M. Bartberger

发表

A Standard Set of Pericyclic Reactions of Hydrocarbons for the Benchmarking of Computational Methods: The Performance of ab Initio, Density Functional, CASSCF, CASPT2, and CBS-QB3 Methods for the Prediction of Activation Barriers, Reaction Energetics, and Transition State Geometries

Andrew G. Leach, K. Houk, V. Güner, 2003 .

From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Yuan Cheng, Thomas Nixey, Yi Luo, 2011, Journal of medicinal chemistry.

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.

B. Beno, N. Meanwell, K. Yeung, 2015, Journal of medicinal chemistry.

Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity.

Alexander W. Sun, Jeff F. Miller, B. Stoltz, 2019, Bioorganic & medicinal chemistry letters.

Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation.

Yuan Cheng, D. Whittington, M. Bartberger, 2018, Bioorganic & medicinal chemistry letters.

Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease.

M. P. Bourbeau, M. Bartberger, Matthew P Bourbeau, 2015, Journal of medicinal chemistry.

Application of 1,1-ADEQUATE, HMBC, and Density Functional Theory To Determine Regioselectivity in the Halogenation of Pyridine N-Oxides.

M. Bartberger, T. Hwang, Y. Chen, 2016, Organic letters.

C-nitroso donors of nitric oxide.

E. Toone, H. Chakrapani, M. Bartberger, 2009, The Journal of organic chemistry.

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.

Shannon Rumfelt, N. Chen, S. Hitchcock, 2013, Bioorganic & medicinal chemistry letters.

Systematic Study of the Glutathione (GSH) Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.

J. McCarter, T. Arvedson, M. Bartberger, 2020, Journal of medicinal chemistry.

Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).

Jiandong Zhang, R. Syed, R. Hungate, 2010, Journal of medicinal chemistry.

The magnitude of [C-H...O] hydrogen bonding in molecular and supramolecular assemblies.

J. F. Stoddart, K. Houk, F. Raymo, 2001, Journal of the American Chemical Society.

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.

Kristin L. Andrews, Jiandong Zhang, S. Chmait, 2015, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors.

Guomin Yao, M. Bartberger, J. Bailis, 2014, European journal of medicinal chemistry.

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

S. Hitchcock, A. Cheng, Yuan Cheng, 2015, Bioorganic & medicinal chemistry letters.

Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase.

J. B. Jordan, Yuan Cheng, D. Whittington, 2016, Journal of medicinal chemistry.

An efficient one-pot construction of substituted pyrimidinones

C. Dominguez, M. Bartberger, P. Ibrahim, 2006 .

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.

M. Fielden, D. Whittington, M. Bartberger, 2017, MedChemComm.

Discovery of the imidazole-derived GPR40 agonist AM-3189.

Rajiv Sharma, Zhihua Ma, G. Tonn, 2016, Bioorganic & medicinal chemistry letters.

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.

Xiao Mei Zheng, R. Wahl, S. Hitchcock, 2015, ACS medicinal chemistry letters.

Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.

R. Wahl, S. Hitchcock, M. Citron, 2013, Bioorganic & medicinal chemistry letters.

Structure guided P1' modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease.

S. Hitchcock, H. Monenschein, M. Bartberger, 2012, Bioorganic & medicinal chemistry letters.

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.

Yuan Cheng, Yi Luo, Wenge Zhong, 2012, ACS medicinal chemistry letters.

Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.

Yuan Cheng, Wenge Zhong, Michael D Bartberger, 2012, Journal of medicinal chemistry.

Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

R. Wahl, S. Hitchcock, Yuan Cheng, 2012, Journal of medicinal chemistry.

Anion-aromatic bonding: a case for anion recognition by pi-acidic rings.

Michael D Bartberger, Alan Armstrong, Mark Mascal, 2002, Journal of the American Chemical Society.

Insertion of Helium and Molecular Hydrogen Through the Orifice of an Open Fullerene.

K. Houk, Y. Rubin, M. Saunders, 2001, Angewandte Chemie.

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

H. Monenschein, M. Horner, M. Bartberger, 2018, Journal of medicinal chemistry.

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.

S. Chmait, M. Bartberger, S. Jordan, 2015, Journal of medicinal chemistry.

Experimental Study of the Stereomutation of 1,1-Difluoro-2-ethyl-3-methylcyclopropane Confirms the Predicted Preference for Disrotatory Ring Opening and Closure

W. R. Dolbier, F. Tian, M. Bartberger, 1998 .

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

D. Kass, D. Wink, E. Ford, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cyclization reactivities of fluorinated hex-5-enyl radicals

W. R. Dolbier, Zhenqiang Yang, M. Bartberger, 1998 .

Conformation-dependent state selectivity in O-O cleavage of ONOONO: an "inorganic cope rearrangement" helps explain the observed negative activation energy in the oxidation of nitric oxide by dioxygen.

K. Houk, M. Bartberger, L. Olson, 2002, Journal of the American Chemical Society.

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Conformation‐Dependent State Selectivity in O—O Cleavage of ONOONO: An “Inorganic Cope Rearrangement” Helps Explain the Observed Negative Activation Energy in the Oxidation of Nitric Oxide by Dioxygen

K. Houk, M. Bartberger, L. Olson, 2002 .

Theory, Spectroscopy, and Crystallographic Analysis of S-Nitrosothiols: Conformational Distribution Dictates Spectroscopic Behavior

K. Houk, E. Toone, M. Bartberger, 2000 .

N-substituted azaindoles as potent inhibitors of Cdc7 kinase.

Guomin Yao, M. Bartberger, E. Doherty, 2013, Bioorganic & medicinal chemistry letters.

The First Practical and Efficient One-Pot Synthesis of 6-Substituted 7-Azaindoles via a Reissert-Henze Reaction

S. Sukits, M. Bartberger, C. Wilde, 2008 .

Development of a Practical Synthesis of a p38 MAP Kinase Inhibitor

Michal M. Achmatowicz, M. Bartberger, T. L. Correll, 2009 .

Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.

J. McCarter, T. Arvedson, A. Tasker, 2015, Journal of medicinal chemistry.

Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.

D. Citrin, D. Wink, N. Paolocci, 2003, Journal of inorganic biochemistry.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

EXPERIMENTAL AND THEORETICAL STUDIES ON THE REACTIVITIES OF PARTIALLY AND FULLY FLUORINATED PRIMARY ALKYL RADICALS φ φIssued as NRC No. 40813

W. R. Dolbier, M. Bartberger, K. Ingold, 1997 .

Structural resolution of 4-substituted proline diastereomers with ion mobility spectrometry via alkali metal ion cationization.

Iain D. G. Campuzano, M. Bartberger, T. Flick, 2015, Analytical chemistry.

Baseline resolution of isomers by traveling wave ion mobility mass spectrometry: investigating the effects of polarizable drift gases and ionic charge distribution.

M. Eberlin, I. Campuzano, R. J. Daroda, 2013, Journal of mass spectrometry : JMS.

Ketone-Catalyzed Decomposition of Peroxynitrite via Dioxirane Intermediates

Dan Yang, M. Bartberger, L. Olson, 1999 .

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.

Iain D G Campuzano, R. Fucini, Andrew M. Sawayama, 2019, ACS medicinal chemistry letters.

Mechanisms of peroxynitrite oxidations and rearrangements: the theoretical perspective.

K. Houk, M. Bartberger, L. Olson, 1998, Chemical research in toxicology.

Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.

H. Monenschein, M. Bartberger, Yunxin Y Bo, 2014, Journal of medicinal chemistry.

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

M. Bartberger, Yunxin Y Bo, N. Gavva, 2012, Journal of medicinal chemistry.

The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide.

K. Houk, D. Wink, N. Paolocci, 2005, Chemical research in toxicology.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.

R. Kunz, S. Chmait, M. Bartberger, 2014, Journal of medicinal chemistry.

The reduction potential of nitric oxide (NO) and its importance to NO biochemistry

K. Houk, D. Wink, C. Switzer, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.

Xin Huang, Paul Shaffer, Daqing Sun, 2014, ACS medicinal chemistry letters.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic α-Quaternary Ketones.

B. Stoltz, M. Bartberger, S. Virgil, 2017, Organic letters.

Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines.

B. Stoltz, M. Bartberger, E. Welin, 2020, ACS catalysis.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.

M. Fielden, M. Véniant, Minghan Wang, 2013, Journal of medicinal chemistry.

Insertion of Helium and Molecular Hydrogen Through the Orifice of an Open Fullerene.

K. Houk, Y. Rubin, M. Saunders, 2001, Angewandte Chemie.

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

R. Wahl, Jiandong Zhang, S. Chmait, 2013, Nature.

Ir-Catalyzed Asymmetric Allylic Alkylation of Dialkyl Malonates Enabling the Construction of Enantioenriched All-Carbon Quaternary Centers.

B. Stoltz, M. Bartberger, Zachary P Sercel, 2022, Journal of the American Chemical Society.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.

S. Chmait, M. Bartberger, S. Jordan, 2014, Journal of medicinal chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.

R. Kunz, Jiandong Zhang, S. Chmait, 2014, Journal of medicinal chemistry.

On the acidity and reactivity of HNO in aqueous solution and biological systems

K. Houk, M. Bartberger, J. Fukuto, 2001, Proceedings of the National Academy of Sciences of the United States of America.

2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.

Jiandong Zhang, E. Homan, Meredith Williams, 2008, Journal of medicinal chemistry.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Xin Huang, Paul Shaffer, Steve Schneider, 2013, Journal of medicinal chemistry.

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.

Xin Huang, Klaus Michelsen, Michael D Bartberger, 2009, Journal of medicinal chemistry.

Nitroxyl disulfides, novel intermediates in transnitrosation reactions.

J. Stamler, K. Houk, E. Toone, 2003, Journal of the American Chemical Society.

S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates.

J. Stamler, K. Houk, E. Toone, 2001, Journal of the American Chemical Society.

The chemical biology of HNO signaling.

M. Bartberger, J. Fukuto, J. Toscano, 2017, Archives of biochemistry and biophysics.

Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.

Jiandong Zhang, R. Hungate, M. Véniant, 2008, Journal of medicinal chemistry.

Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocks via palladium-catalyzed decarboxylative allylic alkylation of cyclic siloxyketones†

B. Stoltz, M. Bartberger, Aurapat Ngamnithiporn, 2020, Chemical science.

The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

Jiandong Zhang, R. Hungate, Meredith Williams, 2007, Bioorganic & medicinal chemistry letters.

Accelerating effect of triazolyl and related heteroaryl substituents on SNAr reactions: evidence of hydrogen-bond stabilized transition states.

M. Bartberger, Wenyuan Qian, Hao Wang, 2015, Journal of the American Chemical Society.

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.

Sean P. Brown, J. Medina, M. Bartberger, 2013, ACS medicinal chemistry letters.

C62, a Non-Classical Fullerene Incorporating a Four-Membered Ring

Charles L. Wilkins, Kendall N. Houk, Yves Rubin, 2000 .

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.

N. Chen, D. Whittington, M. Bartberger, 2020, Bioorganic & medicinal chemistry letters.

Peroxynitrate and peroxynitrite: a complete basis set investigation of similarities and differences between these NOx species.

K. Houk, M. Bartberger, L. Olson, 2003, Journal of the American Chemical Society.

Peroxynitrate and Peroxynitrite: A Complete Basic Set Investigation of Similarities and Differences Between These NOx Species.

K. Houk, M. Bartberger, L. Olson, 2003 .

One-pot microwave assisted preparation of pyrazoloquinazolinone libraries

Thomas E. Vasquez, C. Hulme, B. Chenera, 2004, Molecular diversity.

The Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in vivo Selectivity over BACE2.

D. Whittington, Michael G. Johnson, M. Bartberger, 2020, Journal of medicinal chemistry.

Stacking with No Planarity?

Hakan Gunaydin, Michael D Bartberger, M. Bartberger, 2016, ACS medicinal chemistry letters.

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.

Yuan Cheng, D. Whittington, M. Bartberger, 2017, MedChemComm.

Divergent Catalysis: Catalytic Asymmetric [4+2] Cycloaddition of Palladium Enolates

W. Goddard, B. Stoltz, M. Bartberger, 2023, Journal of the American Chemical Society.

Crankshaft motion in a highly congested bis(triarylmethyl)peroxide.

K. Houk, M. Bartberger, M. Garcia‐Garibay, 2004, Journal of the American Chemical Society.

N-substituted azaindoles as potent inhibitors of Cdc7 kinase.

Guomin Yao, M. Bartberger, E. Doherty, 2013, Bioorganic & medicinal chemistry letters.

Reactions of 1,3-Dibromo-1,1-difluoro Compounds with 1,8-Diazabicyclo[5.4.0]undec-7-ene.

S. Elsheimer, M. Bartberger, M. D. Bartberger, 1996, The Journal of organic chemistry.