R. Painter

发表

High-throughput screening of antibiotic-resistant bacteria in picodroplets.

C. A. Smith, G. Whyte, M. Rehak, 2016, Lab on a chip.

Selective small-molecule inhibition of an RNA structural element

John J. Cummings, T. Roemer, T. Fischmann, 2015, Nature.

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012, Antimicrobial Agents and Chemotherapy.

Discovery of FabH/FabF Inhibitors from Natural Products

Jun Wang, John F. Barrett, Lynn L. Silver, 2006, Antimicrobial Agents and Chemotherapy.

Broadening the Spectrum of (cid:1) -Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012 .

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, Olga Genilloud, Sang Ho Lee, 2006, Nature.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

R. Painter, K. Ellsworth, W. Geissler, 2001, Bioorganic & Medicinal Chemistry Letters.

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.

Amjad Ali, R. Painter, K. Ellsworth, 2003, Journal of medicinal chemistry.

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Jun Wang, Olga Genilloud, Oscar Salazar, 2007, Proceedings of the National Academy of Sciences.

Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors*

D. Schmatz, D. Cully, R. Painter, 2005, Journal of Biological Chemistry.

Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.

J. Hermes, N. Sharma, P. Fitzgerald, 2010, Bioorganic & medicinal chemistry letters.

Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

B. Nare, F. Vicente, D. Wisniewski, 2015, Chemistry & biology.

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

Jun Wang, Francisca Vicente, Katherine Young, 2006, Journal of natural products.

Outbreak of Klebsiella pneumoniae Producing a New Carbapenem-Hydrolyzing Class A β-Lactamase, KPC-3, in a New York Medical Center

Neil Woodford, John Kornblum, Lynn L. Silver, 2004, Antimicrobial Agents and Chemotherapy.

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.

J. Hermes, G. Scapin, N. Sharma, 2014, Bioorganic & medicinal chemistry letters.

4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.

R. Painter, K. Young, Young-whan Park, 2010, Bioorganic & medicinal chemistry letters.

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

T. Roemer, T. Silhavy, Adam G Schwaid, 2019, Proceedings of the National Academy of Sciences.

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

D. Wyss, A. Therien, T. Fischmann, 2022, Journal of Medicinal Chemistry.

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.

Scott K. Smith, J. Phillips, Jesús Martín, 2011, Chemistry & biology.

Imipenem/Relebactam Resistance in Clinical Isolates of Extensively Drug Resistant Pseudomonas aeruginosa: Inhibitor-Resistant β-Lactamases and Their Increasing Importance

D. Fouts, R. Bonomo, A. Hujer, 2022, Antimicrobial agents and chemotherapy.

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

M. Erion, D. Kemp, S. Prahalada, 2017, Science.

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus.

Terry Roemer, Sang Ho Lee, Katherine Young, 2009, Chemistry & biology.

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.

J. Hermes, G. Scapin, N. Sharma, 2011, Bioorganic & medicinal chemistry letters.

Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins

T. Roemer, T. Silhavy, N. W. Rigel, 2018, Proceedings of the National Academy of Sciences.

Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.

R. Ebright, Xinwei Sher, David Degen, 2017, ACS chemical biology.

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

T. Roemer, Xinwei Sher, G. Scapin, 2017, PloS one.

In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

D. Wisniewski, M. Motyl, N. Murgolo, 2019, BMC Microbiology.

C-terminal Loop Mutations Determine Folding and SecretionProperties of PCSK9

D. Johns, T. Vogt, D. Wisniewski, 2016 .