S. Ishiura

发表

Usefulness of Monitoring γ-H2AX and Cell Cycle Arrest in HepG2 Cells for Estimating Genotoxicity Using a High-Content Analysis System

Masamitsu Ando, K. Yoshikawa, Y. Iwase, 2014, Journal of biomolecular screening.

Identification of a dopamine receptor from Caenorhabditis elegans

S. Ishiura, S. Suo, N. Sasagawa, 2002, Neuroscience Letters.

A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors.

K. Suzuki, H. Sorimachi, S. Ishiura, 2000, Journal of virological methods.

Dopamine receptors in C. elegans.

H. V. Van Tol, S. Ishiura, S. Suo, 2004, European journal of pharmacology.

Purification of native p94, a muscle-specific calpain, and characterization of its autolysis.

H. Kawasaki, K. Suzuki, H. Sorimachi, 1998, The Biochemical journal.

Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme.

K. Suzuki, T. Tabira, E. Kominami, 1991, Biochemical and biophysical research communications.

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

Koji Abe, Sumio Sugano, Akio Ikeda, 2018, Nature Genetics.

Exon Skipping by Ultrasound-Enhanced Delivery of Morpholino with Bubble Liposomes for Myotonic Dystrophy Model Mice.

Y. Negishi, Y. Endo-Takahashi, S. Ishiura, 2018, Methods in molecular biology.

Splicing of human chloride channel 1

Michinori Koebis, S. Ishiura, Natsumi Ohsawa-Yoshida, 2015, Biochemistry and biophysics reports.

Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.

I. Nishino, C. Toyoshima, H. Ogawa, 2015, Biochimica et biophysica acta.

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice

I. Nishino, S. Takeda, S. Ishiura, 2013, Scientific Reports.

Ultrasound-enhanced delivery of Morpholino with Bubble liposomes ameliorates the myotonia of myotonic dystrophy model mice

H. Yamaura, D. Yanagihara, M. Sonoo, 2013, Scientific Reports.

Immunolocalization of myotonic dystrophy protein kinase in corbular and junctional sarcoplasmic reticulum of human cardiac muscle

Takayoshi Kobayashi, H. Ueda, S. Ishiura, 1998, The Histochemical Journal.

Direct Evidence that EXP / muscleblind Interacts with CCUG Tetranucleotide Repeats

Y. Kino, S. Ishiura, N. Sasagawa, 2003 .

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

Y. Ihara, N. Dohmae, C. Haass, 2003, The Journal of biological chemistry.

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein*

Y. Ihara, N. Dohmae, C. Haass, 2003, Journal of Biological Chemistry.

In vitro reconstitution of gamma-secretase activity using yeast microsomes.

E. Futai, S. Ishiura, S. Yagishita, 2008, Biochemical and biophysical research communications.

Studies of a calcium-activated neutral protease from chicken skeletal muscle. II. Substrate specificity.

K. Imahori, K. Suzuki, S. Ishiura, 1979, Journal of biochemistry.

Expanded CTG repeats in myotonin protein kinase suppresses myogenic differentiation

K. Suzuki, H. Sorimachi, S. Ishiura, 1997, Neuroreport.

Aβ46 Is Processed to Aβ40 and Aβ43, but Not to Aβ42, in the Low Density Membrane Domains*

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, Journal of Biological Chemistry.

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, The Journal of biological chemistry.

beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.

Kazuki Saito, Y. Kiso, Y. Hamada, 2006, Bioorganic & medicinal chemistry letters.

The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy.

M. Nakagawa, I. Nonaka, I. Nishino, 2002, Journal of biochemistry.

Mutation of potential N-linked glycosylation sites in the Alzheimer's disease amyloid precursor protein (APP)

T. Tsuchiya, H. Sorimachi, S. Ishiura, 1996, Neuroscience Letters.

Changes of lysosomal proteinase activities and their expression in rat cultured keratinocytes during differentiation.

T. Tsukahara, E. Kominami, S. Ishiura, 1991, Biochimica et biophysica acta.

Structure and physiological functions of ubiquitous and tissue-specific calpain species. Muscle-specific calpain, p94, interacts with connectin/titin.

K. Suzuki, H. Sorimachi, H. Yajima, 1996, Advances in biophysics.

Skeletal muscle-specific calpain, p49: structure and physiological function.

K. Suzuki, H. Sorimachi, S. Ishiura, 1998, Biochemical pharmacology.

Studies of a calcium-activated neutral protease from chicken skeletal muscle. I. Purification and characterization.

K. Imahori, K. Suzuki, S. Ishiura, 1978, Journal of biochemistry.

Calcium-activated neutral protease. Its localization in the myofibril, especially at the Z-band.

K. Imahori, S. Ishiura, H. Sugita, 1980, Journal of biochemistry.

Degradation of nicastrin involves both proteasome and lysosome

H. Qing, S. Ishiura, Y. Tong, 2007, Journal of neurochemistry.

Presenilin 1 is involved in the maturation of β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1)

S. Shimohama, R. Takahashi, T. Kihara, 2007 .

Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue

T. Tsukahara, Hisashi Ito, T. Nishikawa, 1990, Neuroscience Letters.

Identification of a putative amyloid A4‐generating enzyme as a prolyl endopeptidase

T. Tabira, T. Tsukahara, S. Ishiura, 1990 .

Putative N‐terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cells

T. Tabira, T. Tsukahara, S. Ishiura, 1989, FEBS letters.

Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum‐free medium

M. Asashima, A. Kurisaki, S. Ishiura, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Overexpression of human myotonic dystrophy protein kinase in Schizosaccharomyces pombe induces an abnormal polarized and swollen cell morphology.

Y. Kino, S. Ishiura, N. Sasagawa, 2003, Journal of biochemistry.

Transgenic Rice Expressing Amyloid β-peptide for Oral Immunization

E. Futai, Yuichiro Watanabe, S. Ishiura, 2011, International journal of biological sciences.

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Y. Kiso, Y. Hamada, S. Ishiura, 2014, Bioorganic & medicinal chemistry letters.

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Y. Kiso, Y. Hamada, S. Ishiura, 2012, Bioorganic & medicinal chemistry letters.

Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.

Y. Kiso, Y. Hamada, S. Ishiura, 2009, Bioorganic & medicinal chemistry letters.

BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.

K. Suzuki, H. Sorimachi, T. Saido, 1999, The Biochemical journal.

ADAM19 is tightly associated with constitutive alzheimer's disease APP α-secretase in A172 cells

A. Sehara-Fujisawa, S. Ishiura, N. Sasagawa, 2007 .

Alzheimer Amyloid α‐Secretase: A Special Target for Drug Development

B. Szabó, S. Ishiura, N. Sasagawa, 2001 .

Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation

I. Nonaka, S. Ishiura, N. Sunohara, 1981, Journal of the Neurological Sciences.

ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.

A. Iwase, S. Mizutani, F. Kikkawa, 2004, Biochemical and biophysical research communications.

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

T. Ueno, E. Kominami, T. Yamaji, 2008, Autophagy.

Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.

M. Asashima, K. Yasuda, K. Ohnuma, 2010, The International journal of developmental biology.

Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains

S. Ishiura, H. Sugita, S. Kwak, 1991, Neuroscience Letters.

Addition of ATP increases the apparent molecular mass of the multicatalytic proteinase, ingensin

T. Tsukahara, S. Ishiura, H. Sugita, 1989, FEBS letters.

Multicatalytic proteinase is associated with characteristic oval structures in cortical Lewy bodies: an immunocytochemical study with light and electron microscopy

S. Ishiura, H. Sugita, S. Kwak, 1994, Journal of the Neurological Sciences.

26S multicatalytic proteinase complexes decrease during the differentiation of murine erythroleukemia cells.

T. Tsukahara, S. Ishiura, H. Sugita, 1991, Biochimica et biophysica acta.

Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase. Existence of N-terminal conserved and C-terminal diverged sequences among subunits.

H. Kawasaki, K. Suzuki, T. Tsukahara, 1990, European journal of biochemistry.

RNA degrading activity is tightly associated with the multicatalytic proteinase, ingensin

T. Tsukahara, K. Tanaka, S. Ishiura, 1989, FEBS letters.

Isolation of two forms of the high‐molecular‐mass serine protease, ingensin, from porcine skeletal muscle

S. Ishiura, H. Sugita, Motoki Sano, 1985, FEBS letters.

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.

B. Szabó, Y. Kiso, Tooru Kimura, 2003, Bioorganic & medicinal chemistry letters.

Effect of rice-expressed amyloid β in the Tg2576 Alzheimer's disease transgenic mouse model.

D. Yanagihara, S. Aoki, Yuichiro Watanabe, 2011, Vaccine.

Cleavage at the N-terminal site of Alzheimer amyloid beta/A4 protein is essential for its secretion.

S. Ishiura, H. Asada, Y. Kawamura, 1994, Biochemical and biophysical research communications.

Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.

N. Hattori, N. Nukina, Y. Kino, 2015, Human molecular genetics.

Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.

K. Suzuki, S. Ishiura, K. Maruyama, 1993, Biochemical and biophysical research communications.

An ATP-dependent protease and ingensin, the multicatalytic proteinase, in K562 cells.

T. Tsukahara, S. Ishiura, H. Sugita, 1988, European journal of biochemistry.

Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver.

S. Ishiura, H. Sugita, M. Nojima, 1986, Biochimica et biophysica acta.

Ingensin, a fatty acid-activated serine proteinase from rat liver cytosol.

S. Ishiura, H. Sugita, M. Nojima, 1986, Biochimica et biophysica acta.

Two-step mechanism of myofibrillar protein degradation in acute plasmocid-induced muscle necrosis.

H. Nakase, S. Ishiura, H. Sugita, 1984, Biochimica et biophysica acta.

Dystrophin diagnosis: comparison of dystrophin abnormalities by immunofluorescence and immunoblot analyses.

L. Kunkel, E. Hoffman, T. Tsukahara, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Immunohistochemical localization of AMP deaminase in rimmed vacuoles in human skeletal muscle

I. Nonaka, S. Ishiura, I. Higuchi, 1987, Muscle & nerve.

Alzheimer’s disease and proteinases

S. Ishiura, 1999 .

Decreased Expression of Alpha-B-crystallin in C 2 C 12 Cells that Express Human DMPK / 160 CTG Repeats

S. Ishiura, N. Sasagawa, Y. Takeshita, 2003 .

[Myotonic dystrophy].

Michinori Koebis, S. Ishiura, Kosuke Oana, 2013, Rinsho shinkeigaku = Clinical neurology.

Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.

T. Hamamoto, Y. Kagawa, M. Ikeda, 2004, Biochemical and biophysical research communications.

Myosin light chain components in single muscle fibers of duchenne muscular dystrophy

I. Nonaka, S. Ishiura, H. Sugita, 1982, Muscle & nerve.

Effect of denervation of neonatal rat sciatic nerve on the differentiation of myosin in a single muscle fiber

T. Mikawa, I. Nonaka, S. Ishiura, 1981, Experimental Neurology.

Localization of mature neprilysin in lipid rafts

E. Futai, M. Murata, S. Ishiura, 2012, Journal of neuroscience research.

Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System*

T. Iwatsubo, E. Futai, S. Ishiura, 2011, The Journal of Biological Chemistry.

CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators

E. Futai, S. Ishiura, S. Yagishita, 2012, Neuroscience Letters.

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

T. Iwatsubo, T. Saido, S. Ishiura, 1996, Biochemical and biophysical research communications.

Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex.

E. Futai, Y. Murakami, S. Ishiura, 2012, Biochemical and biophysical research communications.

In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat

S. Ishiura, K. Eto, I. Higuchi, 2001, Neuroscience Letters.

Trial of a cysteine proteinase inhibitor, EST, in experimental chloroquine myopathy in rats

S. Ishiura, I. Higuchi, H. Sugita, 1987, Muscle & nerve.

ISOLATION AND CHARACTERIZATION OF AUTOLYSOSOMES INDUCED BY A LONG-TERM ADMINISTRATION OF CHLOROQUINE

H. Tsukagoshi, S. Ishiura, H. Sugita, 1987 .

Alzheimer's therapy: a BACE in the hand?

R. Vassar, S. Ishiura, 2011, Nature Medicine.

Inhibitory Smad proteins promote the differentiation of mouse embryonic stem cells into ependymal-like ciliated cells.

M. Asashima, A. Kurisaki, K. Ohnuma, 2010, Biochemical and biophysical research communications.

A high-salinity solution with calcium chloride enables RNase-free, easy plasmid isolation within 55 minutes.

Michinori Koebis, S. Ishiura, N. Sasagawa, 2013, Bioscience trends.

Autolysis of calcium-activated neutral protease of chicken skeletal muscle.

K. Imahori, K. Suzuki, S. Ishiura, 1981, Journal of biochemistry.

Calcium‐Activated neutral protease in the peripheral nerve, which requires μM order Ca2+, and its effect on the neurofilament triplet

K. Suzuki, S. Ishiura, Y. Toyokura, 1985, Journal of neuroscience research.

Association and dissociation of the calcium-binding domains of calpain by Ca2+.

K. Suzuki, H. Sorimachi, S. Ishiura, 1999, Biochemical and biophysical research communications.

Overexpression, purification, and characterization of human m-calpain and its active site mutant, m-C105S-calpain, using a baculovirus expression system.

K. Suzuki, H. Sorimachi, T. Yoshizawa, 1998, Journal of biochemistry.

Molecular cloning and characterization of cDNAs for the mu-type large subunit and the small subunit of chicken calpain.

K. Suzuki, H. Sorimachi, S. Ishiura, 1997, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Calpain Dissociates into Subunits in the Presence Ions

Kazuo Suzuki, H. Sorimachi, T. Yoshizawa, 1995 .

A catalytic subunit of calpain possesses full proteolytic activity

K. Suzuki, H. Sorimachi, T. Yoshizawa, 1995, FEBS letters.

Calpain dissociates into subunits in the presence of calcium ions.

K. Suzuki, H. Sorimachi, T. Yoshizawa, 1995, Biochemical and biophysical research communications.

A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.

K. Suzuki, H. Sorimachi, S. Ishiura, 1993, The Journal of biological chemistry.

Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA–RNA interaction

S. Ishiura, N. Sasagawa, H. Nakase, 2004, Neuroscience Research.

ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.

E. Futai, S. Ishiura, N. Sasagawa, 2010, Biochemical and biophysical research communications.

Immunoblot analysis of dystrophin-related protein (DRP).

M. Takemitsu, I. Nonaka, S. Ishiura, 1993, Biochimica et biophysica acta.

Therapeutic trial with protease inhibitor (Leupeptin) in chicken muscular dystrophy

I. Nonaka, S. Ishiura, H. Sugita, 1982, Acta Neuropathologica.

Pathophysiology of muscle fiber necrosis induced by bupivacaine hydrochloride (Marcaine)

I. Nonaka, H. Nakase, S. Ishiura, 2004, Acta Neuropathologica.

Ca‐activated neutral protease and its inhibitors: In vitro effect on intact myofibrils

K. Imahori, K. Suzuki, S. Ishiura, 1980, Muscle & nerve.

Negative immunostaining of Duchenne muscular dystrophy(DMD) and mdx muscle surface membrane with antibody against synthetic peptide fragment predicted from DMD cDNA.

T. Tsukahara, I. Nonaka, S. Ishiura, 1988 .

Denervation enhances the expression of SHPS-1 in rat skeletal muscle.

S. Ishiura, N. Sasagawa, Y. Hayashi, 2005, Journal of biochemistry.

Phosphorylation of placental membrane proteins by a calcium- and phospholipid-dependent protein kinase.

S. Ishiura, T. Okuyama, C. Villee, 1986, Placenta.

M. Takemitsu, I. Nonaka, S. Ishiura, 1991, Biochemical and biophysical research communications.

Production of the herb Ruta chalepensis L. expressing amyloid β-GFP fusion protein

Yuichiro Watanabe, S. Ishiura, Taiji Yoshida, 2019, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Antibody against the C-terminal portion of dystrophin crossreacts with the 400 kDa protein in the pia mater of dystrophin-deficient mdx mouse brain.

T. Tsukahara, I. Nonaka, S. Ishiura, 1990, Journal of biochemistry.

Metabolism of amyloid precursor protein in COS cells transfected with a β-secretase candidate

Z. Kouchi, T. Maeda, H. Sorimachi, 2000, Cytotechnology.

Mature 98,000‐dalton acid α‐glucosidase is deficient in Japanese quails with acid maltase deficiency

T. Tsukahara, S. Ishiura, H. Sugita, 1989, Muscle & nerve.

Purification of an endogenous 68,000-dalton inhibitor of Ca2+-activated neutral protease from chicken skeletal muscle.

K. Suzuki, S. Ishiura, H. Murofushi, 1982, Biochimica et biophysica acta.

Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes.

S. Ishiura, H. Mitsuhashi, Shoin Tei, 2015, Biochemical and biophysical research communications.

Identification of Ca2+‐Activated Neutral Protease in the Peripheral Nerve and Its Effects on Neurofilament Degeneration

S. Ishiura, Y. Toyokura, H. Sugita, 1983, Journal of neurochemistry.

Identification of Ca 2+ -activated neutral protease (CANP) in the rat peripheral nerve

S. Ishiura, Y. Toyokura, H. Sugita, 1982 .

Effect of phosphatidyl-L-serine and vinculin on actin polymerization.

S. Ishiura, H. Sugita, M. Nojima, 1987, The International journal of biochemistry.

Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.

E. Perry, S. Ishiura, G. Falkous, 1996, Clinica chimica acta; international journal of clinical chemistry.

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression

S. Fuke, S. Ishiura, S. Suo, 2001, The Pharmacogenomics Journal.

Novel non-peptidic and small-sized BACE1 inhibitors.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

Minireview: Calcium-dependent proteolysis in living cells

S. Ishiura, 1981 .

MBNL1 associates with YB‐1 in cytoplasmic stress granules

E. Futai, Y. Kino, S. Ishiura, 2008, Journal of neuroscience research.

Structure and physiological function of calpains.

K. Suzuki, H. Sorimachi, S. Ishiura, 1997, The Biochemical journal.

Reappearance of embryonic neutral α-glucosidase isoenzyme in acid maltase-deficient muscle of Japanese quail

S. Ishiura, I. Higuchi, H. Sugita, 1988, Experimental Neurology.

α‐Glucosidase isoenzymes in normal and acid maltase‐deficient human skeletal muscles

I. Nonaka, S. Ishiura, H. Sugita, 1988, Muscle & nerve.

Dysbindin-1, a Schizophrenia-Related Protein, Functionally Interacts with the DNA- Dependent Protein Kinase Complex in an Isoform-Dependent Manner

Y. Hosoi, E. Futai, S. Ishiura, 2009, PloS one.

Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

H. Sorimachi, S. Ishiura, S. Ohno, 1995 .

Degradative activity of granzyme A on skeletal muscle proteins in vitro: A possible molecular mechanism for muscle fiber damage in polymyositis

Koichiro Nakamura, S. Ishiura, M. Osame, 1993, Neuromuscular Disorders.

Identification of Elastase as a Secretory Protease from Cultured Rat Microglia

S. Ishiura, S. Kohsaka, H. Sugita, 1992, Journal of neurochemistry.

Colocalization of prolyl endopeptidase and amyloid β-peptide in brains of senescence-accelerated mouse

Akira Kato, T. Yoshimoto, S. Ishiura, 1994, Neuroscience Letters.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Progression in nemaline myopathy

I. Nonaka, S. Ishiura, Kunio Ii, 2004, Acta Neuropathologica.

Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy

L. Kunkel, T. Tsukahara, I. Nonaka, 1991, Journal of the Neurological Sciences.

Mosaic expression of dystrophin in symptomatic carriers of Duchenne's muscular dystrophy.

T. Tsukahara, I. Nonaka, S. Ishiura, 1989, The New England journal of medicine.

Putative function of ADAM9, ADAM10, and ADAM17 as APP -secretase

B. Szabó, S. Ishiura, N. Sasagawa, 2003 .

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.

B. Szabó, S. Ishiura, N. Sasagawa, 2003, Biochemical and biophysical research communications.

Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs.

K. Suzuki, W. Linke, C. Gregorio, 1997, Journal of molecular biology.

Zygotic VegT is required for Xenopus paraxial mesoderm formation and is regulated by Nodal signaling and Eomesodermin.

Shuji Takahashi, Yoshikazu Haramoto, M. Asashima, 2010, The International journal of developmental biology.

Calcium activated neutral protease from human skeletal muscle

K. Imahori, S. Ishiura, Koichi Suzuki, 1979, FEBS letters.

Fragment of an endogenous inhibitor produced in Escherichia coli for calcium‐activated neutral protease (CANP) retains an inhibitory activity

K. Imahori, H. Kawasaki, Y. Emori, 1987, FEBS letters.

Calpain: novel family members, activation, and physiologic function.

K. Suzuki, H. Sorimachi, T. Yoshizawa, 1995, Biological chemistry Hoppe-Seyler.

Expression of polyalanine stretches induces mitochondrial dysfunction

E. Futai, Y. Kino, S. Ishiura, 2008, Journal of neuroscience research.

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1

N. Nukina, Y. Kino, S. Ishiura, 2009, Nucleic acids research.

The CUG-binding protein binds specifically to UG dinucleotide repeats in a yeast three-hybrid system.

K. Suzuki, S. Ishiura, N. Sasagawa, 2000, Biochemical and biophysical research communications.

Detection of a fast isoform of C-protein with an antiserum directed against the N-terminal portion of dystrophin.

T. Tsukahara, T. Tsuchiya, T. Obinata, 1990, Biochemical and Biophysical Research Communications - BBRC.

Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis.

K. Suzuki, Z. Kouchi, T. Saido, 1999 .

Functional Defects of a Muscle-specific Calpain, p94, Caused by Mutations Associated with Limb-Girdle Muscular Dystrophy Type 2A*

K Suzuki, J. Beckmann, H. Sorimachi, 1998, The Journal of Biological Chemistry.

Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs.

K. Suzuki, H. Sorimachi, S. Ishiura, 1997, Archives of biochemistry and biophysics.

Intracellular Localization of Homopolymeric Amino Acid-containing Proteins Expressed in Mammalian Cells*

Y. Kino, S. Ishiura, N. Sasagawa, 2004, Journal of Biological Chemistry.

Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3

S. Ishiura, S. Suo, Min Wang, 2014, Neuroscience Letters.

Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system

S. Fuke, T. Tsukahara, Y. Saga, 2006, Journal of neuroscience research.

Physical interaction between Tbx6 and mespb is indispensable for the activation of bowline expression during Xenopus somitogenesis.

Keisuke Hitachi, M. Asashima, A. Kurisaki, 2008, Biochemical and biophysical research communications.

Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human.

K. Suzuki, H. Sorimachi, S. Ishiura, 1996, Biochimica et biophysica acta.

Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression

Keisuke Hitachi, T. Michiue, M. Asashima, 2008, Proceedings of the National Academy of Sciences.

Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene.

S. Fuke, S. Ishiura, N. Sasagawa, 2005, Journal of biochemistry.

Acid maltase deficiency in the Japanese quail; early morphological event in skeletal muscle

I. Nonaka, S. Ishiura, I. Higuchi, 2004, Acta Neuropathologica.

Developmental study of α‐glucosidases in japanese quails with acid maltase deficiency

S. Ishiura, H. Sugita, F. Usuki, 1986 .

Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.

H. Kawasaki, K. Suzuki, H. Sorimachi, 1993, The Journal of biological chemistry.

Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system.

K. Suzuki, H. Sorimachi, S. Ishiura, 1999, Archives of biochemistry and biophysics.

Efficient four‐drug cocktail therapy targeting amyloid‐β peptide for Alzheimer's disease

T. Iwatsubo, T. Saido, N. Iwata, 2010, Journal of neuroscience research.

High AMP deaminase activity in rimmed vacuoles of skeletal muscle

I. Nonaka, S. Ishiura, I. Higuchi, 1986, Journal of the Neurological Sciences.

ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1

I. Nishino, Michinori Koebis, S. Ishiura, 2015, Genes to cells : devoted to molecular & cellular mechanisms.

Immunocytochemical localization of cathepsin B in degenerating rat skeletal muscle induced by a local anesthetic, bupivacaine.

H. Nakase, S. Ishiura, H. Sugita, 1983, Journal of biochemistry.

Interaction between emerin and nuclear lamins.

S. Ishiura, N. Sasagawa, H. Koike, 2001, Journal of biochemistry.

Transmural electrical stimulation-induced relaxation of the guinea-pig gall bladder.

S. Ishiura, M. Yoshida, 1981, Journal of pharmacobio-dynamics.

Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide

Hideo Sugita, Ikuya Nonaka, T. Tsukahara, 1988, Nature.

Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy

Takayoshi Kobayashi, H. Ueda, H. Mizusawa, 1999, Journal of the Neurological Sciences.

Calcium-dependent proteolysis in living cells.

S. Ishiura, 1981, Life Science.

Proteolytic Cleavage of the Alzheimer's Disease Amyloid A4 Precursor Protein

S. Ishiura, 1991 .

Biochemical aspects of bupivacaine-induced acute muscle degradation.

S. Ishiura, H. Sugita, I. Nonaka, 1986, Journal of cell science.

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy

Eric T. Wang, E. Wang, M. Swanson, 2016, Nature Communications.

Myotonic Dystrophy Protein Kinase Is a Sarcoplasmic Reticulum Protein Specifically Localized in Type I Muscle Fibers without Colocalization of SERCAII ATPase

Takayoshi Kobayashi, H. Ueda, H. Mizusawa, 2007 .

Plant-based vaccines for Alzheimer’s disease

S. Ishiura, Taiji Yoshida, 2019, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Characterization of a novel D2‐like dopamine receptor with a truncated splice variant and a D1‐like dopamine receptor unique to invertebrates from Caenorhabditis elegans

S. Fuke, H. V. Van Tol, S. Ishiura, 2005, Journal of neurochemistry.

Cloning and characterization of a Caenorhabditis elegans D2‐like dopamine receptor

S. Ishiura, S. Suo, N. Sasagawa, 2003, Journal of neurochemistry.

Muscle-specific Calpain, p94, Responsible for Limb Girdle Muscular Dystrophy Type 2A, Associates with Connectin through IS2, a p94-specific Sequence (*)

H. Sorimachi, S. Ishiura, N. Sasagawa, 1995, The Journal of Biological Chemistry.

Molecular Mechanisms of Myotonic Dystrophy: RNA-Mediated Pathogenesis and RNA-Binding Proteins

J. Satoh, Y. Kino, S. Ishiura, 2018 .

Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.

K. Suzuki, H. Yonekawa, I. Nonaka, 2000, Human molecular genetics.

Retinoic acid metabolizing factor xCyp26c is specifically expressed in neuroectoderm and regulates anterior neural patterning in Xenopus laevis.

T. Michiue, M. Asashima, Hiroki Danno, 2008, The International journal of developmental biology.

Regulation of body size in Caenorhabditis elegans: effects of environmental factors and the nervous system.

S. Ishiura, S. Suo, T. Nagashima, 2017, The International journal of developmental biology.

Human skeletal muscle contains two major aminopeptidases: an anion-activated aminopeptidase B and an aminopeptidase M-like enzyme.

S. Ishiura, H. Sugita, M. Nojima, 1987, Journal of Biochemistry (Tokyo).

Inhibition of epoxide derivatives on chicken calcium-activated neutral protease (CANP) in vitro and in vivo.

K. Imahori, K. Suzuki, S. Ishiura, 1980, Journal of biochemistry.

Dopamine regulates body size in Caenorhabditis elegans.

N. Kutsuna, S. Ishiura, S. Suo, 2016, Developmental biology.

Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay*

K. Ogata, A. Yamashita, S. Ishiura, 2007, Journal of Biological Chemistry.

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases

I. Kanazawa, E. Wanker, J. Botas, 2007, Nature Cell Biology.

xCOUP-TF-B regulates xCyp26 transcription and modulates retinoic acid signaling for anterior neural patterning in Xenopus.

T. Michiue, M. Asashima, S. Ishiura, 2012, The International journal of developmental biology.

CHLORIDE-ACTIVATED CYSTINE AMINOPEPTIDASE: A NEW ENZYME IN HUMAN SKELETAL MUSCLE

S. Ishiura, H. Sugita, M. Yamamoto, 1988 .

Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA-transfected C2C12 cell lines.

S. Ishiura, N. Sasagawa, F. Usuki, 2000, Biochemical and biophysical research communications.

Expanded CTG repeats in myotonin protein kinase increase susceptibility to oxidative stress

S. Ishiura, F. Usuki, 1998, Neuroreport.

BACE1 interacts with nicastrin.

T. Saido, Y. Kino, S. Ishiura, 2002, Biochemical and biophysical research communications.

Processing and secretion of Alzheimer's disease amyloid precursor protein.

K. Suzuki, H. Sorimachi, S. Ishiura, 1994, The Tohoku journal of experimental medicine.

Inhibitory spectra of purified protease nexin-II and related proteins towards cellular proteinases.

K. Suzuki, T. Miyatake, S. Ishiura, 1993, Biochimie.

Amyloid β/A4 Precursor Protein (APP) Processing in Lysosomes a

S. Ishiura, K. Tagawa, K. Maruyama, 1992 .

Mutation of Glu693 to Gln or Val717 to Ile has no effect on the processing of Alzheimer amyloid precursor protein expressed in COS-1 cells by cDNA transfection

S. Ishiura, K. Tagawa, K. Maruyama, 1991, Neuroscience Letters.

Interactions between homopolymeric amino acids (HPAAs)

Y. Kino, S. Ishiura, N. Sasagawa, 2007, Protein science : a publication of the Protein Society.

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.

T. Saido, N. Iwata, S. Ishiura, 2007, Biochemical and biophysical research communications.

Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells.

K. Suzuki, Z. Kouchi, T. Maeda, 2001, Journal of biochemistry.

MKBP, a Novel Member of the Small Heat Shock Protein Family, Binds and Activates the Myotonic Dystrophy Protein Kinase

I. Nonaka, Michihiko Yoshida, A. Suzuki, 1998, The Journal of cell biology.

Aspergillus oryzae palBory encodes a calpain-like protease: homology to Emericella nidulans PalB and conservation of functional regions.

K. Suzuki, E. Futai, K. Kitamoto, 1999, Journal of bioscience and bioengineering.

S. Ishiura, H. Sugita, R. Nakamura, 1994, Journal of neuroscience research.

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

S. Ishiura, N. Sasagawa, S. Kohsaka, 2007, Biochemical and biophysical research communications.

Molecular cloning and functional analysis of three subunits of yeast proteasome

K Suzuki, H Sugita, H. Kawasaki, 1991, Molecular and cellular biology.

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.

E. Futai, C. Kaether, S. Ishiura, 2016, Biochemical and biophysical research communications.

Speci fi c combinations of presenilins and Aph 1 s affect the substrate speci fi city and activity of g-secretase

E. Futai, C. Kaether, S. Ishiura, 2016 .

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities*

E. Futai, S. Ishiura, T. Tomita, 2015, The Journal of Biological Chemistry.

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations*S⃞

E. Futai, S. Ishiura, S. Yagishita, 2009, Journal of Biological Chemistry.

Changes in proteinase activities during the differentiation of murine erythroleukemia cells.

T. Tsukahara, E. Kominami, S. Ishiura, 1990, Experimental cell research.

Effect of cycloheximide administration on bupivacaine-induced acute muscle degradation.

S. Ishiura, H. Sugita, I. Nonaka, 1983, Journal of biochemistry.

Apolipoprotein B is a major perforin inhibitor protein in human serum.

H. Koizumi, H. Kawasaki, S. Ishiura, 1991, Molecular immunology.

Localization of BLT serine esterase is distinct from that of perforin in cytotoxic T lymphocyte.

T. Tsukahara, H. Koizumi, S. Ishiura, 1988 .

Effects of heparin and other acid mucopolysaccharides on the activity of a cytolytic pore-forming protein (perforin) from cytotoxic T-lymphocytes.

T. Tsukahara, H. Koizumi, S. Ishiura, 1988, Journal of biochemistry.

Isolation of a Ca-dependent erythrolytic protein (perforin) from cytotoxic T-lymphocytes.

H. Koizumi, S. Ishiura, K. Arahata, 1987, Journal of Biochemistry (Tokyo).

Genetic Heterozygous Carriers in Hereditary Muscular Dystrophy of Chickens

S. Ebashi, I. Nonaka, S. Ishiura, 1981 .

Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex

Y. Ihara, S. Murayama, M. Morishima-kawashima, 2005, Neurology.

An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model

T. Saido, N. Iwata, S. Ishiura, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins

S. Ishiura, H. Kubota, Miho Shimizu, 2011, Neuroscience Letters.

ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells.

A. Sehara-Fujisawa, S. Ishiura, N. Sasagawa, 2007, Biochemical and biophysical research communications.

Inhibition by KMI‐574 leads to dislocalization of BACE1 from lipid rafts

E. Futai, Y. Kiso, S. Ishiura, 2009, Journal of neuroscience research.

Spectrin extractability from erythrocyte in Duchenne muscular dystrophies and the effect of proteases on erythrocyte ghosts.

K. Imahori, S. Ishiura, H. Sugita, 1981, Clinica chimica acta; international journal of clinical chemistry.

Immunocytochemical localization of a full-length myotonin protein kinase in rat L6 myoblasts

H. Sorimachi, S. Ishiura, N. Sasagawa, 1996, Neuroscience Letters.

Alcoholism and Alternative Splicing of Candidate Genes

S. Ishiura, Shoichi Ishiura, Toshikazu Sasabe, 2010, International journal of environmental research and public health.

Arachidonate metabolites affect the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein.

K. Suzuki, H. Sorimachi, S. Ishiura, 1995, Biochemical and biophysical research communications.

Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β

E. Futai, Yuichiro Watanabe, S. Ishiura, 2011, Bioscience, biotechnology, and biochemistry.

Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients

Susumu Higuchi, S. Higuchi, S. Ishiura, 2007, Neuroscience Letters.

The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation

K. Suzuki, T. Maeda, E. Futai, 1999, Molecular and General Genetics MGG.

Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice

Tsuyoshi Koide, A. Takahashi, S. Ishiura, 2014, Journal of neuroscience research.

The androgen receptor facilitates inhibition of human dopamine transporter (DAT1) reporter gene expression by HESR1 and HESR2 via the variable number of tandem repeats

S. Ishiura, Kouta Kanno, 2012, Neuroscience Letters.

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

S. Ishiura, Kouta Kanno, 2011, Journal of neuroscience research.

Genetic Variants of the Dopaminergic System in Humans and Model Organisms

S. Ishiura, Kouta Kanno, 2011 .

RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells.

M. Raghunath, S. Arai, T. Tsuboi, 2018, Angewandte Chemie.

Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice

D. Yanagihara, Y. Urano, S. Ishiura, 2015, Bioscience, biotechnology, and biochemistry.

1,3-Capryloyl-2-arachidonoyl glycerol activates α-secretase activity and suppresses Aβ40 secretion in A172 cells

E. Futai, S. Ishiura, N. Sasagawa, 2009, Neuroscience Letters.

Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse

A. Sawa, K. Wada, H. Osaka, 2009, Neurochemistry International.

Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.

K. Suzuki, Z. Kouchi, H. Sorimachi, 1999, Biochemical and biophysical research communications.

BACE1 interacts with lipid raft proteins

S. Mizutani, T. Saido, S. Ishiura, 2006, Journal of neuroscience research.

Establishment of myoid cells from bone marrow.

A. Kikuchi, S. Furukawa, S. Ishiura, 1990, Cell biology international reports.

Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells.

K. Suzuki, Z. Kouchi, H. Sorimachi, 1999, Journal of biochemistry.

The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space

M. Shichiri, S. Ishiura, S. Nishimura, 2011, Hypertension Research.

Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease

E. Perry, R. Perry, S. Ishiura, 1995, Journal of the Neurological Sciences.

Endoplasmic reticulum stress caused by aggregate‐prone proteins containing homopolymeric amino acids

S. Ishiura, N. Sasagawa, I. Tanida, 2007, The FEBS journal.

Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.

S. Ishiura, H. Sugita, I. Nonaka, 1981, Journal of biochemistry.

BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin

Satoshi Tanaka, K. Shiota, M. Asashima, 2009, In Vitro Cellular & Developmental Biology - Animal.

Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1

I. Nishino, Michinori Koebis, Y. Kino, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

Reduction of amyloid beta-peptide accumulation in Tg2576 transgenic mice by oral vaccination.

E. Futai, Yuichiro Watanabe, S. Ishiura, 2010, Biochemical and biophysical research communications.

μ‐type calcium‐activated neutral protease in the rat peripheral nerve

S. Ishiura, H. Sugita, K. Kamakura, 1986 .

Nonredundant function of two highly homologous octopamine receptors in food‐deprivation‐mediated signaling in Caenorhabditis elegans

Midori Yoshida, S. Ishiura, S. Suo, 2014, Journal of neuroscience research.

Dopamine Modulates Acetylcholine Release via Octopamine and CREB Signaling in Caenorhabditis elegans

S. Ishiura, S. Suo, 2013, PloS one.

Expression, purification, and neurotrophic activity of amyloid precursor protein-secreted forms produced by yeast.

Y. Imai, S. Ishiura, S. Kohsaka, 1995, Biochemical and biophysical research communications.

Myotonic Dystrophy Protein Kinase [DMPK or Myotonin Protein Kinase (MtPK)]

S. Ishiura, N. Sasagawa, 2002 .

Expression of amyloid-beta 1-40 and 1-42 peptides in Capsicum annum var. angulosum for oral immunization.

B. Szabó, Yuichiro Watanabe, S. Ishiura, 2004, Assay and drug development technologies.

Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins

Yuichiro Watanabe, Y. Kino, S. Ishiura, 2009, Journal of neuroscience research.

The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice

B. Szabó, T. Saido, Y. Kiso, 2006 .

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.

B. Szabó, T. Saido, Y. Kiso, 2006, Journal of neurochemistry.

Molecular Cloning and Characterization of a Novel Tissue-Specific Calpain Predominantly Expressed in the Digestive Tract

H. Sorimachi, S. Ishiura, Koichi Suzuki, 1998, Biological chemistry.

Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.

Michinori Koebis, S. Ishiura, S. Suo, 2012, Biochemical and biophysical research communications.

β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the “Swedish Mutant” Amyloid Precursor Protein

E. Futai, S. Ishiura, S. Yagishita, 2009, The Journal of Biological Chemistry.

Novel isoform of myotonin protein kinase: gene product of myotonic dystrophy is localized in the sarcoplasmic reticulum of skeletal muscle.

K. Suzuki, H. Sorimachi, H. Ueda, 1997, The American journal of pathology.

Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin‐like domain in COS cells

H. Sorimachi, S. Ishiura, N. Sasagawa, 1994, FEBS letters.

Decreased myotonin-protein kinase in the skeletal and cardiac muscles in myotonic dystrophy.

T. Tsukahara, I. Nonaka, S. Ishiura, 1994, Biochemical and biophysical research communications.

Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts.

K. Suzuki, H. Sorimachi, S. Ishiura, 1995, FEBS letters.

Ingensin, a high-molecular-mass alkaline protease from rabbit reticulocyte.

S. Ishiura, H. Sugita, 1986, Journal of biochemistry.

An expanded CTG trinucleotide repeat causes trans RNA interference: a new hypothesis for the pathogenesis of myotonic dystrophy.

K. Suzuki, S. Ishiura, N. Sasagawa, 1999, Biochemical and biophysical research communications.

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis.

K. Suzuki, Z. Kouchi, H. Sorimachi, 1998, European journal of biochemistry.

DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase†

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006 .

Autolysis of Calpain Large Subunit Inducing Irreversible Dissociation of Stoichiometric Heterodimer of Calpain

H. Sorimachi, T. Yoshizawa, T. Saido, 2000, Bioscience, biotechnology, and biochemistry.

Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP).

K. Suzuki, H. Sorimachi, S. Ishiura, 1997, Journal of biochemistry.

Quantitative analysis of CUG-BP1 binding to RNA repeats.

Y. Kino, S. Ishiura, N. Sasagawa, 2007, Journal of biochemistry.

Polyalanine tracts directly induce the release of cytochrome c, independently of the mitochondrial permeability transition pore, leading to apoptosis

E. Futai, B. Turk, S. Ishiura, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006, Biochemistry.

Biochemical analysis of oligomerization of expanded polyalanine repeat proteins

E. Futai, B. Turk, S. Ishiura, 2009, Journal of neuroscience research.

Comparative analysis of the cytotoxicity of homopolymeric amino acids.

Yoshihiro Kino, Y. Kino, S. Ishiura, 2005, Biochimica et biophysica acta.

Highly conserved structure in the promoter region of the gene for muscle-specific calpain, p94.

J. Beckmann, K. Suzuki, I. Richard, 1996, Biological chemistry.

Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy.

I. Nishino, Michinori Koebis, S. Ishiura, 2011, Biochemical and biophysical research communications.

Identification of a third ubiquitous calpain species--chicken muscle expresses four distinct calpains.

K. Suzuki, T. Tsukahara, H. Sorimachi, 1995, Biochimica et biophysica acta.

Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.

T. Iwatsubo, F. Kametani, H. Mori, 2000, International journal of molecular medicine.

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1

N. Nukina, Y. Kino, S. Ishiura, 2009 .

Csk‐homologous kinase interacts with SHPS‐1 and enhances neurite outgrowth of PC12 cells

I. Nishino, E. Futai, S. Ishiura, 2008, Journal of neurochemistry.

Overexpression of myotonic dystrophy protein kinase in C2C12 myogenic culture involved in the expression of ferritin heavy chain and interleukin-1α mRNAs

H. Sorimachi, S. Ishiura, N. Sasagawa, 1999, Journal of the Neurological Sciences.

A secreted form of human ADAM9 has an α-secretase activity for APP☆

S. Ishiura, N. Sasagawa, H. Koike, 2002 .

A secreted form of human ADAM9 has an alpha-secretase activity for APP.

S. Ishiura, N. Sasagawa, H. Koike, 2002, Biochemical and biophysical research communications.

QUANTITATIVE ANALYSIS OF DYSTROPHIN IN HUMAN AND RODENT MUSCLES

I. Nonaka, S. Ishiura, K. Arahata, 1992 .

ATP‐dependent proteolysis, a fine system or a meaningless one? A reply

T. Yoshimoto, S. Ishiura, C. Villee, 1987 .

Identification of an estrogenic hormone receptor in Caenorhabditis elegans.

M. Usami, S. Ishiura, N. Sasagawa, 2007, Biochemical and biophysical research communications.

Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy

I. Nishino, Y. Kino, S. Ishiura, 2007, Neuromuscular Disorders.

Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats.

Y. Kino, S. Ishiura, N. Sasagawa, 2004, Human molecular genetics.

Secretion of Alzheimer β/A4 Protein(1-40) and Intracellular Retention of β/A4-Protein(1-42) in Transfected COS Cells

S. Ishiura, K. Tagawa, H. Asada, 1995 .

Autolysis of Calpain Large Subunit Inducing of Stoichiometric Heterodimer of Calpain Irreversible Dissociation

T. Saido, S. Ishiura, H. Kitagaki, 2017 .

APP α-Secretase, a Novel Target for Alzheimer Drug Therapy

S. Ishiura, N. Sasagawa, S. Tanuma, 2013 .

Effect of metal ions on the structure and activity of calcium-activated neutral protease (CANP).

K. Suzuki, S. Ishiura, 1983, Journal of biochemistry.

Beta-secretase inhibitor potency is decreased by aberrant beta-cleavage location of the “Swedish mutant” amyloid precursor protein

E. Futai, S. Ishiura, Hidekuni Yamakawa, 2010, Alzheimer's & Dementia.

Amyloid precursor protein is found in lysosomes.

K. Suzuki, H. Sorimachi, S. Ishiura, 1993, Gerontology.

Calpain: novel family members, activation, and physiologic function.

H. Sorimachi, T. Yoshizawa, S. Ishiura, 1995, Biological chemistry Hoppe-Seyler.

Studies on a Ca2+-activated neutral proteinase of rabbit skeletal muscle. II. Characterization of sulfhydryl groups and a role of Ca2+ ions in this enzyme.

K. Imahori, K. Suzuki, S. Ishiura, 1981, Journal of biochemistry.

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

S. Sugano, Yutaka Suzuki, A. Fujiyama, 2018, Nature Genetics.

Purification and characterization of a high-molecular-weight protease, ingensin, from human placenta.

S. Ishiura, H. Sugita, H. Furuya, 1986, Journal of Biochemistry (Tokyo).

Localization of ingensin in rat central nervous system and skeletal muscle

I. Nonaka, S. Ishiura, Keiko Kamakura, 1988, Journal of neuroscience research.

The multicatalytic proteinase: a high-Mr endopeptidase.

P. Kloetzel, T. Tsukahara, M. Rechsteiner, 1988, Biochemical Journal.

BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?

Y. Kiso, Y. Hamada, S. Ishiura, 2012, ACS medicinal chemistry letters.

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.

Y. Kiso, Y. Hamada, S. Ishiura, 2012, Bioorganic & medicinal chemistry letters.