J. Lappalainen

发表

Evaluation of the effect of Naloxegol on cardiac repolarization: a randomized, placebo- and positive-controlled crossover thorough QT/QTc study in healthy volunteers.

C. Gottfridsson, G. Carlson, J. Lappalainen, 2013, Clinical therapeutics.

Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.

R. Gueorguieva, J. Gelernter, V. Coric, 2007, Biological psychiatry.

Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration

R. Gueorguieva, J. Gelernter, V. Coric, 2007, Biological Psychiatry.

Population Exposure‐Response Modeling of Naloxegol in Patients With Noncancer‐Related Pain and Opioid‐Induced Constipation

N. Al-Huniti, J. Lappalainen, M. Sostek, 2016, CPT: pharmacometrics & systems pharmacology.

Effects of chronic SCH 23390 treatment on dopamine autoreceptor function in rat brain.

J. Hietala, J. Lappalainen, E. Syvälahti, 1990, European journal of pharmacology.

The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit‐selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels

J. V. van Gerven, A. Cross, M. D. de Kam, 2015, Clinical pharmacology in drug development.

Ethanol administration does not alter dopamine D1 and D2 receptor characteristics in rat brain

J. Hietala, J. Lappalainen, E. Syvälahti, 1990, Neuroscience Letters.

GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans

C. Halldin, K. Varnäs, L. Farde, 2016, Psychopharmacology.

Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population.

J. Krystal, J. Gelernter, H. Kranzler, 2005, Alcoholism, clinical and experimental research.

Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding

M. Koulu, J. Hietala, J. Lappalainen, 2005, Psychopharmacology.

Temporal association of onset of daily smoking with adolescent substance use and psychiatric morbidity

M. Timonen, J. Lappalainen, P. Räsänen, 2008, European Psychiatry.

Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region.

D. Goldman, N. Ozaki, M. Linnoila, 1995, American journal of medical genetics.

Chronic clozapine treatment down-regulates serotonin 5-HT-1c receptors in rat brain

M. Koulu, J. Hietala, J. Lappalainen, 1992, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).

D. Goldman, N. Ozaki, M. Linnoila, 1995, Genomics.

A sequencing‐based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls

H. Blumberg, Z. Bhagwagar, E. Walderhaug, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Quantification of SCH 39166, a novel selective D1 dopamine receptor antagonist, in rat brain and blood

J. Hietala, J. Lappalainen, E. Syvälahti, 2005, Psychopharmacology.

Smoking and suicidality among adolescent psychiatric patients.

M. Timonen, M. Marttunen, J. Lappalainen, 2004, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

Chronic D1‐receptor blockade: effects on D2‐receptor agonist‐induced yawning in rats

J. Hietala, J. Lappalainen, E. Syvälahti, 1991, The Journal of pharmacy and pharmacology.

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

L. Webster, J. Lappalainen, M. Sostek, 2013, PAIN®.

Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects.

M. Koulu, J. Hietala, J. Lappalainen, 1990, European journal of pharmacology.

Dopamine D1 receptor antagonism in schizophrenia: is there reduced risk of extrapyramidal side-effects?

M. Koulu, J. Hietala, J. Lappalainen, 1990, Trends in pharmacological sciences.

Differential tolerance to cataleptic effects of SCH 23390 and haloperidol after repeated administration

J. Hietala, J. Lappalainen, E. Syvälahti, 2004, Psychopharmacology.

A tryptophan hydroxylase gene marker for suicidality and alcoholism.

Gerald L. Brown, J. Long, D. Goldman, 1998, Archives of general psychiatry.

Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine β-Hydroxylase

T. Kosten, J. Lappalainen, D. Nielsen, 2013, Biological Psychiatry.

Randomised clinical trial: the long‐term safety and tolerability of naloxegol in patients with pain and opioid‐induced constipation

W. Chey, L. Webster, J. Tack, 2014, Alimentary pharmacology & therapeutics.

Naloxegol for opioid-induced constipation in patients with noncancer pain.

W. Chey, L. Webster, J. Tack, 2014, The New England journal of medicine.

Nicotine use and dependence and their association to psychiatric disorders in a large sample of adolescent psychiatric inpatients.

M. Timonen, J. Lappalainen, P. Räsänen, 2006, Addictive behaviors.

Mapping of the serotonin 5-HT1D beta autoreceptor gene on chromosome 6 and direct analysis for sequence variants.

D. Goldman, M. Linnoila, M. Dean, 1995, American journal of medical genetics.

Direct analysis of candidate genes in impulsive behaviours.

D. Goldman, N. Ozaki, J. Lappalainen, 1996, Ciba Foundation symposium.

Two naturally occurring amino acid substitutions of the 5-HT2A receptor: Similar prevalence in patients with seasonal affective disorder and controls

U. Pesonen, D. Goldman, N. Ozaki, 1996, Biological Psychiatry.

Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus

J. Krystal, G. Page, J. Gelernter, 2004, Molecular Psychiatry.

A Naturally Occurring Amino Acid Substitution of the Human Serotonin 5‐HT2A Receptor Influences Amplitude and Timing of Intracellular Calcium Mobilization

H. Manji, D. Goldman, N. Rosenthal, 1997, Journal of neurochemistry.

Mutation screen of the GAD2 gene and association study of alcoholism in three populations

M. Stein, J. Krystal, J. Gelernter, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies

J. Gelernter, H. Kranzler, Bao-Zhu Yang, 2006, Neuropsychopharmacology.

Apolipoprotein E genotype and outcome after aneurysmal subarachnoid hemorrhage.

S. Juvela, J. Siironen, J. Lappalainen, 2009, Journal of neurosurgery.

The Met Allele of the BDNF Val66Met Polymorphism Predicts Poor Outcome Among Survivors of Aneurysmal Subarachnoid Hemorrhage

J. Vilkki, S. Juvela, J. Hernesniemi, 2007, Stroke.

Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment.

T. George, T. Kosten, J. Cubells, 2014, Drug and alcohol dependence.

Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.

J. Gelernter, H. Kranzler, E. Krupitsky, 2006, Human molecular genetics.

NOTCH4 gene haplotype is associated with schizophrenia in African Americans

R. Rosenheck, D. Charney, J. Kennedy, 2004, Biological Psychiatry.

Population admixture modulates risk for alcohol dependence

G. Pearlson, J. Cramer, M. Stein, 2009, Human Genetics.

ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies

J. Gelernter, H. Kranzler, Bao-Zhu Yang, 2005, Pharmacogenetics and genomics.

Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian Population

J. Krystal, J. Gelernter, H. Kranzler, 2005 .

CALCYON gene variation, schizophrenia, and cocaine dependence

R. Rosenheck, D. Charney, J. Gelernter, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations.

Gerald L. Brown, J. Long, D. Goldman, 1998, Archives of general psychiatry.

The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.

P. Maruff, J. V. van Gerven, M. D. de Kam, 2014, British journal of clinical pharmacology.

Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response

J. Tack, J. Lappalainen, M. Sostek, 2015, United European gastroenterology journal.

Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity

Hani M. Elwafi, E. Grigorenko, A. Nairn, 2009, Pharmacogenetics and genomics.

Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene.

J. Gelernter, H. Kranzler, J. Lappalainen, 2002, Alcoholism, clinical and experimental research.

Role of the serotonin transporter promoter polymorphism in anxiety-related traits.

M Linnoila, J. Long, D. Bengel, 1998, Archives of general psychiatry.

Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies.

J. Hernesniemi, R. Raj, M. Skrifvars, 2016, Journal of neurosurgery.

Acute alcohol intoxication and long-term outcome in patients with traumatic brain injury.

J. Hernesniemi, R. Raj, M. Skrifvars, 2015, Journal of neurotrauma.

AZD6280, a Novel Partial &ggr;-Aminobutyric Acid A Receptor Modulator, Demonstrates a Pharmacodynamically Selective Effect Profile in Healthy Male Volunteers

P. Maruff, J. V. van Gerven, Mark A. Smith, 2015, Journal of clinical psychopharmacology.

GABAergic Agents for the Treatment of Nicotine Dependence

J. Lappalainen, M. Sofuoglu, 2006 .

HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses

J. Long, D. Goldman, N. Ozaki, 1999, Biological Psychiatry.

Factors correlating with delayed trauma center admission following traumatic brain injury

T. Brinck, R. Raj, M. Skrifvars, 2013, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.

Mutation screen of the glutamate decarboxylase‐67 gene and haplotype association to unipolar depression

Ellen S. Hibbard, J. Krystal, L. Price, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Efficacy of Naloxegol in a Subpopulation of Patients with Opioid-induced Constipation and an Inadequate Baseline Response to Laxatives: Results from Two Prospective, Randomized Controlled Trials: 1884

W. Chey, L. Webster, J. Tack, 2013 .

900 Efficacy and Safety of Naloxegol in Patients With Opioid-Induced Constipation: Results From 2 Prospective, Randomized, Controlled Trials

W. Chey, L. Webster, J. Tack, 2013 .

A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.

S. Southwick, R. Rosenheck, J. Cramer, 2002, Archives of general psychiatry.

Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype

B. Greenberg, Benjamin D. Greenberg, D. Murphy, 2003, Molecular Psychiatry.

Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.

J. Krystal, J. Staley, R. Harris, 2006, Archives of general psychiatry.

Temporal relationship between the age of onset of phobic disorders and development of substance dependence in adolescent psychiatric patients.

M. Timonen, J. Lappalainen, P. Räsänen, 2004, Drug and alcohol dependence.

Interactive Effects of Sex and 5-HTTLPR on Mood and Impulsivity During Tryptophan Depletion in Healthy People

Alexander Neumeister, Nils Inge Landrø, A. Neumeister, 2007, Biological Psychiatry.

Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence

Joel Gelernter, Steven Southwick, S. Southwick, 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons.

M. Koulu, J. Lappalainen, B. Sjöholm, 1989, European journal of pharmacology.

RELATIONSHIP OF THE MET ALLELE OF THE BRAIN‐DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM TO MEMORY AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE

J. Vilkki, S. Juvela, J. Hernesniemi, 2008, Neurosurgery.

Regulation of dopamine D1 receptors by chronic administration of structurally different D1 receptor antagonists: a quantitative autoradiographic study.

J. Hietala, T. Pohjalainen, J. Lappalainen, 1992, European journal of pharmacology.

Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.

J. Krystal, J. Staley, R. Harris, 2006, Archives of general psychiatry.

A multicenter, open-label trial of ganaxolone in children with PCDH19 epilepsy (P5.236)

J. Gécz, J. Sullivan, J. Lappalainen, 2017 .

Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research

J. Gelernter, H. Kranzler, T. Kosten, 2007, BMC Genetics.

Quantification of SCH 39166, a novel selective D1 dopamine receptor in rat brain and blood antagonist,

J. Hietala, T. Sepp, J. Lappalainen, 1992 .

Naloxegol for opioid-induced constipation in patients with noncancer pain.

W. Chey, L. Webster, J. Tack, 2014, The New England journal of medicine.

Chronic treatment with SCH 23390, a selective dopamine D-1 receptor antagonist, decreases dopamine metabolism in rat caudate nucleus.

M. Koulu, U. Pesonen, J. Hietala, 1988, European journal of pharmacology.