J. Trevino

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A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage

Quan P. Ly, M. Bloomston, M. Dillhoff, 2017, Annals of surgery.

Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms

Geoffrey G. Zhang, R. Gillies, D. Coppola, 2016, Oncotarget.

Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis

Emalie J. Clement, Nicholas T. Woods, J. Trevino, 2022, Cancers.

Altered Gemcitabine and Nab-paclitaxel Scheduling Improves Therapeutic Efficacy Compared with Standard Concurrent Treatment in Preclinical Models of Pancreatic Cancer

A. Chakravarti, T. Williams, J. Trevino, 2020, Clinical Cancer Research.

Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors.

L. Ellis, Douglas B. Evans, J. Trevino, 2005, Cancer research.

Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells

B. Aryal, J. Trevino, V. A. Rao, 2020, Cell Death & Disease.

It's more than just cancer biology: Health disparities in patients with pancreatic neuroendocrine tumors

S. Hughes, J. Trevino, J. Rose, 2021, Journal of surgical oncology.

c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer.

S. Hughes, J. Trevino, K. Behrns, 2014, World journal of gastroenterology.

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors

Huan Yang, S. Fletcher, J. Fleming, 2019, Clinical Cancer Research.

Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

L. Ellis, F. Fan, D. Hicklin, 2006, British Journal of Cancer.

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.

L. Moldawer, S. Wallet, C. Mathews, 2017, Cancer research.

Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma

G. Sarosi, S. Hughes, J. Trevino, 2013, PloS one.

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

A. Loguinov, C. Vulpe, R. Hromas, 2021, Molecular Cancer Therapeutics.

A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating?

D. Coppola, Y. Balagurunathan, N. Merchant, 2017, Cancer biology & medicine.

Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery

T. George, A. Judge, J. Trevino, 2021, Cancer medicine.

Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine

S. Wallet, A. Judge, S. Hughes, 2018, International journal of molecular sciences.

A clinically applicable muscular index predicts long‐term survival in resectable pancreatic cancer

G. Sarosi, T. George, A. Judge, 2017, Surgery.

Partnering to advance early detection and prevention efforts for pancreatic cancer: the Florida Pancreas Collaborative.

N. Merchant, M. Malafa, J. Trevino, 2016, Future oncology.

Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer

L. Moldawer, S. Wallet, T. George, 2015, Cancer Immunology, Immunotherapy.

Pancreatic Mucinous Cystic Neoplasm Communicating with Main Pancreatic Duct: An Unrecognized Presentation of Pancreatic Mucinous Neoplasm?

Weixun Zhou, J. Lai, J. Trevino, 2017, Anticancer research.

Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models

A. Fodor, C. Jobin, M. Reinhard, 2018, Carcinogenesis.

Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia

A. Judge, S. Hughes, J. Trevino, 2020, Cancers.

Primary outgrowth cultures are a reliable source of human pancreatic stellate cells

G. Sarosi, S. Wallet, S. Hughes, 2015, Laboratory Investigation.

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

J. Trevino, T. Sawyer, W. Shakespeare, 2005, Molecular Cancer Therapeutics.

A Randomized Prospective Multicenter Trial of Pancreaticoduodenectomy With and Without Routine Intraperitoneal Drainage

M. Bloomston, Q. Mo, W. Fisher, 2014, Annals of surgery.

Phase II Study of 5-Fluorouracil, Oxaliplatin plus Dasatinib (FOLFOX-D) in First-Line Metastatic Pancreatic Adenocarcinoma.

Ji‐Hyun Lee, C. Allegra, T. George, 2021, The oncologist.

Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice.

I. Fidler, J. Trevino, G. Gallick, 2006, International journal of oncology.

Biliary intervention rates during neoadjuvant therapy for adenocarcinoma of the pancreatic head.

S. Hughes, J. Trevino, S. Kirkpatrick, 2020, HPB : the official journal of the International Hepato Pancreato Biliary Association.

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

C. Gwede, J. Arnoletti, S. Vadaparampil, 2021, Cancers.

Molecular therapeutic strategies targeting pancreatic cancer induced cachexia

J. Trevino, Miles E. Cameron, A. Yakovenko, 2018, World journal of gastrointestinal surgery.

A case report of recurrent acute pancreatitis associated with life threatening atypical hemolytic uremic syndrome

J. Trevino, Jonathan J. Cho, Elizabeth M. Jean-Marie, 2020, Medicine.

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI

J. Trevino, J. Rosenberg, Edward Agyare, 2020, Cancer Nanotechnology.

Src inhibition is still a relevant target in pancreatic cancer.

T. George, J. Trevino, Chen Liu, 2014, The oncologist.

c-Src Regulates Constitutive and EGF-mediated VEGF Expression in Pancreatic Tumor Cells Through Activation of Phosphatidyl Inositol-3 Kinase and p38 MAPK

J. Trevino, G. Gallick, C. Baker, 2005, Pancreas.

Local pancreatic head resection: the search for optimal indications through quality of life assessments.

S. Hughes, J. Trevino, K. Behrns, 2015, American journal of surgery.

Disconnected pancreatic duct syndrome: disease classification and management strategies.

S. Hughes, J. Trevino, K. Behrns, 2014, Journal of the American College of Surgeons.

Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.

A. Judge, D. Stapleton, J. Trevino, 2018, Cancer research.

Targeting Pheochromocytoma/Paraganglioma with polyamine inhibitors.

Abhishek K. Jha, J. Bibb, A. Tischler, 2020, Metabolism: clinical and experimental.

Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies

G. Sarosi, T. George, S. Hughes, 2016, Journal of Gastrointestinal Surgery.

Characteristics and outcomes of adenosquamous carcinoma of the pancreas.

T. George, J. Trevino, Michael M. Feely, 2013, Gastrointestinal cancer research : GCR.

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

H. Derendorf, J. Trevino, Qi-Yin Chen, 2018, Investigational New Drugs.

SRC inhibitors as potential therapeutic agents for human cancers.

J. Trevino, G. Gallick, J. Summy, 2006, Mini reviews in medicinal chemistry.

Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism*

A. Sood, S. Cole, Yang Li, 2007, Journal of Biological Chemistry.

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies

D. Bentrem, J. Trevino, M. Shields, 2021, Cancers.

MIR-198 IN PANCREATIC CANCER PROGRESSION AND MANAGEMENT By OLORUNSEUN OLATUNJI OGUNWOBI A THESIS PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE UNIVERSITY OF FLORIDA

J. Trevino, W. T. McCormack, 2013 .

Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas

R. Gillies, D. Coppola, Y. Balagurunathan, 2017, Scientific Reports.

IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy

A. Judge, J. Trevino, Michael R. Deyhle, 2019, Cancers.

Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma.

Liz Y. Han, A. Sood, C. Landen, 2006, Cancer research.

Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells

D. McConkey, P. Chiao, J. Trevino, 2006, Angiogenesis.

Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis.

J. Trevino, G. Gallick, M. Nilsson, 2005, Cancer research.

Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls.

P. Starostik, Hanlin L. Wang, J. Lai, 2019, The Journal of surgical research.

Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

Huan Yang, J. Fleming, S. Sebti, 2021, Clinical Cancer Research.

Cytotoxic effects of gemcitabine-loaded solid lipid nanoparticles in pancreatic cancer cells.

S. Krishnan, J. Trevino, Edward Agyare, 2020, Journal of drug delivery science and technology.

Abnormal hematological indices associated with metastatic choriocarcinoma in a young man.

J. Trevino, C. Lox, 1983, Journal of medicine.

Hepatocyte Growth Factor from a Clinical Perspective: A Pancreatic Cancer Challenge

W. Rizwani, J. Trevino, Amanda Allen, 2015, Cancers.

Pancreatic Cancer Related Health Disparities: A Commentary

Thomas D. Schmittgen, D. Wilkie, V. Setiawan, 2018, Cancers.

Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle

A. Judge, J. Trevino, Daniel Delitto, 2020, Journal of cachexia, sarcopenia and muscle.

A deeper understanding of the tumor microenvironment in pancreatic cancer: the key to developing effective immunotherapies.

J. Trevino, Patrick W. Underwood, 2019, Annals of translational medicine.

δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis

D. Coppola, S. Sebti, M. Malafa, 2017, Oncotarget.

Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

D. Coppola, J. Padmanabhan, S. Chellappan, 2015, Oncotarget.

β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition.

G. Bepler, S. Chellappan, E. Haura, 2015, Cancer research.

b-Arrestin-1 Mediates Nicotine-Induced Metastasis through E 2 F 1 Target Genes That Modulate Epithelial – Mesenchymal Transition

G. Bepler, S. Chellappan, E. Haura, 2015 .

XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

A. Rana, K. Ratia, J. Trevino, 2022, Proceedings of the National Academy of Sciences.

FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness

A. Judge, D. Neyroud, J. Trevino, 2021, Journal of cachexia, sarcopenia and muscle.

Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.

F. Lee, N. Donato, D. Hong, 2006, The American journal of pathology.

Nicotine Reduces Survival via Augmentation of Paracrine HGF–MET Signaling in the Pancreatic Cancer Microenvironment

Xiaomin Lu, G. Sarosi, S. Wallet, 2015, Clinical Cancer Research.

Failure to follow evidence-based best practice guidelines in the treatment of severe acute pancreatitis.

S. Hughes, J. Trevino, K. Behrns, 2013, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

Xueqi Fu, M. Tan, J. Trevino, 2016, Oncotarget.

A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells

A. Cheema, V. Singh, J. Trevino, 2021, bioRxiv.

The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy

M. Korc, A. Rana, J. Trevino, 2021, Frontiers in Oncology.

Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review

T. George, S. Hughes, J. Trevino, 2018, Journal of Gastrointestinal Cancer.

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

G. Sarosi, L. Moldawer, S. Wallet, 2015, BMC Cancer.

Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.

G. Sarosi, S. Wallet, Kien Pham, 2015, The American journal of pathology.

Multidisciplinary neoadjuvant management for potentially curable pancreatic cancer

T. George, R. Zlotecki, S. Hughes, 2015, Cancer medicine.

Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density--implications in tumor progression.

D. Boyd, J. Trevino, Y. Kitadai, 2006, Cancer research.

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

D. Coppola, S. Chellappan, S. Altiok, 2012, Molecular Cancer.

Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells

B. Aryal, J. Trevino, V. A. Rao, 2020, Cell Death & Disease.

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Huan Yang, S. Sebti, Shengyan Xiang, 2018, Nature Communications.

The Microbiota and Cancer Cachexia

J. Trevino, A. Riner, Miles E. Cameron, 2019, International journal of molecular sciences.

Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy

T. George, S. Hughes, J. Trevino, 2017, Journal of Gastrointestinal Surgery.

Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia

S. Wallet, T. George, A. Judge, 2016, Oncotarget.

Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC

B. Kallakury, A. Goel, J. Trevino, 2018, Carcinogenesis.

The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma

Thomas D. Schmittgen, S. Hughes, J. Trevino, 2016, Oncotarget.

Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.

Xiaomin Lu, G. Sarosi, T. George, 2016, American journal of surgery.

Effect of nicotine on chemoresistant phenotype as mediated through Src-dependent Id1 expression in pancreatic adenocarcinoma cells.

S. Chellappan, J. Trevino, S. Pillai, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

R. Hwang, A. Rana, M. Fishel, 2020, Cancer Research.

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease

T. George, A. Judge, S. Hughes, 2017, Pancreas.

Atypical presentation of a hepatic artery pseudoaneurysm: A case report and review of the literature.

J. Trevino, Amy Collinsworth, C. Luckhurst, 2016, World journal of hepatology.

The Florida Pancreas Collaborative Next-Generation Biobank: State-wide Infrastructure to Reduce Disparities and Improve Survival for a Racially and Ethnically Diverse Cohort of Patients with Pancreatic Cancer

C. Gwede, J. Arnoletti, T. George, 2020, medRxiv.

Selective Disruption of Rb–Raf-1 Kinase Interaction Inhibits Pancreatic Adenocarcinoma Growth Irrespective of Gemcitabine Sensitivity

S. Sebti, S. Chellappan, J. Trevino, 2013, Molecular Cancer Therapeutics.

Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma.

S. Chellappan, W. Fulp, J. Trevino, 2012, Neoplasia.

Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival

A. Judge, J. Trevino, Miles E. Cameron, 2018, JNCI cancer spectrum.

Racial and ethnic disparities in a state‐wide registry of patients with pancreatic cancer and an exploratory investigation of cancer cachexia as a contributor to observed inequities

C. Gwede, T. George, J. Fleming, 2019, Cancer medicine.

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.

Chelsey S Simmons, Daniel Delitto, S. Hughes, 2017, Acta biomaterialia.

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.

T. George, A. Judge, S. Hughes, 2017, Pancreas.

Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.

C. Forsmark, S. Hughes, J. Trevino, 2020, Journal of the American College of Surgeons.

Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited

J. Trevino, Miles E. Cameron, A. Yakovenko, 2018, Journal of oncology.

Diversification of Academic Surgery, Its Leadership, and the Importance of Intersectionality.

K. McGuire, G. Upchurch, S. Hughes, 2021, JAMA surgery.

Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.

S. Wallet, T. George, Kien Pham, 2016, The American journal of pathology.

Diversity and Inclusion in Pancreatic Cancer Clinical Trials.

T. George, S. Hughes, J. Trevino, 2021, Gastroenterology.

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Huan Yang, S. Sebti, Shengyan Xiang, 2018, Nature Communications.

Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer

S. Krishnan, J. Trevino, Edward Agyare, 2020, Scientific Reports.

Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer

A. Rana, J. Trevino, H. Munshi, 2022, Frontiers in Oncology.

Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer

Raviteja Bulusu, J. Trevino, Edward Agyare, 2023, BMC Cancer.

Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models

S. Krishnan, J. Trevino, Edward Agyare, 2020, International journal of pharmaceutics: X.

MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer

B. Roberts, A. Judge, G. Walter, 2020, Cancer Research.

Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells

M. Kunnimalaiyaan, T. Gamblin, J. Trevino, 2015, Molecular Cancer Therapeutics.

Stereotactic body radiation therapy for oligoprogression of metastatic disease from gastrointestinal cancers: A novel approach to extend chemotherapy efficacy

P. Okunieff, T. George, R. Zlotecki, 2016, Oncology letters.

Combined activity of dasatinib (BMS-354825) and oxaliplatin in an orthotopic model of metastatic colorectal carcinoma

F. Lee, N. Donato, D. Hong, 2006 .

S. Hughes, J. Trevino, D. Gonzalo, 2014, Journal of Gastrointestinal Surgery.

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

A. Loguinov, C. Vulpe, R. Hromas, 2021, Molecular Cancer Therapeutics.

Final results for gemcitabine with nab-paclitaxel in neoadjuvant treatment of resectable pancreatic adenocarcinoma: GAIN-1 study.

Xiaomin Lu, C. Allegra, S. Chauhan, 2014 .

Disparities in Pancreatic Ductal Adenocarcinoma—The Significance of Hispanic Ethnicity, Subgroup Analysis, and Treatment Facility on Clinical Outcomes

T. George, N. Merchant, S. Chamala, 2020, Cancer medicine.

β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition.

G. Bepler, S. Chellappan, E. Haura, 2015, Cancer research.

Primary Gastric EBV-positive Diffuse Large B Cell Lymphoma (DLBCL) of the Elderly with Plasmablastic Differentiation.

J. Lai, J. Trevino, D. Cao, 2018, In vivo.

Gastrointestinal stromal tumors: a paradigm for therapeutic options in solid organ tumors.

J. Trevino, C. Novak, 2010, Mini reviews in medicinal chemistry.