L. Kwong

发表

Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity.

R. S. Sohal, W. Orr, R. J. Mockett, 2003, Free Radical Biology & Medicine.

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.

J. Trojanowski, J. Plotkin, M. Grossman, 2008, Human molecular genetics.

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Bruce L. Miller, Murray Grossman, John Q. Trojanowski, 2006, Science.

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

Bin Zhang, John Q. Trojanowski, Michiyo Iba, 2013, Cell.

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies*

J. Trojanowski, A. Chen-Plotkin, M. Neumann, 2009, Journal of Biological Chemistry.

Missense mutations in exon 5 of the human lipoprotein lipase gene. Inactivation correlates with loss of dimerization.

M. Emi, A. Hata, B. Guy-grand, 1992, The Journal of biological chemistry.

Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.

J. Trojanowski, M. Grossman, C. Clark, 2007, Archives of neurology.

A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.

G. Schellenberg, T. Montine, V. Lee, 2007, Brain : a journal of neurology.

Molecular screening of the lipoprotein lipase gene in hypertriglyceridemic members of familial noninsulin-dependent diabetes mellitus families.

J. Lalouel, L. Kwong, D. Wilson, 1994, The Journal of clinical endocrinology and metabolism.

Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

J. Trojanowski, V. Lee, N. Cairns, 2007, Annals of neurology.

TDP-43 skeins show properties of amyloid in a subset of ALS cases

John L. Robinson, J. Trojanowski, V. Lee, 2012, Acta Neuropathologica.

A90V TDP‐43 variant results in the aberrant localization of TDP‐43 in vitro

G. Schellenberg, B. Miller, J. Trojanowski, 2008, FEBS letters.

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.

J. Trojanowski, V. Lee, M. Neumann, 2007, Archives of neurology.

Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.

W. Samlowski, L. Kwong, J. Ward, 1997, The Journal of clinical endocrinology and metabolism.

TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease

J. Trojanowski, V. Lee, M. Neumann, 2007, Acta Neuropathologica.

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration

J. Trojanowski, M. Grossman, V. Lee, 2017, Acta Neuropathologica.

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

J. Trojanowski, M. Grossman, C. Clark, 2008, Journal of neuropathology and experimental neurology.

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

J. Trojanowski, M. Grossman, C. Clark, 2008, The American journal of pathology.

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation*

J. Trojanowski, V. Lee, L. Kwong, 2008, Journal of Biological Chemistry.

Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice.

R. S. Sohal, M. Forster, L. Kwong, 1999, Free radical biology & medicine.

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

J. Trojanowski, J. Phillips, M. Grossman, 2016, Acta Neuropathologica.

Plasma apolipoprotein E, high density lipoprotein1 (HDL1) and urinary mevalonate excretion in pancreatectomized diabetic dogs: effects of insulin and lovastatin.

A. Alberts, L. Kwong, D. Wilson, 1990, Atherosclerosis.

Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat.

R. S. Sohal, C. Jana, M. Forster, 2002, Free radical biology & medicine.

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43

J. Trojanowski, V. Lee, L. Kwong, 2015, Acta Neuropathologica.

R. S. Sohal, L. Kwong, 2000, Archives of biochemistry and biophysics.

The nature of maturational decline of intestinal lactase activity.

D. Stevenson, P. Sunshine, L. Kwong, 1985, Biochimica et biophysica acta.

Intestinal and Hepatic Cholesterogenesis in Hypercholesterolemic Dyslipidemia of Experimental Diabetes in Dogs

J. D. Karkas, K. Feingold, A. Alberts, 1991, Diabetes.

Tauopathy with hippocampal 4‐repeat tau immunoreactive spherical inclusions: a report of three cases

J. Trojanowski, M. Grossman, V. Lee, 2018, Brain pathology.

Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease

J. Trojanowski, V. Lee, E. Zimmerman, 2007, Acta Neuropathologica.

Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.

J. Trojanowski, V. Lee, S. Xie, 2008, Archives of neurology.

Diabetes increases hepatic hydroxymethyl glutaryl coenzyme A reductase protein and mRNA levels in the small intestine.

K. Feingold, C. Grunfeld, A. Moser, 1994, Metabolism: clinical and experimental.

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration

J. Trojanowski, G. Dreyfuss, V. Lee, 2007, Acta Neuropathologica.

Pathological TDP-43 in parkinsonism–dementia complex and amyotrophic lateral sclerosis of Guam

J. Trojanowski, D. Perl, D. Galasko, 2007, Acta Neuropathologica.

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

J. Trojanowski, D. Irwin, L. Kwong, 2014, Acta neuropathologica communications.

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice

J. Trojanowski, V. Lee, L. Kwong, 2016, Acta Neuropathologica Communications.

Targeting Amyloid-β Peptide (Aβ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Aβ Precursor Protein (APP) Transgenic Mice*

J. Trojanowski, T. Abel, Eddie B. Lee, 2006, Journal of Biological Chemistry.

Tissue-specific mitochondrial production of H2O2: its dependence on substrates and sensitivity to inhibitors.

R. S. Sohal, L. Kwong, 2002, Methods in enzymology.

Hydrogen gas excretion after sucrose gavage in the fasted rat.

D. Stevenson, L. Kwong, H. Vreman, 1984, The American journal of clinical nutrition.

Decreased mitochondrial hydrogen peroxide release in transgenic Drosophila melanogaster expressing intramitochondrial catalase.

R. S. Sohal, W. Orr, R. J. Mockett, 2000, Archives of biochemistry and biophysics.

Antiproliferative agents and differential survival between normal and cancer cells.

L. Kwong, K. Tsuboi, 1978, Cancer research.

Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.

L. Kwong, K. Tsuboi, N. Edmunds, 1977, Cancer research.

TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

J. Trojanowski, M. Grossman, V. Lee, 2012, The Journal of Neuroscience.

Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion

John L. Robinson, J. Trojanowski, M. Grossman, 2012, Acta Neuropathologica.

Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases

J. Trojanowski, V. Lee, S. Porta, 2015, Journal of neuropathology and experimental neurology.

TMEM106B,theRiskGeneforFrontotemporalDementia,Is RegulatedbythemicroRNA-132/212ClusterandAffects ProgranulinPathways

L. Kwong, Y. Lee, M. Gallagher, 2012 .

The acetylation of tau inhibits its function and promotes pathological tau aggregation.

J. Trojanowski, V. Lee, L. Kwong, 2011, Nature communications.

Detection of gastric contents in tracheal fluid of infants by lactose assay.

D. Stevenson, R. Ariagno, L. Kwong, 1983, The Journal of pediatrics.

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

J. Trojanowski, Eddie B. Lee, S. Porta, 2018, Nature Communications.

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice.

J. Trojanowski, L. Kwong, A. Walker, 2015, Human molecular genetics.

Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases

John Q. Trojanowski, Maria Martinez-Lage, J. Trojanowski, 2009, Journal of Neurology.

Clinical and pathological continuum of multisystem TDP-43 proteinopathies.

John L. Robinson, J. Trojanowski, M. Grossman, 2009, Archives of neurology.

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.

J. Morris, J. Trojanowski, V. Lee, 2007, The American journal of pathology.

Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.

J. Trojanowski, M. Grossman, V. Lee, 2006, The American journal of pathology.

Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria.

R. S. Sohal, L. Kwong, R S Sohal, 1998, Archives of biochemistry and biophysics.

Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

Murray Grossman, John L. Robinson, J. Trojanowski, 2013, Annals of neurology.

Intestinal lactase in the neonatal rat. Maturational changes in intracellular processing and brush-border degradation.

L. Kwong, G. M. Gray, K. Tsuboi, 1990, Journal of Biological Chemistry.

Maturational patterns of carbohydrases in the ileal remnant of rats after jejunectomy at infancy.

P. Sunshine, L. Kwong, K. Tsuboi, 1988, American Journal of Clinical Nutrition.

Sugar hydrolases of the infant rat intestine and their arrangement of the brush border membrane.

P. Sunshine, L. Kwong, K. Tsuboi, 1979, Biochimica et biophysica acta.

Effects of hydrocortisone on carbohydrase concentrations, de novo synthesis and turnover patterns in immature rat intestine

P. Sunshine, L. Kwong, K. Tsuboi, 1986, Cell biochemistry and function.

Alterations in Postnatal Intestinal Function during Chronic Hypoxemia

D. Bernstein, L. Kwong, R. Castillo, 1992, Pediatric Research.

Altered maturation of small intestinal function in the absence of intraluminal nutrients: rapid normalization with refeeding.

D. Stevenson, L. Kwong, R. Castillo, 1991, The American journal of clinical nutrition.

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

J. Trojanowski, V. Lee, E. Kremmer, 2009, Acta Neuropathologica.

Carbon monoxide in blood: an improved microliter blood-sample collection system, with rapid analysis by gas chromatography.

D. Stevenson, L. Kwong, H. Vreman, 1984, Clinical chemistry.

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

J. Trojanowski, T. Abel, Eddie B. Lee, 2006, The Journal of biological chemistry.

Nature of elevated rat intestinal carbohydrase activities after high-carbohydrate diet feeding.

O. Koldovský, P. Sunshine, L. Kwong, 1985, The American journal of physiology.

A proposed mechanism of normal intestinal lactase decline in the postweaned mammal.

J. Neu, P. Sunshine, L. Kwong, 1981, Biochemical and biophysical research communications.

Delayed ontogenic development in the bypassed ileum of the infant rat

T. Colby, P. Sunshine, L. Kwong, 1981 .

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

John L. Robinson, J. Trojanowski, M. Grossman, 2017, Acta neuropathologica communications.

Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.

John L. Robinson, J. Trojanowski, P. Moberg, 2010, Archives of neurology.

TDP-43 Proteinopathies: Neurodegenerative Protein Misfolding Diseases without Amyloidosis

J. Trojanowski, V. Lee, K. Uryu, 2007, Neurosignals.

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

J. Trojanowski, Eddie B. Lee, A. Chen-Plotkin, 2011, The Journal of clinical investigation.

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

J. Trojanowski, Eddie B. Lee, S. Porta, 2018, Nature Communications.

Sugar hydrolases and their arrangement on the rat intestinal microvillus membrane

P. Sunshine, L. Kwong, K. Tsuboi, 1979, The Journal of Membrane Biology.

Human intestinal lactase-phlorizin hydrolase: isolation and preparation of a specific antiserum.

L. Kwong, K. Tsuboi, A. Reisenauer, 1989, Biochemical and biophysical research communications.

TDP-43-Positive White Matter Pathology in Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions

Murray Grossman, John Q Trojanowski, J. Trojanowski, 2007, Journal of neuropathology and experimental neurology.

Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin-dependent diabetes.

J. Lalouel, A. Hata, L. Kwong, 1993, The Journal of clinical investigation.

TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Murray Grossman, Peachie Moore, John Q Trojanowski, 2007, Archives of neurology.

The Role of Bilirubin Production in Breast-fed Infants with Elevated Serum Bilirubin Concentrations at 2 Weeks of Life

L. Kwong, H. Vreman, D. K. Stevenson, 1984, La Clinica pediatrica.

Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy

J. Trojanowski, V. Lee, S. Xie, 2011, Acta Neuropathologica.

Effect of Tin Protoporphyrin on the Excretion Rate of Carbon Monoxide in Newborn Rats After Hematoma Formation

D. Stevenson, A. Posselt, L. Kwong, 1985, Journal of pediatric gastroenterology and nutrition.

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

J. Trojanowski, P. Ryvkin, B. Gregory, 2015, PloS one.

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice

J. Trojanowski, V. Lee, L. Kwong, 2016, Acta neuropathologica communications.

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy

J. Trojanowski, L. Kwong, V. Lee, 2016, The Journal of Neuroscience.

Supporting Online Material for Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

M. Grossman, E. Masliah, C. Clark, 2006 .

Recovery of Exogenous Heme as Carbon Monoxide and Biliary Heme in Adult Rats After Tin Protoporphyrin Treatment

S. Hintz, L. Kwong, H. Vreman, 1987, Journal of pediatric gastroenterology and nutrition.

Red cell destruction and bilirubin production in adult rats with short-term biliary obstruction.

D. Stevenson, L. Kwong, H. Vreman, 1986, Journal of pediatric gastroenterology and nutrition.

Suppression of carbon monoxide excretion rate by tin protoporphyrin.

D. Stevenson, A. Posselt, L. Kwong, 1986, American journal of diseases of children.

Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin-dependent diabetes.

J. Lalouel, L. Kwong, P. Iverius, 1993, The Journal of clinical investigation.

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies*

J. Trojanowski, A. Chen-Plotkin, M. Neumann, 2009, Journal of Biological Chemistry.

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

John L. Robinson, J. Trojanowski, V. Lee, 2017, Acta Neuropathologica Communications.