J. Silva

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Allyl alcohol- and acrolein-induced toxicity in isolated rat hepatocytes.

P. O'Brien, J. Silva, 1989, Archives of biochemistry and biophysics.

The metabolism of N-acetyl-3,5-dimethyl-p-benzoquinone imine in isolated hepatocytes involves N-deacetylation.

P. O'Brien, J. Silva, L. Mcgirr, 1988, Molecular pharmacology.

Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor.

Y. Leblanc, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.

P. O'Brien, J. Silva, 1993, British Journal of Cancer.

Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe.

J. Marois, J. Gauthier, J. Yergey, 1999, Analytical biochemistry.

Nitrofurantoin-mediated oxidative stress cytotoxicity in isolated rat hepatocytes.

P. O'Brien, J. Silva, L. Mcgirr, 1988, Biochemical pharmacology.

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.

H. Perrier, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

D. Riendeau, R. Young, P. Prasit, 2000, Bioorganic & medicinal chemistry letters.

Toxicity of synthetic flavorings, nature identical and artificial, to hematopoietic tissue cells of rodents.

A. Peron, J. Silva, J. M. C. Sousa, 2017, Brazilian journal of biology = Revista brasleira de biologia.

Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential.

P. O'Brien, J. Silva, W. Wong, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells.

P. O'Brien, J. Silva, 1992, International journal of radiation oncology, biology, physics.

Determination of genotoxic effect of trifluralin on Colossoma macropomum (Teleostei: Characidae: Serrasalminae, Cuvier, 1816) using a multibiomarker approach

J. Silva, F. Abreu, R. Rodarte, 2017 .

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

D. Riendeau, C. Brideau, J. Mancini, 2001, Bioorganic & medicinal chemistry letters.

Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes.

J. Silva, José M. Silva, D. Nicoll-Griffith, 1999, Chemico-biological interactions.

Refinement of an in vitro cell model for cytochrome P450 induction.

B. Kennedy, T. Rushmore, P. Payette, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Prevention of nitrofurantoin-induced cytotoxicity in isolated hepatocytes by fructose.

P. O'Brien, J. Silva, L. Mcgirr, 1991, Archives of biochemistry and biophysics.

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor.

J. Falgueyret, D. Riendeau, Z. Wang, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Diaziquone-induced cytotoxicity in isolated rat hepatocytes.

P. O'Brien, J. Silva, 1989, Cancer research.

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Chun Xing Li, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes.

P. O'Brien, J. Silva, S. Khan, 1993, Biochemical pharmacology.

Cryopreservation of rat and human liver slices by rapid freezing.

J. Silva, José M. Silva, D. Nicoll-Griffith, 1999, Cryobiology.

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel.

G. L. Kedderis, A. Li, J. Hengstler, 1999, Chemico-biological interactions.

Molecular mechanisms of nitrofurantoin-induced hepatocyte toxicity in aerobic versus hypoxic conditions.

P. O'Brien, J. Silva, S. Khan, 1993, Archives of biochemistry and biophysics.

Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.

P. O'Brien, J. Silva, D. N. Rao, 1992, Cancer research.

Primaquine-induced oxidative stress in isolated hepatocytes as a result of reductive activation.

P. O'Brien, J. Silva, 1991, Advances in Experimental Medicine and Biology.