J. Uetrecht

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Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity.

S. Iverson, J. Uetrecht, Suzanne L. Iverson, 2001, Chemical research in toxicology.

Investigation of the Involvement of Macrophages and T Cells in D-Penicillamine-Induced Autoimmunity in the Brown Norway Rat

J. Uetrecht, M. Masson, M. Teranishi, 2004, Journal of immunotoxicology.

Deferiprone‐induced agranulocytosis: 20 years of clinical observations

J. Palmblad, M. Spino, R. Galanello, 2016, American journal of hematology.

New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system.

J. Uetrecht, J P Uetrecht, 1999, Chemical research in toxicology.

Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid.

J. Uetrecht, G. Miyamoto, N. Zahid, 1997, Chemical research in toxicology.

Idiosyncratic Drug Reactions

J. Uetrecht, Z. Wojcinski, 2012 .

Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.

I. Guest, J. Uetrecht, 2001, Experimental hematology.

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges

J. Uetrecht, A. Jee, S. C. Sernoskie, 2021, International journal of molecular sciences.

Mechanistic Studies of Idiosyncratic DILI: Clinical Implications

J. Uetrecht, 2019, Front. Pharmacol..

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Jianghong Rao, Lina Cui, Kanyi Pu, 2014, Nature Biotechnology.

Current trends in drug-induced autoimmunity.

J. Uetrecht, 2005, Toxicology.

N-Chlorination and oxidation of procainamide by myeloperoxidase: toxicological implications.

J. Uetrecht, N. Zahid, 1991, Chemical research in toxicology.

Study of the sequence of events involved in nevirapine-induced skin rash in Brown Norway rats.

M. Popović, J. Uetrecht, B. Mannargudi, 2006, Chemical research in toxicology.

PharmRev: The emerging role of the innate immune response in idiosyncratic drug reactions 1 Pharmacological Reviews: The emerging role of the innate immune response in idiosyncratic drug reactions PHARMREV-AR-2020-000090

J. Uetrecht, A. Jee, S. C. Sernoskie, 2021 .

Bioactivation of drugs in the skin: relationship to cutaneous adverse drug reactions

J. Uetrecht, Amy M Sharma, Amy M. Sharma, 2014, Drug metabolism reviews.

Lack of liver injury in Wistar rats treated with the combination of isoniazid and rifampicin

Imir G. Metushi, J. Uetrecht, 2014, Molecular and Cellular Biochemistry.

Drug Metabolism: Chemical and Enzymatic Aspects

W. Trager, J. Uetrecht, 2007 .

Oxidation Pathways and the Enzymes That Mediate Them

W. Trager, J. Uetrecht, 2007 .

Oxidation of a metabolite of indomethacin (Desmethyldeschlorobenzoylindomethacin) to reactive intermediates by activated neutrophils, hypochlorous acid, and the myeloperoxidase system.

J. Uetrecht, C. Ju, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat.

J. Uetrecht, L. Waldhauser, 1996, Toxicology.

Adverse Immune Reactions to Drugs (Gold, Procainamide) and Environmental Chemicals (Mercury, Platinum): The Role of Phagocytic Cells in Generating Immunogenic Metabolites

H. Schuppe, C. Goebel, J. Uetrecht, 1993 .

Idiosyncratic Adverse Drug Reactions: Current Concepts

D. Naisbitt, J. Uetrecht, 2013, Pharmacological Reviews.

Idiosyncratic drug reactions: past, present, and future.

J. Uetrecht, 2008, Chemical research in toxicology.

Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils.

J. Uetrecht, S. Furst, Jack Uetrecht, 1993, Biochemical pharmacology.

The effect of carbamazepine and its reactive metabolite, 9-acridine carboxaldehyde, on immune cell function in vitro.

J. Uetrecht, S. Furst, 1995, International journal of immunopharmacology.

How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction.

J. Uetrecht, Tiffany Cho, 2017, Chemical research in toxicology.

Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis.

J. Uetrecht, I. Gardner, N. Zahid, 2000, Drug metabolism and disposition: the biological fate of chemicals.

A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.

J. Leeder, J. Uetrecht, I. Gardner, 1998, Molecular pharmacology.

The Effects of Immune Modulators on Amodiaquine-Induced Liver Injury.

J. Uetrecht, A. Mak, Tiffany Cho, 2018, Chemical research in toxicology.

Exploring an animal model of amodiaquine-induced liver injury in rats and mice

Imir G. Metushi, F. Liu, J. Uetrecht, 2016, Journal of immunotoxicology.

Treatment of PD‐1−/− mice with amodiaquine and anti‐CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

Imir G. Metushi, J. Uetrecht, M. Hayes, 2015, Hepatology.

Isoniazid-induced liver injury and immune response in mice

Imir G. Metushi, J. Uetrecht, 2014, Journal of immunotoxicology.

Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.

J. Uetrecht, Y. Ijiri, R. Kato, 2020, The Journal of toxicological sciences.

Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI

J. Uetrecht, R. Kato, A. Mak, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash

Yoshiro Saito, D. Naisbitt, J. Uetrecht, 2018, Journal of immunotoxicology.

Inhibition of immune tolerance unmasks drug‐induced allergic hepatitis

N. Kaplowitz, J. Uetrecht, 2015, Hepatology.

Drugs that induce neutropenia/agranulocytosis may target specific components of the stromal cell extracellular matrix.

I. Guest, J. Uetrecht, 1999, Medical hypotheses.

Drug metabolism by leukocytes and its role in drug-induced lupus and other idiosyncratic drug reactions.

J. Uetrecht, Jack Uetrecht, 1990, Critical reviews in toxicology.

Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.

J. Uetrecht, A. Lobach, 2014, Chemical research in toxicology.

Metabolism of procainamide in the perfused rat liver.

R. W. Freeman, J. Oates, J. Uetrecht, 1981, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes.

J. Oates, J. Uetrecht, R. Woosley, 1984, Drug metabolism and disposition: the biological fate of chemicals.

Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis

D. McNally, J. Uetrecht, B. Mannargudi, 2009, Drug Metabolism and Disposition.

Microsoft Word-42454773-file00

J. Uetrecht, B. Mannargudi, David McNally, 2009 .

The Effect of Cimetidine on Anesthetic Metabolism and Toxicity

J. Uetrecht, A. Wood, S. Shay, 1986, Anesthesia and analgesia.

Testing the hypothesis that selenium deficiency is a risk factor for clozapine-induced agranulocytosis in rats.

J. Uetrecht, J. Ip, 2008, Chemical research in toxicology.

Changes in Gene Expression Induced by Carbamazepine and Phenytoin: Testing the Danger Hypothesis

Wei Yang Lu, Xujian Li, J. Uetrecht, 2008, Journal of immunotoxicology.

Drug-Induced Lupus Erythematosus

J. Uetrecht, 2005 .

METABOLISM OF DRUGS BY LEUKOCYTES

J. Uetrecht, 1994, Drug metabolism and drug interactions.

Acetylator Phenotype and Lupus Erythematosus

J. Uetrecht, R. Woosley, 1981, Clinical pharmacokinetics.

Drugs toxic to the bone marrow that target the stromal cells.

I. Guest, J. Uetrecht, 2000, Immunopharmacology.

Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury

J. Uetrecht, A. Mak, 2015, Journal of immunotoxicology.

Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone-induced agranulocytosis.

J. Uetrecht, N. Zahid, D. Whitfield, 1994, The Journal of pharmacology and experimental therapeutics.

The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4.

J. Uetrecht, A. Mak, 2015, Chemical research in toxicology.

Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury

J. Uetrecht, M. A. Hayes, M. Novalen, 2012, Chemical research in toxicology.

Hepatic effects of aminoglutethimide: A model aromatic amine

Imir G. Metushi, J. Uetrecht, Winnie Ng, 2015, Journal of immunotoxicology.

A novel TH17-type cell is rapidly increased in the liver in response to acetaminophen-induced liver injury: TH17 cells and the innate immune response

J. Uetrecht, Xu Zhu, X. Zhu, 2013, Journal of immunotoxicology.

Effect of clozapine on neutrophil kinetics in rabbits.

S. Iverson, J. Uetrecht, A. Kautiainen, 2010, Chemical research in toxicology.

Myeloperoxidase-mediated activation of xenobiotics by human leukocytes.

J. Uetrecht, A. Hofstra, A. Hofstra, 1993, Toxicology.

PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE

J. Leeder, J. Uetrecht, R. Pearce, 2005, Drug Metabolism and Disposition.

The Combination of Anti-CTLA-4 and PD1-/- Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury.

J. Uetrecht, A. Mak, 2015, Chemical research in toxicology.

Mild isoniazid-induced liver injury in humans is associated with an increase in Th17 cells and T cells producing IL-10.

Imir G. Metushi, M. Gardam, J. Uetrecht, 2014, Chemical research in toxicology.

Detection of anti‐isoniazid and anti–cytochrome P450 antibodies in patients with isoniazid‐induced liver failure

William M. Lee, Imir G. Metushi, J. Uetrecht, 2014, Hepatology.

Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type and N-Acetyltransferase–Deficient Mice

Imir G. Metushi, D. Grant, J. Uetrecht, 2014, Drug Metabolism and Disposition.

IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure.

William M. Lee, Imir G. Metushi, J. Uetrecht, 2014, Chemical research in toxicology.

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

Imir G. Metushi, J. Uetrecht, T. Nakagawa, 2012, Chemical research in toxicology.

Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by Leukocytes

J. Uetrecht, 1989, Pharmaceutical Research.

A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes.

J. Uetrecht, D. MacCrimmon, I. Gardner, 1998, Molecular pharmacology.

T cells ignore the parent drug propylthiouracil but are sensitized to a reactive metabolite generated in vivo.

H. Schuppe, C. Goebel, J. Uetrecht, 1996, Clinical immunology and immunopathology.

Neutrophils and drug metabolism.

C. Goebel, J. Uetrecht, S. von Schmiedeberg, 1995, Science.

Antimyeloperoxidase antibodies and adverse reactions to clozapine

J. Uetrecht, N. Shear, F. Claas, 1992, The Lancet.

Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV‐infected patients: toxicological and pathological implications

P. G. Wells, Maureen L. Harrison, S. Walmsley, 1997, AIDS.

REVIEW Mechanisms of Immune-Mediated Liver Injury

D. Adams, S. Ramaiah, J. Uetrecht, 2010 .

Dapsone and sulfapyridine.

J. Uetrecht, 1989, Clinics in dermatology.

Mechanisms of neutropenia: The role of Neutrophil‐specific pathways of drug metabolism

S. Spielberg, J. Uetrecht, 1993 .

Reactive intermediates in the oxidation of hydralazine by HOCl: the major oxidant generated by neutrophils.

J. Uetrecht, A. Hofstra, 1993, Chemico-biological interactions.

The Respiratory Burst and Drug Metabolism: Implications for Idiosyncratic Drug Reactions and Antiinflammatory Effects

J. Uetrecht, 1993 .

The role of N -oxidation by leukocytes in drug-induced agranulocytosis and other drug hypersensitivity reactions

J. Uetrecht, 1991 .

Metabolism of drugs by activated leukocytes: implications for drug-induced lupus and other drug hypersensitivity reactions.

J. Uetrecht, 1991, Advances in experimental medicine and biology.

Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes.

J. Uetrecht, 1989, Trends in pharmacological sciences.

Metabolism of procainamide to a hydroxylamine by human neutrophils and mononuclear leukocytes.

J. Uetrecht, N. Zahid, R. Rubin, 1988, Chemical research in toxicology.

Oxidation Pathways and the Enzymes That Mediate Them

W. Trager, J. Uetrecht, 2007 .

Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury

J. Uetrecht, A. Mak, 2019, Journal of immunotoxicology.

Dose‐dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor

J. Henck, J. Uetrecht, T. McNearney, 2018, British journal of clinical pharmacology.

D-penicillamine-induced autoimmunity: relationship to macrophage activation.

J. Uetrecht, Jinze Li, 2009, Chemical research in toxicology.

Identification of danger signals in nevirapine-induced skin rash.

Xiaochu Zhang, J. Uetrecht, Amy M. Sharma, 2013, Chemical research in toxicology.

Liver Toxicity Mediated by Leukocytes and Kupffer Cells

R. Billings, A. Wendel, R. Thurman, 1995 .

Cytokine and autoantibody patterns in acute liver failure

William M. Lee, F. Liu, J. Uetrecht, 2010, Journal of immunotoxicology.

Mechanism of drug-induced lupus.

J. Uetrecht, 1988, Chemical research in toxicology.

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis

J. Uetrecht, R. Kato, A. Jee, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Section Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Drug-induced lupus: Possible mechanisms and their implications for prediction of which new drugs may induce lupus

J. Uetrecht, 1996 .

Nevirapine hypersensitivity.

M. Popović, J. Uetrecht, B. Mannargudi, 2010, Handbook of experimental pharmacology.

Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin

Wei Yang Lu, J. Uetrecht, 2008, Drug Metabolism And Disposition.

Spironolactone pharmacokinetics and pharmacodynamics in patients with cirrhotic ascites.

S. Walker, J. Uetrecht, C. Pappas, 1992, Gastroenterology.

Animal models of idiosyncratic drug reactions.

Feng Liu, Winnie Ng, Xu Zhu, 2012, Advances in pharmacology.

Covalent binding of penicillamine to macrophages: implications for penicillamine-induced autoimmunity.

J. Uetrecht, B. Mannargudi, Jinze Li, 2009, Chemical research in toxicology.

Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.

J. Uetrecht, B. Mannargudi, Ling Xu, 2008, Chemical research in toxicology.

Testing the hypothesis that vitamin C deficiency is a risk factor for clozapine-induced agranulocytosis using guinea pigs and ODS rats.

J. Uetrecht, John X. Wilson, J. Ip, 2008, Chemical research in toxicology.

In vitro and animal models of drug-induced blood dyscrasias.

J. Uetrecht, J. Ip, 2006, Environmental toxicology and pharmacology.

Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.

M. Popović, J. Uetrecht, M. Masson, 2005, Chemical research in toxicology.

Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions.

R. Pieters, S. Nierkens, M. Popović, 2004, Chemical research in toxicology.

Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated.

J. Uetrecht, M. Masson, 2004, Chemical Research in Toxicology.

Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.

M. Abu-Asab, J. Uetrecht, M. Teranishi, 2003, Chemical research in toxicology.

Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis.

I. Guest, J. Uetrecht, B. Sokoluk, 1998, Toxicology.

Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1.

J. Uetrecht, M. Suiko, Y. Sakakibara, 2022, Biochemical pharmacology.

Nevirapine-induced liver lipid-SER inclusions and other ultrastructural aberrations

M. Abu-Asab, J. Uetrecht, M. Campos, 2018, Ultrastructural pathology.

The contribution of N‐hydroxylation and acetylation to dapsone pharmacokinetics in normal subjects

J. A. Porter, R. Branch, J. Uetrecht, 1990, Clinical pharmacology and therapeutics.

Contrasting Effects on Halothane Hepatotoxicity in the Phenobarbital-Hypoxia and Triiodothyronine Model: Mechanistic Implications

J. Uetrecht, A. Wood, M. Wood, 1983, Anesthesiology.

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions.

J. Uetrecht, 1992, Drug metabolism reviews.

N-chlorination of phenytoin by myeloperoxidase to a reactive metabolite.

J. Uetrecht, N. Zahid, 1988, Chemical research in toxicology.

Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis.

R. McClelland, J. Uetrecht, H. M. Ma, 1995, Chemical Research in Toxicology.

Current trends in drug-induced autoimmunity.

J. Uetrecht, 1997, Autoimmunity reviews.

The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions

J. Uetrecht, A. Jee, S. Sernoskie, 2021, Pharmacological Reviews.

Idiosyncratic Drug Reactions and the Potential Role of Metabolism

J. Uetrecht, 2012 .

Role of animal models in the study of drug-induced hypersensitivity reactions

J. Uetrecht, Jack Uetrecht, 2005, The AAPS Journal.

Chapter 5 Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses

J. Uetrecht, 2006 .

Drug‐induced hypothyroidism: The thyroid as a target organ in hypersensitivity reactions to anticonvulsants and sulfonamides

M. Rieder, J. Uetrecht, N. Shear, 1992, Clinical pharmacology and therapeutics.

Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells.

J. Uetrecht, N. Shear, N. Zahid, 1988, The Journal of pharmacology and experimental therapeutics.

Animal models of idiosyncratic drug reactions.

J. Uetrecht, J. Shenton, Jacintha M Shenton, 2004, Chemico-biological interactions.

Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites.

M. Rieder, S. Spielberg, J. Uetrecht, 1989, Annals of internal medicine.

Reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide.

J. Uetrecht, 1985, The Journal of pharmacology and experimental therapeutics.

Changes In Gene Expression Induced by Tienilic Acid and Sulfamethoxazole: Testing the Danger Hypothesis

P. Boutros, M. Popović, J. Uetrecht, 2007, Journal of immunotoxicology.

Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity.

J. Uetrecht, 2005, Toxicology.

Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes.

J. Uetrecht, N. Zahid, W. G. Lai, 1999, The Journal of pharmacology and experimental therapeutics.

Idiosyncratic drug reactions: the reactive metabolite syndromes

S. Knowles, J. Uetrecht, N. Shear, 2000, The Lancet.

Idiosyncratic drug reactions: current understanding.

J. Uetrecht, Jack Uetrecht, 2007, Annual review of pharmacology and toxicology.

Severe cutaneous adverse reaction associated with antiseizure medications: Diagnosis, management, and prevention

J. Uetrecht, L. Mcguire, C. Brandt, 2021, Epilepsy & Behavior.

Possible Bioactivation Pathways of Lamotrigine

Wei Yang Lu, J. Uetrecht, 2007, Drug Metabolism and Disposition.

Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.

J. Uetrecht, Z. Liu, Zhao Liu, 1995, The Journal of pharmacology and experimental therapeutics.

Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury

J. Uetrecht, Ming Liu, A. Jee, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Metabolism of Clozapine by Neutrophils

J. Uetrecht, 1992, Drug safety.

Biochemical mechanisms of drug toxicity

P. G. Wells, D. Grant, J. Uetrecht, 2022, Atkinson's Principles of Clinical Pharmacology.

Mechanisms of immune-mediated liver injury.

D. Adams, H. Jaeschke, S. Ramaiah, 2010, Toxicological Sciences.

Role of the Adaptive Immune System in Idiosyncratic Drug-Induced Liver Injury

J. Uetrecht, Jack Uetrecht, 2013 .

Nevirapine bioactivation and covalent binding in the skin.

J. Uetrecht, K. Klarskov, Amy M. Sharma, 2013, Chemical research in toxicology.

A Study of the Specificity of Lymphocytes in Nevirapine-Induced Skin Rash

J. Uetrecht, B. Mannargudi, Xin Chen, 2009, Journal of Pharmacology and Experimental Therapeutics.

Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis

J. Uetrecht, A. Johnston, 2015, Expert opinion on drug metabolism & toxicology.

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome.

P. G. Wells, S. D. de Morais, J. Uetrecht, 1992, Gastroenterology.

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2000, Molecular pharmacology.

Metabolism of 35S- and 14C-labeled propylthiouracil in a model in vitro system containing thyroid peroxidase.

J. Uetrecht, A. Taurog, F. S. Guziec, 1989, Endocrinology.

Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.

R. Fontana, P. Watkins, H. Bonkovsky, 2020, Journal of autoimmunity.

Involvement of the immune system in idiosyncratic drug reactions.

F. Liu, Xiaochu Zhang, J. Uetrecht, 2011, Drug metabolism and pharmacokinetics.

Metabolism of isoniazid by activated leukocytes. Possible role in drug-induced lupus.

J. Uetrecht, A. Hofstra, S. M. Li-Muller, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Minocycline, perinuclear antineutrophilic cytoplasmic antibody, and pigment: the biochemical basis.

J. Uetrecht, N. Shear, L. Shapiro, 2001, Journal of the American Academy of Dermatology.

The danger hypothesis applied to idiosyncratic drug reactions.

J. Uetrecht, B. Séguin, Jack P. Uetrecht, 2003, Handbook of experimental pharmacology.

Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm.

J. Uetrecht, E. Sayeh, Jack Uetrecht, 2001, Toxicology.

Reactive metabolites and agranulocytosis

J. Uetrecht, 1996, European journal of haematology. Supplementum.

T lymphocytes ignore procainamide, but respond to its reactive metabolites in peritoneal cells: demonstration by the adoptive transfer popliteal lymph node assay.

C. Goebel, J. Uetrecht, E. Gleichmann, 1993, Toxicology and applied pharmacology.

Possible Implications for Clozapine-Induced Agranulocytosis

J. Uetrecht, 2022 .

Mechanisms of idiosyncratic drug-induced liver injury.

J. Uetrecht, 2019, Advances in pharmacology.

Immune-mediated adverse drug reactions.

J. Uetrecht, Jack Uetrecht, 2009, Chemical research in toxicology.

Myeloperoxidase as a generator of drug free radicals.

J. Uetrecht, 1995, Biochemical Society symposium.

Evaluation of Which Reactive Metabolite, If Any, Is Responsible for a Specific Idiosyncratic Reaction

J. Uetrecht, 2006, Drug metabolism reviews.

Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine

Wei Yang Lu, J. Leeder, M. Correia, 2008, Drug Metabolism and Disposition.

Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury

J. Uetrecht, A. Mak, Tiffany Cho, 2018, Journal of immunotoxicology.

Immune mechanisms of idiosyncratic drug-induced liver injury

J. Uetrecht, A. Mak, 2017, Journal of clinical and translational research.

Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury

J. Uetrecht, A. Mak, A. Johnston, 2017, Journal of immunotoxicology.

Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.

Imir G. Metushi, J. Uetrecht, R. Hanzlik, 2016, Chemical research in toxicology.

Idiosyncratic Adverse Drug Reactions

J. Uetrecht, A. Mak, 2014 .

Covalent binding of carbamazepine oxidative metabolites to neutrophils.

J. Uetrecht, P. Sukhai, S. Furst, 1995, Drug metabolism and disposition: the biological fate of chemicals.

A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo.

M. Popović, J. Uetrecht, I. Gardner, 2005, Chemical research in toxicology.

Oxidation of 5-aminosalicylic acid by hypochlorous acid to a reactive iminoquinone. Possible role in the treatment of inflammatory bowel diseases.

J. Uetrecht, Z. Liu, R. McCLELLAND, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides.

M. Rieder, S. Spielberg, J. Uetrecht, 1988, The Journal of pharmacology and experimental therapeutics.

Cytotoxicity of oxidative metabolites of procainamide.

J. Uetrecht, R. Rubin, J. Jones, 1987, The Journal of pharmacology and experimental therapeutics.

Mechanism of isoniazid‐induced hepatotoxicity: then and now

Imir G. Metushi, E. Phillips, J. Uetrecht, 2016, British journal of clinical pharmacology.

Screening for the potential of a drug candidate to cause idiosyncratic drug reactions.

J. Uetrecht, Jack Uetrecht, 2003, Drug discovery today.

Changes in gene expression induced by aromatic amine drugs: Testing the danger hypothesis

J. Uetrecht, Winnie Ng, 2013, Journal of immunotoxicology.

Detection of 2-hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate.

J. Uetrecht, C. Ju, 1999, The Journal of pharmacology and experimental therapeutics.

Structural features associated with reactive metabolite formation in clozapine analogues.

J. Uetrecht, N. Zahid, J. Fu, 1997, Chemico-biological interactions.

Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset

Imir G. Metushi, F. Liu, J. Uetrecht, 2015, Journal of immunotoxicology.

Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis.

J. Uetrecht, Winnie Ng, Rossoune Kennar, 2014, Chemical research in toxicology.

Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.

S. Iverson, J. Uetrecht, N. Zahid, 2002, Chemico-biological interactions.

Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system.

J. Uetrecht, J P Uetrecht, C Ju, 2002, Current drug metabolism.

Kinetics of R and S warfarin enantiomers

C. Hignite, C. Tschanz, J. Uetrecht, 1980 .

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

R. Teschke, J. Uetrecht, 2020, Annals of translational medicine.

Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis.

J. Uetrecht, L. Waldhauser, L Waldhauser, 1991, Drug metabolism and disposition: the biological fate of chemicals.

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Hypochlorous Acid, a Major Oxidant Produced by Activated Neutrophils, Has Low Effect on Two Pyridobenzazepine Derivatives, JL 3 and JL 13

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D-penicillamine-induced granulomatous hepatitis in brown Norway rats

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Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d-Tryptophan or Acetaminophen

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How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction.

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Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin

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The danger hypothesis applied to idiosyncratic drug reactions

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Possible Bioactivation Pathways of Lamotrigine

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