H. Van Remmen

发表

Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.

R. Hamilton, Michael E Walsh, H. Van Remmen, 2012, Journal of clinical & experimental pathology.

Does oxidative damage to DNA increase with age?

Zhongmao Guo, H. Van Remmen, M. Hamilton, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

M. Emond, P. Rabinovitch, D. Wallace, 2005, Science.

Trends in oxidative aging theories.

F. Muller, A. Richardson, H. Van Remmen, 2007, Free radical biology & medicine.

Is the oxidative stress theory of aging dead?

A. Bokov, V. Pérez, A. Richardson, 2009, Biochimica et biophysica acta.

Comparative studies of oxidative stress and mitochondrial function in aging.

Yun Shi, R. Buffenstein, H. Van Remmen, 2010, Integrative and comparative biology.

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

T. D. Pugh, R. Weindruch, T. Prolla, 2005, Science.

G protein‐coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress

H. Van Remmen, C. Ferrario, Hao Wang, 2018, Translational research : the journal of laboratory and clinical medicine.

Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle

W. Freeman, Dustin R Masser, H. Van Remmen, 2016, AGE.

Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts.

Hong-Mei Zhang, Yun Shi, Yiqiang Zhang, 2010, Free radical biology & medicine.

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.

F. Muller, T. Shirasawa, Takahiko Shimizu, 2012, Biochemical and biophysical research communications.

Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice

J. Wren, W. Fok, Vivian Diaz, 2018, Aging cell.

Rapamycin extends life and health in C57BL/6 mice.

S. Austad, W. Ward, A. Bokov, 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling.

H. Van Remmen, D. Claflin, S. Brooks, 2021, Free radical biology & medicine.

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.

C. Epstein, M. Csete, J. Faulkner, 2006, Free radical biology & medicine.

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase.

A. Salmon, Arlan Richardson, H. Van Remmen, 2013, Biochemical and biophysical research communications.

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

O. Ilkayeva, C. Newgard, A. Olson, 2016, Diabetes.

Microwave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury.

C. Jaramillo, A. Lin, J. Gelfond, 2014, Translational proteomics.

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates.

F. Muller, M. Abdul-Ghani, H. Van Remmen, 2008, The Biochemical journal.

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

E. White, Xin Zhang, D. G. Pestov, 2021, Nature Communications.

Mitochondrial dysfunction in aging and longevity: a causal or protective role?

H. Van Remmen, D. Pulliam, A. Bhattacharya, 2013, Antioxidants & redox signaling.

D. C. Cabelof, L. Matherly, H. Van Remmen, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes

H. Chung, B. Yu, A. Richardson, 1996, Journal of cellular physiology.

Dietary restriction attenuates age‐associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

F. Muller, E. Verdin, A. Richardson, 2012, Aging cell.

Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity

J. Faulkner, H. Remmen, M. Jackson, 2006, Aging cell.

Current thoughts on the role of mitochondria and free radicals in the biology of aging.

Dean P. Jones, H. Van Remmen, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice

K. Sataranatarajan, H. Van Remmen, David E. Lee, 2018, Journal of cachexia, sarcopenia and muscle.

P. Rabinovitch, A. Bartke, G. Martin, 2005, Experimental eye research.

Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis.

C. Epstein, H. Yang, A. Richardson, 2001, American journal of physiology. Heart and circulatory physiology.

Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse.

C. Epstein, H. Remmen, H. Yang, 1999, Archives of biochemistry and biophysics.

MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart.

J. Lawler, A. Richardson, H. Van Remmen, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Yun Shi, M. Jackson, Yiqiang Zhang, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice

A. Salmon, A. Richardson, H. Van Remmen, 2012, Pathobiology of aging & age related diseases.

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Yun Shi, M. Jackson, Yiqiang Zhang, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of superoxide–nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase

F. McArdle, M. Jackson, A. Richardson, 2011, Aging cell.

M. Jackson, A. Richardson, A. McArdle, 2010, Aging cell.

Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

S. Austad, S. Shoelson, P. Osmulski, 2017, Aging cell.

Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs β-Cell Function

R. DeFronzo, G. Weir, G. Muscogiuri, 2013, Diabetes.

PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

Huiyun Liang, W. Ward, A. Bokov, 2011, Muscle & nerve.

Catalase transgenic mice: characterization and sensitivity to oxidative stress.

J. Vijg, A. Richardson, Xinlian Chen, 2004, Archives of biochemistry and biophysics.

Role of mitochondrial superoxide dismutase in contraction-induced generation of reactive oxygen species in skeletal muscle extracellular space.

C. Epstein, J. Faulkner, M. Jackson, 2004, American journal of physiology. Cell physiology.

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes.

T. Prolla, A. Richardson, L. Roberts, 2003, Free radical biology & medicine.

Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

B. Nair, W. Fok, Michael E Walsh, 2016, Free radical biology & medicine.

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

D. Borchelt, A. Richardson, H. Van Remmen, 2008, Muscle & nerve.

Formation of 3‐nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

J. Faulkner, R. Beynon, D. Simpson, 2007, Proteomics. Clinical applications.

Butyrate prevents muscle atrophy after sciatic nerve crush

Michael E Walsh, H. Van Remmen, Yuhong Liu, 2015, Muscle & nerve.

Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels.

W. Ward, A. Richardson, L. Roberts, 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

Oxidative Damage to DNA and Aging

A. Richardson, H. Van Remmen, M. Hamilton, 2003, Exercise and sport sciences reviews.

Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.

H. Remmen, A. Richardson, H. Van Remmen, 1995, The Journal of nutrition.

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

A. Richardson, R. Strong, James L. Roberts, 2006, Journal of neuroscience research.

Effect of cAMP-induced transcription on the repair of the phosphoenolpyruvate carboxykinase gene by hepatocytes isolated from young and old rats.

A. Richardson, H. Van Remmen, W. Wu, 1998, Mutation research.

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.

H. Van Remmen, M. Ivannikov, 2015, Free radical biology & medicine.

Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice

L. Suva, M. Ronis, T. Badger, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

A. Richardson, H. Van Remmen, D. Claflin, 2018, Journal of cachexia, sarcopenia and muscle.

Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells.

M. Csete, J. Faulkner, F. McArdle, 2006, Free Radical Biology & Medicine.

H. Van Remmen, Hongyang Xu, S. Bhaskaran, 2022, Frontiers in Aging Neuroscience.

Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems

Jeongmoon J. Choi, Jeongmoon J Choi, F. Muller, 2020, GeroScience.

Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.

M. Jackson, A. Richardson, A. McArdle, 2018, Antioxidants & redox signaling.

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

H. Van Remmen, D. Claflin, S. Brooks, 2021, International journal of molecular sciences.

Removal of p16 INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

J. Markworth, A. McArdle, H. Van Remmen, 2022, Frontiers in Aging.

Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice

Michael P. Siegel, R. Beyer, A. Salmon, 2011, PloS one.

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock

A. Richardson, H. Van Remmen, J. Charchaflieh, 2012, Journal of inflammation research.

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.

V. Pérez, A. Richardson, H. Van Remmen, 2008, Free radical biology & medicine.

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury

D. S. St. Clair, H. Van Remmen, T. Oberley, 2011, PloS one.

Immune Cell Toll-Like Receptor 4 Is Required for Cardiac Myocyte Impairment During Endotoxemia

Samantha A. Tavener, P. Kubes, S. Robbins, 2004, Circulation research.

Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and Demyelination

Yun Shi, Yiqiang Zhang, R. Buffenstein, 2013, PloS one.

Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

Patrick D. Shipman, T. Griffin, P. Shipman, 2021, Journal of cachexia, sarcopenia and muscle.

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

H. Van Remmen, S. S. Deepa, Sabira Mohammed, 2022, bioRxiv.

Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

T. Griffin, A. Batushansky, Shouan Zhu, 2021, Cartilage.

Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

T. Griffin, A. Batushansky, Shouan Zhu, 2020, bioRxiv.

The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice

C. Jaramillo, Yun Shi, Yiqiang Zhang, 2014, PloS one.

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria.

Yun Shi, H. Van Remmen, M. Lustgarten, 2011, Free radical biology & medicine.

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

K. Sataranatarajan, M. Jackson, Yiqiang Zhang, 2015, Redox biology.

Protein misfolding, mitochondrial dysfunction and muscle loss are not directly dependent on soluble and aggregation state of mSOD1 protein in skeletal muscle of ALS.

H. Van Remmen, A. Chaudhuri, Yuhong Liu, 2012, Biochemical and biophysical research communications.

Changes in Expression of Antioxidant Enzymes Affect Cell-Mediated LDL Oxidation and Oxidized LDL-Induced Apoptosis in Mouse Aortic Cells

C. Epstein, J. Vijg, Y. Ho, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity

K. Sataranatarajan, H. Van Remmen, M. Beckstead, 2022, bioRxiv.

Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia

W. Freeman, M. Kinter, H. Van Remmen, 2022, Aging cell.

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

T. Griffin, W. Freeman, A. Richardson, 2019, Journal of cachexia, sarcopenia and muscle.

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

T. Kiss, S. Tarantini, Z. Ungvari, 2018, Redox biology.

Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction‐induced fatigue or recovery

S. Powers, I. Vrabas, Wook Song, 2010, Experimental physiology.

Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

J. Wren, V. O’Donnell, C. Georgescu, 2022, Redox biology.

GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis.

F. Regnier, F. Muller, Alexander B. Taylor, 2008, Journal of molecular biology.

Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

J. Wren, C. Georgescu, H. Van Remmen, 2020, International journal of molecular sciences.

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

Arlan Richardson, H. Van Remmen, Hongyang Xu, 2021, Journal of cachexia, sarcopenia and muscle.

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

J. Faulkner, M. Jackson, A. Richardson, 2019, Free radical biology & medicine.

The anti-ageing action of dietary restriction.

A. Richardson, H. Van Remmen, Z. Guo, 2001, Novartis Foundation symposium.

Raising the antioxidant levels within mouse muscle fibres does not affect contraction‐induced injury

J. Faulkner, Wook Song, A. Richardson, 2006, Experimental physiology.

A novel approach for screening the proteome for changes in protein conformation.

A. Richardson, H. Van Remmen, A. Chaudhuri, 2006, Biochemistry.

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

Tommy L. Lewis, S. Plafker, N. Smith, 2022, Redox biology.

Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation

H. Van Remmen, B. Ahn, Hongyang Xu, 2022, Science advances.

Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

M. Jackson, A. Richardson, A. McArdle, 2020, Aging cell.

Insulin resistance is a cellular antioxidant defense mechanism

D. James, N. Turner, G. Cooney, 2009, Proceedings of the National Academy of Sciences.

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.

Wook Song, A. Richardson, J. Lechleiter, 2009, Free radical biology & medicine.

Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane*

F. Muller, H. Van Remmen, Yuhong Liu, 2004, Journal of Biological Chemistry.

Methionine oxidation and aging.

Arlan Richardson, E. Stadtman, R. Levine, 2005, Biochimica et biophysica acta.

Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis*

A. Richardson, L. Roberts, B. Herman, 2004, Journal of Biological Chemistry.

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

L. McManus, F. Muller, T. Shirasawa, 2009, American journal of physiology. Cell physiology.

Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA-Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells

Ting-Ting Huang, A. Richardson, H. Van Remmen, 2011, Cancer Prevention Research.

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome.

D. C. Cabelof, J. Taub, L. Matherly, 2009, Blood.

Gpx4 protects mitochondrial ATP generation against oxidative damage.

A. Richardson, J. Lechleiter, H. Van Remmen, 2007, Biochemical and biophysical research communications.

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.

A. Richardson, H. Van Remmen, Qitao Ran, 2012, Free radical biology & medicine.

Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.

F. Muller, Wook Song, A. Richardson, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

C. Epstein, J. Vijg, A. Bokov, 2008, Aging cell.

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase

T. Aw, Ting-Ting Huang, A. Richardson, 2012, Cancer science.

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells.

K. Lew, H. Van Remmen, D. Ferrington, 2006, Experimental eye research.

Role of Signaling Molecules in Mitochondrial Stress Response

K. Sataranatarajan, H. Van Remmen, Shauna Hill, 2018, Front. Genet..

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

P. Dahia, T. Shirasawa, Takahiko Shimizu, 2011, Aging cell.

Overexpression of Mn superoxide dismutase does not increase life span in mice.

C. Epstein, Wook Song, A. Salmon, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

M. Zeviani, Yun Shi, N. Musi, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging

M. Csete, H. Van Remmen, Sukkyoo Lee, 2009, Aging cell.

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

W. Freeman, M. Kinter, L. Szweda, 2018, Molecular metabolism.

Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function

M. Kinter, H. Van Remmen, Sreemathi Logan, 2019, Molecular Neurobiology.

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

S. Austad, Z. Ungvari, Yun Shi, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Cancer cachexia in a mouse model of oxidative stress

Chase A. Brown, B. Miller, A. Richardson, 2020, Journal of cachexia, sarcopenia and muscle.

Muscle fiber type diversification during exercise and regeneration.

H. Van Remmen, R. Qaisar, S. Bhaskaran, 2016, Free radical biology & medicine.

Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione

K. Sataranatarajan, H. Van Remmen, M. Beckstead, 2023, Neuropharmacology.

Analysis of the transcriptional activity of the 5′‐flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice

H. Van Remmen, C. Walter, A. Richardson, 1998, Journal of cellular physiology.

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

Yan Li, Arlan Richardson, Alex Bokov, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse

S. Espinoza, M. Jackson, A. Richardson, 2017, GeroScience.

The role of insulin and insulin-like growth factor-I in mammalian ageing.

F. Liu, J. Nelson, M. Adamo, 2004, Best practice & research. Clinical endocrinology & metabolism.

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.

C. Epstein, G. Freeman, Hong Yang, 2004, Free radical biology & medicine.

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

C. Epstein, M. Pahlavani, Ting-Ting Huang, 2003, Physiological genomics.

Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice

Caroline S. Kinter, K. Sataranatarajan, M. Kinter, 2019, Front. Neurosci..

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.

Arlan Richardson, Hanyu Liang, T. Prolla, 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.

Dean P. Jones, K. Tominaga, J. Yodoi, 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase.

J. Vijg, A. Richardson, H. Van Remmen, 2006, Antioxidants & redox signaling.

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.

Jason G. Belter, T. Prolla, A. Richardson, 2003, Free radical biology & medicine.

Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?

A. Salmon, Arlan Richardson, H. Van Remmen, 2012, Free radical biology & medicine.

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

R. DeFronzo, L. Mandarino, B. Bowen, 2011, Diabetes.

Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function

W. Freeman, J. Wren, Arlan Richardson, 2021, GeroScience.

The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

H. Van Remmen, Hongyang Xu, 2021, Skeletal Muscle.

A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis

T. Griffin, B. Miller, F. Peelor, 2021, Function.

Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice.

Yun Shi, R. Hamilton, Michael E Walsh, 2013, Journal of biochemical and pharmacological research.

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

K. Sataranatarajan, H. Van Remmen, D. Pulliam, 2016, Redox biology.

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice*

C. Epstein, H. Van Remmen, C. C. Conrad, 1998, The Journal of Biological Chemistry.

A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA.

I. Thompson, S. Austad, D. Troyer, 2001, Nucleic acids research.

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

T. Nyström, H. Bayır, K. Davies, 2022, Nature Metabolism.

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress

K. Davies, H. Van Remmen, D. Bota, 2002, FEBS letters.

Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging

H. Van Remmen, Shauna Hill, 2014, Redox Biology.

The in vivo gene expression signature of oxidative stress.

C. Epstein, F. Muller, H. Remmen, 2008, Physiological genomics.

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.

C. Epstein, D. Pessayre, B. Fromenty, 2009, Toxicology and applied pharmacology.

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.

R. DeFronzo, F. Muller, F. Folli, 2008, American journal of physiology. Endocrinology and metabolism.

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence

D. Sosnowska, Yiqiang Zhang, A. Richardson, 2016, Redox biology.

Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.

Hong-Mei Zhang, C. Jaramillo, A. Bokov, 2013, Free radical biology & medicine.

Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

A. Salmon, A. Richardson, H. Van Remmen, 2008, Aging cell.

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective.

M. Csete, H. Van Remmen, P. Shireman, 2006, Free radical biology & medicine.

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

H. Van Remmen, Y. Ikeno, G. Hubbard, 2018, Pathobiology of aging & age related diseases.

High oxidative damage levels in the longest‐living rodent, the naked mole‐rat

Rochelle Buffenstein, Anson Pierce, T. O'Connor, 2006, Aging cell.

The effects of dietary restriction on oxidative stress in rodents.

Yun Shi, Michael E Walsh, H. Van Remmen, 2014, Free radical biology & medicine.

Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics.

Arlan Richardson, F. Regnier, W. Ward, 2004, Journal of proteome research.

Lifespan extension in genetically modified mice

P. Treuting, A. Richardson, R. Strong, 2009, Aging cell.

Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation.

E. Feldman, A. Richardson, H. Van Remmen, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

K. Sataranatarajan, L. Sloane, M. Kinter, 2015, Aging cell.

Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems

Jeongmoon J. Choi, Jeongmoon J Choi, Young C. Jang, 2020, GeroScience.

Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia

Caroline S. Kinter, W. Freeman, J. Wren, 2020, GeroScience.

Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

F. Muller, A. Salmon, A. Richardson, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Emerging roles for histone deacetylases in age-related muscle atrophy

Michael E Walsh, H. Van Remmen, 2016, Nutrition and healthy aging.

Effect of aging and caloric restriction on the mitochondrial proteome.

W. Ward, A. Richardson, J. Cornell, 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing

M. Jackson, A. Richardson, A. McArdle, 2017, The Journal of physiology.

Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia

W. Freeman, J. Wren, K. Sataranatarajan, 2020, Scientific Reports.

Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice.

S. Austad, A. Richardson, L. Sloane, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation

Z. Ungvari, H. Van Remmen, Rojina Ranjit, 2020, JCSM rapid communications.

Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.

Yiqiang Zhang, R. Hamilton, H. Van Remmen, 2014, Free radical biology & medicine.

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.

A. Richardson, Lily Q. Dong, H. Van Remmen, 2009, American Journal of Physiology. Endocrinology and Metabolism.

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses.

M. Zeviani, Yun Shi, L. Sloane, 2014, The Biochemical journal.

Molecular changes associated with spinal cord aging

B. Miller, K. Sataranatarajan, M. Zalles, 2020, GeroScience.

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

K. Sataranatarajan, H. Van Remmen, R. Qaisar, 2018, Redox biology.

Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis

M. Agbaga, M. Kinter, H. Van Remmen, 2022, The Journal of Neuroscience.

Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function

M. Kinter, H. Van Remmen, Sreemathi Logan, 2019, Molecular Neurobiology.

Denervation Induces Cytosolic Phospholipase A2-mediated Fatty Acid Hydroperoxide Generation by Muscle Mitochondria*

F. Muller, Wook Song, H. Van Remmen, 2009, Journal of Biological Chemistry.

The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

H. Van Remmen, Hongyang Xu, 2021, Skeletal muscle.

Deletion of Sod1 in Motor Neurons Exacerbates Age-Related Changes in Axons and Neuromuscular Junctions in Mice

A. McArdle, H. Van Remmen, Alex Richardson, 2023, eNeuro.

Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

A. McArdle, H. Van Remmen, A. Vasilaki, 2022, bioRxiv.

Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice

P. Fox, T. Duong, M. Zeviani, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness

K. Sataranatarajan, V. O’Donnell, M. Kinter, 2023, Redox biology.

Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy

N. Smith, D. Saunders, R. Towner, 2019, Redox biology.

Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency

M. Fallahi, L. Szweda, H. Petrie, 2015, Cell reports.

Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia

H. Van Remmen, B. Ahn, Rojina Ranjit, 2022, Antioxidants.

Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells☆

V. Pérez, Y. Liu, H. Van Remmen, 2013, Redox biology.

Tumor burden negatively impacts protein turnover as a proteostatic process in non-cancerous liver, heart, and muscle, but not brain.

B. Miller, H. Van Remmen, Jacob L Brown, 2021, Journal of applied physiology.

Effect of age on induction of hepatic phosphoenolpyruvate carboxykinase by fasting.

W. Ward, H. Van Remmen, 1994, The American journal of physiology.