I. Trounce

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Neuroinflammation in glaucoma: A new opportunity

Pete A. Williams, M. Raff, A. Di Polo, 2017, Experimental eye research.

Mechanisms of Retinal Ganglion Cell Injury in Aging and Glaucoma

Jonathan G. Crowston, Ian A. Trounce, J. Crowston, 2010, Ophthalmic Research.

Partial cytochrome oxidase (aa 3) deficiency in chronic progressive external ophthalmoplegia Histochemical and biochemical studies

I. Trounce, E. Byrne, X. Dennett, 1985, Journal of the Neurological Sciences.

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

Ian A. Trounce, Matthew McKenzie, I. Trounce, 2012, Nucleic acids research.

Mitochondrial theory of senescence: Respiratory chain protein studies in human skeletal muscle

I. Trounce, E. Byrne, X. Dennett, 1991, Mechanisms of Ageing and Development.

Affinity chromatography isolation of human cytochrome oxidase and small-scale Western immunoblot probing of the enzyme complex in mitochondrial cytopathy patients.

I. Trounce, S. Marzuki, E. Byrne, 1991, Biochemical medicine and metabolic biology.

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Jonathan G. Crowston, Ian A. Trounce, David A. Mackey, 2015, PloS one.

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

J. Crowston, A. Hill, A. Bush, 2019, Molecular Neurobiology.

Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex III.

C. Pinkert, I. Trounce, M. McKenzie, 2003, Molecular biology and evolution.

Oxidative stress and mitochondrial dysfunction in glaucoma.

J. Crowston, I. Trounce, V. Chrysostomou, 2013, Current opinion in pharmacology.

Oxidative phosphorylation measurement in cell lines and tissues.

J. Crowston, I. Trounce, N. V. Van Bergen, 2014, Mitochondrion.

Targeting retinal ganglion cell recovery

E. Fahy, I. Trounce, V. Chrysostomou, 2017, Eye.

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

J. Crowston, J. Duce, I. Trounce, 2017, Scientific Reports.

Amyloid precursor protein‐mediated mitochondrial regulation and Alzheimer's disease

P. van Wijngaarden, I. Trounce, M. I. L. Lopez Sanchez, 2019, British journal of pharmacology.

Copper‐dependent inhibition of cytochrome c oxidase by Aβ1−42 requires reduced methionine at residue 35 of the Aβ peptide

C. Masters, P. Crouch, J. Duce, 2006 .

Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model

M. Cook, R. Cotton, I. Trounce, 2010, Epilepsy Research.

Pathoetiology of motor neuron disease: new insights from genetics and animal models

I. Trounce, E. Byrne, S. Feeney, 2003, Journal of Clinical Neuroscience.

Development and Initial Characterization of Xenomitochondrial Mice

C. Pinkert, I. Trounce, M. McKenzie, 2004, Journal of bioenergetics and biomembranes.

Dominantly inherited cardioskeletal myopathy with lysosomal glycogen storage and normal acid maltase levels.

J. Sands, I. Trounce, B. Crotty, 1986, Brain : a journal of neurology.

The Role of PI3/Akt Pathway in the Protective Effect of Insulin against Corticosterone Cell Death Induction in Hippocampal Cell Culture

I. Trounce, M. Yousefpour, N. Naghdi, 2008, Neuroendocrinology.

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells

I. Trounce, M. McKenzie, M. I. L. Lopez Sanchez, 2020, International journal of molecular sciences.

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

J. Crowston, C. Pinkert, M. Ziemann, 2020, PloS one.

Recharacterization of the RGC-5 retinal ganglion cell line.

J. Crowston, R. Weinreb, R. Casson, 2009, Investigative ophthalmology & visual science.

Chronic fatigue and myalgia syndrome: mitochondrial and glycolytic studies in skeletal muscle.

I. Trounce, E. Byrne, 1987, Journal of neurology, neurosurgery, and psychiatry.

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

I. Trounce, E. Byrne, X. Dennett, 1985, Australian and New Zealand journal of medicine.

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

Merlin C. Thomas, Merlin C Thomas, R. MacIsaac, 2016, Diabetes.

Biochemical and morphological studies of skeletal muscle in experimental chronic alcoholic myopathy

I. Trounce, E. Byrne, X. Dennett, 1990, Acta neurologica Scandinavica.

Genetics: Optic nerve genetics—more than meets the eye

D. Mackey, I. Trounce, 2010, Nature Reviews Neurology.

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies.

E. O'Neill, J. Crowston, I. Trounce, 2011, Experimental eye research.

Chronic alcoholic proximal wasting: physiological, morphological and biochemical studies in skeletal muscle.

I. Trounce, E. Byrne, J. Santamaria, 1987, Australian and New Zealand journal of medicine.

Generation of ρ0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

P. Seibel, G. Krohne, C. Kukat, 2008, Nucleic acids research.

Generation of Xenomitochondrial Embryonic Stem Cells for the Production of Live Xenomitochondrial Mice.

I. Trounce, M. McKenzie, Jessica Ackerley, 2016, Methods in molecular biology.

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

D. Mackey, A. Hewitt, A. Pébay, 2016, Aging.

Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β1-42

C. Masters, R. Cherny, R. Cappai, 2005, The Journal of Neuroscience.

Modifying Mitochondrial Genetics

C. Pinkert, I. Trounce, M. H. Irwin, 2014 .

Production of transmitochondrial mice.

C. Pinkert, I. Trounce, 2002, Methods.

Effect of anterior chamber cannulation and acute IOP elevation on retinal macrophages in the adult mouse.

J. Crowston, P. McMenamin, I. Trounce, 2013, Investigative ophthalmology & visual science.

Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts.

E. O'Neill, Y. Kong, J. Crowston, 2012, Investigative ophthalmology & visual science.

Restored degradation of the Alzheimer’s amyloid‐β peptide by targeting amyloid formation

C. Masters, R. Cherny, P. Crouch, 2009, Journal of neurochemistry.

An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse.

Bang V Bui, John C Morrison, Trung M Dang, 2015, Experimental eye research.

[Visual recovery as the target for glaucoma].

F. Grus, P. van Wijngaarden, I. Trounce, 2019, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

Progression from MERRF to MELAS phenotype in a patient with combined respiratory complex I and IV deficiencies

I. Trounce, S. Marzuki, E. Byrne, 1988, Journal of the Neurological Sciences.

muscle . glycolytic studies in skeletal syndrome : mitochondrial and Chronic fatigue and myalgia

I. Trounce, E. Byrne, 2022 .

Transgenic Animals: Mitochondrial Genome Modification

C. Pinkert, I. Trounce, L. Smith, 2010 .

Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model

G. Rohrer, L. Cree, I. Trounce, 2016, Genetics.

Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.

C. Pinkert, A. Brooks, M. Cannon, 2011, Mitochondrion.

Functional changes in the retina during and after acute intraocular pressure elevation in mice.

Algis J Vingrys, Y. Kong, J. Crowston, 2009, Investigative ophthalmology & visual science.

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

P. Crouch, I. Trounce, Anthony R. White, 2011, Proceedings of the National Academy of Sciences.

Antimitochondrial autoantibodies of primary biliary cirrhosis as a novel probe in the study of 2-oxo acid dehydrogenases in patients with mitochondrial myopathies

H. Sudoyo, I. Trounce, S. Marzuki, 1990, Journal of the Neurological Sciences.

Functional Analysis of Lymphoblast and Cybrid Mitochondria Containing the 3460, 11778, or 14484 Leber's Hereditary Optic Neuropathy Mitochondrial DNA Mutation*

D. Wallace, M. Brown, A. Jun, 2000, The Journal of Biological Chemistry.

Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines.

D. Wallace, Y. L. Kim, A. Jun, 1996, Methods in enzymology.

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

D. Wallace, B. Graham, B. Cottrell, 1997, Nature Genetics.

Linker histone H1 binds to disease associated amyloid-like fibrils.

Colin L Masters, C. Masters, P. Crouch, 2006, Journal of molecular biology.

Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies.

J. Crowston, D. Mackey, I. Trounce, 2016, Pharmacology & therapeutics.

Mitochondrial Oxidative Phosphorylation Compensation May Preserve Vision in Patients with OPA1-Linked Autosomal Dominant Optic Atrophy

J. Crowston, D. Mackey, A. Hewitt, 2011, PloS one.

Mitochondrial Dysfunction and Glaucoma

J. Crowston, I. Trounce, N. V. Van Bergen, 2009, Journal of glaucoma.

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

Vincent Procaccio, Martin Picard, Shawn Levy, 2014, Proceedings of the National Academy of Sciences.

Genetic control of oxidative phosphorylation and experimental models of defects.

I. Trounce, 2000, Human reproduction.

Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency

L. Delbridge, L. Corben, A. Hewitt, 2017, Aging.

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy

D. Mackey, A. Hewitt, A. Pébay, 2017, Aging.

Mitochondrial replacement in an iPSC model of Leber’s hereditary optic neuropathy

D. Mackey, A. Hewitt, A. Pébay, 2017, bioRxiv.

The Effects of Nuclear Reprogramming on Mitochondrial DNA Replication

P. Verma, I. Trounce, M. McKenzie, 2013, Stem Cell Reviews and Reports.

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

D. Wallace, S. Ballinger, J. Shoffner, 1992, Nature Genetics.

Expression of Rattus norvegicus mtDNA inMus musculus Cells Results in Multiple Respiratory Chain Defects*

I. Trounce, M. McKenzie, 2000, The Journal of Biological Chemistry.

Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

William Lee, I. Trounce, D. Gough, 2017, Cell Death Discovery.

Chapter 3 – Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation

A. Godwin, R. Cotton, E. Nicolas, 2010 .

The mitochondrial genome sequence of Mus terricolor: comparison with Mus musculus domesticus and implications for xenomitochondrial mouse modeling.

C. Pinkert, I. Trounce, W. Pogozelski, 2008, Gene.

Cybrid models of mtDNA disease and transmission, from cells to mice.

C. Pinkert, I. Trounce, 2007, Current topics in developmental biology.

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

Edward Byrne, Sangkot Marzuki, I. Trounce, 1989, The Lancet.

Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.

D. Wallace, I. Trounce, S. Neill, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondria in Retinal Neurodegeneration and Stem Cell Models

I. Trounce, 2014 .

Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells

William Lee, D. Nisbet, J. Forsythe, 2013, Stem cells.

Chronic fatigue andmyalgia syndrome: mitochondrial andglycolytic studies inskeletal muscle

I. Trounce, E. Byrne, 1987 .

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Ian A. Trounce, R. Palanivel, S. Jørgensen, 2012, Diabetes.

Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.

D. Wallace, M. Brown, S. Hosseini, 2000, Nucleic acids research.

Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseases.

C. Pinkert, I. Trounce, 2007, Methods in cell biology.

Production of transmitochondrial mouse cell lines by cybrid rescue of rhodamine-6G pre-treated L-cells

D. Wallace, I. Trounce, 1996, Somatic cell and molecular genetics.

Cybrids in the Study of Animal Mitochondrial Genetics and Pathology

C. Pinkert, I. Trounce, 2005 .

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

J. Crowston, J. Duce, I. Trounce, 2017, Scientific Reports.

Mitochondrial disorders and the eye.

E. O'Neill, J. Crowston, R. Chakrabarti, 2011, Eye and brain.

Animal Modeling: From Transgenesis to Transmitochondrial Models

C. Pinkert, I. Trounce, 2005 .

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide.

C. Masters, P. Crouch, J. Duce, 2006, Journal of neurochemistry.

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial

Pete A. Williams, M. Coote, J. Crowston, 2020, Clinical and Experimental Ophthalmology.

Antifibrotic activity of bevacizumab on human Tenon's fibroblasts in vitro.

E. O'Neill, P. Connell, M. Coote, 2010, Investigative ophthalmology & visual science.

MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data

Larry N. Singh, D. Rader, S. Damrauer, 2021, PLoS computational biology.

Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF‐dependent pathway

J. Crowston, G. Steinberg, P. van Wijngaarden, 2016, Aging cell.

Forced exercise protects the aged optic nerve against intraocular pressure injury

J. Crowston, I. Trounce, V. Chrysostomou, 2014, Neurobiology of Aging.

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes.

M. Cooper, K. Sourris, J. Forbes, 2016, Clinical science.

Mitochondrial dysfunction and complications associated with diabetes.

I. Trounce, R. Blake, 2014, Biochimica et biophysica acta.

Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury

Y. Kong, J. Crowston, A. Vingrys, 2011, Aging cell.

Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia

D. Wallace, M. Brown, J. Shoffner, 1996, Molecular and cellular biology.

Role of extracellular vesicles in mitochondrial eye diseases

Sushma Anand, L. Gangoda, I. Trounce, 2022, IUBMB life.

Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury

Y. Kong, J. Crowston, A. Vingrys, 2012, Neurobiology of Aging.

A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I.

A. Torroni, D. Wallace, M. Lott, 1992, American journal of human genetics.

The optic nerve head in acquired optic neuropathies

E. O'Neill, P. Connell, M. Coote, 2010, Nature Reviews Neurology.

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

J. Crowston, A. Hill, A. Bush, 2019, Molecular Neurobiology.

Flow cytometry in the study of mitochondrial respiratory chain disorders.

J. Christodoulou, D. Thorburn, I. Trounce, 2002, Mitochondrion.

Functional respiratory chain studies in mitochondrial cytopathies. Support for mitochondrial DNA heteroplasmy in myoclonus epilepsy and ragged red fibers (MERRF) syndrome

S. Berkovic, T. Ozawa, I. Trounce, 2004, Acta Neuropathologica.

Loss of mitochondrial DNA‐encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly

I. Trounce, N. V. Van Bergen, M. McKenzie, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain

R. Cotton, I. Trounce, M. McKenzie, 2014, Human Mutation.

Oxygen electrode studies with human skeletal muscle mitochondria in vitro A re-appraisal

I. Trounce, E. Byrne, 1985, Journal of the Neurological Sciences.

Functional respiratory chain studies in subjects with chronic progressive external ophthalmoplegia and large heteroplasmic mitochondrial DNA deletions

F. Mastaglia, S. Berkovic, H. Sudoyo, 1991, Journal of the Neurological Sciences.

Protein synthesis in mitochondria isolated from human skeletal muscle Detection of polymorphism in mitochondrial translation products

I. Trounce, S. Marzuki, E. Byrne, 1988, Journal of the Neurological Sciences.

Mitochondrial studies in Kearns‐Sayre syndrome

I. Trounce, S. Marzuki, E. Byrne, 1987, Neurology.

Mitochondrial myoneuropathy with respiratory failure and myoclonic epilepsy A case report with biochemical studies

I. Trounce, E. Byrne, J. Burdon, 1985, Journal of the Neurological Sciences.

MTTOCHONDRIAL DNA DELETION IN ENCEPHALOMYOPATHY

I. Trounce, S. Marzuki, E. Byrne, 1988, The Lancet.

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Larry N. Singh, J. Crowston, D. Mackey, 2018, Investigative ophthalmology & visual science.

Mitochondria in aging and Alzheimer's disease.

A. Bush, P. Crouch, J. Duce, 2007, Rejuvenation research.

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells.

P. Crouch, I. Trounce, M. McKenzie, 2013, Biochimica et biophysica acta.

Characterization of the retinal pigment epithelium in Friedreich ataxia

L. Corben, Tejal Kulkarni, A. Pébay, 2015, Biochemistry and biophysics reports.

Mitochondrial DNA mutations in human degenerative diseases and aging.

D. Wallace, M. Lott, S. Ballinger, 1995, Biochimica et biophysica acta.

Oxidative energy failure in post-mitotic cells: a major factor in senescence.

I. Trounce, E. Byrne, X. Dennett, 1991, Revue neurologique (Paris).

Improvement in Inner Retinal Function in Glaucoma in Response to Nicotinamide (Vitamin B3 Supplementation: A Crossover Randomized Clinical Trial

M. Coote, J. Crowston, K. Martin, 2020, medRxiv.

Production of homoplasmic xenomitochondrial mice.

C. Pinkert, I. Trounce, M. McKenzie, 2004, Proceedings of the National Academy of Sciences of the United States of America.

OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy.

D. Mackey, A. Hewitt, L. Kearns, 2020, Mitochondrion.