Slava Ziegler

发表

Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

A. Hyman, A. Bird, S. Grimme, 2012, Nature chemical biology.

De novo branching cascades for structural and functional diversity in small molecules

Claude Ostermann, Carsten Strohmann, Christian Unkelbach, 2015, Nature Communications.

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity

H. Waldmann, C. Golz, Slava Ziegler, 2017, Nature Communications.

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

Herbert Waldmann, Daniel Rauh, Hans Preut, 2010, Nature Chemistry.

Target identification for small bioactive molecules: finding the needle in the haystack.

Herbert Waldmann, Verena Pries, Slava Ziegler, 2013, Angewandte Chemie.

Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling.

Herbert Waldmann, Carsten Strohmann, Slava Ziegler, 2015, Angewandte Chemie.

Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.

Herbert Waldmann, Daniel Rauh, Slava Ziegler, 2015, Angewandte Chemie.

Scaffold Diversity Synthesis Delivers Complex, Structurally, and Functionally Distinct Tetracyclic Benzopyrones

Sayantani Roy, Slava Ziegler, Kamal Kumar, 2018, ChemistryOpen.

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.

H. Waldmann, Slava Ziegler, A. Antonchick, 2019, Cell chemical biology.

Development of a PDEδ‐Targeting PROTACs that Impair Lipid Metabolism

H. Waldmann, U. Koch, P. Janning, 2019, Angewandte Chemie.

Development of a PDEδ‐Targeting PROTACs that Impair Lipid Metabolism

H. Waldmann, U. Koch, P. Janning, 2020, Angewandte Chemie (International Ed. in English).

Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.

Herbert Waldmann, Thomas Henkel, Slava Ziegler, 2014, Bioorganic & medicinal chemistry.

Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets

H. Waldmann, Slava Ziegler, S. Sievers, 2020, Chembiochem : a European journal of chemical biology.

Total Synthesis of (−)‐Doliculide, Structure–Activity Relationship Studies and Its Binding to F‐Actin

H. Waldmann, Sayantani Roy, A. Minnaard, 2012, Chembiochem : a European journal of chemical biology.

Discovery of a Novel Hedgehog Signaling Pathway Inhibitor by Cell-based Compound Discovery and Target Prediction

G. Schneider, H. Waldmann, B. Klebl, 2017 .

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling

H. Waldmann, P. Schröder, Slava Ziegler, 2017, Chembiochem : a European journal of chemical biology.

Small-Molecule Inhibition of the UNC119-Cargo Interaction.

A. Wittinghofer, H. Waldmann, C. Ehrt, 2017, Angewandte Chemie.

Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.

H. Waldmann, M. Uesugi, Shin-ichi Sato, 2019, ACS chemical biology.

Chemical Genetics Reveals a Role of dCTP Pyrophosphatase 1 in Wnt Signaling

H. Waldmann, T. Förster, P. Janning, 2019, Angewandte Chemie.

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

H. Waldmann, Slava Ziegler, Mark Dow, 2022, bioRxiv.

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Herbert Waldmann, Gisbert Schneider, Claudia Pommerenke, 2018, Cell chemical biology.

Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation

H. Waldmann, Nancy E. Martinez, A. Zychlinsky, 2017, Chembiochem : a European journal of chemical biology.

C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.

H. Waldmann, C. Merten, Slava Ziegler, 2018, Angewandte Chemie.

C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.

H. Waldmann, C. Merten, Slava Ziegler, 2018, Angewandte Chemie.

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile.

R. Fröhlich, H. Waldmann, Hongyan Sun, 2011, Angewandte Chemie.

Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.

H. Waldmann, C. Merten, Slava Ziegler, 2018, Angewandte Chemie.

Enantioselective Formal C(sp3 )−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives

H. Waldmann, C. Merten, Slava Ziegler, 2018, Angewandte Chemie.

Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.

H. Waldmann, A. Choidas, Slava Ziegler, 2019, Cell chemical biology.

Unravelling the Synthesis and Chemistry of Stable, Acyclic, and Double-Deficient 1,3-Butadienes: An endo-Selective Diels-Alder Route to Hedgehog Pathway Inhibitors.

Slava Ziegler, Kamal Kumar, C. Strohmann, 2019, Chemistry.

Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.

S. Knapp, H. Waldmann, B. Berger, 2019, Angewandte Chemie.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.

H. Waldmann, H. Osada, Slava Ziegler, 2017, Bioorganic & medicinal chemistry.

An enantioselective inverse-electron-demand imino Diels-Alder reaction.

H. Waldmann, Slava Ziegler, Kamal Kumar, 2014, Angewandte Chemie.

Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ob02272j Click here for additional data file.

H. Waldmann, Magnus Sellstedt, Slava Ziegler, 2015, Organic & biomolecular chemistry.

A Scaffold‐Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides

Slava Ziegler, Kamal Kumar, C. Strohmann, 2019, Chemistry.

Biology‐Oriented Synthesis of a Tetrahydroisoquinoline‐Based Compound Collection Targeting Microtubule Polymerization

Herbert Waldmann, Slava Ziegler, Christian Hedberg, 2013, Chembiochem : a European journal of chemical biology.

Enantioselective Organocatalytic Synthesis of a Secoyohimbane‐Inspired Compound Collection with Neuritogenic Activity

H. Waldmann, T. Förster, Slava Ziegler, 2017, Chembiochem : a European journal of chemical biology.

Synthesis of Indomorphan Pseudo‐Natural Product Inhibitors of Glucose Transporters GLUT‐1 and ‐3

Claude Ostermann, H. Waldmann, K. Winklhofer, 2019, Angewandte Chemie.

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3

Claude Ostermann, H. Waldmann, Slava Ziegler, 2018, Nature Chemistry.

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

O. Werz, D. Steinhilber, S. Fulda, 2016, Pharmacology & therapeutics.

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Herbert Waldmann, Tobias Seitz, David J Beech, 2015, Angewandte Chemie.

Small-Molecule Target Engagement in Cells.

H. Waldmann, P. Janning, Slava Ziegler, 2016, Cell chemical biology.

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.

H. Waldmann, A. Brockmeyer, P. Janning, 2013, Angewandte Chemie.

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.

H. Schöler, I. Vetter, H. Waldmann, 2016, Cell chemical biology.

Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis.

H. Waldmann, P. Janning, Slava Ziegler, 2021, Cell chemical biology.

Morphological profiling of small molecules.

H. Waldmann, Slava Ziegler, S. Sievers, 2021, Cell chemical biology.

Hunting the Targets of Natural Product-Inspired Compounds

Slava Ziegler, Herbert Waldmann, H. Waldmann, 2012 .

Identification of novel PDEδ interacting proteins.

H. Waldmann, P. Janning, Slava Ziegler, 2017, Bioorganic & medicinal chemistry.

Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds.

H. Waldmann, Slava Ziegler, S. Sievers, 2021, Cell chemical biology.

Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.

H. Waldmann, H. Osada, B. Wünsch, 2021, Cell chemical biology.

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

H. Waldmann, H. Osada, P. Janning, 2020, Bioscience, biotechnology, and biochemistry.

Novel approaches to map small molecule-target interactions.

Herbert Waldmann, Slava Ziegler, H. Waldmann, 2016, Bioorganic & medicinal chemistry.

Chronological expression of Wnt target genes Ccnd1, Myc, Cdkn1a, Tfrc, Plf1 and Ramp3

Slava Ziegler, T. Grunwald, O. Müller, 2009, Cell biology international.

Lipocalin 24p3 is regulated by the Wnt pathway independent of regulation by iron.

L. Tickenbrock, N. Jakubowski, Slava Ziegler, 2007, Cancer genetics and cytogenetics.

Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation

I. Vetter, T. Möröy, L. Klein-Hitpass, 2005, The FEBS journal.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

H. Waldmann, R. Riedl, F. Bono, 2018, Cell chemical biology.

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

H. Schöler, T. Schroer, H. Waldmann, 2018, Cell chemical biology.

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

M. Araúzo-Bravo, H. Schöler, H. Waldmann, 2016, Cell reports.

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

H. Schöler, H. Waldmann, Takanari Inoue, 2019, Angewandte Chemie.

Joint Knowledge and Technology for Systems Chemical Biology

Akira Wada, Naoki Kato, Slava Ziegler, 2013, Chembiochem : a European journal of chemical biology.

2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

H. Waldmann, T. Förster, H. Osada, 2019, European Journal of Organic Chemistry.

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Herbert Waldmann, Gisbert Schneider, Slava Ziegler, 2017, Angewandte Chemie.

Identification of the Targets of Natural‐Product‐Inspired Mitotic Inhibitors

Slava Ziegler, Kamal Kumar, 2014 .

Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling.

H. Waldmann, T. Förster, P. Janning, 2019, Angewandte Chemie.

The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

H. Waldmann, D. Schade, F. Rastinejad, 2022, Journal of medicinal chemistry.

Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.

H. Waldmann, L. Kremer, Slava Ziegler, 2013, Angewandte Chemie.

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics

D. Auld, Zhuyin Li, B. Oliver, 2016, EBioMedicine.

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Hacer Karatas, I. Vetter, H. Waldmann, 2019, Nature Chemical Biology.

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

H. Waldmann, A. Messeguer, A. Brockmeyer, 2015, Chembiochem : a European journal of chemical biology.

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay

C. Nowak, Slava Ziegler, Jie Liu, 2022, Chembiochem : a European journal of chemical biology.

Illumina Dark Chemical Matter using the Cell Painting Assay

Slava Ziegler, Jie Liu, B. Schölermann, 2023, bioRxiv.

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

H. Waldmann, Slava Ziegler, Mark Dow, 2022, bioRxiv.

Identification of the targets of biologically active small molecules using quantitative proteomics.

H. Waldmann, A. Brockmeyer, P. Janning, 2015, Methods in molecular biology.

Enantioselective Synthesis of Spirooxindoles Inspired byNatural Products

H. Waldmann, M. Schürmann, H. Preut, 2010 .

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

H. Waldmann, Slava Ziegler, B. Schölermann, 2022, Chemistry.

Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h

S. Knapp, H. Waldmann, B. Berger, 2019 .

Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

B. Berger, K. Paruch, Slava Ziegler, 2018, Angewandte Chemie.

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of

Slava Ziegler, Andrei Ursu, D. J. Illich, 2016 .