T. Koch

发表

Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs.

D. Taatjes, V. Bierbaum, S. Kato, 2000, Chemical research in toxicology.

Aptamer-based multiplexed proteomic technology for biomarker discovery

Tracy R. Keeney, Jonathan D. Vaught, Sheri K. Wilcox, 2010, Nature Precedings.

Diagnostic potential of PhotoSELEX-evolved ssDNA aptamers.

M. Willis, T. Koch, M. C. Golden, 2000, Journal of biotechnology.

Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate.

T. Koch, P. Cogan, 2003, Journal of medicinal chemistry.

Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.

Laura E Wiener, G. Koch, T. Koch, 2016, Journal of medicinal chemistry.

Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.

G. Koch, Zhiyong Zhang, T. Koch, 2009, Journal of medicinal chemistry.

Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases.

R. Shoemaker, T. Koch, Jordan W Nafie, 2006, Journal of medicinal chemistry.

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.

J. Espinosa, T. Koch, Brian T. Kalet, 2007, Journal of medicinal chemistry.

Mechanistic Studies of the 5-Iodouracil Chromophore Relevant to Its Use in Nucleoprotein Photo-Cross-Linking

T. Koch, P. Meisenheimer, C. L. Norris, 1996 .

Redox chemistry of anthracycline antitumor drugs and use of captodative radicals as tools for its elucidation and control.

T. Koch, G. Gaudiano, 1991, Chemical research in toxicology.

Evaluation of the Epidoxorubicin–Formaldehyde Conjugate, Epidoxoform, in a Mouse Mammary Carcinoma Model

D. Taatjes, B. Powers, T. Koch, 2002, Cancer investigation.

Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells.

D. Taatjes, T. Koch, 2001, Current medicinal chemistry.

An RNA-protein contact determined by 5-bromouridine substitution, photocrosslinking and sequencing.

O. Uhlenbeck, M. Willis, T. Koch, 1994, Nucleic acids research.

β-Carboxyaspartic acid

R. Barkley, T. Koch, W. Kirsch, 1984 .

Anthracycline-formaldehyde conjugates and their targeted prodrugs.

T. Koch, D. J. Burkhart, B. Barthel, 2008, Topics in current chemistry.

Doxorubicin-formaldehyde conjugates targeting αvβ3 integrin

M. Coleman, T. Koch, Brian T. Kalet, 2004, Molecular Cancer Therapeutics.

Doxorubicin-formaldehyde conjugates targeting alphavbeta3 integrin.

M. Coleman, T. Koch, D. J. Burkhart, 2004, Molecular cancer therapeutics.

Doxorubicin-induced skin necrosis in the swine model: protection with a novel radical dimer.

N. Bachur, T. Koch, S. Averbuch, 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Formaldehyde in human cancer cells: detection by preconcentration-chemical ionization mass spectrometry.

V. Bierbaum, S. Kato, P. Burke, 2001, Analytical chemistry.

Radical dimer rescue of toxicity and improved therapeutic index of adriamycin in tumor-bearing mice.

N. Bachur, T. Koch, S. Averbuch, 1985, Cancer research.

DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.

S. Cutts, T. Koch, D. Phillips, 2008, Mutation research.

Nucleoprotein photo-cross-linking using halopyrimidine-substituted RNAs.

T. Koch, P. Meisenheimer, K. Meisenheimer, 2000, Methods in enzymology.

Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron.

D. Taatjes, T. Koch, G. Gaudiano, 1997, Chemical research in toxicology.

Aptamer-based multiplexed proteomic technology for biomarker discovery

Tracy R. Keeney, Jonathan D. Vaught, Sheri K. Wilcox, 2010, PloS one.

Detection and possible origins of aminomalonic acid in protein hydrolysates.

S. Copley, T. Koch, W. Kirsch, 1992, Analytical biochemistry.

Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs.

T. Koch, B. Yan, D. Shi, 2013, Biochemical pharmacology.

Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque.

R. Barkley, T. Koch, W. Kirsch, 1984, Proceedings of the National Academy of Sciences of the United States of America.

PHOTOCHEMICAL REDUCTION OF 5‐BROMOURACIL BY CYSTEINE DERIVATIVES AND COUPLING OF 5‐BROMOURACIL TO CYSTINE DERIVATIVES

T. Koch, T. Dietz, 1989, Photochemistry and photobiology.

PHOTOCHEMICAL COUPLING OF 5‐BROMOURACIL TO TRYPTOPHAN, TYROSINE AND HISTIDINE, PEPTIDE‐LIKE DERIVATIVES IN AQUEOUS FLUID SOLUTION

T. Koch, T. Dietz, 1987, Photochemistry and photobiology.

Photochemical coupling of 5-bromouracil (BU) to a peptide linkage. A model for BU-DNA protein photocrosslinking

T. Koch, T. Dietz, R. J. V. Trebra, 1987 .

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

P. Potter, T. Koch, C. Edwards, 2008, Journal of medicinal chemistry.

Photocross-linking of nucleic acids to associated proteins.

T. Koch, K. Meisenheimer, Tad H. Koch, 1997, Critical reviews in biochemistry and molecular biology.

Photochemical reactivity of keto imino ethers

J. M. Burns, T. Koch, R. Sluski, 1978 .

2+2 Photocycloaddition to a carbon nitrogen double bond II. 2-phenyl-2-oxazolin-4-one

T. Koch, R. Rodehorst, 1972 .

Photochemical synthesis of a cyclopropanone precursor

T. Koch, R. Sluski, 1970 .

Di-tert-butyl nitroxide quenching of the photoaddition of olefins to the carbon-nitrogen double bond of 3-ethoxyisoindolenone

R. H. Moseley, T. Koch, J. Keute, 1977 .

Photochemical reactivity of keto imino ethers. V. (2 + 2) Photocycloaddition to the carbon-nitrogen double bond of 3-ethoxyisoindolone

T. Koch, Kent A. Howard, 1975 .

Photochemical reactivity of conjugated imino ethers. II. 6,7-Dihydro-2-methoxy-4,6,6-trimethyl-5H-azepine (III)

T. Koch, M. Geigel, Chun-che Tsai, 1973 .

2+2 Photocycloaddition to a carbon nitrogen double bond I. 3-ethoxyisoindolone

T. Koch, K. H. Howard, 1972 .

Photochemical rearrangement of 4,4-disubstituted-4-sila-2,5-cyclohexadienones

T. Koch, J. Soderquist, T. Kinstle, 1974 .

Synthesis of a capto-dative diradical and its reversible oligomerization to macrocycles of coronand structure

T. Koch, R. Haltiwanger, G. Gaudiano, 1984 .

Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells.

P. Burke, T. Koch, 2004, Journal of medicinal chemistry.

A Preferred Method for Imide Preparation

T. Koch, Barry J. Swanson, David R. Anderson, 1981 .

Structure and properties of some new dihydropyrazine–tetracyanoquinodimethane charge transfer salts

T. Koch, D. J. Brook, 1997 .

2,3-Bis(trimethylsilyloxy)-1,3-butadiene as a useful reactive diene in the Diels-Alder reaction

T. Koch, David R. Anderson, 1978 .

Quantitative investigation of the photochemical conversion of diaminomaleonitrile to diaminofumaronitrile and 4-amino-5-cyanoimidazole

T. Koch, R. Rodehorst, 1974 .

Photochemical reactivity of keto imino ethers. VI. Type I rearrangement and (2 + 2) photocycloaddition to the carbon-nitrogen double bond of 2-oxazolin-4-ones

T. Koch, R. Rodehorst, 1975 .

Photochemical reactivity of keto imino ethers. IV. Type I and type II reactions

R. H. Moseley, T. Koch, R. Sluski, 1973 .

Photochemical Ring Contraction of 2‐Ethoxypyrrolin‐5‐ones to Cyclopropanone Derivatives: tert‐Butyl N‐(1‐Ethoxycyclopropyl)carbamate

T. Koch, Geoffrey C. Crockett, 2003 .

An azetine from a photocycloaddition reaction followed by a retro diels-alder fragmentation☆

T. Koch, H. Schuster, R. H. Higgins, 1977 .

2+2‐PHOTOCYCLOADDITION AN EINE C=N‐DOPPELBINDUNG 1. MITT. AETHOXYISOINDOLON

T. Koch, K. H. Howard, 1972 .

Synthesis and structure of di-μ-bromo-bis[(1,5-dimethyl-6-oxo-3-(2-pyridyl)verdazyl)copper(I)]

T. Koch, B. Noll, G. T. Yee, 2000 .

Photochemical reactivity of imino lactones. Photoreduction and photoelimination

T. Koch, J. Olesen, James DeNiro, 1975 .

Photochemical reactivity of the di-tert-butyl nitroxide .pi.,.pi.* state and di-tert-butyl nitroxide halocarbon charge-transfer excited states

T. Koch, J. Keute, David R. Anderson, 1981 .

Electron-transfer photochemistry of di-tert-butyl nitroxide

T. Koch, J. Keute, David R. Anderson, 1979 .

Upper excited state photochemistry of di-tert-butyl nitroxide

T. Koch, David R. Anderson, 1977 .

Crystal and molecular structure of the photoreductive dimer of 5,6-dihydro-3,5,5-trimethyl-1,4-oxazin-2-one

T. Koch, R. Haltiwanger, C. S. Kim, 1977 .

Unusually weak carbon-carbon single bond

T. Koch, J. Olesen, James DeNiro, 1975 .

Two-photon laser photochemistry of a coumarin laser dye

T. Koch, R. J. V. Trebra, 1987 .

Coordination chemistry of verdazyl radicals: group 12 metal (Zn, Cd, Hg) complexes of 1,4,5,6-tetrahydro-2,4-dimethyl-6-(2 pyridiyl)-1,2,4,5-tetrazin -3(2H)-one (pvdH3) and 1,5-dimethyl-3-(2 pyridil)-6-oxoverdazyl (pvd).

W. Eisfeld, T. Koch, D. J. Brook, 2000, Inorganic chemistry.

Synthesis, structure, and reactivity of an antiaromatic, 2,5-dicarboxy-stabilized 1,4-dihydropyrazine

David J. R. Brook, R. Curtis Haltiwanger, T. Koch, 1992 .

New Type of Charge Transfer Complex from an Antiaromatic Electron Donor. Possible Radical Cation Stabilization by the Captodative Effect

T. Koch, R. Haltiwanger, D. J. Brook, 1991 .

Kinetic and thermodynamic parameters for the formation of 3,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3). A negative activation energy for radical combination

T. Koch, J. Olson, 1986 .

Chemical stabilization of the coumarin 1 dye laser

T. Koch, R. J. V. Trebra, 1983 .

Borohydride anion exchange resin stabilization of flash-lamp-pumped coumarin dye lasers

T. Koch, R. Mahoney, 1991 .

Formation kinetics of an amino carboxy type merostabilized free radical

T. Koch, R. W. Bennett, D. L. Wharry, 1980 .

Mechanistic investigation of reduction of daunomycin and 7-deoxydaunomycinone with bi(3,5,5-trimethyl-2-oxomorpholin-3-yl)

T. Koch, D. L. Kleyer, 1984 .

7-Deoxydaunomycinone, a catalyst for achieving a two electron reduction with a one electron reducing agent

T. Koch, D. L. Kleyer, 1983 .

Spectroscopic observation of the tautomer of 7-deoxydaunomycinone from elimination of daunosamine from daunomycin hydroquinone

T. Koch, D. L. Kleyer, 1983 .

Synthesis and redox chemistry of 5-deoxydaunomycin. A long-lived hydroquinone tautomer

T. Koch, B. Schweitzer, 1993 .

2-Oxomorpholin-3-YL Radicals

T. Koch, 1986 .

Unusual zwitterion of D,L-beta-carboxyaspartic acid: pKa and X-ray crystallographic measurements.

S. Gill, T. Koch, R. Haltiwanger, 1982, Biochemistry.

Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.

K. Resing, D. Taatjes, T. Koch, 1996, Journal of medicinal chemistry.

Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.

O. Uhlenbeck, T. Cech, M. Willis, 1993, Science.

Photochemical transformations. XXV. Two triplet mechanisms in photochemical addition of 2-cyclohexenones to 1,1-dimethoxyethylene

T. Koch, E. Brown, O. Chapman, 1968 .

PHOTOCHEMICAL EXCHANGE REACTION OF MICHLER'S KETONE.

T. Koch, A. H. Jones, 1970 .

Doxorubicin-formaldehyde conjugate, doxoform: induction of apoptosis relative to doxorubicin.

P. Burke, T. Koch, 2001, Anticancer research.

Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands.

L. Gold, K. Jensen, M. Willis, 1995, Proceedings of the National Academy of Sciences of the United States of America.

High yield photocrosslinking of a 5-iodocytidine (IC) substituted RNA to its associated protein.

M. Willis, T. Koch, P. Meisenheimer, 1996, Nucleic acids research.

Coupling of the anthracycline antitumor drug menogaril to 2'-deoxyguanosine through reductive activation

M. Egholm, T. Koch, 1989 .

PHOTOREDUCTION OF 5-BROMOURACIL. IONIC AND FREE-RADICAL PATHWAYS

T. Koch, Barry J. Swanson, J. Kutzer, 1981 .

Bond dissociation energies of 3,5,5- and 4,5,5-trimethyl-2-oxomorpholine by photoacoustic calorimetry. An assessment of the additivity of substituent effects

T. Koch, K. Brady Clark, Danial D. M. Wayner, 1993 .

Reaction of the quinonemethide from reductive glycosidic cleavage of daunomycin with molecular oxygen. Evidence for semiquinonemethide formation

T. Koch, G. Gaudiano, 1990 .

A specific, UV-induced RNA-protein cross-link using 5-bromouridine-substituted RNA.

O. Uhlenbeck, M. Willis, T. Koch, 1991, Biochemistry.

Mechanistic Studies Relevant to Bromouridine‐Enhanced Nucleoprotein Photocrosslinking: Possible Involvement of an Excited Tyrosine Residue of the Protein

T. Koch, C. L. Norris, K. Meisenheimer, 1997 .

Synthetic aspects of the photochemistry of keto imino ethers. A facile synthesis of functionalized bicyclo[n.1.0] systems

T. Koch, Geoffrey C. Crockett, 1977 .

Photochemical valence isomerization of a conjugated imino ether

T. Koch, D. Brown, 1971 .

Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera.

T. Koch, P. Cogan, 2004, Journal of medicinal chemistry.

Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Inhibition of glutathione S-transferase p1-1 by glutathione conjugates from anthracyclines.

T. Koch, A. Serafino, M. Lo Bello, 2000, Biochemical pharmacology.

Chemical ionization mass spectrometric determination of acrolein in human breast cancer cells.

V. Bierbaum, S. Kato, T. Koch, 2002, Analytical Biochemistry.

Spectroscopic and kinetic evidence for the tautomer of 7-deoxyalklavinone as an intermediate in the reductive coupling of aclacinomycin A

T. Koch, G. Gaudiano, D. L. Kleyer, 1984 .

Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine.

T. Cech, M. Willis, T. Koch, 1994, Biochemistry.

Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.

K. Resing, D. Taatjes, T. Koch, 1997, Journal of medicinal chemistry.

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

Rachel Ostroff, Glenn Sanders, Dan Schneider, 2010, PLoS ONE.

Mass spectral characterization of a protein—nucleic acid photocrosslink

K. Resing, M. Willis, T. Koch, 1999, Protein science : a publication of the Protein Society.

Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells.

D. J. Harrington, E. Podell, D. Taatjes, 1999, Acta crystallographica. Section D, Biological crystallography.

Photoactivatable Prodrug of Doxazolidine Targeting Exosomes.

Jan Grimm, J. Grimm, H. Yin, 2019, Journal of medicinal chemistry.

Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA.

T. Koch, J. Hagadorn, D. J. Burkhart, 2005, Journal of medicinal chemistry.

Equilibrium between 2-oxomorpholin-3-yl radicals and viologen radicals. Determination of reduction potentials

P. Fretwell, T. Koch, R. L. Mauldin, 1992 .

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence.

B. Shoichet, R. Al-awar, M. Shoichet, 2019, ACS chemical biology.

Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.

B. Shoichet, M. Shoichet, T. Koch, 2017, Molecular pharmaceutics.

The new amino acid .beta.-carboxyaspartic acid (asa). Laboratory synthesis and identification in the ribosomal proteins of E. coli

R. Barkley, T. Koch, W. Kirsch, 1981 .

Carbonyl and thiocarbonyl stabilized 1,4-dihydropyrazines: synthesis and characterization

T. Koch, B. Noll, D. J. Brook, 1998 .

REACTION OF ANTHRACYCLINE ANTITUMOR DRUGS WITH REDUCED GLUTATHIONE. FORMATION OF AGLYCON CONJUGATES

K. Resing, T. Koch, G. Gaudiano, 1994 .

Synthesis and biological characterization of protease-activated prodrugs of doxazolidine.

T. Koch, T. Kirby, D. J. Burkhart, 2012, Journal of medicinal chemistry.

Doxsaliform: A Novel N-Mannich Base Prodrug of a Doxorubicin Formaldehyde Conjugate

T. Koch, Cate Fowler, P. Cogan, 2004 .

Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells.

D. Taatjes, D. Fenick, T. Koch, 1997, Journal of medicinal chemistry.

Sensitivity and Specificity of Photoaptamer Probes*

T. Koch, Jim Heil, B. Collins, 2003, Molecular & Cellular Proteomics.

Cytoplasmic localization of anthracycline antitumor drugs conjugated with reduced glutathione: a possible correlation with multidrug resistance mechanisms.

G. Rasi, E. Garaci, T. Koch, 1998, Anticancer research.

Prevention of adriamycin toxicity

T. Koch, A. Banks, T. Jones, 2004, Cancer Chemotherapy and Pharmacology.

N-Alkyl-5,5-dimethyl-2-oxomorpholin-3-yl radicals. Characterization and reaction with molecular oxygen

T. Koch, R. Haltiwanger, S. Demirdji, 1991 .

Synthesis and reactivity of captodative diradical oligomers incorporating the 3,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3) unit

T. Koch, R. Haltiwanger, G. Gaudiano, 1988 .

Synthesis of a capto-dative diradical and its reversible oligomerization to macrocycles of coronand structure

T. Koch, R. Haltiwanger, G. Gaudiano, 1984 .

SUBSTITUENT EFFECTS ON THE FORMATION OF AMINOCARBOXY-TYPE CAPTO-DATIVE FREE RADICALS

T. Koch, A. Barone, R. Himmelsbach, 1983 .

Synthesis and characterization of the 3,5,5-trimethyl-2-piperazinon-3-yl radical. An aminocarboxamido-type merostabilized free radical

T. Koch, R. Haltiwanger, D. L. Kleyer, 1983 .

Dioxygen Oxidation of a Stable 1,4-Dihydropyrazine

T. Koch, D. J. Brook, A. Noll, 1997 .

DABCO Stabilization of Coumarin Dye Lasers

T. Koch, R. J. V. Trebra, 1982 .

Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound.

N. Bachur, T. Koch, S. Averbuch, 1988, The Journal of clinical investigation.

Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells.

D. Taatjes, D. Fenick, T. Koch, 1998, Journal of medicinal chemistry.

Kinetic analysis of site-specific photoaptamer-protein cross-linking.

D. Zichi, T. Koch, Drew Smith, 2004, Journal of molecular biology.

Coupling of the Anthracycline Antitumor Drug Menogaril to 2′-Deoxyguanosine Through Reductive Activation.

M. Egholm, T. Koch, 1990 .

Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines.

D. Taatjes, D. Fenick, T. Koch, 1999, Chemical research in toxicology.

Leucodaunomycins, new intermediates in the redox chemistry of daunomycin

T. Koch, G. Gaudiano, D. Bird, 1991 .

A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer.

D. Taatjes, D. Fenick, T. Koch, 1970, Current pharmaceutical design.