without chaperone activity.

P. Pascutti, D. Foguel, C. Ramos, 2014, Biochemistry.