I. Romero‐Canelón

发表

Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

P. Sadler, V. Brabec, J. Kašpárková, 2018, Dalton transactions.

Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

P. Sadler, A. Habtemariam, G. Clarkson, 2018, Nature Chemistry.

Synchrotron XRF imaging of Alzheimer’s disease basal ganglia reveals linear dependence of high-field magnetic resonance microscopy on tissue iron concentration

L. Hazrati, J. Dobson, M. Finnegan, 2019, Journal of Neuroscience Methods.

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action.

P. Sadler, N. Carragher, A. Munro, 2018, Metallomics : integrated biometal science.

Synthesis and Mode of Action Studies on Iridium(I)–NHC Anticancer Drug Candidates

P. Sadler, L. Messori, I. Romero‐Canelón, 2018 .

Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.

P. Sadler, L. Young, I. Romero‐Canelón, 2019, Dalton Transactions.

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells.

P. Sadler, I. Romero‐Canelón, S. Shnyder, 2014, Metallomics : integrated biometal science.

Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells.

P. Sadler, D. Gianolio, R. Tucoulou, 2019, Chemical communications.

Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex.

P. Sadler, I. Romero‐Canelón, K. Geraki, 2018, Journal of inorganic biochemistry.

Lysyl Oxidase Like‐2 (LOXL2): An Emerging Oncology Target

I. Romero‐Canelón, Alan M. Jones, Vriddhi Chopra, 2020 .

Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs

P. Sadler, V. Brabec, O. Novakova, 2018, Inorganic chemistry.

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

P. Sadler, U. McDermott, N. Carragher, 2015, Proceedings of the National Academy of Sciences.

Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes.

P. Sadler, A. Habtemariam, G. Clarkson, 2022, Dalton transactions.

Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.

P. Sadler, G. Clarkson, V. Avery, 2018, Chemistry.

Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.

P. Sadler, V. Avery, I. Romero‐Canelón, 2021, Journal of inorganic biochemistry.

Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry

P. Sadler, L. Young, A. Habtemariam, 2019, Inorganica chimica acta.

Systems approach to metal-based pharmacology

P. Sadler, I. Romero‐Canelón, 2015, Proceedings of the National Academy of Sciences.

The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.

P. Sadler, L. Salassa, I. Romero‐Canelón, 2013, Journal of medicinal chemistry.

Platinum(iv)-azido monocarboxylato complexes are photocytotoxic under irradiation with visible light†

P. Sadler, A. Habtemariam, G. Clarkson, 2021, Dalton transactions.

A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells

C. Bertoli, Rob A. M. de Bruin, I. Romero‐Canelón, 2022, Metallomics : integrated biometal science.

Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands

P. Sadler, A. Habtemariam, G. Clarkson, 2015, Organometallics.

University of Birmingham Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells

I. Turel, I. Romero‐Canelón, James P. C. Coverdale, 2021 .

Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.

Frederik Lermyte, I. Romero‐Canelón, M. Barrow, 2020, Journal of the American Society for Mass Spectrometry.

Towards Identification of Essential Structural Elements of Organoruthenium(II)-Pyrithionato Complexes for Anticancer Activity.

I. Turel, I. Romero‐Canelón, I. Ott, 2019, Chemistry.

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

G. Challis, I. Romero‐Canelón, J. Masschelein, 2020, Angewandte Chemie.

Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?

Frederik Lermyte, I. Romero‐Canelón, M. Barrow, 2018, Chemical communications.

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.

G. Challis, J. Parkhill, P. Coupland, 2017, Journal of the American Chemical Society.

Novel tetranuclear PdII and PtII anticancer complexes derived from pyrene thiosemicarbazones.

P. Sadler, G. Clarkson, I. Romero‐Canelón, 2020, Dalton transactions.

Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.

P. Sadler, A. Desideri, A. Batista, 2019, Dalton transactions.

The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts.

P. Sadler, I. Romero‐Canelón, Zhe Liu, 2016, Dalton transactions.

Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands

P. Sadler, A. Habtemariam, G. Clarkson, 2014, Organometallics.

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

P. Sadler, A. Habtemariam, G. Clarkson, 2014, Angewandte Chemie.

Next-generation metal anticancer complexes: multitargeting via redox modulation.

P. Sadler, I. Romero‐Canelón, 2013, Inorganic chemistry.

Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes.

P. Sadler, A. Habtemariam, G. Clarkson, 2016, Inorganic chemistry.

Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity

P. Sadler, A. Habtemariam, G. Clarkson, 2018, Organometallics.

Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes.

P. Sadler, A. Habtemariam, Ana M. Pizarro, 2012, Metallomics : integrated biometal science.

Correction to Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

P. Sadler, I. Romero‐Canelón, Zhe Liu, 2013, ACS Chemical Biology.

Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

P. Sadler, I. Romero‐Canelón, Zhe Liu, 2013, ACS chemical biology.

Half-sandwich rhodium(III) transfer hydrogenation catalysts: Reduction of NAD(+) and pyruvate, and antiproliferative activity.

P. Sadler, A. Habtemariam, Joan J. Soldevila‐Barreda, 2015, Journal of inorganic biochemistry.

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

P. Sadler, A. Habtemariam, Joan J. Soldevila‐Barreda, 2015, Nature Communications.

New activation mechanism for half-sandwich organometallic anticancer complexes

P. Sadler, A. Habtemariam, G. Clarkson, 2018, Chemical science.

Cyclic Peptide-Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes.

Johannes C. Brendel, P. Sadler, K. Jolliffe, 2018, Biomacromolecules.

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes

P. Sadler, A. Habtemariam, G. Clarkson, 2016, Angewandte Chemie.

Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT)

P. Sadler, N. Kirby, Joan J. Soldevila‐Barreda, 2015 .

Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.

P. Sadler, N. Kirby, Corinne J. Smith, 2014, Faraday discussions.

Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation

P. Sadler, I. Romero‐Canelón, Magdalena Moś, 2015, Journal of medicinal chemistry.

Supramolecular Photoactivatable Anticancer Hydrogels.

P. Sadler, A. Habtemariam, N. Mishra, 2017, Journal of the American Chemical Society.

Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.

P. Sadler, I. Romero‐Canelón, James P. C. Coverdale, 2019, Metallomics : integrated biometal science.

NMR studies of group 8 metallodrugs: 187Os-enriched organo-osmium half-sandwich anticancer complex

P. Sadler, A. Habtemariam, G. Clarkson, 2021, Dalton transactions.

Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells

A. Lapkin, G. Barker, I. Romero‐Canelón, 2014, ChemMedChem.

Nanoparticles of chitosan conjugated to organo-ruthenium complexes

P. Sadler, A. Habtemariam, I. Romero‐Canelón, 2016 .

Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?

I. Romero‐Canelón, James P. C. Coverdale, Thaisa Laroiya-McCarron, 2019, Inorganics.

The potent anti-cancer activity of Dioclea lasiocarpa lectin.

P. Sadler, C. Nagano, B. Cavada, 2017, Journal of inorganic biochemistry.

Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells

P. Cloetens, P. Sadler, S. Bohic, 2017, Chemistry.

A novel ferronucleoside that targets DNA replication in pancreatic cancer cells

C. Bertoli, I. Romero‐Canelón, Joanna R. Morris, 2021 .

A novel dual-functioning ruthenium(II)-arene complex of an anti-microbial ciprofloxacin derivative - Anti-proliferative and anti-microbial activity.

P. Sadler, B. Twamley, I. Romero‐Canelón, 2016, Journal of inorganic biochemistry.

Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents.

P. Sadler, A. Habtemariam, G. Clarkson, 2020, Journal of inorganic biochemistry.

Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors

P. Sadler, I. Romero‐Canelón, Elizabeth M. Bolitho, 2023, JBIC Journal of Biological Inorganic Chemistry.

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

P. Sadler, I. Romero‐Canelón, Ji-Inn Song, 2018, Journal of medicinal chemistry.

Organoruthenium Complexes with Benzo-Fused Pyrithiones Overcome Platinum Resistance in Ovarian Cancer Cells

I. Turel, I. Romero‐Canelón, James P. C. Coverdale, 2021, Cancers.

Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex.

P. Sadler, A. Habtemariam, I. Romero‐Canelón, 2016, Dalton transactions.

Young Researcher Presentations

P. Sadler, P. Kondaiah, I. Khan, 2014, JBIC Journal of Biological Inorganic Chemistry.

Effect of Regiochemistry and Methylation on the Anticancer Activity of a Ferrocene‐Containing Organometallic Nucleoside Analogue

L. Male, I. Romero‐Canelón, J. H. Tucker, 2020, Chembiochem : a European journal of chemical biology.

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts

P. Sadler, V. Brabec, J. Kašpárková, 2018, Organometallics.

Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes† †Electronic supplementary information (ESI) available. CCDC 1522104. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03216a

P. Sadler, A. Habtemariam, G. Clarkson, 2017, Chemical science.

University of Birmingham A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — Anti-proliferative and anti-microbial activity

P. Sadler, B. Twamley, I. Romero‐Canelón, 2016 .

Discovery and biosynthesis of persiathiacins: Unusual polyglycosylated thiopeptides active against multi-drug resistant tuberculosis

G. Challis, S. Cole, J. Overmann, 2021, bioRxiv.

Determination of the Aggregate Binding Site of Amyloid Protofi-brils Using Electron Capture Dissociation Tandem MS

Frederik Lermyte, I. Romero‐Canelón, M. Barrow, 2020 .