Yong-Sung Kim

发表

Bacterial Cell Surface Display of an Enzyme Library for Selective Screening of Improved Cellulase Variants

Yong-Sung Kim, Heung-Chae Jung, Jae-Gu Pan, 2000, Applied and Environmental Microbiology.

Heavy and Light Chain Variable Single Domains of an Anti-DNA Binding Antibody Hydrolyze Both Double- and Single-stranded DNAs without Sequence Specificity*

Jeong-Sun Kim, Yong-Sung Kim, Woo-ram Lee, 2006, Journal of Biological Chemistry.

Construction and characterization of a pseudo-immune human antibody library using yeast surface display.

Jeong-Sun Kim, Yong-Sung Kim, Seung-Hyun Lee, 2006, Biochemical and biophysical research communications.

Engineering of a tumor cell-specific, cytosol-penetrating antibody with high endosomal escape efficacy.

S. Shin, Yong-Sung Kim, Ji-sun Kim, 2018, Biochemical and biophysical research communications.

Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris.

Yong-Sung Kim, Dong-Ki Choi, Chang-Han Lee, 2010, Protein expression and purification.

Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity

Yong-Sung Kim, Hae‐Sim Park, Seung-Hyun Kim, 2019, Scientific Reports.

Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy

Yong-Sung Kim, K. Jung, Jeong-Ah Kim, 2022, Molecular cancer.

Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells

Junho Chung, Yong-Sung Kim, A. Kim, 2010, Apoptosis.

A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

Yong-Sung Kim, Seung-Hyun Lee, M. Kwon, 2009, Molecular Cancer Therapeutics.

Dual-targeting of EGFR and Neuropilin-1 Attenuates Resistance to EGFR-targeted Antibody Therapy in KRAS-mutant Non-Small Cell Lung Cancer.

B. Cho, Daechan Park, Yong-Sung Kim, 2019, Cancer letters.

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

Junho Chung, Yong-Sung Kim, Seung-Hyun Lee, 2009, Biochemical and biophysical research communications.

Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis.

T. Shin, Ji-Ho Park, Yong-Sung Kim, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL.

Y. S. Shin, J. Chang, Yong-Sung Kim, 2016, Cancer letters.

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells.

K. Choi, Eun-Hee Kim, Yong-Sung Kim, 2007, Cancer research.

Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer

S. Shin, J. E. Lee, Yong-Sung Kim, 2021, Biomolecules & therapeutics.

The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells.

Yong-Sung Kim, Kyung-Jin Park, H. Choi, 2012, Experimental cell research.

A Neuropilin-1 Antagonist Exerts Antitumor Immunity by Inhibiting the Suppressive Function of Intratumoral Regulatory T Cells

Yong-Sung Kim, K. Jung, Jeong-Ah Kim, 2019, Cancer Immunology Research.

Immunoglobulin Fc-Fused Peptide without C-Terminal Arg or Lys Residue Augments Neuropilin-1-Dependent Tumor Vascular Permeability.

Yong-Sung Kim, Ye-Jin Kim, Du-San Baek, 2017, Molecular pharmaceutics.

Enhancement of the Tumor Penetration of Monoclonal Antibody by Fusion of a Neuropilin-Targeting Peptide Improves the Antitumor Efficacy

T. Shin, Yong-Sung Kim, Se-ho Kim, 2014, Molecular Cancer Therapeutics.

Cellular Internalization Mechanism and Intracellular Trafficking of Filamentous M13 Phages Displaying a Cell-Penetrating Transbody and TAT Peptide

T. Shin, S. Shin, Yong-Sung Kim, 2012, PloS one.

A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

Sunghoon Kim, S. Shin, Yong-Sung Kim, 2014, mAbs.

Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

Yong-Sung Kim, Hae‐Sim Park, Jungeun Kim, 2021, Frontiers in Immunology.

Characterization of a novel anti-human TNF-α murine monoclonal antibody with high binding affinity and neutralizing activity

Yong-Sung Kim, K. Baek, Mooyoung Song, 2008, Experimental & Molecular Medicine.

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo

Jeong-Sun Kim, Soohyun Kim, Yong-Sung Kim, 2010, Proceedings of the National Academy of Sciences.

Production of recombinant single chain antibodies (scFv) in vegetatively reproductive Kalanchoe pinnata by in planta transformation

Sukchan Lee, C. Auh, Y. Rhee, 2009, Plant Cell Reports.

Immunoglobulin Fc Heterodimer Platform Technology: From Design to Applications in Therapeutic Antibodies and Proteins

Yong-Sung Kim, J. Ha, Jungeun Kim, 2016, Front. Immunol..

Proinsulin shares a motif with IL-1  and induces inflammatory cytokine via interleukin-1 receptor 1

Yong-Sung Kim, Jaewoo Hong, Suyoung Bae, 2016 .

Construction of a large synthetic human Fab antibody library on yeast cell surface by optimized yeast mating.

Yong-Sung Kim, Du-San Baek, 2014, Journal of microbiology and biotechnology.

AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation.

Y. S. Shin, Yong-Sung Kim, Chul-Ho Kim, 2013, Endocrine-related cancer.

AY 4 , an agonistic anti-death receptor 4 MAB , induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation

Y. S. Shin, Yong-Sung Kim, Chul-Ho Kim, 2013 .

Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1.

T. Kang, Soohyun Kim, Yong-Sung Kim, 2016, Cytokine.

Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape.

Hyun-soo Cho, S. Shin, Yong-Sung Kim, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Antitumor Effects Dendritic Cells and Potentiates Therapeutic in Antigen to the Cross-Presentation Pathway An Anti-Nucleic Acid Antibody Delivers

Yong-Sung Kim, M. Kwon, M. Woo, 2012 .

A nucleic acid hydrolyzing recombinant antibody confers resistance to curtovirus infection in tobacco

Sukchan Lee, C. Auh, Yong-Sung Kim, 2013, Plant Cell, Tissue and Organ Culture (PCTOC).

Death Receptors 4 and 5 Activate Nox1 NADPH Oxidase through Riboflavin Kinase to Induce Reactive Oxygen Species-mediated Apoptotic Cell Death*

Yong-Sung Kim, K. Jeong, A. Kim, 2011, The Journal of Biological Chemistry.

A Tat-grafted anti-nucleic acid antibody acquires nuclear-localization property and a preference for TAR RNA.

Yong-Sung Kim, M. Kwon, Dong-sik Kim, 2011, Biochemical and biophysical research communications.

Viral genome RNA degradation by sequence-selective, nucleic-acid hydrolyzing antibody inhibits the replication of influenza H9N2 virus without significant cytotoxicity to host cells.

Yong-Sung Kim, A. Kim, M. Kwon, 2012, Antiviral research.

Affinity Maturation of a T-Cell Receptor-Like Antibody Specific for a Cytomegalovirus pp65-Derived Peptide Presented by HLA-A*02:01

Yong-Sung Kim, K. Jung, Jeong-Ah Kim, 2021, International journal of molecular sciences.

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy

Yong-Sung Kim, K. Jung, So-Yeol Yoo, 2022, Frontiers in Immunology.

Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape.

S. Shin, J. E. Lee, Yong-Sung Kim, 2021, Cancer letters.

Improvement of virus safety of an antihemophilc factor IX by virus filtration process.

Y. Choi, I. Kim, Yong-Sung Kim, 2008, Journal of microbiology and biotechnology.

Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1*

Yong-Sung Kim, Jaewoo Hong, Suyoung Bae, 2016, The Journal of Biological Chemistry.

Isomaltulose production via yeast surface display of sucrose isomerase from Enterobacter sp. FMB-1 on Saccharomyces cerevisiae.

S. Ha, Yong-Sung Kim, J. Cha, 2011, Bioresource technology.

Critical issues in the development of immunotoxins for anticancer therapy.

Yong-Sung Kim, Ji-sun Kim, Sei-Yong Jun, 2019, Journal of pharmaceutical sciences.

KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.

S. Shin, Yong-Sung Kim, Soon-Sun Hong, 2018, Cancer letters.

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

S. Shin, Yong-Sung Kim, Ji-sun Kim, 2017, Nature Communications.

Domain-level Antibody Epitope Mapping through Yeast Surface Display of Epidermal Growth Factor Receptor Fragments

J. Cochran, K. Wittrup, Yong-Sung Kim, 2022 .

Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor*

K Dane Wittrup, Gerd Ritter, Nathan E Hall, 2004, Journal of Biological Chemistry.

RNA virus accumulation is inhibited by ribonuclease activity of 3D8 scFv in transgenic Nicotiana tabacum

Sukchan Lee, C. Auh, Yong-Sung Kim, 2013, Plant Cell, Tissue and Organ Culture (PCTOC).

Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

Su In Lee, Sangkyu Park, Younghee Lee, 2016, Oncotarget.

Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth

Y. Cho, S. Shin, Dakeun Lee, 2020, Science Advances.

An Anti-Nucleic Acid Antibody Delivers Antigen to the Cross-Presentation Pathway in Dendritic Cells and Potentiates Therapeutic Antitumor Effects

Sun Park, Yong-Sung Kim, M. Kwon, 2012, The Journal of Immunology.

Comparative analyses of complex formation and binding sites between human tumor necrosis factor-alpha and its three antagonists elucidate their different neutralizing mechanisms.

Yong-Sung Kim, Seung-Hyun Lee, Mooyoung Song, 2007, Journal of molecular biology.

An agonistic antibody to human death receptor 4 induces apoptotic cell death in head and neck cancer cells through mitochondrial ROS generation.

Y. S. Shin, Yong-Sung Kim, S. Kang, 2012, Cancer letters.

Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity.

Jin‐Kyoo Kim, D. Park, Yong-Sung Kim, 2010, Molecular immunology.

Current perspectives on therapeutic antibodies

Junho Chung, Yong-Sung Kim, Soomin Yoon, 2010 .

Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells

Yong-Sung Kim, J. Ha, Chul-Ho Kim, 2018, Oncoimmunology.

Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif.

Yong-Sung Kim, Du-San Baek, 2015, Biochemical and biophysical research communications.

IL-32-induced Inflammatory Cytokines Are Selectively Suppressed by α1-antitrypsin in Mouse Bone Marrow Cells

E. Chan, Yong-Sung Kim, X. Bai, 2017, Immune network.

Interfering transbody-mediated Her2 gene silencing induces apoptosis by G0/G1 cell cycle arrest in Her2-overexpressing SK-BR-3 breast cancer cells

Yong-Sung Kim, A. Kim, M. Kwon, 2012, Biotechnology and Bioprocess Engineering.

Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

Jeong-Sun Kim, Yong-Sung Kim, M. Kwon, 2009, Nucleic acids research.

Generation of humanized anti-DNA hydrolyzing catalytic antibodies by complementarity determining region grafting.

Jeong-Sun Kim, Yong-Sung Kim, Seung-Hyun Lee, 2009, Biochemical and biophysical research communications.

A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab.

Yong-Sung Kim, Y. S. Kim, Seung-Hyun Lee, 2010, Journal of biotechnology.

Crystal structure of single‐domain VL of an anti‐DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals

Jeong-Sun Kim, Suk‐Youl Park, Yong-Sung Kim, 2008, Proteins.

An RNA-hydrolyzing recombinant antibody exhibits an antiviral activity against classical swine fever virus.

Sun Park, Yong-Sung Kim, S. Lee, 2010, Biochemical and biophysical research communications.

Optimized serological isolation of lung-cancer-associated antigens from a yeast surface-expressed cDNA library.

Jhingook Kim, Yong-Sung Kim, Hyejin Choi, 2007, Journal of microbiology and biotechnology.

Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast

J. Kuriyan, J. Cochran, K. Wittrup, 2005, Proteins.

Cell‐free production and streamlined assay of cytosol‐penetrating antibodies

Ji-Ho Park, Dong-Myung Kim, T. Yoo, 2016, Biotechnology and bioengineering.

Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay.

Dong-Myung Kim, T. Yoo, S. Shin, 2015, Biochemical and biophysical research communications.

HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells

Yong-Sung Kim, Ho-Ryun Won, Y. Kim, 2018, Scientific Reports.

A Heterodimeric Fc-Based Bispecific Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity

Yong-Sung Kim, Yong-Sung Kim, Hye-Ji Choi, 2013, Molecular Cancer Therapeutics.

Production of recombinant human procollagen type I C-terminal propeptide and establishment of a sandwich ELISA for quantification

Yong-Sung Kim, Won Suk Yang, Sujin Kang, 2017, Scientific Reports.

Effect of a novel fully human monovalent antigen-binding fragment on the survival of cancer cell lines.

Y. Jang, Yong-Sung Kim, Hyun-wook Lee, 2007, Oncology reports.

Preclinical Efficacy and Safety of an Anti-Human VEGFA and Anti-Human NRP1 Dual-Targeting Bispecific Antibody (IDB0076)

Seong-Wook Lee, Yong-Sung Kim, Youngmin Lee, 2020, Biomolecules.

Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors.

Yeon-Woo Ryu, Myung-Hee Kwon, Yong-Sung Kim, 2005, Biochemical and biophysical research communications.

Reduced expression of the RNA‐binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis

R. Kulkarni, S. Nam, J. Rho, 2018, The Journal of pathology.

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

Motomu Shimaoka, Gang Song, Yong-Sung Kim, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening

Yong-Sung Kim, Dong-Ki Choi, Ye-Jin Kim, 2015, PloS one.

A nucleic acid hydrolyzing recombinant antibody confers resistance to curtovirus infection in tobacco

Sukchan Lee, C. Auh, Yong-Sung Kim, 2013, Plant Cell, Tissue and Organ Culture (PCTOC).

Improved mutants from directed evolution are biased to orthologous substitutions.

Shaun M Lippow, Jennifer R Cochran, Yong-Sung Kim, 2006, Protein engineering, design & selection : PEDS.

MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants

Man-Seong Park, J. Seok, K. Cho, 2021, Frontiers in Immunology.

Generation of bivalent and bispecific kringle single domains by loop grafting as potent agonists against death receptors 4 and 5.

O. Kwon, Yong-Sung Kim, K. Jeong, 2011, Journal of molecular biology.

Large Molecule Therapeutics A Heterodimeric Fc-Based Bispeci fi c Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity

Yong-Sung Kim, Ye-Jin Kim, Hye-Ji Choi, 2013 .

Valproic Acid Sensitizes TRAIL-Resistant Anaplastic Thyroid Carcinoma Cells to Apoptotic Cell Death

J. Chang, Yong-Sung Kim, Chul-Ho Kim, 2013, Annals of Surgical Oncology.

Inducing rigid local structure around the zinc-binding region by hydrophobic interactions enhances the homotrimerization and apoptotic activity of zinc-free TRAIL.

Jeong-Sun Kim, M. Jin, Yong-Sung Kim, 2007, Biochemical and biophysical research communications.

A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

Yong-Sung Kim, Seung-Hyun Lee, M. Kwon, 2009, Molecular Cancer Therapeutics.

Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation.

Yong-Sung Kim, M. Seo, S. Seok, 2015, Molecular immunology.

Cell‐free production and streamlined assay of cytosol‐penetrating antibodies

Ji-Ho Park, Dong-Myung Kim, T. Yoo, 2016, Biotechnology and bioengineering.

Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments.

Yong-Sung Kim, R. Bhandari, K. Wittrup, 2004, Journal of immunological methods.

Extracellular Release of CD11b by TLR9 Stimulation in Macrophages

Keunwook Lee, Younghee Lee, H. Kwon, 2016, PloS one.

HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells

Yong-Sung Kim, Ho-Ryun Won, Y. Kim, 2018, Scientific Reports.

Crystal structure of single‐domain VL of an anti‐DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals

Jeong-Sun Kim, Suk‐Youl Park, Yong-Sung Kim, 2008, Proteins.