D. Thakker

发表

Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.

K. Brouwer, M. Cohen-Wolkowiez, I. Cheifetz, 2017, The journal of extra-corporeal technology.

Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters.

X. Ming, D. Thakker, B. Knight, 2011, Molecular pharmaceutics.

DMD048181 1179..1186

K. Brouwer, M. Radtke, D. Thakker, 2013 .

Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells

G. M. Pollack, D. Thakker, D. Bourdet, 2006, Pharmaceutical Research.

Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

D. Thakker, D. Bourdet, 2006, Pharmaceutical Research.

Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability

H. Ouyang, D. Thakker, P. Ward, 2003, Journal of Pharmacology and Experimental Therapeutics.

Structure-activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers.

D. Thakker, S. Morris-Natschke, L. Kucera, 1999, Journal of pharmaceutical sciences.

Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers.

D. Thakker, E. LeCluyse, D. Z. Liu, 1999, Journal of pharmaceutical sciences.

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

K. Brouwer, D. Benjamin, P. Annaert, 2010, Drug Metabolism and Disposition.

Tumorigenic activity of 3-methylcholanthrene metabolites on mouse skin and in newborn mice.

D. Jerina, A. Conney, D. Thakker, 1979, Cancer research.

Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122*

Stephanie N. Hicks, J. Sondek, D. Thakker, 2011, The Journal of Biological Chemistry.

Prodrugs of anticancer agents

D. Thakker, A. K. Sinhababu, A. Sinhababu, 1996 .

Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens.

D. Jerina, A. Conney, P. Thomas, 1982, Drug metabolism reviews.

Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes.

D. Jerina, P. van Bladeren, D. Thakker, 1983, Molecular pharmacology.

Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.

D. Jerina, D. Thakker, O. Hernandez, 1977, Journal of the American Chemical Society.

Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10-epoxide metabolites induced by changes in pH.

D. Jerina, D. Thakker, H. Yagi, 1977, Journal of the American Chemical Society.

Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists

D. Thakker, L. Gan, Dhiren R. Thakker, 2004, Pharmaceutical Research.

Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes

D. Benjamin, P. Annaert, P. Augustijns, 2008, Drug Metabolism and Disposition.

Efflux Ratio Cannot Assess P-Glycoprotein-Mediated Attenuation of Absorptive Transport: Asymmetric Effect of P-Glycoprotein on Absorptive and Secretory Transport Across Caco-2 Cell Monolayers

D. Thakker, M. Troutman, 2003, Pharmaceutical Research.

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

X. Ming, J. Hall, D. Thakker, 2009, Drug Metabolism and Disposition.

P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.

K. Brouwer, P. Annaert, D. Thakker, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge.

D. Thakker, M. Troutman, B. Knight, 2006, Current opinion in pharmacology.

Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

D. Jerina, A. Conney, P. Thomas, 1981, Molecular pharmacology.

ABSOLUTE STEREOCHEMISTRY OF THE HIGHLY MUTAGENIC 7,8‐DIOL 9,10‐EPOXIDES DERIVED FROM THE POTENT CARCINOGEN TRANS‐7,8‐DIHYDROXY‐7,8‐DIHYDROBENZO(A)PYRENE

D. Jerina, D. Thakker, H. Yagi, 1977 .

Synthesis and assignment of absolute configuration to the trans 3,4-dihydrodiols and 3,4-diol-1,2-epoxides of benzo[c]phenanthrene

D. Jerina, D. Thakker, H. Yagi, 1983 .

An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide.

T. Slaga, D. Jerina, J. Karle, 1980, The Journal of biological chemistry.

SYNTHESIS AND ASSIGNMENT OF ABSOLUTE CONFIGURATION TO THE TRANS-3,4-DIHYDRODIOLS AND -3,4-DIOL-1,2-EPOXIDES OF BENZO(C)PHENANTHRENE

D. Jerina, D. Thakker, H. Yagi, 1983 .

Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

D. Jerina, A. Conney, D. Thakker, 1977, Chemico-biological interactions.

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.

D. Jerina, A. Conney, D. Thakker, 1978, Cancer research.

Differential Substrate and Inhibitory Activities of Ranitidine and Famotidine toward Human Organic Cation Transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

D. Thakker, D. Bourdet, J. B. Pritchard, 2005, Journal of Pharmacology and Experimental Therapeutics.

Mutagenicity of the enantiomers of the diastereomeric bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides in bacterial and mammalian cells.

D. Jerina, A. Conney, D. Thakker, 1983, Cancer research.

Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models.

D. Jerina, A. Conney, D. Thakker, 1986, Cancer research.

Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.

D. Jerina, A. Conney, D. Thakker, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Role of Purified Cytochrome P-448 and Epoxide Hydrase in the Activation and Detoxification of Benzo[a]pyrene

A. Y. Lu, D. Jerina, A. Conney, 1977 .

Metabolism and tumorigenicity of 7-, 8-, 9-, and 10-fluorobenzo(a)pyrenes.

T. Slaga, D. Jerina, D. Buhler, 1982, Cancer research.

Stereoselective metabolism of the optical isomers of trans-1,2-dihydroxy-1,2-dihydrophenanthrene to bay-region diol epoxides by rat liver microsomes.

D. Jerina, A. Conney, D. Thakker, 1982, Chemico-Biological Interactions.

Catechol O-methyltransferase. 9. Mechanism of inactivation by 6-hydroxydopamine.

R. Borchardt, D. Thakker, J. Reid, 1976, Journal of medicinal chemistry.

Rhodamine 123 Requires Carrier-Mediated Influx for Its Activity as a P-Glycoprotein Substrate in Caco-2 Cells

D. Thakker, M. Troutman, 2003, Pharmaceutical Research.

Evidence for sulfhydryl groups at the active site of catechol-O-methyltransferase.

R. Borchardt, D. Thakker, 1976, Biochimica et biophysica acta.

Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny

D. Thakker, Michael Zhuo Wang, Nicole R. Zane, 2016, Drug Metabolism and Disposition.

Phospholipase C-γ Modulates Epithelial Tight Junction Permeability through Hyperphosphorylation of Tight Junction Proteins*

D. Thakker, M. Troutman, P. Ward, 2002, The Journal of Biological Chemistry.

Mutagenicity of the enantiomers of the diastereomeric bay-region benz(a)anthracene 3,4-diol-1,2-epoxides in bacterial and mammalian cells.

D. Jerina, P. van Bladeren, A. Conney, 1983, Cancer research.

Effect of a 6-fluoro substituent on the metabolism and biological activity of benzo(a)pyrene.

T. Slaga, D. Jerina, D. Buhler, 1983, Cancer research.

Regio- and stereoselectivity of hepatic cytochrome P-450 toward polycyclic aromatic hydrocarbon substrates.

D. Jerina, A. Conney, D. Thakker, 1981, Advances in experimental medicine and biology.

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

M. A. Moseley, P. Augustijns, D. Thakker, 1996, Drug metabolism and disposition: the biological fate of chemicals.

DMD049965 642..650

D. Thakker, B. Knight, Arlene S. Bridges, 2013 .

[28] Analysis of polycyclic aromatic hydrocarbons and their metabolites by high-pressure liquid chromatography

D. Jerina, D. Thakker, H. Yagi, 1978 .

Higher clearance of micafungin in neonates compared with adults: role of age‐dependent micafungin serum binding

P. Smith, D. Benjamin, P. Annaert, 2011, Biopharmaceutics & drug disposition.

The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics.

D. Thakker, Cuiping Chen, 2002, The Journal of pharmacology and experimental therapeutics.

Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites

K. Brouwer, M. Radtke, D. Thakker, 2013, Drug Metabolism and Disposition.

Exploring the role of the pharmacist in global health.

P. Joyner, D. Thakker, David R Steeb, 2014, Journal of the American Pharmacists Association : JAPhA.

O-, N-, and S-methyltransferases

D. Thakker, C. Creveling, 1994 .

Determination of the Androgen Receptor Inhibitor Enzalutamide and its Metabolites in Animal Plasma and Brain Homogenates Using LC-MS/MS and its Application to Pharmacokinetic Studies

Yoshiaki Ohtsu, D. Thakker, K. Tsubota, 2015 .

Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine.

D. Thakker, D. Bourdet, Kiho Lee, 2004, Journal of medicinal chemistry.

Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.

D. Jerina, A. Conney, P. Thomas, 1982, Molecular pharmacology.

Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.

D. Jerina, D. Thakker, O. Hernandez, 1977, Journal of the American Chemical Society.

Differences in mutagenicity and cytotoxicity of (+)- and (-)-benzo[a]pyrene 4,5-oxide: a synergistic interaction of enantiomers.

D. Jerina, A. Conney, D. Thakker, 1979, Proceedings of the National Academy of Sciences of the United States of America.

The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes.

D. Jerina, A. Conney, P. Thomas, 1979, Molecular pharmacology.

Stereoselective Metabolic Activation of Polycyclic Aromatic Hydrocarbons

D. Jerina, J. Karle, A. Conney, 1979 .

Marked differences in the carcinogenic activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in newborn mice.

D. Jerina, A. Conney, D. Thakker, 1978, Cancer research.

Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).

R. Iyer, D. Thakker, W. Egan, 1994, Journal of pharmaceutical sciences.

Appendix I – Update to Vol. IIA: Polycyclic Aromatic Hydrocarbons and Carcinogenesis: The Bay-Region Theory

D. Jerina, A. Conney, D. Thakker, 1982 .

The effect of steric strain in the bay-region of polycyclic aromatic hydrocarbons: tumorigenicity of alkyl-substituted benz[a]anthracenes.

D. Jerina, A. Conney, D. Thakker, 1983, Cancer letters.

Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug

D. Boykin, D. Thakker, M. Paine, 2013, Drug Metabolism and Disposition.

In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

J. Ibrahim, D. Benjamin, P. Annaert, 2010, Drug Metabolism and Disposition.

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Thomas J. Raub, P. Artursson, K. Audus, 2016, Journal of pharmaceutical sciences.

Carcinogenicity of benzo[a]pyrene derivatives: the bay region theory

D. Jerina, A. Conney, D. Thakker, 1978 .

Highly tumorigenic bay-region diol epoxides from the weak carcinogen benzo[c]phenanthrene.

D. Jerina, A. Conney, D. Thakker, 1981, Advances in experimental medicine and biology.

8 – The Bay-Region Theory of Carcinogenesis by Polycyclic Aromatic Hydrocarbons

M. Schaefer-Ridder, D. Jerina, J. Karle, 1978 .

Synthesis of acyloxyalkyl acylphosphonates as potential prodrugs of the antiviral, trisodium phosphonoformate (foscarnet sodium)

H. Mitsuya, R. Iyer, D. Thakker, 1989 .

A Novel Reaction between Acetone and the Benzo[c]phenanthrene K-Region o-Quinone Containing a Peri-Fluoro Substituent

D. Thakker, S. Unger, S. Mirsadeghi, 1991 .

General acid catalysis in the hydrolysis of benzo[a]pyrene 7,8-diol 9,10-epoxides [19]

D. Jerina, D. Thakker, J. Montemarano, 1979 .

Affinity labeling of catechol O-methyltransferase by N-haloacetyl derivatives of 3,5-dimethoxy-4-hydroxyphenylethylamine and 3,4-dimethoxy-5-hydroxyphenylethylamine. Kinetics of inactivation.

R. Borchardt, D. Thakker, 1975, Biochemistry.

A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children

D. Thakker, Dhiren R Thakker, Nicole R Zane, 2014, Clinical Pharmacokinetics.

Affinity labeling of catechol-O-methyltransferase with N-iodoacetyl-3,5-dimethoxy-4-hydroxyphenylethylamine.

R. Borchardt, D. Thakker, 1973, Biochemical and biophysical research communications.

Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides.

D. Jerina, A. Conney, D. Thakker, 1977, Biochemical and biophysical research communications.

Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-3,4-dihydroxy-3,4-dihydrobenz[a]anthracene by rat liver microsomes and by a purified and reconstituted cytochrome P-450 system.

D. Jerina, A. Conney, P. Thomas, 1982, The Journal of biological chemistry.

Tumorigenicity of the diastereomeric benz[a]anthracene 3,4-diol-1,2-epoxides and the (+)- and (-)-enantiomers of benz[a]anthracene 3,4-dihydrodiol in newborn mice.

D. Jerina, A. Conney, D. Thakker, 1979, Journal of the National Cancer Institute.

Metabolic formation of 1,9,10-trihydroxy-9,10-dihydro-3-methylcholanthrene: a potential proximate carcinogen from 3-methylcholanthrene.

D. Jerina, A. Conney, D. Thakker, 1978, Journal of the American Chemical Society.

Biological activity of benzo[e]pyrene. An assessment based on mutagenic activities and metabolic profiles of the polycyclic hydrocarbon and its derivatives.

N. Whittaker, D. Jerina, A. Conney, 1979, The Journal of biological chemistry.

Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells.

D. Jerina, A. Conney, P. Thomas, 1978, Cancer research.

Nuclear metabolism of benzo(a)pyrene and of (+/-)-trans-7-8-dihydroxy-7-8,-dihydrobenzo(a)pyrene. Comparative chromatographic analysis of alkylated DNA.

D. Jerina, E. Bresnick, D. Thakker, 1977, Archives of biochemistry and biophysics.

Absolute stereochemistry of the trans-dihydrodiols formed from benzo[a]anthracene by liver microsomes.

D. Jerina, A. Conney, S. Turujman, 1979, Chemico-biological interactions.

High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz(a)anthracene in the expression of tumorigenic activity in murine tumor models.

D. Jerina, A. Conney, D. Thakker, 1984, Cancer research.

METABOLIC FORMATION OF 1,9,10-TRIHYDROXY-9,10-DIHYDRO-3-METHYLCHOLANTHRENE- A POTENTIAL PROXIMATE CARCINOGEN FROM 3-METHYLCHOLANTHRENE

D. Jerina, A. Conney, D. Thakker, 1978 .

Cellular Delivery of Nucleoside Diphosphates: A Prodrug Approach

B. Mitchell, J. G. Cory, D. Thakker, 1997, Pharmaceutical Research.

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

A. Y. Lu, A. Conney, D. Thakker, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

D. Jerina, A. Conney, D. Thakker, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Absolute Stereochemistry of the Highly Mutagenic 7,8-Diol 9,10-Epoxides Derived from the Potent Carcinogen trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene

D. Jerina, D. Thakker, H. Yagi, 1977 .

absolute configuration of the k-region 4,5-dihydrodiols and 4,5-oxide of benzo[a]pyrene

D. Jerina, R. Armstrong, D. Thakker, 1981 .

Stereoselective formation of benz[a]anthracene (+)-(5S,6R)-oxide and (+)-(8R,9S)-oxide by a highly purified and reconstituted system containing cytochrome P-450c.

D. Jerina, P. van Bladeren, P. Thomas, 1982, Biochemical and biophysical research communications.

Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues

D. Thakker, Souzan B. Yanni, 2007 .

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis.

X. Ming, D. Thakker, W. Proctor, 2016, Journal of pharmaceutical sciences.

Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.

X. Ming, D. Thakker, Xin Ming, 2010, Biochemical pharmacology.

Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers

Liang-Shang Gan, D. Thakker, L. Gan, 1993, Pharmaceutical Research.

Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

D. Thakker, G. Veal, Nicole R. Zane, 2019, CPT: pharmacometrics & systems pharmacology.

Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours

D. Thakker, H. Cai, R. Everett, 2019, British journal of pharmacology.

Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes

K. Brouwer, D. Thakker, Chester Costales, 2013, Molecular Pharmacology.

In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters

X. Ming, D. Thakker, W. Proctor, 2010 .

Mechanisms Underlying Saturable Intestinal Absorption of Metformin

D. Thakker, W. Proctor, William R Proctor, 2008, Drug Metabolism and Disposition.

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

D. Thakker, L. Gan, Dhiren R. Thakker, 1997 .

In Vitro Characterization of Intestinal and Hepatic Transporters: MRP2

D. Thakker, S. Dallas, J. Kunta, 2014 .

Cation‐selective transporters are critical to the AMPK‐mediated antiproliferative effects of metformin in human breast cancer cells

D. Thakker, T. Han, H. Cai, 2016, International journal of cancer.

Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.

D. Boykin, Lianwen Zhou, J. Hall, 2002, Journal of mass spectrometry : JMS.

Regioselectivity of catechol O-methyltransferase. The effect of pH on the site of O-methylation of fluorinated norepinephrines.

D. Thakker, K. Kirk, K L Kirk, 1986, The Journal of biological chemistry.

Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds

D. Thakker, 2006 .

Differential Substrate and Inhibitory Activities of Ranitidine and Famotidine toward hOCT1 (SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

D. Thakker, D. Bourdet, J. B. Pritchard, 2005 .

Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl)Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug

D. Boykin, Lianwen Zhou, J. Hall, 2002, Pharmaceutical Research.

USE OF CACO-2 CELLS AS AN IN VITRO INTESTINAL ABSORPTION AND METABOLISM MODEL

D. Thakker, L. Gan, P. Hsyu, 1994 .

Secretory Transport of Ranitidine and Famotidine across Caco-2 Cell Monolayers

K. Brouwer, D. Thakker, Kiho Lee, 2002, Journal of Pharmacology and Experimental Therapeutics.

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism.

D. Thakker, J. H. Ansede, J. Ansede, 2004, Journal of pharmaceutical sciences.

Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers

D. Thakker, Chester Costales, W. Proctor, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Novel Experimental Parameters to Quantify the Modulation of Absorptive and Secretory Transport of Compounds by P-Glycoprotein in Cell Culture Models of Intestinal Epithelium

Matthew D. Troutman, D. Thakker, M. Troutman, 2003, Pharmaceutical Research.

Metabolism of benzo[c]phenanthrene by rat liver microsomes and by a purified monooxygenase system reconstituted with different isozymes of cytochrome P-450.

D. Jerina, A. Conney, P. Thomas, 1983, Chemico-biological interactions.

Stereoselective metabolism of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-3,4-dihydroxy-3,4-dihydrobenzo[c]-phenanthrene by rat and mouse liver microsomes and by a purified and reconstituted cytochrome P-450 system.

D. Jerina, A. Conney, P. Thomas, 1986, The Journal of biological chemistry.

High mutageniticity of metabolically activated chrysene 1,2 dihydrodiol: evidence for bay region activation of chrysene.

D. Jerina, A. Conney, P. Thomas, 1977, Biochemical and biophysical research communications.

BAY-REGION ACTIVATION OF POLYCYCLIC AROMATIC HYDROCARBONS TO ULTIMATE MUTAGENS AND CARCINOGENS

D. Jerina, A. Conney, D. Thakker, 1980 .

SYNTHESIS OF THE ENANTIOMERIC BAY-REGION DIOL EPOXIDES OF BENZ(A)ANTHRACENE AND CHRYSENE

D. Jerina, D. Thakker, H. Yagi, 1982 .

Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group.

D. Thakker, G. K. Prasad, 1991, Biochemical and biophysical research communications.

Stereoselective formation of benzo(c)phenanthrene (+)-(3S,4R) and (+)-(5S,6R)-oxides by cytochrome P450c in a highly purified and reconstituted system.

D. Jerina, P. van Bladeren, P. Thomas, 1987, Biochemical and biophysical research communications.

Metabolism of trans-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide.

A. Y. Lu, D. Jerina, A. Conney, 1978, Molecular pharmacology.

Synthesis of the enantiomeric bay-region diol epoxides of benz[a]anthracene and chrysene

D. Jerina, D. Thakker, H. Yagi, 1982 .

Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

A. Y. Lu, D. Jerina, A. Conney, 1977, The Journal of biological chemistry.

Benzo-ring diol epoxides of benzo[e]pyrene and triphenylene

D. Jerina, D. Thakker, H. Yagi, 1979 .

Carcinogenicity of Polycyclic Aromatic Hydrocarbons: The Bay-Region Theory

D. Jerina, A. Conney, D. Thakker, 1980 .

BENZO-RING DIOL EPOXIDES OF BENZO(E)PYRENE AND TRIPHENYLENE

D. Jerina, D. Thakker, H. Yagi, 1980 .

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport.

P. Augustijns, D. Thakker, D R Thakker, 1993, Biochemical and biophysical research communications.

Purification of catechol-O-methyltransferase by affinity chromatography.

R. Borchardt, D. Thakker, C. Cheng, 1975, Biochemical and biophysical research communications.

Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers.

T. Tippin, D. Thakker, 2008, Journal of pharmaceutical sciences.

Response to: “Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach”

D. Thakker, Nicole R. Zane, 2015, Clinical Pharmacokinetics.

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers.

D. Thakker, K Lee, D R Thakker, 1999, Journal of pharmaceutical sciences.

P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

D. Thakker, B. Knight, Arlene S. Bridges, 2013, Drug Metabolism and Disposition.

Cytochrome P450 and Flavin-containing Monooxygenase Families: Age-Dependent Differences in Expression and Functional Activity

D. Thakker, Michael Zhuo Wang, Nicole R. Zane, 2017, Pediatric Research.

Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.

D. Jerina, A. Conney, D. Thakker, 1981, Cancer research.

Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption

D. Thakker, Arlene S. Bridges, M. Dufek, 2013, Drug Metabolism and Disposition.

Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells.

D. Jerina, Subodh Kumar, A. Conney, 1980, Cancer research.

Metabolism of benzo[a]anthracene to its tumorigenic 3,4-dihydrodiol.

D. Jerina, J. Karle, A. Conney, 1979, Molecular pharmacology.

Stereoselective metabolism of polycyclic aromatic hydrocarbons to carcinogenic metabolites

D. Jerina, A. Conney, D. Thakker, 1985 .

Evidence for the role of OATP and PEPT1 transporters in the intestinal apical transport of amoxicillin

D. Thakker, Christine M. M. Lee, 2018 .

A Physiologically Based Pharmacokinetic Model Incorporating Extrahepatic Metabolism Explains Voriconazole Pediatric Bioavailability Differences

D. Thakker, Nicole R. Zane, 2013 .

Special Section on Pediatric Drug Disposition and Pharmacokinetics Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny s

D. Thakker, Nicole R. Zane, Yao Chen, 2016 .

Effects of a 6-fluoro substituent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes.

D. Jerina, A. Conney, D. Thakker, 1984, Journal of Biological Chemistry.

Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihydrodiol of triphenylene.

D. Jerina, P. Thomas, D. Thakker, 1991, Archives of biochemistry and biophysics.

Enzymatic O-methylation of norepinephrine: Studies on the site of methylation by high pressure liquid chromatography

D. Thakker, K. Kirk, C. Creveling, 1982 .

Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes

K. Brouwer, D. Thakker, Chester Costales, 2013, Molecular Pharmacology.

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

J. Hall, D. Thakker, R. Tidwell, 2009, Drug Metabolism and Disposition.

Metformin modulates glucose uptake and transport in Caco-2 cell monolayers

D. Thakker, B. Mackowiak, Chester Costales, 2013 .

Enhancing paracellular permeability by modulating epithelial tight junctions.

D. Thakker, Ward, Thakker, 2000, Pharmaceutical science & technology today.

Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability

D. Thakker, P. Ward, Ouyang Hui, 2003, Journal of Pharmacology and Experimental Therapeutics.

Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites

K. Brouwer, M. Radtke, D. Thakker, 2013, Drug Metabolism and Disposition.

Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry.

D. Boykin, Lianwen Zhou, J. Hall, 2002, Rapid communications in mass spectrometry : RCM.