H. Kupferberg

发表

Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro.

A. Li, I. Kapetanovic, W. Santos, 2002, Chemico-biological interactions.

Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.

D. Woodbury, W. Yonekawa, H. Kupferberg, 1980, The Journal of pharmacology and experimental therapeutics.

The clinical value of free phenytoin levels

W. Theodore, I. Kapetanovic, W. Yonekawa, 1985, Annals of neurology.

Diphenylhydantoin, Phenobarbital, and Primidone in Saliva, Plasma, and Cerebrospinal Fluid

H. Kupferberg, D. Schmidt, 1975, Epilepsia.

The National Institutes of Health Anticonvulsant Drug Development Program: screening for efficacy.

H. Kupferberg, H. White, H. Wolf, 1998, Advances in neurology.

Mechanism of valproate‐phenobarbital interaction in epileptic patients

W. Theodore, I. Kapetanovic, J. Penry, 1981, Clinical pharmacology and therapeutics.

Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.

W. Theodore, M. Newmark, H. Kupferberg, 1982, British journal of clinical pharmacology.

Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats

R. Sofia, H. Kupferberg, E. A. Swinyard, 1986, Epilepsia.

Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy

N. Walton, J. Stables, H. Kohn, 2007, Epilepsy Research.

Antiepileptic Drug Development: I. History and a Program for Progress

J. Penry, H. Kupferberg, R. Krall, 1978, Epilepsia.

Comparative Anticonvulsant Activity and Neurotoxicity of Clobazam, Diazepam, Phenobarbital, and Valproate in Mice and Rats

H. Kupferberg, J. T. Miyahara, A. Shenoy, 1982, Epilepsia.

Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

J. Penry, B. G. White, H. Kupferberg, 1978, Epilepsia.

Use of stable isotopes and gas chromatography-mass spectrometry in the study of different pools of neurotransmitter amino acids in brain slices.

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1990, Journal of chromatography.

A radioimmunoassay for diphenylhydantoin.

J. Inman, H. Kupferberg, R. Rapport, 1973, Clinica chimica acta; international journal of clinical chemistry.

Antiepileptic Drug Development Program.

B. G. White, H. Kupferberg, J. Cereghino, 1984, Cleveland Clinic quarterly.

The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond

H. Kupferberg, R. Porter, 2017, Neurochemical Research.

Strategies for identifying and developing new anticonvulsant drugs

H. Kupferberg, 1992, Pharmaceutisch Weekblad.

The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models

H. Kupferberg, H. White, H. Wolf, 1995, The Italian Journal of Neurological Sciences.

Correlations Among Minimal Neurotoxicity, Anticonvulsant Activity, and Displacing Potencies in [3H]Flunitrazepam Binding of Benzodiazepines

H. Kupferberg, E. A. Swinyard, H. Wolf, 1983, Epilepsia.

The NIH Anticonvulsant Drug Development ( ADD ) Program : preclinical anticonvulsant screening project

J. Stables, H. Kupferberg, 2000 .

Effects of Diphenylhydantoin on Local Cerebral Blood Flow

C. Kennedy, H. Kupferberg, G. Grave, 1975 .

Effects of Antiepileptic Drugs on Pentylenetetrazole‐Induced Epileptiform Activity in the In Vitro Hippocampus

W. Yonekawa, H. Kupferberg, S. Piredda, 1986, Epilepsia.

Dose-response evaluations of a circadian rhythmic change in susceptibility of mice to ouabain.

F. Halberg, H. Kupferberg, W. Nelson, 1971, Toxicology and applied pharmacology.

Pharmacologic basis for the increased sensitivity of the newborn rat to morphine.

H. Kupferberg, E. Way, 1963, The Journal of pharmacology and experimental therapeutics.

Changes in brain metabolites induced by convulsants or electroshock: effects of anticonvulsant agents.

J. Penry, J. Passonneau, W. Yonekawa, 1978, Molecular pharmacology.

Animal Models Used in the Screening of Antiepileptic Drugs

H. Kupferberg, H Kupferberg, 2001, Epilepsia.

The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models

J. Stables, H. Kupferberg, H. White, 2008, Epilepsia.

Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)

René H. Levy, T. Tomson, E. Perucca, 2007, Epilepsy Research.

Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.

I. Kapetanovic, C. D. Torchin, W. Yonekawa, 1988, Biochemical pharmacology.

FLUOROMETRIC IDENTIFICATION OF SUB-MICROGRAM AMOUNTS OF MORPHINE AND RELATED COMPOUNDS ON THIN-LAYER CHROMATOGRAPHS.

H. Kupferberg, E. Way, A. Burkhalter, 1964, Journal of chromatography.

Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.

H. Kupferberg, 1970, Clinica chimica acta; international journal of clinical chemistry.

A SENSITIVE FLUOROMETRIC ASSAY FOR MORPHINE IN PLASMA AND BRAIN.

H. Kupferberg, E. Way, A. Burkhalter, 1964, The Journal of pharmacology and experimental therapeutics.

Nafimidone, an imidazole anticonvulsant, and its metabolite as potent inhibitors of microsomal metabolism of phenytoin and carbamazepine.

I. Kapetanovic, H. Kupferberg, 1984, Drug metabolism and disposition: the biological fate of chemicals.

A Gas Chromatographic Method for the Determination of Ethotoin (3-Ethyl-5-Phenylhydantoin) in Human Plasma

W. Yonekawa, H. Kupferberg, F. Cantor, 1975 .

Animal Experimental Methods in the Study of Antiepileptic Drugs

W. Koella, H. Kupferberg, E. A. Swinyard, 1985 .

Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)

T. Tomson, E. Perucca, M. Bialer, 2004, Epilepsy Research.

The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1995, Epilepsy Research.

Quantitative studies of the antagonism of morphine by nalorphine and naloxone.

J. W. Miller, A. Takemori, H. Kupferberg, 1969, The Journal of pharmacology and experimental therapeutics.

The effects of anticonvulsant compounds on 4-aminopyridine-induced de novo synthesis of neurotransmitter amino acids in rat hippocampus in vitro

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1995, Epilepsy Research.

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1993, Journal of neurochemistry.

Determination of 4-aminobutyric acid, aspartate, glutamate and glutamine and their 13C stable-isotopic enrichment in brain tissue by gas chromatography-mass spectrometry.

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1987, Journal of chromatography.

Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI)

E. Perucca, P. Loiseau, M. Bialer, 2002, Epilepsy Research.

Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V)

E. Perucca, P. Loiseau, M. Bialer, 2001, Epilepsy Research.

Sodium valproate

F. Dreifuss, S. Sato, J. Penry, 1980, Neurology.

Stability and comparative metabolism of selected felbamate metabolites and postulated fluorofelbamate metabolites by postmitochondrial suspensions.

J. Stables, J. Strong, H. Kupferberg, 2005, Chemical research in toxicology.

Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes.

I. Kapetanovic, C. D. Torchin, J. Strong, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)

E. Perucca, P. Loiseau, M. Bialer, 1999, Epilepsy Research.

Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.

W. Theodore, I. Kapetanovic, H. Kupferberg, 1981, British journal of clinical pharmacology.

Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures.

S. Schachter, D. Schomer, M. Mikati, 1989, Clinical neuropharmacology.

Progress report on new antiepileptic drugs A summary of the Second Eilat Conference

E. Perucca, P. Loiseau, M. Bialer, 1995, Epilepsy Research.

Serum clonazepam concentrations in children with absence seizures

S. Sato, F. Dreifuss, J. Penry, 1975, Neurology.

Inhibition of ouabain-H3 uptake by liver slices and its excretion into the bile and by compounds having a steroid nucleus.

H. Kupferberg, 1969, Life sciences.

249 The influence of biologie disposition on the sensitivity of young rats to morphine

H. Kupferberg, E. Way, 1961 .

GLC determination of carbamazepine in plasma.

H. Kupferberg, 1972, Journal of pharmaceutical sciences.

A Single‐Dose Study of Mexiletine (Kö 1173)

J. Penry, B. G. White, W. Yonekawa, 1975, Epilepsia.

Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro.

C. D. Thompson, I. Kapetanovic, T. Macdonald, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics of W‐554 (ADD 03055) in Epileptic Patients

H. Kupferberg, P. Friel, L. Ojemann, 1985, Epilepsia.

Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference

E. Perucca, P. Loiseau, M. Bialer, 1996, Epilepsy Research.

Antiepileptic drugs: detection, quantification, and evaluation.

H. Kupferberg, E. A. Swinyard, 1985, Federation proceedings.

Effect of methylphenidate on plasma anticonvulsant levels

D. Hunninghake, H. Kupferberg, W. Jeffery, 1972, Clinical pharmacology and therapeutics.

A Multiple‐Dose Study of Mexiletine (Kö 1173)

B. G. White, H. Kupferberg, J. Penry, 1975, Epilepsia.

Analysis of p-hydroxyphenytoin in microsomal reactions by high-performance liquid chromatography with electrochemical detection.

I. Kapetanovic, H. Kupferberg, 1984, Journal of chromatography.

Valproic acid versus ethosuximide in the treatment of absence seizures

B G White, J. Sackellares, F. Dreifuss, 1982, Neurology.

Sodium-valproate

H. Kupferberg, 1988, The Lancet.

PHENYTOIN:AN INHIBITORAND INDUCER OFPRIMIDONE METABOLISM INAN EPILEPTICPATIENT

W. Theodore, M. Newmark, H. Kupferberg, 1982 .

GC and GC-mass spectrometric determination of p-hydroxyphenobarbital extracted from plasma, urine, and hepatic microsomes.

I. Kapetanovic, H. Kupferberg, 1981, Journal of pharmaceutical sciences.

Metabolism of dimethoxymethylphenobarbital in mice. relationship between brain phenobarbital levels and anticonvulsant activity.

H. Kupferberg, R. Rapport, 1973, Journal of medicinal chemistry.

Biliary secretion of ouabain-3H and its uptake by liver slices in the rat.

H. Kupferberg, L. S. Schankl, 1968, The American journal of physiology.

Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.

W. Yonekawa, H. Kupferberg, 1979, Journal of Chromatography A.

The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (Nirvanol) in mice in relation to anticonvulsant activity.

W. Yonekawa, H. Kupferberg, 1975, Drug metabolism and disposition: the biological fate of chemicals.

Gas chromatographic-mass spectrometric studies on the metabolic fate of ethotoin in man.

W. Yonekawa, H. Kupferberg, D. L. Bius, 1980, Drug metabolism and disposition: the biological fate of chemicals.

In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slices.

I. Kapetanovic, C. D. Torchin, J. Strong, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Flunarizine for treatment of partial seizures

J. Sackellares, G. Pledger, S. Schachter, 1994, Neurology.

Pharmacokinetic Profile of Flunarizine After Single and Multiple Dosing in Epileptic Patients Receiving Comedication

D. Treiman, I. Kapetanovic, C. D. Torchin, 1988, Epilepsia.

Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.

H. Kupferberg, E. A. Swinyard, H. Wolf, 1985, Life sciences.

Measurement of progabide and its deaminated metabolite in plasma by high-performance liquid chromatography and electrochemical detection.

W. Yonekawa, H. Kupferberg, T. Lambert, 1983, Journal of chromatography.

Automated capillary gas chromatographic determination of flunarizine.

I. Kapetanovic, C. D. Torchin, W. Yonekawa, 1986, Journal of chromatography.

Hyperthermia in d-amphetamine toxicity in aggregated mice of different strains.

H. Kupferberg, A. L. Craig, 1972, The Journal of pharmacology and experimental therapeutics.

Stereochemical studies on medicinal agents. VI. Bicyclic bases. Synthesis and pharmacology of epimeric bridged analogs of meperidine, 2-methyl-5-phenyl-5-carbethoxy-2-azabicyclo[2.2.1]heptane.

P. Portoghese, H. Kupferberg, A. Mikhail, 1968, Journal of medicinal chemistry.

The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro

I. Kapetanovic, W. Yonekawa, H. Kupferberg, 1995, Epilepsy Research.

Antiepileptic Drug Development Program: A Cooperative Effort of Government and Industry

H. Kupferberg, 1989, Epilepsia.

Mechanisms of action of anti-seizure drugs and the anticonvulsant screening program of the National Institute of Neurological Disorders and Stroke.

H. Kupferberg, R. Porter, B. J. Hessie, 2015, International journal of clinical pharmacology and therapeutics.

Heat production and heat loss in d-amphetamine hyperthermia in aggregated Swiss Webster and BDF mice.

J. W. Miller, H. Kupferberg, A. Craigmill, 1973, Toxicology and applied pharmacology.

Stable isotope methodology and gas chromatography mass spectrometry in a pharmacokinetic study of phenobarbital.

I. Kapetanovic, H. Kupferberg, I M Kapetanović, 1980, Biomedical mass spectrometry.

Inhibition of microsomal phenytoin metabolism by nafimidone and related imidazoles. Potency and structural considerations.

I. Kapetanovic, H. Kupferberg, 1985, Drug metabolism and disposition: the biological fate of chemicals.

The Effect of Chronic Felbamate Administration on Anticonvulsant Activity and Hepatic Drug‐Metabolizing Enzymes in Mice and Rats

R. Sofia, H. Kupferberg, E. A. Swinyard, 1987, Epilepsia.

Potassium, Pentylenetetrazol, and Anticonvulsants in Mouse Hippocampal Slices

W. Yonekawa, H. Kupferberg, S. Piredda, 1985, Epilepsia.

Preclinical testing.

H. Kupferberg, J. Cereghino, 1993, Epilepsy research. Supplement.

Inhibition of microsomal phenobarbital metabolism by valproic acid.

I. Kapetanovic, H. Kupferberg, 1981, Biochemical pharmacology.

High-performance liquid chromatographic assay of flunarizine, (E)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine, in plasma of epileptic patients.

I. Kapetanovic, C. D. Torchin, W. Yonekawa, 1988, Journal of chromatography.

Interlaboratory variability of valproic acid determinations.

U. Klotz, R. Gugler, H. Schulz, 1977, Arzneimittel-Forschung.

Linear Relationship between Plasma Concentration and Dosage of Sodium Valproate

J. Nutt, H. Kupferberg, Harvey J. Kupferberg, 1979, Epilepsia.

The Development of Tolerance to the Anticonvulsant Effect of Phenobarbital in Mice

W. Yonekawa, H. Kupferberg, J. Penry, 1980, Epilepsia.