J. Johnston

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Assessment of treatment response in chronic constipation clinical trials

S. Shiff, C. Ervin, S. Fehnel, 2014, Clinical and experimental gastroenterology.

Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.

M. Currie, S. Brierley, L. Blackshaw, 2013, Gastroenterology.

Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation.

M. Currie, A. Lembo, M. Baird, 2010, Gastroenterology.

Efficacy of linaclotide for patients with chronic constipation.

M. Currie, A. Lembo, J. Johnston, 2010, Gastroenterology.

Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial.

A. Rascu, P. Emery, G. Panayi, 2002, Rheumatology.

Clarification of linaclotide clinical trial information in a recent review on constipation.

J. Johnston, Taryn Weissman, 2013, Gastroenterology.

Impact of linaclotide treatment on work productivity and activity impairment in adults with irritable bowel syndrome with constipation: results from 2 randomized, double-blind, placebo-controlled phase 3 trials.

R. Carson, J. Johnston, S. Tourkodimitris, 2014, American health & drug benefits.

Treatment of active refractory rheumatoid arthritis with humanized monoclonal antibody CAMPATH-1H administered by daily subcutaneous injection.

E. Matteson, E. S. St. Clair, J. Johnston, 1995, Arthritis and rheumatism.

Responders vs clinical response: a critical analysis of data from linaclotide phase 3 clinical trials in IBS-C

M. Currie, S. Shiff, A. Lembo, 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

D. Drossman, M. Currie, A. Lembo, 2009, The American Journal of Gastroenterology.

A randomized controlled and long‐term linaclotide study of irritable bowel syndrome with constipation patients in Japan

M. Currie, K. Haruma, S. Fukudo, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions

M. Currie, Xizhong Shen, J. Johnston, 2018, Journal of gastroenterology and hepatology.

Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.

A. Zinsmeister, M. Camilleri, M. Currie, 2007, Gastroenterology.

Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia.

D. Symmons, J. Isaacs, G. Hale, 2001, Arthritis and rheumatism.

Linaclotide Significantly Improved Abdominal Pain, Constipation and Global Assessments in Adults with Irritable Bowel Syndrome with Constipation: Results from a Large Twelve-Week, Randomized, Double-Blind, Placebo-Controlled Study

M. Currie, A. Lembo, M. Baird, 2008 .

Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation.

M. Currie, S. Shiff, E. Quigley, 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

An evaluation of the FDA Responder Endpoint for IBS‐C clinical trials: analysis of data from linaclotide Phase 3 clinical trials

L. Nelson, M. Currie, S. Shiff, 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

M. Camilleri, M. Currie, S. Shiff, 2013 .

Randomised clinical trials: linaclotide phase 3 studies in IBS‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints

W. Chey, M. Currie, S. Shiff, 2013, Alimentary pharmacology & therapeutics.

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

W. Chey, M. Currie, S. Shiff, 2012, The American Journal of Gastroenterology.

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

M. Currie, S. Shiff, A. Lembo, 2012, The American Journal of Gastroenterology.

The Use of Interferon-α in Virus Infections

N. Sheron, J. Johnston, G. Scott, 1991, Drugs.

Antibodies in patients with recurrent respiratory papillomatosis treated with lymphoblastoid interferon.

L. Thurmond, J. Johnston, B. Leventhal, 1991, The Journal of laboratory and clinical medicine.

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls

Gulzar Singh, R. Spiller, W. D. de Vos, 2019, International Journal of Molecular Sciences.

Two randomized trials of linaclotide for chronic constipation.

M. Currie, S. Shiff, A. Lembo, 2011, The New England journal of medicine.

Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis

M. Currie, S. Shiff, A. Lembo, 2019, Expert review of gastroenterology & hepatology.

High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extension study in Japan

M. Currie, T. Ohkusa, S. Fukudo, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Dose‐finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double‐blind, and placebo‐controlled study

M. Currie, T. Ohkusa, S. Fukudo, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Response to Miner et al.

M. Currie, S. Shiff, J. Johnston, 2017, The American Journal of Gastroenterology.

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

M. Currie, S. Shiff, A. Lembo, 2015, PloS one.

The impact of abdominal pain on global measures in patients with chronic idiopathic constipation, before and after treatment with linaclotide: a pooled analysis of two randomised, double-blind, placebo-controlled, phase 3 trials

M. Currie, L. Chang, S. Shiff, 2014, Alimentary pharmacology & therapeutics.

Psychometric validation of patient-reported outcome measures assessing chronic constipation

L. Nelson, S. Fehnel, M. Baird, 2014, Clinical and experimental gastroenterology.

A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes

L. Corey, M. Levin, J. Bosso, 1986, Antimicrobial Agents and Chemotherapy.

Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging

L. Marciani, Gulzar Singh, R. Spiller, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

CAMPATH-1H in rheumatoid arthritis--an intravenous dose-ranging study.

T. Schnitzer, E. Matteson, J. Isaacs, 1996, British journal of rheumatology.

A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.

M. Swaminathan, M. Fink, G. Roach, 2009, Journal of cardiothoracic and vascular anesthesia.

Nosocomial Outbreak of Hand-Foot-and-Mouth Disease Among Operating Suite Personnel

J. Burke, J. Johnston, 1986, Infection Control.

Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large 4-Week, Randomized, Double-Blind, Placebo-Controlled Study

D. Drossman, M. Currie, A. Lembo, 2008 .

Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS-C

L. Nelson, M. Camilleri, M. Currie, 2015, United European gastroenterology journal.

Measuring the Symptoms of Pediatric Constipation and Irritable Bowel Syndrome with Constipation: Expert Commentary and Literature Review

S. Shiff, J. Hyams, R. Carson, 2014, The Patient - Patient-Centered Outcomes Research.