A. Matsuzawa

发表

Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

H. Ji, H. Ichijo, T. Harada, 2010, EMBO molecular medicine.

The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1

A. Matsuzawa, T. Noguchi, T. Shimada, 2021, International journal of molecular sciences.

Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes

A. Matsuzawa, T. Noguchi, M. Tsuchida, 2016, International journal of molecular sciences.

Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B.

E. Warabi, K. Uchida, A. Matsuzawa, 2020, The Journal of toxicological sciences.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

T Takahashi, T. Noda, K. Miyazono, 2001, EMBO reports.

Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.

H. Ichijo, Kazuhiko Yoshida, T. Harada, 2006, The American journal of pathology.

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

H. Ichijo, Y. Shimizu, K. Kataoka, 2012, Nature Communications.

Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-Induced Angiogenesis

T. Murohara, T. Yukimura, H. Iwao, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-Induced

T. Murohara, T. Yukimura, Y. Izumi, 2005 .

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.

J. Miyazaki, M. Hori, M. Taniike, 2004, The Journal of clinical investigation.

Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II–Induced Cardiac Hypertrophy and Remodeling

Shokei Kim, H. Iwao, H. Ichijo, 2003, Circulation research.

Effect of Continuous Ang II Infusion on Cardiac Superoxide Production and ASK 1 , MAPK Activation , and Cardiac Hypertrophy in Wild-Type Mice

Shokei Kim, H. Iwao, H. Ichijo, 2003 .

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.

T. Horie, H. Ichijo, H. Nishitoh, 2003, American journal of respiratory and critical care medicine.

Map Kinases in Redox Signaling

H. Ichijo, K. Takeda, H. Nishitoh, 2003 .

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation*

H. Ichijo, K. Sakamaki, S. Yonehara, 2000, The Journal of Biological Chemistry.

Title Cardiac-specific disruption of the c-raf-1 geneinduces cardiac dysfunction and apoptosis

J. Miyazaki, M. Hori, M. Taniike, 2022 .

Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

H. Ichijo, A. Matsuzawa, Mayumi Soga, 2012, International journal of cell biology.

Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.

Gary Hardiman, Guobin He, Guann-Yi Yu, 2008, Cancer cell.

Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X7-ROS-ASK1-p38 Axis in Microglial Cell Lines.

K. Fukunaga, Gi-Wook Hwang, A. Matsuzawa, 2020, Biological & pharmaceutical bulletin.

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

T. Inada, T. Natsume, H. Ichijo, 2017, Cell reports.

Thioredoxin and redox signaling: Roles of the thioredoxin system in control of cell fate.

A. Matsuzawa, 2017, Archives of biochemistry and biophysics.

ASK1 promotes apoptosis of normal and malignant plasma cells.

H. Ichijo, C. Chung, A. Matsuzawa, 2012, Blood.

Mitogen-activated protein kinases in mammalian oxidative stress responses.

H. Ichijo, Christopher Runchel, A. Matsuzawa, 2011, Antioxidants & redox signaling.

Regulation of apoptosis signal-regulating kinase 1 in redox signaling.

H. Ichijo, A. Matsuzawa, K. Katagiri, 2010, Methods in enzymology.

Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1

H. Ichijo, K. Takeda, A. Matsuzawa, 2007, Molecular and Cellular Biology.

Phosphorylation-dependent Scaffolding Role of JSAP1/JIP3 in the ASK1-JNK Signaling Pathway

Michihiko Ito, H. Ichijo, K. Yoshioka, 2002, The Journal of Biological Chemistry.

Nucleotide polymorphism in the carrot late embryogenesis abundant gene DC8/ECP63.

H. Kamada, K. Kurokawa, A. Matsuzawa, 2010 .

Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival

H. Ichijo, M. Steinbeck, A. Matsuzawa, 2014, Cell Death and Disease.

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin

Scott A. Brown, M. Karin, Ping-Hui Tseng, 2008, Proceedings of the National Academy of Sciences.

Regulatory Factor 3 by Lipopolysaccharide Species-Mediated Activation of IFN Kinase 1 Is Required for Reactive Oxygen Cutting Edge : Apoptosis-Regulating Signal

H. Ichijo, A. Matsuzawa, Oanh T Dang, 2006 .

Cutting Edge: Apoptosis-Regulating Signal Kinase 1 Is Required for Reactive Oxygen Species-Mediated Activation of IFN Regulatory Factor 3 by Lipopolysaccharide1

M. David, H. Ichijo, A. Matsuzawa, 2006, The Journal of Immunology.

ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds

H. Aburatani, N. Osaka, K. Moriyama, 2007, The Journal of cell biology.

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis‐linked SOD1 mutants

S. Tsuji, H. Ichijo, H. Nishitoh, 2012, Annals of neurology.

Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival.

T. Inada, T. Natsume, T. Udagawa, 2021, Cell reports.

PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.

K. Yoshinari, A. Matsuzawa, S. Kodama, 2016, The Biochemical journal.

The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin

A. Matsuzawa, T. Noguchi, T. Shimada, 2022, International journal of molecular sciences.

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation*

A. Yoshimura, H. Ichijo, A. Matsuzawa, 2014, The Journal of Biological Chemistry.

Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?

A. Matsuzawa, T. Noguchi, Tomohiro Kagi, 2021, Oncotarget.

Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells

A. Naganuma, Gi-Wook Hwang, A. Matsuzawa, 2022, Fundamental Toxicological Sciences.

Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

S. Grinstein, A. Volchuk, A. Matsuzawa, 2022, Current Biology.

trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway

K. Fukunaga, J. Aoki, K. Kano, 2017, The Journal of Biological Chemistry.

Characterization of PC12 Cell Subclones with Different Sensitivities to Programmed Thermal Stimulation

J. Nakai, Tada-aki Kudo, A. Matsuzawa, 2020, International journal of molecular sciences.

Physiological roles of ASK family members in innate immunity and their involvement in pathogenesis of immune diseases.

A. Matsuzawa, 2017, Advances in biological regulation.

Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation

A. Matsuzawa, T. Noguchi, Yusuke Hirata, 2019, The Journal of Antibiotics.

Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals.

A. Matsuzawa, T. Koizumi, A. Matsuzawa, 2003, The Journal of toxicological sciences.

CHIP‐dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

H. Shibuya, Keiji Tanaka, H. Ichijo, 2010, The EMBO journal.

cDNA Cloning and Expression of Intracellular Platelet-activating Factor (PAF) Acetylhydrolase II

Hiroyuki Arai, J. Aoki, M. Tsujimoto, 1996, The Journal of Biological Chemistry.

Expression of foreign aquaporin genes in lily pollen protoplasts

Keiji Yamada, A. Matsuzawa, I. Tanaka, 2011 .

TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms

A. Matsuzawa, T. Noguchi, Tomohiro Kagi, 2020, International Journal of Molecular Sciences.

Stress-responsive protein kinases in redox-regulated apoptosis signaling.

H. Ichijo, A. Matsuzawa, 2005, Antioxidants & redox signaling.

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

H. Ichijo, K. Takeda, H. Nishitoh, 2013, Molecular cell.

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.

H. Ichijo, A. Matsuzawa, Hidenori Ichijo, 2008, Biochimica et biophysica acta.

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

A. Ryo, A. Kudoh, H. Ichijo, 2015, Nature Communications.

The ASK1-MAP kinase cascades in mammalian stress response.

H. Ichijo, K. Takeda, A. Matsuzawa, 2004, Journal of biochemistry.

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.

Kiyoshi Inoue, H. Ichijo, K. Takeda, 2002, Genes & development.

Physiological Roles of ASK 1-Mediated Signal Transduction in Oxidative Stress-and Endoplasmic Reticulum Stress-Induced Apoptosis : Advanced Findings from ASK 1 Knockout Mice

H. Ichijo, K. Takeda, H. Nishitoh, 2003 .

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

H. Ichijo, K. Takeda, H. Nishitoh, 2002, Antioxidants & redox signaling.

Apoptosis signaling kinases: from stress response to health outcomes.

H. Ichijo, K. Takeda, H. Nishitoh, 2011, Antioxidants & redox signaling.

Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms

Gi-Wook Hwang, A. Matsuzawa, T. Noguchi, 2021, Cell death & disease.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Hiromi Nakamura, S. Kōzuma, Y. Taketani, 2009, The EMBO journal.

Protection against Oxidative Stress-induced Cell Death by Intracellular Platelet-activating Factor-Acetylhydrolase II*

H. Arai, J. Aoki, A. Matsuzawa, 1997, The Journal of Biological Chemistry.

Title ASK 1 restores the antiviral activity of APOBEC 3 G bydisrupting HIV-1 Vif-mediated counteraction

A. Ryo, A. Kudoh, H. Ichijo, 2017 .

The ASK1-MAP kinase pathways in immune and stress responses.

H. Ichijo, K. Takeda, A. Matsuzawa, 2006, Microbes and infection.

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Kunihiro Matsumoto, H. Ichijo, S. Koyasu, 2005, Nature Immunology.

[Studies on the blood coagulation factor XIII in patients with increased levels of FDP D-dimer].

S. Kawasaki, F. Terasawa, A. Matsuzawa, 1995, Rinsho byori. The Japanese journal of clinical pathology.

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A*

H. Ichijo, T. Mitchell, A. Matsuzawa, 2009, The Journal of Biological Chemistry.

The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages

Gi-Wook Hwang, A. Matsuzawa, T. Noguchi, 2021, The Journal of Antibiotics.

Post-Translational Modifications of the TAK1-TAB Complex

A. Matsuzawa, T. Noguchi, Miki Takahashi, 2017, International journal of molecular sciences.

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

J. Keats, P. L. Bergsagel, M. Karin, 2008, Nature Immunology.

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

M. Karin, Ping-Hui Tseng, Jun-Li Luo, 2008, Science.

Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes

T. Hosaka, K. Yoshinari, A. Matsuzawa, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Functional Interaction between Pregnane X Receptor and Yes-Associated Protein in Xenobiotic-Dependent Liver Hypertrophy and Drug Metabolism

T. Hosaka, K. Yoshinari, A. Matsuzawa, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Involvement of ASK1 in Ca2+‐induced p38 MAP kinase activation

J. Ninomiya-Tsuji, Kunihiro Matsumoto, H. Ichijo, 2004, EMBO reports.

Physiological roles of stress-activated protein kinases in skin

H. Aburatani, K. Moriyama, H. Ichijo, 2005 .

The DEAH-Box RNA Helicase DHX15 Activates NF-κB and MAPK Signaling Downstream of MAVS During Antiviral Responses

H. Ichijo, K. Takeda, T. Nagano, 2014, Science Signaling.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

H. Ichijo, K. Takeda, A. Matsuzawa, 2009, Molecular cell.

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death*

J. Inoue, J. Gohda, H. Nakano, 2005, Journal of Biological Chemistry.

Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1*

H. Ichijo, K. Takeda, A. Matsuzawa, 2007, Journal of Biological Chemistry.

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

M. Karin, E. Janssen, A. Matsuzawa, 2007, Nature Immunology.

Bacillus subtilis SalA (YbaL) Negatively Regulates Expression of scoC, Which Encodes the Repressor for the Alkaline Exoprotease Gene, aprE

H. Yoshikawa, M. Ogura, Teruo Tanaka, 2004, Journal of bacteriology.

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

M. Karin, Ping-Hui Tseng, D. Vignali, 2010, Nature Immunology.

Als-linked Mutant Sod1 Induces Er Stress-and Ask1-dependent Motor Neuron Death by Targeting Derlin-1 -induced Cell Death Remains Controversial. Here We Show That Sod1 Mut Specifically Interacted with Derlin-1, a Component of Endoplasmic Reticulum (er)-associated Degradation (erad) Machinery and Trig

Takanori Yokota, H. Ichijo, K. Takeda, 2022 .

trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

N. Kono, A. Matsuzawa, T. Noguchi, 2020, Scientific Reports.

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

Z. Ronai, H. Ichijo, P. Aza-Blanc, 2014, Science Signaling.

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage*

H. Ichijo, K. Takeda, A. Matsuzawa, 2008, Journal of Biological Chemistry.

Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.

H. Ichijo, A. Matsuzawa, H Ichijo, 2001, Journal of biochemistry.

Activation of Apoptosis Signal-Regulating Kinase 1 in Injured Artery and Its Critical Role in Neointimal Hyperplasia

Shokei Kim, H. Iwao, H. Ichijo, 2003, Circulation.

Execution of ASK 1-induced Apoptosis by the Mitochondria-dependent Caspase Activation *

H. Ichijo, K. Sakamaki, S. Yonehara, 2000 .

Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

Gi-Wook Hwang, J. Aoki, A. Matsuzawa, 2018, Cell Death & Disease.

The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages

Gi-Wook Hwang, A. Matsuzawa, T. Noguchi, 2021, The Journal of Antibiotics.

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid

T. Hosaka, K. Yoshinari, A. Matsuzawa, 2016, Archives of Toxicology.

A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs

Emiko Sato, A. Matsuzawa, T. Noguchi, 2023, Scientific Reports.

Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos

A. Matsuzawa, T. Noguchi, Midori Suzuki, 2023, The Journal of biological chemistry.

The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases.

A. Matsuzawa, T. Noguchi, Tomohiro Kagi, 2023, Journal of Immunology.

trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway

A. Matsuzawa, T. Noguchi, Miki Takahashi, 2021, Scientific Reports.

The Antibiotic Cefotaxime Works as Both an Activator of Nrf2 and an Inducer of HSP70 in Mammalian Cells

Gi-Wook Hwang, A. Matsuzawa, T. Noguchi, 2020, BPB Reports.

Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.

A. Matsuzawa, T. Noguchi, T. Shimada, 2020, The Journal of toxicological sciences.

The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.

A. Matsuzawa, T. Noguchi, Yuki Kudoh, 2019, The Journal of toxicological sciences.

Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia

A. Naganuma, Yoshiro Saito, Gi-Wook Hwang, 2021, Scientific Reports.

SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells

J. Nakai, A. Matsuzawa, Y. Hayashi, 2022, International journal of molecular sciences.

Change in curcumin content of rhizome in turmeric and yellow zedoary.

Tetsuya Kobayashi, A. Matsuzawa, T. Shimamura, 2010 .

Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis.

C. Chatgilialoglu, C. Ferreri, A. Matsuzawa, 2023, Free radical biology & medicine.

Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion.

G. Atsumi, M. Murakami, K. Imai, 1996, The Biochemical journal.

Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

Gi-Wook Hwang, J. Aoki, A. Matsuzawa, 2018, Cell Death & Disease.

Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth

A. Naganuma, Gi-Wook Hwang, A. Matsuzawa, 2023, Archives of Toxicology.

BPB Reports

Gi-Wook Hwang, A. Matsuzawa, T. Noguchi, 2020 .