Y. Ikeno

发表

Is the oxidative stress theory of aging dead?

A. Bokov, V. Pérez, A. Richardson, 2009, Biochimica et biophysica acta.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

L. Ferrucci, D. Allison, R. de Cabo, 2016, Cell metabolism.

Caspase-2 deficiency enhances aging-related traits in mice

Arlan Richardson, G. Mundy, B. Herman, 2007, Mechanisms of Ageing and Development.

MRG 15 Regulates Embryonic Development and Cell Proliferation

M. Matzuk, K. Tominaga, O. Pereira-smith, 2005 .

MRG15 Regulates Embryonic Development and Cell Proliferation

M. Matzuk, K. Tominaga, O. Pereira-smith, 2005, Molecular and Cellular Biology.

Housing density does not influence the longevity effect of calorie restriction.

J. Nelson, Vivian Diaz, A. Richardson, 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

The influence of long‐term Aloe vera ingestion on age‐related disease in male Fischer 344 rats

B. Yu, Shuko Lee, Y. Ikeno, 2002, Phytotherapy research : PTR.

Rapamycin extends life and health in C57BL/6 mice.

S. Austad, W. Ward, A. Bokov, 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice

Hong Yang, Vivian Diaz, Arlan Richardson, 2002, Mechanisms of Ageing and Development.

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

R. de Cabo, D. Ingram, M. Aon, 2019, Cell metabolism.

Endocrine and Metabolic Dysfunction During Aging and Senescence Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I X

R. McCARTER, A. Salmon, Y. Ikeno, 2015 .

Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I.

R. McCARTER, A. Salmon, Y. Ikeno, 2015, American journal of physiology. Endocrinology and metabolism.

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase.

A. Salmon, Arlan Richardson, H. Van Remmen, 2013, Biochemical and biophysical research communications.

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

D. Allison, P. Cohen, N. Barzilai, 2018, Nature Communications.

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

R. McCARTER, A. Lorenzini, Y. Ikeno, 2010, PloS one.

Thioredoxin and aging: What have we learned from the survival studies?

Y. Ikeno, G. Hubbard, T. Saunders, 2020, Aging pathobiology and therapeutics.

Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

Y. Ikeno, G. Hubbard, T. Saunders, 2018, GeroScience.

The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas

K. Tominaga, M. Shigenaga, K. Uchida, 2011, Pathobiology of aging & age related diseases.

A case of synchronous multiple lung cancers associated with hamartoma in the same lobe

Y. Ikeno, N. Suyama, J. Araki, 1992 .

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

Leonid Peshkin, Kevin G Becker, Nancy Pleshko, 2008, Cell metabolism.

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity.

R. Bronson, A. Bartke, Shuko Lee, 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice

A. Salmon, A. Richardson, H. Van Remmen, 2012, Pathobiology of aging & age related diseases.

Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice

J. Kopchick, Y. Ikeno, E. List, 2011, AGE.

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

N. Musi, A. Bartke, J. Kopchick, 2019, GeroScience.

Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?—a pathological point of view

Shuko Lee, Y. Ikeno, G. Hubbard, 2006, AGE.

Senolytics Improve Physical Function and Increase Lifespan in Old Age

D. Allison, N. LeBrasseur, S. Khosla, 2018, Nature Medicine.

Running head : Igf 1 allele and resistance to high-fat diet 4 5

R. McCARTER, A. Salmon, Y. Ikeno, 2015 .

Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.

R. McCARTER, A. Lorenzini, A. Salmon, 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

Exploring the Mechanism of Aging Using Rodent Models

H. Remmen, Y. Ikeno, 2003 .

Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL/6 mice

Y. Ikeno, G. Hubbard, Yidong Bai, 2020 .

Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice

H. Remmen, Y. Ikeno, T. Saunders, 2020, Aging pathobiology and therapeutics.

The paradoxical role of thioredoxin on oxidative stress and aging.

Yiqiang Zhang, A. Salmon, J. Gelfond, 2015, Archives of biochemistry and biophysics.

Thioredoxin, oxidative stress, cancer and aging

Yiqiang Zhang, A. Salmon, Shuko Lee, 2012, Longevity & healthspan.

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

C. Livi, Diane Jones, P. Hasty, 2013, Aging.

Regional difference of ROS generation, lipid peroxidaton, and antioxidant enzyme activity in rat brain and their dietary modulation

H. Chung, B. Yu, M. Yoo, 1999, Archives of pharmacal research.

Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.

J. Barnes, P. Ghosh, M. S. Katz, 2012, The Journal of endocrinology.

Effects of aging and caloric restriction on IGF-I, IGF-I receptor, IGFBP-3 and IGFBP-4 gene expression in the rat stomach and colon

G. Greeley, E. Englander, Y. Ikeno, 2000, Regulatory Peptides.

GFAP expression in the subcutaneous tumors of immature glial cell line (HITS glioma) derived from ENU-induced rat glioma

Y. Higami, I. Shimokawa, Y. Ikeno, 1993, Journal of Neuro-Oncology.

The Properties of An Immature Glial Cell Line (HITS Glioma) Derived from Ethylnitrosourea (ENU)-Induced Rat Glioma

Y. Ikeno, 1993 .

Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

S. Yakar, J. Kopchick, Y. Ikeno, 2021, Aging cell.

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.

V. Pérez, A. Richardson, H. Van Remmen, 2008, Free radical biology & medicine.

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

N. LeBrasseur, S. Khosla, J. Farr, 2022, Aging cell.

Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker.

Y. Ikeno, Yidong Bai, Chen Zhou, 2020, Mitochondrion.

Local formation and degradation of endothelin-1 in guinea pig airway tissues.

K. Matsuyama, Y. Tsukada, Y. Ikeno, 1991, Biochemical and biophysical research communications.

San Antonio Nathan Shock Center: your one-stop shop for aging research

N. Musi, A. Salmon, M. Javors, 2021, GeroScience.

Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?

A. Bartke, Shuko Lee, Y. Ikeno, 2013, Pathobiology of aging & age related diseases.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

G. Enikolopov, T. von Zglinicki, Y. Ikeno, 2019, Cell metabolism.

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

D. Liggitt, M. Ciol, R. McIndoe, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Pathology is a critical aspect of preclinical aging studies

D. Liggitt, P. Treuting, W. Ladiges, 2013, Pathobiology of aging & age related diseases.

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

T. Serre, K. Bath, N. Neretti, 2015, Cell.

Senescent terminal weight loss in the male F344 rat.

C. McMahan, M. S. Katz, Y. Ikeno, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Byung Pal Yu, Hae Young Chung, H. Chung, 2002, Archives of gerontology and geriatrics.

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

S. Groshen, M. Vinciguerra, B. Kennedy, 2015, Cell metabolism.

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

N. LeBrasseur, S. Khosla, J. Farr, 2021, Nature Communications.

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

N. LeBrasseur, N. LaRusso, J. Wren, 2015, Aging cell.

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

P. Nelson, C. Benz, P. Kapahi, 2015, Nature Cell Biology.

Overexpression of Mn superoxide dismutase does not increase life span in mice.

C. Epstein, Wook Song, A. Salmon, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

An Autopsy Case of Klippel‐Feil Syndrome with Cardiovascular Anomalies and Upper Limb Anomaly

I. Shimokawa, Y. Ikeno, T. Ikeda, 1991 .

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

D. Allison, P. Cohen, N. Barzilai, 2018, Nature Communications.

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.

A. Bartke, J. Kopchick, Shuko Lee, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

Z. Ungvari, A. Csiszar, C. Georgescu, 2017, GeroScience.

IGF‐1 Regulates Vertebral Bone Aging Through Sex‐Specific and Time‐Dependent Mechanisms

Z. Ungvari, A. Csiszar, Y. Ikeno, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reductions in serum IGF-1 during aging impair health span

O. Kennedy, R. Farrar, M. Adamo, 2013, Aging cell.

Does Reduced IGF-1R Signaling in Igf1r +/− Mice Alter Aging?

R. DeFronzo, M. Adamo, N. Musi, 2011, PloS one.

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

Z. Ungvari, A. Csiszar, C. Georgescu, 2017, GeroScience.

Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense

Y. Ikeno, G. Hubbard, B. Chatterjee, 2011, BMC Cancer.

In Memory: Edward J. Masoro, PhD (1924-2020).

R. McCARTER, J. Nelson, M. S. Katz, 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

C. Benz, P. Kapahi, J. Campisi, 2015, Nature Cell Biology.

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

Yan Li, Arlan Richardson, Alex Bokov, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.

R. Loeser, S. Chakrabarty, Shuko Lee, 2005, Endocrinology.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

G. Enikolopov, T. von Zglinicki, Y. Ikeno, 2019, Cell metabolism.

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

C. Epstein, M. Pahlavani, Ting-Ting Huang, 2003, Physiological genomics.

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.

Arlan Richardson, Hanyu Liang, T. Prolla, 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.

Dean P. Jones, K. Tominaga, J. Yodoi, 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19

Yanbao Yu, Y. Xiang, Yi-Han Lin, 2021, Journal of virology.

Health Span and Life Span in Transgenic Mice with Modulated DNA Repair

C. McMahan, M. Hanes, D. Herbert, 2001, Annals of the New York Academy of Sciences.

Title The Properties of An Immature Glial Cell Line ( HITS Glioma ) Derivedfrom Ethylnitrosourea ( ENU )-Induced Rat Glioma

Y. Ikeno, 2016 .

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence

D. Sosnowska, Yiqiang Zhang, A. Richardson, 2016, Redox biology.

Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.

Hong-Mei Zhang, C. Jaramillo, A. Bokov, 2013, Free radical biology & medicine.

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

A. Bartke, J. Schultze, Patrick Günther, 2019, Cell metabolism.

Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

Y. Ikeno, G. Hubbard, T. Saunders, 2018, GeroScience.

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

H. Van Remmen, Y. Ikeno, G. Hubbard, 2018, Pathobiology of aging & age related diseases.

Lifespan extension in genetically modified mice

P. Treuting, A. Richardson, R. Strong, 2009, Aging cell.

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase

M. Hanes, D. Herbert, Kristen Kewitt, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury

C. Ross, W. Ju, M. Bitzer, 2021, Aging cell.

Pathological Analysis in Aging Research

Y. Ikeno, G. Hubbard, 1998 .

Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats

T. Foster, H. Chung, T. Buford, 2011, AGE.

Effects of dietary restriction and exercise on the age-related pathology of the rat

Y. Ikeno, J. T. Herlihy, H. Bertrand, 1997, AGE.

Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice.

Wen-Hwa Lee, Z. D. Sharp, A. Flesken-Nikitin, 2003, Carcinogenesis.

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

H. Remmen, A. Bokov, Yiqiang Zhang, 2016, Mechanisms of Ageing and Development.

The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents

Paul N. Schofield, John P. Sundberg, Jerrold M. Ward, 2016, Veterinary pathology.

Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

D. Féliers, B. Kasinath, J. Barnes, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

The implications of mitochondria in doxorubicin treatment of cancer in the context of traditional and modern medicine

D. Salvadori, Y. Ikeno, L. D. C. M. Souza, 2020, Traditional Medicine and Modern Medicine.

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

A. Bartke, J. Kopchick, M. Masternak, 2015, Aging.

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

R. de Cabo, D. Ingram, J. Speakman, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.

Samuel H. Wilson, D. C. Cabelof, R. Busuttil, 2006, Cancer research.

Significant life extension by ten percent dietary restriction

S. Austad, R. McCARTER, A. Richardson, 2016, Annals of the New York Academy of Sciences.

Plasma glucose and the action of calorie restriction on aging.

V. Monnier, R. McCARTER, R. Strong, 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

Author Correction: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

P. Nelson, C. Benz, P. Kapahi, 2021, Nature Cell Biology.

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.

N. LeBrasseur, S. Khosla, J. Farr, 2023, The Journal of clinical investigation.

Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice

J. Kopchick, Y. Ikeno, E. List, 2012, AGE.

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

B. Schumacher, J. Mason, Y. Ikeno, 2018, GeroScience.

Development of a Geropathology Grading Platform for nonhuman primates

J. Morrison, M. Kuroda, J. Capitanio, 2020, Aging pathobiology and therapeutics.

Thioredoxin - a magic bullet or a double-edged sword for mammalian aging?

Y. Ikeno, 2021, Aging pathobiology and therapeutics.

Physical activity as a factor in the action of dietary restriction on aging: Effects in Fischer 344 rats

C. McMahan, R. McCARTER, B. Yu, 1997, Aging.