G. Painter

发表

Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells.

I. Hermans, O. Gasser, Jeffry S Tang, 2020, Food & function.

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.

P. Lipp, P. Hawkins, L. Stephens, 2002, Molecular cell.

Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d

J. Berzofsky, D. Venzon, D. Zajonc, 2019, Front. Immunol..

Short practical synthesis of (3R,4R,5R,6R)-tetrahydroxyazepane and (3S,4S,5S,6S)-tetrahydroxyazepane from D- and L-chiro-inositol, respectively

G. Painter, A. Falshaw, 2000 .

Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues.

T. Rades, S. Hook, M. Hubert, 2013, Molecular pharmaceutics.

Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

R. Dwek, I. Wilson, B. Beutler, 2009, PloS one.

A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and α-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients

M. Brimble, V. Hinder, I. Hermans, 2018, Cancer Immunology, Immunotherapy.

Phosphatidylinositol di-mannoside and derivates modulate the immune response to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection.

A. Heiser, R. Basaraba, B. Compton, 2012, Vaccine.

A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant

M. Denis, G. Painter, W. Severn, 2009, Immunopharmacology and immunotoxicology.

Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Johannes U. Mayer, Laura Ferrer-Font, D. Godfrey, 2022, Oncoimmunology.

The modular synthesis of multivalent functionalised glycodendrons for the detection of lectins including DC-SIGN

Mattie S. M. Timmer, G. Painter, K. Kodar, 2017 .

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

I. Wilson, Chi‐Huey Wong, B. Beutler, 2006, Nature Immunology.

Primary Dendritic Cells Maturation of Monocyte-Derived and Invariant T Cells Induces CD40L-Dependent Activation of Human Mucosal-Associated

G. Besra, V. Cerundolo, C. González-López, 2017 .

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells

G. Besra, V. Cerundolo, C. González-López, 2017, The Journal of Immunology.

Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins

J. Berzofsky, A. Heiser, I. Hermans, 2017, Scientific Reports.

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

D. Rader, A. Kaser, R. Hegele, 2010, The Journal of clinical investigation.

Isolation and Synthesis of Glycophospholipids from the extremophileChthonomonas calidirosea

J. Ryan, M. Vyssotski, B. Compton, 2020 .

Glycolipid‐peptide conjugate vaccines elicit CD8 + T‐cell responses and prevent breast cancer metastasis

Sung‐Hyun Yang, M. Brimble, I. Hermans, 2022, Clinical & translational immunology.

Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming

C. Ruedl, I. Hermans, G. Painter, 2015, The Journal of Immunology.

Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis.

Christophe Pellefigues, James J. Lee, W. Weninger, 2018, The Journal of investigative dermatology.

Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression.

S. Hook, B. Compton, Regan J. Anderson, 2015, Vaccine.

Analysis of the CD1 Antigen Presenting System in Humanized SCID Mice

D. Moody, Regan J. Anderson, G. Painter, 2011, PloS one.

Complementation Analysis in PtdInsPKinase-deficient Yeast Mutants Demonstrates ThatSchizosaccharomyces pombe and Murine Fab1p Homologues Are Phosphatidylinositol 3-Phosphate 5-Kinases*

R. K. McEwen, Y. Ohya, P. Parker, 1999, The Journal of Biological Chemistry.

Enhance Cross-Priming More Effectively to TLR Engagement and Splenic Dendritic Cell Subsets To Respond Activated NKT Cells Can Condition Different

C. Ruedl, I. Hermans, G. Painter, 2015 .

Using Full‐Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue‐Specific Preparation Protocols

Laura Ferrer-Font, I. Hermans, G. Painter, 2022, Current protocols.

Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside.

W. Martin, J. Harper, B. Compton, 2011, The Journal of organic chemistry.

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine.

K. Kedzierska, S. Turner, M. Brimble, 2017, ACS chemical biology.

MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Johannes U. Mayer, Christophe Pellefigues, D. O’Sullivan, 2021, Allergy.

DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation

P. Lipp, M. Bootman, P. Hawkins, 2000, Current Biology.

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria

G. McFadden, K. Kedzierska, S. Turner, 2020, Science Immunology.

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.

P. Hawkins, L. Stephens, A. Burgess, 2010, Organic & biomolecular chemistry.

General synthesis of 3-phosphorylated myo-inositol phospholipids and derivatives

I. Gilbert, P. Hawkins, L. Stephens, 1999 .

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

R. K. McEwen, P. Parker, A. Holmes, 1998, Current Biology.

Synthesis and biological evaluation of aPtdIns(3,4,5)P3 affinity matrix

P. Hawkins, L. Stephens, A. Holmes, 2001 .

ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms

B. Delahunt, K. Filbey, W. Weninger, 2015, Nature Communications.

VERSATILE SYNTHESIS OF MYO-INOSITOL PHOSPHOLIPID PRECURSORS

I. Gilbert, A. Holmes, G. Painter, 1997 .

Synthesis of dipalmitoyl phosphatidylinositol 3,4-bis(phosphate)and 3,4,5-tris(phosphate) and their enantiomers

P. Hawkins, L. Stephens, A. Holmes, 1997 .

The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers

R. Furneaux, B. Greatrex, T. Rades, 2009 .

Synthesis and Activity of 6″-Deoxy-6″-thio-α-GalCer and Peptide Conjugates.

I. Hermans, B. Compton, G. Painter, 2015, Organic letters.

Natural killer T-cell autoreactivity leads to a specialized activation state.

G. Besra, A. Huttenlocher, G. Painter, 2008, Blood.

MAIT cells activate dendritic cells to promote T follicular helper cell differentiation and humoral immunity

V. Cerundolo, I. Hermans, T. Bird, 2022, bioRxiv.

Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist.

D. Zajonc, M. Brimble, D. Godfrey, 2019, Organic & biomolecular chemistry.

Phosphatidylinositol mannosides: synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides.

M. Denis, G. Painter, D. Larsen, 2006, Bioorganic & medicinal chemistry.

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

F. McCormick, P. Hawkins, L. Stephens, 1998, Science.

Enhanced Protection against Bovine Tuberculosis after Coadministration of Mycobacterium bovis BCG with a Mycobacterial Protein Vaccine-Adjuvant Combination but Not after Coadministration of Adjuvant Alone

H. Vordermeier, R. G. Hewinson, M. Denis, 2008, Clinical and Vaccine Immunology.

Using agonists for iNKT cells in cancer therapy.

I. Hermans, G. Painter, Olivia K. Burn, 2020, Molecular immunology.

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

I. Hermans, O. Gasser, Regan J. Anderson, 2020, Frontiers in Immunology.

Nanoparticle System Based on Amino-Dextran as a Drug Delivery Vehicle: Immune-Stimulatory CpG-Oligonucleotide Loading and Delivery

H. V. Nguyen, G. Walker, G. Painter, 2020, Pharmaceutics.

Influence of Albumin in the Microfluidic Synthesis of PEG-PLGA Nanoparticles.

G. Walker, G. Painter, Bettina Poller, 2019, Pharmaceutical nanotechnology.

Novel synthesis of alpha-galactosyl-ceramides and confirmation of their powerful NKT cell agonist activity.

I. Hermans, G. Painter, A. Lee, 2006, Carbohydrate research.

A PIM₂ analogue suppresses allergic airway disease.

J. Harper, G. Painter, D. Larsen, 2011, Bioorganic & medicinal chemistry.

Synthesis and Toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues.

I. Wilson, W. Martin, J. Harper, 2011, Journal of medicinal chemistry.

6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria

G. McFadden, A. Cozijnsen, I. Hermans, 2022, RSC chemical biology.

Resolution of orthogonally protected myo-inositols with novozym 435 providing an enantioconvergent pathway to Ac2PIM1.

B. Compton, G. Painter, D. Larsen, 2014, The Journal of organic chemistry.

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.

G. Evans, R. Furneaux, V. Schramm, 2005, Journal of medicinal chemistry.

Syntheses of tetrahydroxyazepanes from chiro-inositols and their evaluation as glycosidase inhibitors.

G. Painter, A. Falshaw, P. Eldridge, 2004, Bioorganic & medicinal chemistry.

Energetic Mapping of Transition State Analogue Interactions with Human and Plasmodium falciparum Purine Nucleoside Phosphorylases*♦

G. Evans, R. Furneaux, V. Schramm, 2005, Journal of Biological Chemistry.

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.

G. Evans, R. Furneaux, V. Schramm, 2007, ACS chemical biology.

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.

G. Evans, R. Furneaux, V. Schramm, 2006, Biochemistry.

Resolution of (1,1′-binaphthalene)-2,2′-dithiol via diastereoisomeric dithioacetals derived from

Robin A. J. Smith, G. Painter, U. Bandarage, 1995 .

Total synthesis of Lewis(X) using a late-stage crystalline intermediate.

Mattie S. M. Timmer, G. Painter, G. Gainsford, 2015, Carbohydrate research.

Synthesis and biological activities of d-chiro-inositol analogues with insulin-like actions.

G. Painter, S. Cameron, K. Loomes, 2016, European journal of medicinal chemistry.

Conformation inversion of an inositol derivative by use of silyl ethers: a modified route to 3,6-di-O-substituted-L-ido-tetrahydroxyazepane derivatives.

G. Painter, A. Falshaw, H. Wong, 2004, Organic & biomolecular chemistry.

The dimethoxyphenylbenzyl protecting group: an alternative to the p-methoxybenzyl group for protection of carbohydrates.

G. Painter, D. Larsen, Gregory M. Rankin, 2013, The Journal of organic chemistry.

Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides.

B. Compton, G. Painter, D. Larsen, 2012, The Journal of organic chemistry.

Synthesis and structure of phosphatidylinositol dimannoside.

M. Denis, G. Painter, D. Larsen, 2007, The Journal of organic chemistry.

The rapid and facile synthesis of oxyamine linkers for the preparation of hydrolytically stable glycoconjugates.

Mattie S. M. Timmer, G. Painter, Julien R. C. Prévost, 2015, Organic letters.

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

D. Hay, G. Anderson, G. Painter, 2015, Endocrinology.

Role of Phosphatidylinositol Mannosides in the Interaction between Mycobacteria and DC-SIGN

G. Besra, B. Appelmelk, J. Geurtsen, 2009, Infection and Immunity.

Phosphatidylinositol mannosides: synthesis and suppression of allergic airway disease.

J. Harper, G. Painter, D. Larsen, 2006, Bioorganic & medicinal chemistry.

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids

R. Dwek, I. Wilson, M. Wormald, 2015, Innate immunity.

Role of phosphatidylinositol mannosides in the interaction between mycobacteria 1 and DC-SIGN 2 3

B. Appelmelk, J. Geurtsen, N. N. Driessen, 2009 .

Structural Characterization of Mycobacterial Phosphatidylinositol Mannoside Binding to Mouse CD1d12

Ian A. Wilson, Dirk M. Zajonc, I. Wilson, 2006, The Journal of Immunology.

Mucosal-Associated Invariant T (MAIT) Cell Dysfunction and PD-1 Expression in Prostate Cancer: Implications for Immunotherapy

B. Delahunt, I. Hermans, G. Painter, 2021, Frontiers in Immunology.

Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues.

J. Berzofsky, B. Compton, G. Painter, 2020, Organic & biomolecular chemistry.

Phosphatidylinositol mannoside ether analogues: syntheses and interleukin-12-inducing properties.

M. Denis, G. Painter, Andreas Härer, 2007, The Journal of organic chemistry.

Phosphatidylinositol Mannosides are Efficient Mucosal Adjuvants

M. Denis, G. Painter, A. L. La Flamme, 2008, Immunological investigations.

NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03599b Click here for additional data file. Click here for additional data file.

M. Brimble, I. Hermans, O. Gasser, 2015, Chemical science.

Harnessing NKT cells for vaccination

I. Hermans, G. Painter, Lisa M Connor, 2021, Oxford open immunology.

The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

D. Zajonc, M. Kronenberg, G. Painter, 2010, The Journal of experimental medicine.

Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells

D. Zajonc, M. Kronenberg, G. Painter, 2009, Proceedings of the National Academy of Sciences.

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy.

D. Knight, I. Hermans, F. Ronchese, 2014, Nature chemical biology.

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.

F. McCormick, P. Hawkins, L. Stephens, 1997, Science.

The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli.

C. Raetz, G. Painter, G. Painter, 1984, The Journal of biological chemistry.

Basophils promote barrier dysfunction and resolution in the atopic skin.

Jean X. Jiang, Christophe Pellefigues, K. Filbey, 2021, The Journal of allergy and clinical immunology.

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development

A. Loukas, P. Hotez, M. Bottazzi, 2018, PLoS pathogens.

An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.

I. Hermans, J. Gibbins, B. Compton, 2014, Blood.

Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC).

J. Blanchard, G. Painter, A. Luxenburger, 2007, Biochemistry.

A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma

Rajiv Kumar, M. Brimble, V. Hinder, 2023, Cancer Immunology, Immunotherapy.

Adjuvanticity of a Synthetic Phosphatidylinositol Dimannoside to a SubvirionInfluenza Vaccine in an Influenza Mouse Model

A. Heiser, B. Compton, G. Painter, 2015 .

Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma.

M. Berridge, G. Painter, R. Weinkove, 2020, Immunotherapy.

Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins

J. Berzofsky, A. Heiser, I. Hermans, 2017, Scientific Reports.

Increased Efficacy of NKT Cell-Adjuvanted Peptide Vaccines Through Chemical Conjugation

I. Hermans, G. Painter, C. Hayman, 2018 .

The chemical synthesis, stability and activity of MAIT cell prodrug agonists that access MR1 in recycling endosomes.

V. Cerundolo, C. González-López, I. Hermans, 2020, ACS chemical biology.

MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

V. Cerundolo, M. Quiñones-Mateu, I. Hermans, 2023, Cell Reports.

Synthesis and Biological Evaluation of Peptide-Adjuvant Conjugate Vaccines with Increasing Antigen Content.

I. Hermans, B. Compton, G. Painter, 2023, Bioconjugate chemistry.

Data on the uptake of CpG-loaded amino-dextran nanoparticles by antigen-presenting cells

H. V. Nguyen, G. Walker, G. Painter, 2021, Data in Brief.

Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli*

G. Evans, R. Furneaux, V. Schramm, 2005, Journal of Biological Chemistry.

2-Benzyl-myo-inositol monohydrate

Richard F. G. Fröhlich, G. Painter, G. Gainsford, 2009, Acta crystallographica. Section E, Structure reports online.

mRNA vaccine against malaria tailored for liver-resident memory T cells

G. McFadden, S. Gras, A. Cozijnsen, 2023, Nature Immunology.

Effect of carrier molecular weight on physicochemical properties and the in vitro immune-stimulatory activity of the CpG-dextran conjugates.

H. V. Nguyen, G. Walker, G. Painter, 2022, International journal of pharmaceutics.

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

K. Gaus, M. Ritchie, J. Rossjohn, 2022, The Journal of cell biology.

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

P. Parker, A. Holmes, G. Painter, 1998, Current Biology.

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

D. Hay, G. Anderson, G. Painter, 2015, Endocrinology.