D. Appling

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13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae.

L. Pasternack, D. Laude, D. Appling, 1992, Biochemistry.

The X‐ray structure of the NAD‐dependent 5,10‐methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae

A. Monzingo, J. Robertus, D. Appling, 2000, Protein science : a publication of the Protein Society.

13C NMR analysis of intercompartmental flow of one-carbon units into choline and purines in Saccharomyces cerevisiae.

L. Pasternack, D. Laude, D. Appling, 1994, Biochemistry.

In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.

C. Barlowe, D. Appling, 1988, BioFactors.

Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast.

M. West, D. Appling, A. Thigpen, 1990, The Journal of biological chemistry.

13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae.

L. Pasternack, D. Laude, D. Appling, 1996, Archives of biochemistry and biophysics.

A Common Variant in MTHFD1L is Associated with Increased Risk for Spina Bifida

R. Finnell, D. Appling, Y. Lei, 2018 .

Deletion of the neural tube defect–associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos

Minhye Shin, E. Sentandreu, D. Appling, 2018, The Journal of Biological Chemistry.

Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density.

Minhye Shin, D. Appling, Jessica Momb, 2019, Birth defects research.

Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme

C. Barlowe, D. Appling, 1990, Molecular and cellular biology.

Use of 13C nuclear magnetic resonance to evaluate metabolic flux through folate one-carbon pools in Saccharomyces cerevisiae.

E. Kastanos, L. Pasternack, D. Appling, 1997, Methods in enzymology.

Regulation of expression of the ADE3 gene for yeast C1-tetrahydrofolate synthase, a trifunctional enzyme involved in one-carbon metabolism.

D. Appling, J. Rabinowitz, 1985, The Journal of biological chemistry.

Purification, immunoassay, and tissue distribution of rat C1-tetrahydrofolate synthase.

W. D. Cheek, D. Appling, 1989, Archives of biochemistry and biophysics.

Software Review of Prism 5

D. Appling, 2008 .

Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

D. Appling, A. S. Tibbetts, 2010, Annual review of nutrition.

Evidence of a role for retinoic acid (vitamin A-acid) in the maintenance of testosterone production in male rats.

F. Chytil, D. Appling, 1981, Endocrinology.

Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes

D. Appling, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Evidence for overlapping active sites in a multifunctional enzyme: immunochemical and chemical modification studies on C1-tetrahydrofolate synthase from Saccharomyces cerevisiae.

D. Appling, J. Rabinowitz, Jesse C. Rabinowitz, 1985, Biochemistry.

Site-directed mutagenesis of yeast C1-tetrahydrofolate synthase: analysis of an overlapping active site in a multifunctional enzyme.

C. Barlowe, D. Appling, M. Williams, 1989, Biochemistry.

Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase.

D. Appling, Dean R Appling, Addie S Walkup, 2005, Archives of biochemistry and biophysics.

Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development.

D. Appling, Liwen Zhang, K. Howard, 2003, Gene.

Characterization of Two 5-Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/Inosine Monophosphate Cyclohydrolase Isozymes from Saccharomyces cerevisiae *

D. Appling, A. S. Tibbetts, 2000, The Journal of Biological Chemistry.

Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase.

D. Appling, A. S. Tibbetts, 1997, Archives of biochemistry and biophysics.

Yeast Mitochondrial Initiator tRNA Is Methylated at Guanosine 37 by the Trm5-encoded tRNA (Guanine-N1-)-methyltransferase*

D. Graham, G. Kramer, D. Appling, 2007, Journal of Biological Chemistry.

Nitrous oxide exposure reduces hepatic C1-tetrahydrofolate synthase expression in rats.

C. Barlowe, D. Appling, 1988, Biochemical and biophysical research communications.

Isolation, Characterization, and Functional Expression of cDNAs Encoding NADH-dependent Methylenetetrahydrofolate Reductase from Higher Plants*

Hong Wang, Y. Shachar-Hill, H. Bohnert, 1999, The Journal of Biological Chemistry.

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

S. Vokes, D. Surman, D. Appling, 2012, Proceedings of the National Academy of Sciences.

Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization mass spectrometry imaging

L. Eberlin, D. Appling, Rachel J. DeHoog, 2021, Analytical and Bioanalytical Chemistry.

Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues*

Minhye Shin, D. Appling, J. D. Bryant, 2013, The Journal of Biological Chemistry.

Regulation of S-Adenosylmethionine Levels in Saccharomyces cerevisiae*

D. Appling, Sherwin Y Chan, Dean R Appling, 2003, Journal of Biological Chemistry.

Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2.

G. Kramer, D. Appling, C. Garofalo, 2005, Archives of biochemistry and biophysics.

Mammalian Mitochondrial Initiation Factor 2 Supports Yeast Mitochondrial Translation without Formylated Initiator tRNA*

G. Kramer, B. Hardesty, D. Appling, 2003, Journal of Biological Chemistry.

Purification and characterization of yeast mitochondrial initiation factor 2.

G. Kramer, B. Hardesty, D. Appling, 2003, Archives of biochemistry and biophysics.

Initiation of Protein Synthesis in Saccharomyces cerevisiae Mitochondria without Formylation of the Initiator tRNA

Uttam L. RajBhandary, Yan Li, U. RajBhandary, 2000, Journal of bacteriology.

Mitochondrial one-carbon metabolism and neural tube defects.

D. Appling, Jessica Momb, 2014, Birth defects research. Part A, Clinical and molecular teratology.

Yeast AEP3p Is an Accessory Factor in Initiation of Mitochondrial Translation*

G. Kramer, D. Appling, A. S. Tibbetts, 2009, The Journal of Biological Chemistry.

Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae.

J. Robertus, D. Appling, Huda S Suliman, 2005, Archives of biochemistry and biophysics.

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Minhye Shin, D. Appling, Jessica Momb, 2017, Cancer & Metabolism.

Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues*

D. Appling, J. D. Bryant, Jessica Momb, 2010, The Journal of Biological Chemistry.

Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*

K. Artzt, D. Appling, Schuyler T. Pike, 2009, The Journal of Biological Chemistry.

Cyclohydrolase Expressed in Both Adult Dehydrogenase / Methenyltetrahydrofolate Methylenetetrahydrofolate Cofactor-specific Mitochondrial MTHFD 2 L Is a Dual Redox Metabolism :

D. Appling, J. D. Bryant, Jessica Momb, 2014 .

Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine.

D. Appling, L. F. Garcı́a-Martı́nez, 1993, Biochemistry.

Isolation and characterization of a novel eukaryotic monofunctional NAD(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase.

C. Barlowe, D. Appling, 1990, Biochemistry.

Whole-cell detection by 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyltransferase enzyme system and effect of antifolate exposure in Saccharomyces cerevisiae.

L. Pasternack, D. Laude, D. Appling, 1994, Biochemistry.

Genetic approaches to the study of protein-protein interactions.

D. Appling, 1999, Methods.

Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform.

D. Appling, Priya Prasannan, 2009, Archives of biochemistry and biophysics.

Human Mitochondrial C1-Tetrahydrofolate Synthase

D. Appling, B. Shane, Schuyler T. Pike, 2003, Journal of Biological Chemistry.

Frank Chytil (1924-2010).

D. Appling, D. Ong, 2010, The Journal of nutrition.

Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae.

E. Kastanos, D. Appling, Y. Woldman, 1997, Biochemistry.

A general method for determining the contribution of split pathways in metabolite production in the yeast Saccharomyces cerevisiae.

D. Appling, Y. Woldman, 2002, Metabolic engineering.

Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase.

E. Kastanos, D. Appling, R. K. Raymond, 1999, Archives of biochemistry and biophysics.

Cloning and Characterization of Methenyltetrahydrofolate Synthetase from Saccharomyces cerevisiae *

D. Appling, William B. Holmes, 2002, The Journal of Biological Chemistry.

Metabolic Engineering in Yeast Demonstrates ThatS-Adenosylmethionine Controls Flux through the Methylenetetrahydrofolate Reductase Reaction in Vivo *

A. Hanson, F. Kaplan, D. Horne, 2002, The Journal of Biological Chemistry.

Monofunctional NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae.

M. West, D. Appling, 1997, Methods in enzymology.

Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium.

J. Kreisberg, D. Appling, W. Glass, 1991, The American journal of physiology.

Site-directed mutagenesis of a highly conserved aspartate in the putative 10-formyl-tetrahydrofolate binding site of yeast C1-tetrahydrofolate synthase.

D. Appling, T. J. Kirksey, 1996, Archives of Biochemistry and Biophysics.

Cloning and characterization of the Saccharomyces cerevisiae gene encoding NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase.

M. West, C. Barlowe, D. Appling, 1993, Journal of Biological Chemistry.

The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target.

J. Robertus, D. Appling, Huda S Suliman, 2007, Archives of biochemistry and biophysics.

Crystallization of the NAD‐dependent 5,10‐methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae

M. West, J. Robertus, D. Appling, 1996, Proteins.

A membrane-impermeant, cleavable cross-linker. Dimers of human erythrocyte band 3 subunits cross-linked at the extracytoplasmic membrane face.

J. V. Staros, D. Appling, D. Morgan, 1981, Journal of Biological Chemistry.

Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

D. Appling, A. S. Tibbetts, 2010, Annual review of nutrition.

Yeast AEP3p Is an Accessory Factor in Initiation of Mitochondrial Translation*

G. Kramer, D. Appling, A. S. Tibbetts, 2009, The Journal of Biological Chemistry.

Intensity scan and two photon absorption and nonlinear refraction of C60 in toluene

Huimin Liu, R. Powell, B. Jassemnejad, 1996 .

Global metabolic changes following loss of a feedback loop reveal dynamic steady states of the yeast metabolome.

E. Marcotte, Peng Lu, D. Appling, 2007, Metabolic engineering.