D. Bohmann

发表

Declining signal dependence of Nrf2‐MafS‐regulated gene expression correlates with aging phenotypes

R. Bodmer, M. M. Rahman, G. Sykiotis, 2013, Aging cell.

The genomic response of the Drosophila embryo to JNK signaling.

V. Beneš, W. Ansorge, C. Schwager, 2001, Developmental cell.

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons

Z. Navratilova, P. Etter, M. Ramaswami, 2005, BMC Neuroscience.

Drosophila Jun mediates Ras-dependent photoreceptor determination

M. C. Ellis, L. Staszewski, M. Mlodzik, 1994, Cell.

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

G. Sykiotis, D. Bohmann, 2010, Science Signaling.

The SV40 enhancer influences viral late transcription in vitro and in vivo but not on replicating templates.

P. Shaw, D. Bohmann, A. Sergeant, 1985, The EMBO journal.

Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements.

H. Schöler, P. Gruss, D. Bohmann, 1986, The EMBO journal.

Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.

B. Biteau, H. Jasper, D. Bohmann, 2011, Cell stem cell.

Methylation of the phosphatase‐transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies

J. Hansen, Haitao Li, D. Bohmann, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SIRT 6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species Graphical

Zhengdong D. Zhang, B. Kennedy, V. Gladyshev, 2019 .

An essential function of AP-1 heterodimers in Drosophila development

L. Ciapponi, D. Bohmann, 2002, Mechanisms of Development.

Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors.

A. Papavassiliou, D. Bohmann, K. Bohmann, 1992, Analytical biochemistry.

Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression.

D. Bohmann, 1990, Cancer cells.

Toward the computable transcriptome.

D. Portman, D. Bohmann, 2004, Molecular cell.

Structure and regulation of the growth arrest-specific (gas-1) promoter.

A. Papavassiliou, L. Philipson, D. Bohmann, 1993, The Journal of biological chemistry.

Preserving transcriptional stress responses as an anti‐aging strategy

Julia Wang, D. Bohmann, Yang Cheng, 2021, Aging cell.

The deubiquitination enzyme Fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development

A. Isaksson, M. Mlodzik, D. Bohmann, 1997, Mechanisms of Development.

A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture

D. Bohmann, Nirmalya Chatterjee, 2012, PloS one.

JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

H. Jasper, D. Bohmann, Meng C. Wang, 2005, Cell.

Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation.

A. Musti, D. Bohmann, M. Treier, 1996, Biological chemistry.

Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.

D. Bohmann, M. Uhlirova, Qiong Wang, 2010, Developmental cell.

Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.

I. Davydov, P. Krammer, M. Li‐Weber, 1995, Gene.

Counting the Minutes

S. Mello, D. Bohmann, Stephano S. Mello, 2020, eLife.

Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun.

A. Papavassiliou, D. Bohmann, M. Treier, 1992, Science.

Intramolecular signal transduction in c‐Jun.

D. Bohmann, M. Treier, A. Papavassiliou, 1995, The EMBO journal.

Repression of AP-1-stimulated transcription by c-Ets-1.

Yoav Goldberg, J. Ghysdael, D. Bohmann, 1994, The Journal of biological chemistry.

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

R. Tjian, A. Admon, P. Vogt, 1987, Science.

Fos-associated protein p39 is the product of the jun proto-oncogene.

R. Tjian, B. Franza, T. Curran, 1988, Science.

Differential regulation of c‐Jun by ERK and JNK during PC12 cell differentiation

W. Ansorge, S. Leppä, R. Saffrich, 1998, The EMBO journal.

JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila

D. Bohmann, M. Uhlirova, 2006, The EMBO journal.

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes

H. Schöler, T. Dale, W. Keller, 1987, Nature.

A transcription enhancer acts in vitro over distances of hundreds of base-pairs on both circular and linear templates but not on chromatin-reconstituted DNA.

H. Zentgraf, W. Keller, D. Bohmann, 1984, Journal of molecular biology.

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila.

G. Sykiotis, D. Bohmann, 2008, Developmental cell.

Deregulated Repression of c-Jun Provides a Potential Link to its Role in Tumorigenesis

C. Weiss, D. Bohmann, 2004, Cell cycle.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Zhengdong D. Zhang, B. Kennedy, V. Gladyshev, 2019, Cell.

BET‐ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors

D. Bohmann, Nirmalya Chatterjee, 2018, BioEssays : news and reviews in molecular, cellular and developmental biology.

Transrepression of AP-1 by nuclear receptors in Drosophila

J. Brennecke, C. Weiss, D. Bohmann, 2002, Mechanisms of Development.

Drosophila AP-1: lessons from an invertebrate

D. Bohmann, L. Kockel, Jason Homsy, 2001, Oncogene.

The DEXD/H‐box RNA helicase RHII/Gu is a co‐factor for c‐Jun‐activated transcription

B. Séraphin, W. Ansorge, A. Musti, 2002, The EMBO journal.

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Dirk Bohmann, S. Leppä, D. Bohmann, 1999, Oncogene.

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein

Michael Boutros, Kerstin Spirohn, Dirk Bohmann, 2016, PLoS genetics.

JNK phosphorylation relieves HDAC3‐dependent suppression of the transcriptional activity of c‐Jun

E. Wagner, E. Seto, X. Zhang, 2003, The EMBO journal.

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation

D. Bonofiglio, A. Musti, A. Vivacqua, 2002, Oncogene.

Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells

W. Ansorge, M. Eriksson, S. Leppä, 2001, Molecular and Cellular Biology.

Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites.

D. B. Jackson, L. Ciapponi, M. Mlodzik, 2001, Genes & development.

Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants

J. Zeitlinger, D. B. Jackson, M. Mlodzik, 1997, The EMBO journal.

Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways.

J. Zeitlinger, L. Staszewski, M. Mlodzik, 1997, Genes & development.

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

Dirk Bohmann, A. Musti, D. Bohmann, 1997, Science.

Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation.

P. Plastina, A. Papavassiliou, A. Isaksson, 1996, The EMBO journal.

Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun

R. Tjian, D. Bohmann, 1989, Cell.

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye

Marek Mlodzik, Dirk Bohmann, M. Mlodzik, 1995, Cell.

Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.

H. Jasper, D. Bohmann, M. Uhlirova, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation

O. Puig, Xi Luo, H. Jasper, 2007, The EMBO journal.

A nuclear tyrosine phosphorylation circuit: c‐Jun as an activator and substrate of c‐Abl and JNK

G. Superti-Furga, R. Mangano, S. Gonfloni, 2000, The EMBO journal.

Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription.

G. Tebb, I. Mattaj, D. Bohmann, 1987, Nucleic acids research.

Cell-Type Specificity of Transcription: The Immunoglobulin Heavy Chain Enhancer as a Model System

W. Schaffner, P. Matthias, D. Bohmann, 1987 .

Mechanisms and functions of Nrf2 signaling in Drosophila.

D. Bohmann, Andrew Pitoniak, 2015, Free radical biology & medicine.

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

L. Staszewski, D. Bohmann, M. Treier, 1994, Cell.

The role of the Drosophila TAK homologue dTAK during development

J. Mihály, M. Mlodzik, D. Bohmann, 2001, Mechanisms of Development.

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.

L. Staszewski, D. Bohmann, M. Treier, 1994, Cell.

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

Hai Wu, D. Bohmann, Meng C. Wang, 2009, Mechanisms of Development.

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.

H. Jasper, D. Bohmann, Meng C. Wang, 2003, Developmental cell.

Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.

B. Miotto, Y. Graba, D. Bohmann, 2006, Genes & development.

c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.

M. Al-Rawi, C. Weiss, D. Bohmann, 2011, Biochemical and biophysical research communications.

Modulation of Oxidative Stress by Keap1/Nrf2 Signaling in Drosophila: Implications for Human Diseases

G. Sykiotis, D. Bohmann, Mahidur Rahman, 2011 .

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Petra Sekyrová, D. Bohmann, M. Jindra, 2010, Development.

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

A. Samuelson, G. Sykiotis, D. Bohmann, 2011, Current opinion in clinical nutrition and metabolic care.

Redox Regulation of Stem Cell Function

H. Jasper, D. Bohmann, 2013 .

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway

M. O’Reilly, C. Weiss, D. Bohmann, 2004, The EMBO journal.

Computational systems biology of aging

Andres Kriete, Dirk Bohmann, A. Kriete, 2011, Wiley interdisciplinary reviews. Systems biology and medicine.

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes

M. Boutros, Kerstin Spirohn, D. Bohmann, 2016, Scientific Reports.

Cdk 12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome , Including Nrf 2 Target Genes

M. Boutros, Kerstin Spirohn, D. Bohmann, 2016 .

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

M. Carmo-Fonseca, M. Berciano, J. Tavanez, 2002, Molecular biology of the cell.

Functional dissection of AP-1 transcription factors using the Gal4 adaptor assay.

D. Bohmann, S. E. Smith, 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.

V. Beneš, W. Ansorge, H. Jasper, 2002, Developmental cell.

Stress-activated Protein Kinase Signaling in Drosophila

G. Sykiotis, D. Bohmann, 2007 .

Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

V. Gorgoulis, I. Trougakos, E. Terpos, 2013, Aging cell.

Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.

V. Beneš, W. Ansorge, D. B. Jackson, 1999, Journal of cell science.

Transcriptional regulation by the AP-1 family of enhancer-binding proteins: a nuclear target for signal transduction.

R. Tjian, A. Admon, D. Bohmann, 1988, Cold Spring Harbor symposia on quantitative biology.

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

H. Jäckle, M. Mlodzik, D. Bohmann, 1997, Genes & development.

Ubiquitin in signal transduction and cell transformation.

A. Musti, A. Isaksson, D. Bohmann, 1996, Biochimica et biophysica acta.

Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites.

A. Papavassiliou, D. Bohmann, C. Chavrier, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells.

M. F. Shannon, P. Cockerill, D. Bohmann, 1995, Journal of immunology.

Thorax closure in Drosophila: involvement of Fos and the JNK pathway.

J. Zeitlinger, D. Bohmann, Julia Zeitlinger, 1999, Development.

Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.

D. Bohmann, M. Barone, 2013, Journal of visualized experiments : JoVE.

DREF Is Required for Efficient Growth and Cell Cycle Progression in Drosophila Imaginal Discs

H. Jasper, D. Bohmann, Joogyung Hyun, 2005, Molecular and Cellular Biology.

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

P. Vogt, H. Tsuchie, D. Bohmann, 1988, Cell.

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease

G. Sykiotis, D. Bohmann, M. Barone, 2011, Disease Models & Mechanisms.

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis

H. Jasper, D. Kiehart, Hai Wu, 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

V. Gorgoulis, I. Trougakos, I. Papassideri, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dephosphorylation of phosphoproteins with potato acid phosphatase

A. Papavassiliou, D. Bohmann, 1992 .

Control of G2/M Transition by Drosophila Fos

D. Bohmann, Isabelle Bécam, Joogyung Hyun, 2006, Molecular and Cellular Biology.

Different TRE-related elements are distinguished by sets of DNA-binding proteins with overlapping sequence specificity.

A. Papavassiliou, D. Bohmann, S. E. Smith, 1993, Nucleic acids research.

A CREB‐binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

D. B. Jackson, M. Bienz, D. Bohmann, 1997, The EMBO journal.

Sec 61 β , a subunit of the protein translocation channel , is required during Drosophila development

V. Beneš, W. Ansorge, D. B. Jackson, 1999 .

Drosophila innate immunity: a genomic view of pathogen defense.

H. Jasper, D. Bohmann, 2002, Molecular cell.

Small flies—Big discoveries: Nearly a century of Drosophila genetics and development

Dirk Bohmann, A. Letsou, D. Bohmann, 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

G. Sykiotis, D. Bohmann, 2010, Science Signaling.

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Petra Sekyrová, D. Bohmann, M. Jindra, 2010, Development.

Mechanisms and functions of Nrf2 signaling in Drosophila.

D. Bohmann, Andrew Pitoniak, 2015, Free radical biology & medicine.

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

V. Gorgoulis, I. Trougakos, I. Papassideri, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.