C. Lemieux

发表

Formation Pathways and Opioid Activity Data for 3‐Hydroxypyridinium Compounds Derived from Glucuronic Acid and Opioid Peptides by Maillard Processes

Š. Horvat, P. Schiller, M. Roščić, 2007, Chemical biology & drug design.

Hybrid bivalent ligands with opiate and enkephalin pharmacophores.

D. L. Larson, P. Schiller, P. Portoghese, 1987, Journal of medicinal chemistry.

Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.

P. Schiller, T. M. Nguyen, C. Lemieux, 1999, Journal of receptor and signal transduction research.

A novel cyclic opioid peptide analog showing high preference for mu-receptors.

P. Schiller, T. M. Nguyen, C. Lemieux, 1985, Biochemical and biophysical research communications.

Novel ligands lacking a positive charge for the δ- and μ-opioid receptors

Amos B. Smith, P. Schiller, C. Lemieux, 2000 .

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

A. Misicka, P. Kosson, P. Schiller, 2008, Journal of medicinal chemistry.

Synthesis and in vitro opioid activity profiles of DALDA analogues.

P. Schiller, T. M. Nguyen, C. Lemieux, 2000, European journal of medicinal chemistry.

Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia

P. Schiller, C. Lemieux, T. M. Nguyen, 1999 .

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.

M. Cooper, P. Schiller, E. Wynendaele, 2012, Journal of medicinal chemistry.

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.

P. Schiller, J. Vanden Broeck, F. Porreca, 2011, Journal of medicinal chemistry.

[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.

P. Schiller, Y. Lu, T. M. Nguyen, 2001, Journal of medicinal chemistry.

The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.

P. Schiller, T. M. Nguyen, C. Lemieux, 1999, Biopolymers.

Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1991, Journal of medicinal chemistry.

Synthesis and opioid activity profiles of cyclic dynorphin analogs

P. Schiller, C. Lemieux, T. M. Nguyen, 1988 .

TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1993, Journal of medicinal chemistry.

Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

P. Schiller, C. Lemieux, N. N. Chung, 2012, Chemical biology & drug design.

N‐Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity

P. Schiller, C. Lemieux, N. N. Chung, 2010, Chemical biology & drug design.

Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring‐Closing Metathesis

P. Schiller, C. Lemieux, N. N. Chung, 2009, Chemical biology & drug design.

Potent Opioid Peptide Agonists Containing 4′‐[N‐((4′‐phenyl)‐phenethyl)carboxamido]phenylalanine (Bcp) in Place of Tyr

P. Schiller, C. Lemieux, T. M. Nguyen, 2008, Chemical biology & drug design.

Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.

P. Schiller, C. Lemieux, N. N. Chung, 2007, Journal of medicinal chemistry.

Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt1, d-2-Nal4]endomorphin-1 (Antanal-1) and [Dmt1, d-2-Nal4]endomorphin-2 (Antanal-2)

J. Poels, J. Fichna, A. Janecka, 2007 .

Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2008, The journal of peptide research : official journal of the American Peptide Society.

Dansylated analogues of the opioid peptide [Dmt1]DALDA: in vitro activity profiles and fluorescence parameters.

P. Schiller, B. Zelent, C. Lemieux, 2004, Acta biochimica Polonica.

Highly potent fluorescent analogues of the opioid peptide [Dmt1]DALDA

H. Szeto, P. Schiller, B. Zelent, 2003, Peptides.

Structural Modifications of the N-terminal Tetrapeptide Segment of [D-Ala2]Deltorphin I: Effects on Opioid Receptor Affinities and Activities In Vitro and on Antinociceptive Potency

P. Schiller, C. Lemieux, N. N. Chung, 1997, Peptides.

Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence.

C. Horváth, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

Reverse turn mimics

T. Burks, P. Schiller, R. Walker, 1988 .

Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].

P. Schiller, C. Lemieux, N. N. Chung, 2008, Journal of medicinal chemistry.

Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1989, Journal of medicinal chemistry.

Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.

J. DiMaio, P. Schiller, T. M. Nguyen, 1982, Journal of medicinal chemistry.

Synthesis and Opiate Activity in vitro of Five New p-Nitrophenylalanine4-Enkephalin-like Peptides

J. Fauchère, K. Do, S. Pfenninger, 1983 .

Direct electrophilic fluorination of tyrosine in dermorphin analogues and its effect on biological activity, receptor affinity and selectivity.

P. Schiller, C. Lemieux, K. Kirk, 2009, International journal of peptide and protein research.

Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).

P. Schiller, C. Lemieux, N. N. Chung, 2009, Journal of medicinal chemistry.

Synthesis and pharmacological characterization of a cyclic β-casomorphin analog with mixed μ agonist/δ antagonist properties

P. Schiller, C. Lemieux, N. N. Chung, 1994 .

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.

P. Schiller, J. Vanden Broeck, A. Lipkowski, 2015, European journal of medicinal chemistry.

Cyclic enkephalin analogs containing a cystine bridge.

J. DiMaio, P. Schiller, C. Lemieux, 1981, Biochemical and biophysical research communications.

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

A. Mollica, P. Schiller, J. Streicher, 2017, ACS chemical neuroscience.

Side chain to side chain cyclization of an enkephalin analog results in loss of opioid receptor selectivity.

P. Schiller, C. Lemieux, L. Maziak, 2009, International journal of peptide and protein research.

In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs.

J. V. Edwards, P. Schiller, C. Lemieux, 1986, Biochemical and biophysical research communications.

Comparison of μ-, δ- and κ-receptor binding sites through pharmacologic evaluation of p-nitrophenylalanine analogs of opioid peptides

J. DiMaio, P. Schiller, C. Lemieux, 1983 .

[Aladan3]TIPP: A fluorescent δ‐opioid antagonist with high δ‐receptor binding affinity and δ selectivity

J. Vanderkooi, I. Gryczynski, P. Schiller, 2005, Biopolymers.

The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, No Physical Dependence, and Less Tolerance than Morphine in Rats

Peter W. Schiller, Terence J. Coderre, T. Coderre, 1999 .

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

P. Schiller, C. Lemieux, T. M. Nguyen, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and In Vitro Opioid Activity Profiles of Novel Cyclic Enkephalin Analogs

P. Schiller, C. Lemieux, N. N. Chung, 2006 .

Cyclic dermorphin tetrapeptide analogues obtained via ring-closing metathesis.

P. Schiller, C. Lemieux, N. N. Chung, 2006, Acta biochimica Polonica.

Conversion of δ-, κ- and μ-receptor selective opioid peptide agonists into δ-, κ- and μ-selective antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 2003 .

Synthesis and biological activity of [Leu5]enkephalin derivatives containing D-glucose.

Š. Horvat, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

Synthesis and biological activity of some glucose-enkephalin conjugates.

Š. Horvat, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.

P. Schiller, C. Lemieux, N. N. Chung, 2000, Journal of medicinal chemistry.

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2012, Bioorganic & medicinal chemistry letters.

Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.

P. Schiller, C. Lemieux, N. N. Chung, 2005, The journal of peptide research : official journal of the American Peptide Society.

A novel cyclic enkephalin analogue with potent opioid antagonist activity.

P. Schiller, C. Lemieux, N. N. Chung, 2004, Bioorganic & medicinal chemistry letters.

Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide.

P. Schiller, Y. Lu, C. Lemieux, 2001, Bioorganic & medicinal chemistry letters.

A Novel Cyclic Opioid Peptide Antagonist Containing a Hydroxy Group in Place of the N-Terminal Amino Function

P. Schiller, C. Lemieux, N. N. Chung, 2001 .

SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION IN VITRO OF CYCLIC ENKEPHALIN ANALOGS: EFFECT OF CONFORMATIONAL CONSTRAINTS ON OPIATE RECEPTOR SELECTIVITY

J. DiMaio, P. Schiller, C. Lemieux, 1983 .

The receptor-bound conformation of H-Tyr-Tic-(Phe-Phe)-OH-related delta-opioid antagonists contains all trans peptide bonds.

P. Schiller, C. Lemieux, N. N. Chung, 2009, The journal of peptide research : official journal of the American Peptide Society.

FOUR DIFFERENT TYPES OF OPIOID PEPTIDES WITH MIXED μ AGONIST/δ ANTAGONIST PROPERTIES

P. Schiller, C. Lemieux, T. M. Nguyen, 1995 .

Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.

P. Schiller, C. Lemieux, N. N. Chung, 1994, Journal of medicinal chemistry.

Conformationally restricted deltorphin analogues.

P. Schiller, C. Lemieux, N. N. Chung, 1992, Journal of medicinal chemistry.

"Carba"-analogues of fentanyl are opioid receptor agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2010, Journal of Medicinal Chemistry.

Stereoselective synthesis of (3S)- and (3R)-3-hydroxy-3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acid and its incorporation into a cyclic enkephalin analogue.

P. Schiller, C. Lemieux, N. N. Chung, 2009, Advances in experimental medicine and biology.

Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.

P. Schiller, C. Lemieux, B. Wilkes, 1987, Journal of medicinal chemistry.

A General New Concept for the Development of Opioid Peptide Derived μ-, δ- and κ-Antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 2001 .

'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.

P. Schiller, C. Lemieux, N. N. Chung, 2014, Bioorganic & medicinal chemistry.

A highly potent TIPP-NH2 analog with balanced mixed μ agonist/δ antagonist properties

C. Lemieux, G. Weltrowska, B. Wilkes, 1994, Regulatory Peptides.

TIPP opioid peptides: Development of extraordinarily potent and selective δ antagonists and observation of astonishing structure-intrinsic activity relationships

P. Schiller, C. Lemieux, T. M. Nguyen, 1994 .

Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.

M. Mutter, M. Keller, P. Schiller, 2001, Journal of medicinal chemistry.

TIC2-substitution in dermorphin, deltorphin I and dynorphin A analogs: Effect on opioid receptor binding and opioid activity in vitro

C. Lemieux, R. Schmidt, P. Schiller, 1994, Regulatory Peptides.

Effect of aromatic amino acid substitutions in the 3‐position of cyclic β‐casomorphin analogues on μ‐opioid agonist/δ‐opioid antagonist properties*

P. Schiller, C. Lemieux, N. N. Chung, 2009 .

Synthesis of cyclic dipeptide templates, their incorporation into peptides and studies on their conformational and biological properties.

H. Briem, H. Nar, P. Schiller, 2009, Journal of Peptide Research.

A chimeric opioid peptide with mixed μ agonist/δ antagonist properties

P. Schiller, C. Lemieux, N. N. Chung, 2004 .

Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.

P. Schiller, R. Walker, C. Lemieux, 1989, Journal of medicinal chemistry.

A novel side‐chain‐linked antiparallel cyclic dimer of enkephalin

P. Schiller, C. Lemieux, T. M. Nguyen, 1985, FEBS letters.

Evidence of a peptide backbone contribution toward selective receptor recognition for leucine enkephalin thioamide analogs.

K. Clausen, P. Schiller, C. Lemieux, 1984, Biochemical and biophysical research communications.

Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.

P. Schiller, C. Lemieux, L. Maziak, 1985, Journal of medicinal chemistry.

Analogs of the δ opioid antagonist TIPP with increased lipophilic character

P. Schiller, C. Lemieux, T. M. Nguyen, 2002 .

Antagonism as a consequence of side chain conformational restriction: A new class of potent, δ opioid receptor-selective peptide antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 1993 .

Opioid dipeptide derivatives with a mixed μ antagonist/δ antagonist, partial μ agonist/δ antagonist or μ agonist/partial δ agonist profile

P. Schiller, C. Lemieux, T. M. Nguyen, 2002 .

Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

J. Poels, A. Janecka, J. Broeck, 2007, Journal of Medicinal Chemistry.

The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.

T. Coderre, P. Schiller, C. Lemieux, 1999, Journal of medicinal chemistry.

Effect of aromatic amino acid substitutions in the 3-position of cyclic beta-casomorphin analogues on mu-opioid agonist/delta-opioid antagonist properties.

P. Schiller, C. Lemieux, N. N. Chung, 1996, International journal of peptide & protein research.

Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

P. Schiller, C. Lemieux, N. N. Chung, 2012, Chemical biology & drug design.

"Carba"-analogues of fentanyl are opioid receptor agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2010, Journal of medicinal chemistry.

Electronic, steric, and hydrophobic factors influencing the action of enkephalin-like peptides on opiate receptors.

J. Fauchère, K. Do, R. Schwyzer, 1981, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.