P. Klimko

发表

Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma

N. Sharif, P. Klimko, 2019, British journal of pharmacology.

Pinacol closure of oxygenated taxane skeleta at C-1-C-2 with stereoinduction by oxygen substituents at C-9 and C-10

P. Klimko, Weiming Fan, C. Swindell, 1994 .

Update and commentary on the pro-drug bimatoprost and a putative ‘prostamide receptor’

N. Sharif, P. Klimko, 2009 .

Aryl Hydrocarbon Receptor (AhR) Activation

P. Klimko, 2011 .

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.

Gary W. Williams, N. Sharif, P. Klimko, 2004, Bioorganic & medicinal chemistry letters.

An AC → ABC approach to taxol involving B-ring closure at C-1–C-2

Madhavi C. Chander, P. Klimko, C. Swindell, 1993 .

15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives.

Gary W. Williams, N. Sharif, P. Klimko, 2004, Bioorganic & medicinal chemistry.

Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.

Gary W. Williams, N. Sharif, P. Klimko, 2007, Bioorganic & medicinal chemistry letters.

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.

Gary W. Williams, J. Crider, N. Sharif, 2002, Bioorganic & medicinal chemistry.

Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.

L. Desantis, N. Sharif, E. Sullivan, 2002, Survey of ophthalmology.

AL-8810: A Novel Prostaglandin F2α Analog with Selective Antagonist Effects at the Prostaglandin F2α (FP) Receptor

J. Crider, B. Griffin, N. Sharif, 1999 .

Taxane Synthesis through Intramolecular Pinacol Coupling at C-1−C-2. Construction and Oxidative Transformations of a C-Aromatic Taxane Diene

Madhavi C. Chander, P. Klimko, C. Swindell, 1996 .

6.12 – Ophthalmic Agents

P. Klimko, N. Sharif, 2007 .

(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity.

P. Klimko, S. Pfister, R. Conrow, 2016, Prostaglandins & other lipid mediators.

The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.

P. Klimko, T. Dean, M. Hellberg, 2003, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility

N. Sharif, P. Klimko, 2018, British journal of pharmacology.

AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor.

J. Crider, B. Griffin, N. Sharif, 1999, The Journal of pharmacology and experimental therapeutics.

Silyl group-transfer-mediated serial Michael additions

P. Klimko, D. A. Singleton, 1992 .

Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement.

P. Klimko, U. Argikar, Jennifer L. Dumouchel, 2018, Drug metabolism letters.