Changsheng Zhang

发表

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis† †Electronic supplementary information (ESI) available: The experimental procedures, materials, and characterization of compounds. See DOI: 10.1039/c6sc00771f

Marie-Ève Picard, R. Shi, Weiming Zhu, 2016, Chemical science.

Minimum Information about a Biosynthetic Gene cluster.

Carla S. Jones, M. Smanski, Jan Claesen, 2015, Nature chemical biology.

Recombinant E. coli prototype strains for in vivo glycorandomization.

Gavin J. Williams, Jie Yang, J. Thorson, 2011, ACS chemical biology.

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

R. Ebright, A. Kapanidis, E. Eng, 2017, bioRxiv.

Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2013, Applied Microbiology and Biotechnology.

Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2021, Organic & biomolecular chemistry.

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.

J. Thorson, Hung‐wen Liu, Changsheng Zhang, 2006, Angewandte Chemie.

Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Journal of the American Chemical Society.

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Haibo Zhang, Siwen Niu, Changsheng Zhang, 2011, The Journal of Antibiotics.

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Yan Yan, H. Shan, Liping Zhang, 2020, Acta Pharmaceutica Sinica B.

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

Siwen Niu, Yiguang Zhu, Changsheng Zhang, 2012, Applied and Environmental Microbiology.

Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160.

Jinsong Liu, Yiguang Zhu, Changsheng Zhang, 2012, Journal of natural products.

A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2021, Science China Chemistry.

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019

Fang Peng, Qingbo Zhang, Liping Zhang, 2020, RSC advances.

Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions

J. Thorson, Lingjun Li, Changsheng Zhang, 2006, Science.

Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032.

Qingbo Zhang, Changsheng Zhang, Wenjun Zhang, 2014, Journal of natural products.

Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.

Caiguo Huang, Yuemao Shen, Qingbo Zhang, 2012, Organic letters.

Characterizing amosamine biosynthesis in amicetin reveals AmiG as a reversible retaining glycosyltransferase.

Jinsong Liu, Yiguang Zhu, Changsheng Zhang, 2013, Journal of the American Chemical Society.

Elucidating hydroxylation and methylation steps tailoring piericidin A1 biosynthesis.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2014, Organic letters.

Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U

A. Mándi, T. Kurtán, Yiguang Zhu, 2020, The Journal of Biological Chemistry.

Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis.

Weiming Zhu, Yiguang Zhu, Qingbo Zhang, 2016, ACS chemical biology.

Comparative Genomics Analysis of Streptomyces Species Reveals Their Adaptation to the Marine Environment and Their Diversity at the Genomic Level

Jiayan Wu, Meili Chen, Jingfa Xiao, 2016, Front. Microbiol..

Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2018, Front. Chem..

Assembly Line and Post-PKS Modifications in the Biosynthesis of Marine Polyketide Natural Products

Lijuan Wang, Yiguang Zhu, Qingbo Zhang, 2019 .

α-Pyrones with Diverse Hydroxy Substitutions from Three Marine-Derived Nocardiopsis Strains.

A. Mándi, T. Kurtán, Qingbo Zhang, 2016, Journal of natural products.

Heronamides D-F, polyketide macrolactams from the deep-sea-derived Streptomyces sp. SCSIO 03032.

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2014, Journal of natural products.

Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.

Caiguo Huang, Changsheng Zhang, J. Ju, 2012, Journal of natural products.

Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299

Wenjun Li, Siwen Niu, Changsheng Zhang, 2011, Marine drugs.

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

J. Thorson, Qunjie Gao, Changsheng Zhang, 2006, Chemistry & biology.

Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.

Changsheng Zhang, J. Ju, Hongbo Huang, 2011, Biochemical and biophysical research communications.

Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2017, Organic letters.

Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2015, Chembiochem : a European journal of chemical biology.

Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams

Hongbo Jin, Qingbo Zhang, Liping Zhang, 2019, Marine drugs.

Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived Verrucosispora sp. SCSIO 40062 by Overexpression of PPtase Genes.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2020, Journal of natural products.

Activation and Characterization of Bohemamine Biosynthetic Gene Cluster from Streptomyces sp. CB02009.

Changsheng Zhang, J. Ju, Y. Duan, 2020, Organic letters.

Coordinated Action of NRPS, Baeyer-Villiger Monooxygenase, and Methyltransferase Ensures the Economical Biosynthesis of Bohemamines in Streptomyces sp. CB02009

Changsheng Zhang, J. Ju, Y. Duan, 2020 .

Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U.

A. Mándi, T. Kurtán, Yiguang Zhu, 2020, The Journal of biological chemistry.

Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A 201 A from the Deep-Sea Marine Actinomycete

Wenjun Li, Changsheng Zhang, Hongbo Huang, 2011 .

Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037.

S. Nam, Changsheng Zhang, Su-mei Li, 2013, Journal of natural products.

Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2020, Marine genomics.

Pseudonocardia antitumoralis sp. nov., a deoxynyboquinone-producing actinomycete isolated from a deep-sea sediment.

Wenjun Li, Ying Xu, Lijuan Long, 2013, International journal of systematic and evolutionary microbiology.

Flavin-enabled reductive and oxidative epoxide ring opening reactions

Hung‐wen Liu, A. Mándi, T. Kurtán, 2022, Nature Communications.

Diversifying vancomycin via chemoenzymatic strategies.

J. Thorson, Changsheng Zhang, C. Albermann, 2005, Organic letters.

Antibiotic optimization via in vitro glycorandomization

J. Thorson, Changsheng Zhang, C. Albermann, 2003, Nature Biotechnology.

Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition

Ruibo Wu, Weiming Zhu, Yiguang Zhu, 2020, Communications Biology.

The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification

J. Thorson, Lingjun Li, Changsheng Zhang, 2007, Chembiochem : a European journal of chemical biology.

The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI

Rocco Moretti, J. Thorson, Changsheng Zhang, 2008, Chembiochem : a European journal of chemical biology.

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.

J. Thorson, Changsheng Zhang, C. Albermann, 2006, Journal of the American Chemical Society.

New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039

Haibo Zhang, Yiguang Zhu, Qingbo Zhang, 2012, The Journal of Antibiotics.

Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from the Deep-Sea Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652

Wenjun Li, Changsheng Zhang, J. Ju, 2011, Antimicrobial Agents and Chemotherapy.

Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species.

Jinsong Liu, Changsheng Zhang, Yi Xiao, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

Gavin J. Williams, J. Thorson, Changsheng Zhang, 2008, Chemistry & biology.

New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060

Hongbo Jin, Haibo Zhang, Liping Zhang, 2018, Tetrahedron.

Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers.

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2019, Organic & biomolecular chemistry.

Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2019, Marine drugs.

Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.

Changsheng Zhang, J. Ju, Zhihui Zheng, 2012, Bioorganic & medicinal chemistry letters.

Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2021, Fitoterapia.

Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2020, Organic letters.

RebG‐ and RebM‐Catalyzed Indolocarbazole Diversification

D. V. Van Vranken, J. Thorson, J. Chisholm, 2006, Chembiochem : a European journal of chemical biology.

Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis.

Hongbo Jin, Liping Zhang, Changsheng Zhang, 2020, Organic letters.

Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.

Wenjun Zhang, R. Shi, Haibo Zhang, 2014, Angewandte Chemie.

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme.

Changsheng Zhang, J. Ju, Hongbo Huang, 2012, Journal of the American Chemical Society.

Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.

Gavin J. Williams, J. Thorson, Changsheng Zhang, 2007, Nature chemical biology.

Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation

Mengran Zhao, Yiguang Zhu, Liping Zhang, 2022, Nature Communications.

New Cytochalasins from the Marine-Derived Fungus Xylaria sp. SCSIO 156

Changsheng Zhang, J. Ju, Hongbo Huang, 2011 .

Marininema mesophilum gen. nov., sp. nov., a thermoactinomycete isolated from deep sea sediment, and emended description of the family Thermoactinomycetaceae.

Wenjun Li, Guangxin Zhang, Changsheng Zhang, 2012, International journal of systematic and evolutionary microbiology.

Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.

Wenjun Li, Caiguo Huang, Changsheng Zhang, 2011, Journal of natural products.

Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017, Organic letters.

N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete

A. Mándi, T. Kurtán, Qingbo Zhang, 2012 .

Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Qingbo Zhang, Changsheng Zhang, Wenjun Zhang, 2021, Molecules.

Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430.

Qingbo Zhang, Liping Zhang, Changsheng Zhang, 2021, Organic & biomolecular chemistry.

Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils Spirooxindole Formation Catalyzed by a P450 Enzyme

Weiming Zhu, Yiguang Zhu, Qingbo Zhang, 2020, Angewandte Chemie.

Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils a P450 Enzyme‐catalyzed Spirooxindole Formation

Weiming Zhu, Yiguang Zhu, Qingbo Zhang, 2020 .

Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer.

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2015, Organic letters.

Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Hung‐wen Liu, Yiguang Zhu, Qingbo Zhang, 2018, Nature Communications.

Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase.

Weiming Zhu, Yiguang Zhu, Changsheng Zhang, 2012, Organic letters.

Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM*

G. Phillips, J. Thorson, Changsheng Zhang, 2008, Journal of Biological Chemistry.

Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).

R. Ebright, A. Kapanidis, E. Eng, 2018, Molecular cell.

A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2019, Natural product research.

Discovery of Efrotomycin Congeners and Heterologous Expression-Based Insights into the Self-Resistance Mechanism.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2022, Journal of natural products.

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Changsheng Zhang, Hong Shan, H. Shan, 2020, bioRxiv.

Dissecting glycosylation steps in lobophorin biosynthesis implies an iterative glycosyltransferase.

Yiguang Zhu, Changsheng Zhang, Guangtao Zhang, 2013, Organic letters.

A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2020, Natural Product Research.

Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps.

Changsheng Zhang, Yi-Qiang Cheng, J. Ju, 2011, Angewandte Chemie.

Understand the Specific Regio- and Enantioselectivity of Fluostatin Conjugation in the Post-Biosynthesis

K. Houk, Yuanqi Wang, Yi-Lei Zhao, 2020, Biomolecules.

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification† †Electronic supplementary information (ESI) available: The experimental procedures, materials, and characterization of compounds. See DOI: 10.1039/c7sc01182b Click here for additiona

Hung‐wen Liu, Yuemao Shen, C. Tian, 2017, Chemical science.

Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2019, The Journal of Antibiotics.

Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017 .

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams† †Electronic supplementary information (ESI) available: The experimental procedures, materials, and characterization of the compounds. See DOI: 10.1039/c6sc03875a Click here

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2016, Chemical science.

Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine.

J. Thorson, Changsheng Zhang, S. Rajski, 2006, Journal of the American Chemical Society.

Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway.

Changsheng Zhang, J. Ju, Hongbo Huang, 2011, Organic letters.

Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides.

Hongbo Jin, Yiguang Zhu, Qingbo Zhang, 2020, ACS chemical biology.

Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2012, Journal of the American Chemical Society.

Structural insight into the self-sacrifice mechanism of enediyne resistance.

Changsheng Zhang, John L Markley, Jon S Thorson, 2006, ACS chemical biology.

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8.

Vinay Gopal Jannu, Yiguang Zhu, Qingbo Zhang, 2020, Organic & biomolecular chemistry.

Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis.

G. Phillips, J. Thorson, Changsheng Zhang, 2008, Chemistry & biology.

Insights into caerulomycin A biosynthesis: a two-component monooxygenase CrmH-catalyzed oxime formation.

R. Shi, Weiming Zhu, Yiguang Zhu, 2013, Journal of the American Chemical Society.

Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428

J. Li, Qingbo Zhang, Changsheng Zhang, 2013, Marine drugs.

Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2015, Organic letters.

S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2020, Journal of natural products.

Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis.

R. Shi, Yiguang Zhu, Qingbo Zhang, 2012, Organic letters.

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

Marie-Ève Picard, M. Manenda, R. Shi, 2020, The Journal of Biological Chemistry.

Streptomyces oceani sp. nov., a new obligate marine actinomycete isolated from a deep-sea sample of seep authigenic carbonate nodule in South China Sea

Zhong Chen, Wenjun Li, Ying Xu, 2012, Antonie van Leeuwenhoek.

New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2021, Natural product research.

Discovery and Biosynthesis of Neoenterocins Indicate a Skeleton Rearrangement of Enterocin.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2019, Organic letters.

Characterization of a Single Gene Cluster Responsible for Methylpendolmycin and Pendolmycin Biosynthesis in the Deep Sea Bacterium Marinactinospora thermotolerans

Wenjun Li, Changsheng Zhang, J. Ju, 2012, Chembiochem : a European journal of chemical biology.

Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition

Ruibo Wu, Weiming Zhu, Yiguang Zhu, 2020, Communications Biology.

Discovery of an Unexpected 1,4-Oxazepine-Linked seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP.

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2021, Journal of natural products.

Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017, Applied Microbiology and Biotechnology.

Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2021, Organic & biomolecular chemistry.

Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Hung‐wen Liu, Yiguang Zhu, Qingbo Zhang, 2018, Nature Communications.

Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017, Applied Microbiology and Biotechnology.

Biosynthetic Diversification of Fidaxomicin Aglycones by Heterologous Expression and Promoter Refactoring.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2023, Journal of natural products.

Aromatic Polyketides from the Mangrove-Derived Streptomyces sp. SCSIO 40069.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2023, Journal of natural products.

Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2019, The Journal of Antibiotics.

Two New Phenylhydrazone Derivatives from the Pearl River Estuary Sediment-Derived Streptomyces sp. SCSIO 40020

Qingbo Zhang, Liping Zhang, Changsheng Zhang, 2022, Marine drugs.

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Zengxia Li, Yongjun Dang, Chen-Song Zhang, 2021, Cell Death & Disease.

Streptomyces nanhaiensis sp. nov., a marine streptomycete isolated from a deep-sea sediment.

Wenjun Li, Ying Xu, Lijuan Long, 2012, International journal of systematic and evolutionary microbiology.

Penicisteckins A-F, Isochroman-Derived Atropisomeric Dimers from Penicillium steckii HNNU-5B18.

A. Mándi, T. Kurtán, Qingbo Zhang, 2021, Journal of natural products.

Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-Derived Micromonospora sp. SCSIO 07395

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2023, Molecules.

Configurational Assignment of Malfilamentoside A and a New Furanone Glycoside Malfilamentoside D

Qingbo Zhang, Liping Zhang, Changsheng Zhang, 2022, Chinese Journal of Organic Chemistry.

Characterization of a Sugar‐O‐methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Chembiochem : a European journal of chemical biology.

Characterizing Two Cytochrome P450s in Tiacumicin Biosynthesis Reveals Reaction Timing for Tailoring Modifications.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2019, Organic Letters.

Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant.

Qingbo Zhang, Changsheng Zhang, Wenjun Zhang, 2018, Journal of natural products.

Biosynthesis and Engineered Overproduction of Everninomicins with Promising Activity against Multidrug-Resistant Bacteria.

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2023, ACS synthetic biology.

Minimum Information about a Biosynthetic Gene cluster.

M. Smanski, Jan Claesen, B. Shen, 2015, Nature chemical biology.

Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.

Wenjun Zhang, R. Shi, Haibo Zhang, 2014, Angewandte Chemie.

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Changsheng Zhang, Hua Yu, Kegang Linghu, 2023, Journal of pharmaceutical analysis.

Streptomyces oceani sp. nov., a new obligate marine actinomycete isolated from a deep-sea sample of seep authigenic carbonate nodule in South China Sea

Zhong Chen, Wenjun Li, Ying Xu, 2012, Antonie van Leeuwenhoek.

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme.

Changsheng Zhang, J. Ju, Hongbo Huang, 2012, Journal of the American Chemical Society.

Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams.

Changsheng Zhang, Wenjun Zhang, Guangtao Zhang, 2016, Current topics in medicinal chemistry.

Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams.

Hongbo Jin, Weiguang Sun, Yonghui Zhang, 2024, Organic letters.

Functional characterization of the sulfotransferase TotS in totopotensamides biosynthesis

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2022, Tetrahedron.

Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived Nocardiopsis dassonvillei SCSIO 40065.

Qingbo Zhang, Liping Zhang, Changsheng Zhang, 2021, Organic letters.

Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps.

Changsheng Zhang, Yi-Qiang Cheng, J. Ju, 2011, Angewandte Chemie.

Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition.

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2023, Journal of the American Chemical Society.

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2016, Chemical science.

Expanding the Chemical Diversity of Grisechelins via Heterologous Expression.

Liping Zhang, Changsheng Zhang, Yuchan Chen, 2024, Journal of natural products.