P. Liras

发表

Regulation by aromatic amino acids of the biosynthesis of candicidin by Streptomyces griseus.

J. Martín, J. Gil, P. Liras, 1980, Journal of general microbiology.

Connecting primary and secondary metabolism: AreB, an IclR‐like protein, binds the AREccaR sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production

J. Martín, P. Liras, I. Santamarta, 2007, Molecular microbiology.

Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant.

P. Liras, I. Santamarta, M. T. López-García, 2010, Microbiology.

Evolutionary formation of gene clusters by reorganization: the meleagrin/roquefortine paradigm in different fungi

J. Martín, P. Liras, 2015, Applied Microbiology and Biotechnology.

Phosphate control of pabS gene transcription during candicidin biosynthesis.

J. Martín, P. Liras, J. Asturias, 1990, Gene.

A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds

J. Martín, J. Martín, P. Liras, 1997, Journal of bacteriology.

CcaR Is an Autoregulatory Protein That Binds to the ccaR and cefD-cmcI Promoters of the Cephamycin C-Clavulanic Acid Cluster in Streptomyces clavuligerus

J. Martín, P. Liras, I. Santamarta, 2002, Journal of bacteriology.

ArgR of Streptomyces coelicolor Is a Versatile Regulator

J. Martín, P. Liras, I. Santamarta, 2012, PloS one.

Two Proteins with Ornithine Acetyltransferase Activity Show Different Functions in Streptomyces clavuligerus: Oat2 Modulates Clavulanic Acid Biosynthesis in Response to Arginine

J. Martín, P. Liras, A. Rodríguez-García, 2004, Journal of bacteriology.

ArgR of Streptomyces coelicolor Is a Pleiotropic Transcriptional Regulator: Effect on the Transcriptome, Antibiotic Production, and Differentiation in Liquid Cultures

Á. Manteca, P. Yagüe, P. Liras, 2018, Front. Microbiol..

Role of the cmcH–ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus

P. Liras, G. Özcengiz, A. Kurt, 2013, Applied Microbiology and Biotechnology.

Molecular Mechanisms of Phosphate Sensing, Transport and Signalling in Streptomyces and Related Actinobacteria

J. Martín, P. Liras, 2021, International journal of molecular sciences.

A rhodanese‐like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production

J. Martín, P. Liras, I. Santamarta, 2011, Microbial biotechnology.

β-Lactam Antibiotics

J. Martín, P. Liras, 2009 .

Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.

A. Demain, P. Liras, 2009, Methods in enzymology.

Mutants of Streptomyces clavuligerus with Disruptions in Different Genes for Clavulanic Acid Biosynthesis Produce Large Amounts of Holomycin: Possible Cross-Regulation of Two Unrelated Secondary Metabolic Pathways

J. Martín, P. Liras, Á. de la Fuente, 2002, Journal of bacteriology.

Utilization of ornithine and arginine as specific precursors of clavulanic acid

J. Martín, P. Liras, J. Romero, 1986, Applied and environmental microbiology.

Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production

J. Martín, P. Liras, M. Ludovice, 1992, Journal of bacteriology.

Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans.

J. Martín, J. Cortés, J. Castro, 1987, Journal of general microbiology.

Purification and characterization of the isopenicillin N synthase of Streptomyces lactamdurans.

J. Martín, J. Castro, P. Liras, 1988, Journal of general microbiology.

Purification and characterization of the isopenicillin N epimerase from Nocardia lactamdurans

J. Martín, J. Castro, P. Liras, 1990 .

A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C

J. Martín, J. Coque, F. Enguita, 1995, Journal of bacteriology.

Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up to two-fold increase in cephamycin C production

J. Martín, V. Chary, A. Leitão, 2000, Applied Microbiology and Biotechnology.

Characterization of the cefF gene of Nocardia lactamdurans encoding a 3′-methylcephem hydroxylase different from the 7-cephem hydroxylase

J. Martín, J. Coque, F. Enguita, 2004, Applied Microbiology and Biotechnology.

Biosynthesis and molecular genetics of cephamycins

P. Liras, 2004, Antonie van Leeuwenhoek.

Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid

Y. Martínez-Burgo, P. Liras, A. Rodríguez-García, 2017, BMC Genomics.

Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP

J. Martín, P. Liras, A. Ramos, 2019, Antibiotics.

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

J. Martín, P. Liras, A. Rodríguez-García, 2017, The Journal of Antibiotics.

Cross‐Talk of Global Regulators in Streptomyces

J. Martín, P. Liras, A. Sola-Landa, 2016 .

Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus

J. Martín, J. Martín, P. Liras, 1984, Applied Microbiology and Biotechnology.

Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis.

J. Martín, P. Liras, J. Asturias, 1990, Trends in biotechnology.

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces.

J. Martín, P. Liras, 2010, Current opinion in microbiology.

Two Oligopeptide-Permease-Encoding Genes in the Clavulanic Acid Cluster of Streptomyces clavuligerus Are Essential for Production of the β-Lactamase Inhibitor

J. Martín, P. Liras, I. Santamarta, 2004, Journal of bacteriology.

The PenV vacuolar membrane protein that controls penicillin biosynthesis. is a putative member of a subfamily of stress-gated transient receptor calcium channels

J. Martín, P. Liras, 2021, Current Research in Biotechnology.

Sensing and transduction of nutritional and chemical signals in filamentous fungi: Impact on cell development and secondary metabolites biosynthesis.

J. Martín, E. Ver Loren van Themaat, E. V. V. Themaat, 2019, Biotechnology advances.

Roquefortine C and Related Prenylated Indole Alkaloids

C. García-Estrada, J. Martín, P. Liras, 2014 .

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus

J. Martín, P. Liras, M. Garcia-Dominguez, 1991, Antimicrobial Agents and Chemotherapy.

Analysis of the codon usage of the cephamycin C producer Nocardia lactamdurans

M. Malumbres, J. Martín, J. Coque, 1993 .

Penicillin-Binding Proteins, β-Lactamases, and β-Lactamase Inhibitors in β-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms

J. Martín, P. Liras, R. Álvarez-Álvarez, 2022, International journal of molecular sciences.

The pcd Gene Encoding Piperideine-6-Carboxylate Dehydrogenase Involved in Biosynthesis of α-Aminoadipic Acid Is Located in the Cephamycin Cluster ofStreptomyces clavuligerus

J. Martín, F. Enguita, P. Liras, 1998, Journal of bacteriology.

Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.

J. Haber, J. Mccusker, P. Liras, 1978, Genetics.

lactamdurans.biosynthetic genes in Nocardia alpha-aminoadipic acid, is located in the cluster which forms the beta-lactam precursor A gene encoding lysine 6-aminotransferase,

J. Martín, J. Coque, P. Liras, 2013 .

A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans

J. Martín, J. Coque, P. Liras, 1991, Journal of bacteriology.

A GeneEncoding Lysine 6-Aminotransferase, WhichFormsthe 1-Lactam Precursor oL-Aminoadipic Acid, IsLocated intheCluster ofCephamycin Biosynthetic GenesinNocardia lactamdurans

P. Liras, L. Láiz, 1991 .

1-Lactam Precursor oL-Aminoadipic Acid, Is Located in the Cluster of Cephamycin Biosynthetic Genes in Nocardia lactamdurans

J. Martín, J. Coque, P. Liras, 1991 .

Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Applied Microbiology and Biotechnology.

The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.

J. Martín, P. Liras, R. Bovenberg, 2010, Microbiology.

Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus.

J. Piret, S. Tunca, P. Liras, 2004, Research in microbiology.

Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.

J. Martín, P. Liras, R. Pérez-Redondo, 2000, Journal of molecular microbiology and biotechnology.

A bifunctionalStreptomyces-E. colipromoter-probe vetor

J. Martín, P. Liras, J. Asturias, 1990 .

A bifunctional Streptomyces-E. coli promoter-probe vector.

J. Martín, P. Liras, J. Asturias, 1990, FEMS microbiology letters.

Comparative Molecular Mechanisms of Biosynthesis of Naringenin and Related Chalcones in Actinobacteria and Plants: Relevance for the Obtention of Potent Bioactive Metabolites

J. Martín, P. Liras, 2022, Antibiotics.

Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes.

P. Liras, 1999, Antonie van Leeuwenhoek.

Effect of amplification or targeted disruption of the β-lactamase gene of Nocardia lactamdurans on cephamycin biosynthesis

J. Martín, A. Leitão, P. Liras, 1996, Applied Microbiology and Biotechnology.

Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus

J. Martín, P. Liras, I. Santamarta, 2005, Molecular microbiology.

Characterization of DNA‐binding sequences for CcaR in the cephamycin–clavulanic acid supercluster of Streptomyces clavuligerus

J. Martín, P. Liras, I. Santamarta, 2011, Molecular microbiology.

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.

J. Martín, P. Liras, R. Pérez-Redondo, 1998, Gene.

Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis

J. Martín, Y. Martínez-Burgo, P. Liras, 2018, Applied and Environmental Microbiology.

Deletion of the pyc Gene Blocks Clavulanic Acid Biosynthesis Except in Glycerol-Containing Medium: Evidence for Two Different Genes in Formation of the C3 Unit

J. Martín, P. Liras, R. Pérez-Redondo, 1999, Journal of bacteriology.

Inducing Effect of Diamines on Transcription of the Cephamycin C Genes from the lat and pcbAB Promoters inNocardia lactamdurans

J. Martín, F. Enguita, A. Leitão, 1999, Journal of bacteriology.

Interaction of the Two Proteins of the Methoxylation System Involved in Cephamycin C Biosynthesis

J. Martín, J. Martín, F. Enguita, 1996, The Journal of Biological Chemistry.

An inducible expression system of histidine-tagged proteins in Streptomyces lividans for one-step purification by Ni2+ affinity chromatography.

J. Martín, F. Enguita, P. Liras, 1996, FEMS microbiology letters.

Secondary Metabolites in Cheese Fungi

J. Martín, P. Liras, 2016 .

Biosynthesis and phosphate control of candicidin byStreptomyces acrimycini JI2236: effect of amplification of thepabAB gene

J. Martín, P. Liras, J. Asturias, 1994, Journal of Industrial Microbiology.

Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping

J. Martín, Y. Martínez-Burgo, P. Liras, 2013, Applied Microbiology and Biotechnology.

Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Applied Microbiology and Biotechnology.

Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis.

J. Martín, J. Martín, P. Liras, 1989, Advances in biochemical engineering/biotechnology.

Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures

J. Martín, P. Liras, Á. Rumbero, 2006, Applied Microbiology and Biotechnology.

An improved HPLC assay of the substrate and products of the isopenicillin N synthase

J. Martín, J. Cortés, B. Meesschaert, 1987 .

Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites

J. Martín, P. Liras, 2023, Antibiotics.

Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: key intermediate of the alpha-aminoadipic acid for beta-lactam antibiotics biosynthesis.

J. Martín, P. Liras, Á. Rumbero, 1995, Bioorganic & medicinal chemistry.

Transfer of Secondary Metabolite Gene Clusters: Assembly and Reorganization of the β-Lactam Gene Cluster from Bacteria to Fungi and Arthropods

J. Martín, P. Liras, 2019, Horizontal Gene Transfer.

Evolution of the clusters of genes for β-lactam antibiotics: a model for evolutive combinatorial assembly of new β-lactams

J. Martín, P. Liras, A. Rodríguez-García, 1998 .

The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

J. Martín, J. Coque, P. Liras, 1991, Molecular microbiology.

Conversion of phenylacetyl‐cysteinyl‐valine in vitro into penicillin G by isopenicillin N synthase of Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1986 .

Sequence of candicidin action on yeast cells.

P. Liras, J. Lampen, Paloma Liras, 1974, Biochimica et biophysica acta.

Protection by K+ and Mg2+ of growth and macromolecule synthesis in candicidin-treated yeast.

P. Liras, J. Lampen, 1974, Biochimica et biophysica acta.

Enzymatic transformation of morphine by hydroxysteroid dehydrogenase from Pseudomonas testosteroni.

P. Liras, W. Umbreit, S. Kasparian, 1975, Applied microbiology.

Rapid incorporation of precursors into candicidin by resting cells of Streptomyces griseus.

J. Martín, P. Liras, 1976, The Journal of antibiotics.

Purification and Chemical Characterization of a Potent Acaricide and a Closely Related Inactive Metabolite Produced by Eurotium rubrum C47

J. Martín, P. Liras, L. Cañedo, 2020, Antibiotics.

A cephalosporin C acetylhydrolase is present in the cultures of Nocardia lactamdurans

J. Martín, P. Liras, R. Cardoza, 2000, Applied Microbiology and Biotechnology.

Glucose regulation of cephamycin biosynthesis in Streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin C synthase.

J. Martín, J. Cortés, J. Castro, 1986, Journal of general microbiology.

Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.

J. Martín, P. Liras, Á. Rumbero, 1997, The Biochemical journal.

Enzymatic Transformation of Morphine by Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni

P. Liras, Stephen S. Kasparian, W. Umbreit, 1975 .

Overexpression of the Nocardia lactamduransα‐Aminoadipyl‐Cysteinyl‐Valine Synthetase in Streptomyces lividans

J. Martín, J. Coque, P. Liras, 1996 .

Streptomyces clavuligerus: The Omics Era

J. Martín, P. Liras, 2021, Journal of industrial microbiology & biotechnology.

Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?

J. Martín, P. Liras, 2006, International microbiology : the official journal of the Spanish Society for Microbiology.

Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer 'Amycolatopsis lactamdurans'.

J. Martín, P. Liras, I. Santamarta, 2001, Microbiology.

Clavine Alkaloids Gene Clusters of Penicillium and Related Fungi: Evolutionary Combination of Prenyltransferases, Monooxygenases and Dioxygenases

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Genes.

Transformation of morphine by resting cells and cell-free systems of Arthrobacter sp.

P. Liras, W. Umbreit, 1975, Applied microbiology.

Thin-layer and gas chromatographic parameters of morphine and codeine derivatives.

P. Liras, 1975, Journal of chromatography.

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus

P. Liras, J. Gomez-Escribano, I. Santamarta, 2008, Journal of Industrial Microbiology & Biotechnology.

Biosynthesis and secretion of yeast invertase. Effect of cycloheximide and 2-deoxy-D-glucose.

P. Liras, S. Gascón, 1971, European journal of biochemistry.

Biosynthesis and Secretion of Yeast Invertase

P. Liras, S. Gascón, 1971 .

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene.

J. Barredo, B. Díez, P. Liras, 2002, Microbiology.

Cascades and networks of regulatory genes that control antibiotic biosynthesis.

J. Martín, P. Liras, 2012, Sub-cellular biochemistry.

Sequential expression of macromolecule biosynthesis and candicidin formation in Streptomyces griseus.

J. Martín, P. Liras, J. R. Villanueva, 1977, Journal of general microbiology.

The Relationship Between Primary and Secondary Metabolism in Streptomycetes

A. Corner, R. Callis, S. Baumberg, 1991 .

Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites.

P. Liras, M. F. Martín, M. F. Martín, 1989, Annual review of microbiology.

A natural short pathway synthesizes roquefortine C but not meleagrin in three different Penicillium roqueforti strains

C. García-Estrada, J. Martín, M. Coton, 2015, Applied Microbiology and Biotechnology.

Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.

J. Martín, P. Liras, J. Casqueiro, 2005, Current opinion in microbiology.

Role of the cmcH–ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus

P. Liras, G. Özcengiz, A. Kurt, 2013, Applied Microbiology and Biotechnology.

Glycerol Utilization Gene Cluster in Streptomyces clavuligerus

P. Liras, R. Pérez-Redondo, B. Koekman, 2009, Applied and Environmental Microbiology.

Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources

J. Martín, P. Liras, María Ordóñez-Robles, 2017, Applied Microbiology and Biotechnology.

ATP and adenylate energy charge during phosphate-mediated control of antibiotic synthesis.

J. Martín, A. Demain, P. Liras, 1978, Biochemical and biophysical research communications.

Inhibition by phosphate of the activity of candicidin synthases

J. Martín, A. Demain, P. Liras, 1977 .

Allophane increases the protein levels of several cephamycin biosynthetic enzymes in Nocardia lactamdurans

J. Martín, F. Enguita, A. Leitão, 1996 .

Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster.

Y. Martínez-Burgo, P. Liras, R. Pérez-Redondo, 2014, Journal of biotechnology.

Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.

J. Martín, P. Liras, I. Santamarta, 2013, Journal of biotechnology.

The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity

J. Frère, J. Martín, M. Galleni, 1997, Journal of bacteriology.

A 1.8-Mb-reduced Streptomyces clavuligerus genome: relevance for secondary metabolism and differentiation

J. Martín, Y. Martínez-Burgo, P. Liras, 2014, Applied Microbiology and Biotechnology.

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.

M. Bibb, J. Martín, A. Hesketh, 2008, Microbiology.

An rplKΔ29‐PALG‐32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus

A. Pisabarro, J. Martín, P. Liras, 2006, Molecular microbiology.

Characterization, expression in Streptomyces lividans, and processing of the amylase of Streptomyces griseus IMRU 3570: two different amylases are derived from the same gene by an intracellular processing mechanism

J. Martín, P. Liras, T. Vigal, 1991, Journal of bacteriology.

Cloning and characterization of a phosphate-regulated promoter involved in phosphate control of candicidin biosynthesis.

J. Martín, A. Rebollo, J. Gil, 1989, Gene.

Biosynthesis of β-lactam antibiotics: Design and construction of overproducing strains

J. Martín, P. Liras, 1985 .

Harnessing microbiota interactions to produce bioactive metabolites: communication signals and receptor proteins.

J. Martín, P. Liras, 2019, Current opinion in pharmacology.

Molecular genetics of naringenin biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus

Silvia M. Albillos, J. Martín, P. Liras, 2015, Microbial Cell Factories.

Genes for a beta‐lactamase, a penicillin‐binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans.

J. Coque, P. Liras, J. Martin, 1993, The EMBO journal.

Modulation of Gene Expression in Actinobacteria by Translational Modification of Transcriptional Factors and Secondary Metabolite Biosynthetic Enzymes

J. Martín, P. Liras, S. Sánchez, 2021, Frontiers in Microbiology.

The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors in Streptomyces and Related Actinobacteria

J. Martín, P. Liras, 2020, Frontiers in Microbiology.

Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.

J. Martín, A. Demain, J. Coque, 1994, Microbiology.

Evolution of the clusters of genes for beta-lactam antibiotics: a model for evolutive combinatorial assembly of new beta-lactams.

J. Martín, P. Liras, A. Rodríguez-García, 1998, International microbiology : the official journal of the Spanish Society for Microbiology.

Isolation of mutants deregulated in phosphate control of candicidin biosynthesis.

J. Martín, P. Liras, G. Naharro, 1979, The Journal of antibiotics.

Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway

J. Martín, P. Liras, A. Rodríguez-García, 1997, Molecular microbiology.

Changes in composition of conidia of Penicillium notatum during germination

J. Martín, P. Liras, J. R. Villanueva, 1974, Archives of Microbiology.

Insights into the Structure and Molecular Mechanisms of β-Lactam Synthesizing Enzymes in Fungi

J. Martín, P. Liras, 2017 .

Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer

J. Martín, S. Gutiérrez, P. Liras, 2003, Current Genetics.

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

A. Truman, Y. Martínez-Burgo, P. Liras, 2019, Front. Microbiol..

Substrate analysis and molecular cloning of the extracellular alkaline phosphatase of Streptomyces griseus.

J. Martín, P. Liras, A. Martin, 2001, Microbiology.

Efficient plasmid transformation of the beta-lactam producer Streptomyces clavuligerus

J. Martín, A. Demain, B. Mahro, 1987, Applied and environmental microbiology.

Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

J. Martín, P. Liras, I. Santamarta, 2006, Research in microbiology.

A natural short pathway synthesizes roquefortine C but not meleagrin in three different Penicillium roqueforti strains

C. García-Estrada, J. Martín, M. Coton, 2015, Applied Microbiology and Biotechnology.

Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: Effects on cephamycin C production

J. Piret, P. Liras, G. Özcengiz, 2010, Bioengineered bugs.

Evolutionary formation of gene clusters by reorganization: the meleagrin/roquefortine paradigm in different fungi

J. Martín, P. Liras, 2016, Applied Microbiology and Biotechnology.

Interdependence of Gene Expression for Early Steps of Cephalosporin Synthesis in Streptomyces clavuligerus

J. Martín, A. Demain, J. Piret, 1994, Annals of the New York Academy of Sciences.

Regulation of α-aminoadipyl-cysteinyl-valine, isopenicillin N synthetase, isopenicillin N isomerase and deacetoxycephalosporin C synthetase by nitrogen sources in Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1985, Applied Microbiology and Biotechnology.

Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant

J. Martín, P. Liras, M. Garcia-Dominguez, 1989, Journal of bacteriology.

A 1.8-Mb-reduced Streptomyces clavuligerus genome: relevance for secondary metabolism and differentiation

J. Martín, Y. Martínez-Burgo, P. Liras, 2013, Applied Microbiology and Biotechnology.

Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis.

J. Martín, J. Coque, F. Enguita, 1995, Gene.

Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide.

J. Martín, J. Coque, P. Liras, 1996, European journal of biochemistry.

Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus

P. Liras, 2014, Applied Microbiology and Biotechnology.

The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation

Y. Martínez-Burgo, P. Liras, A. Rodríguez-García, 2015, Applied and Environmental Microbiology.

New type of hexameric ornithine carbamoyltransferase with arginase activity in the cephamycin producers Streptomyces clavuligerus and Nocardia lactamdurans.

P. Liras, Juan Luis, LA De, 1996, The Biochemical journal.

Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid

Y. Martínez-Burgo, P. Liras, A. Rodríguez-García, 2017, BMC Genomics.