Cheng Jiang

发表

Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors.

Bingyan Li, Kang Yang, Dailin Liang, 2021, European journal of medicinal chemistry.

Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity.

Dailin Liang, Cheng Jiang, Ya-Kong Fan, 2019, European journal of medicinal chemistry.

Identification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1.

Huiyong Sun, Cheng Jiang, Yanhong Chen, 2018, Bioorganic chemistry.

ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles.

Kang Xu, Cheng Jiang, Shoujie Shi, 2018, The Journal of organic chemistry.

Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors.

Bin Di, Cheng Jiang, Tongyuan Lin, 2018, Bioorganic & medicinal chemistry.

Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists.

Kun Hao, Z. Meng, Cheng Jiang, 2019, European journal of medicinal chemistry.

Kinesin spindle protein Inhibitors as anticancer agents

Q. You, Q. Guo, Cheng Jiang, 2006 .

Identification of novel peptidomimetics targeting the polo-box domain of polo-like kinase 1.

Huiyong Sun, Cheng Jiang, Zhenguo Zhang, 2019, Bioorganic chemistry.

Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor.

Q. You, Cheng Jiang, Lei Yang, 2008, Biological & pharmaceutical bulletin.

Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma

N. Lu, Cheng Jiang, Zhenguo Zhang, 2020, Cell biology and toxicology.

Kinesin spindle protein inhibitors in cancer: a patent review (2008 – present)

Q. You, Cheng Jiang, 2013, Expert opinion on therapeutic patents.

Recent progress on the discovery of P2Y14 receptor antagonists.

Cheng Jiang, Zhenguo Zhang, Ran Lu, 2019, European journal of medicinal chemistry.

CPUYJ039, a newly synthesized benzimidazole‐based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity

Q. You, Q. Guo, Cheng Jiang, 2011, The Journal of pharmacy and pharmacology.

Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.

Q. You, Cheng Jiang, Lei Yang, 2010, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors.

J. Chern, Q. You, Q. Guo, 2009, Chemical & pharmaceutical bulletin.

An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation

Q. You, Cheng Jiang, 2007 .

Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.

Dailin Liang, Cheng Jiang, Zonghui Ma, 2020, Bioorganic chemistry.

Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y14R Antagonists with Anti-Inflammatory Characters.

Z. Meng, Cheng Jiang, Li-li Xu, 2022, Journal of medicinal chemistry.

HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis.

Cheng Jiang, Zhenguo Zhang, Qinghua Hu, 2022, International immunopharmacology.

Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles.

Kang Xu, Cheng Jiang, Zhenhua Ding, 2019, Organic & biomolecular chemistry.

Discovery of a series of pyridopyrimidine derivatives as potential topoisomerase I inhibitors

N. Lu, Q. Guo, Li Zhao, 2014 .

Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.

Q. You, Weikang Tao, Ren Ren, 2022, Journal of medicinal chemistry.

De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.

Q. You, Q. Guo, Cheng Jiang, 2011, Bioorganic & medicinal chemistry.

Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.

Cheng Jiang, Meng Lei, Yongqiang Zhu, 2016, Bioorganic & medicinal chemistry letters.

Structure, derivatization, and antitumor activity of new griseusins from Nocardiopsis sp.

K. Menzel, A. Maier, H. Fiebig, 2007, Journal of medicinal chemistry.

Synthesis and Evaluation of Gambogic Acid Derivatives as Antitumor Agents. Part III

Q. You, Q. Guo, Cheng Jiang, 2013, Chemistry & biodiversity.

Divergent synthesis of oxazolidines and morpholines via PhI(OAc)2-mediated difunctionalization of alkenes.

Cheng Jiang, Zhenhua Ding, Shuang Yang, 2020, Organic & biomolecular chemistry.

Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma

N. Lu, Cheng Jiang, Zhenguo Zhang, 2020, Cell Biology and Toxicology.

A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells

S. Xie, Cheng Jiang, Q. He, 2023, Molecular Medicine.

Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis.

Q. You, Bin Di, Cheng Jiang, 2020, Journal of medicinal chemistry.

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Wen-long Huang, Hai Qian, Cheng Jiang, 2019, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer

Li Feng, Cheng Jiang, Xue Li, 2021, Molecules.

Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.

Bingyan Li, Dailin Liang, Cheng Jiang, 2021, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis.

Z. Meng, Cheng Jiang, Zhenguo Zhang, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as potential BRD4 inhibitors.

Wen-long Huang, Hai Qian, Cheng Jiang, 2019, Bioorganic & medicinal chemistry.

Docking studies on kinesin spindle protein inhibitors: an important cooperative ‘minor binding pocket’ which increases the binding affinity significantly

Yadong Chen, Q. You, Cheng Jiang, 2007, Journal of molecular modeling.

Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Q. You, Cheng Jiang, Lei Yang, 2010, Bioorganic & medicinal chemistry.

Design, Synthesis, and Evaluation of Non‐ATP‐Competitive Small‐Molecule Polo‐Like Kinase 1 (Plk1) Inhibitors

Cheng Jiang, Meng Liu, Yun-Gen Xu, 2015, Archiv der Pharmazie.