C. Elmore

发表

The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans

C. Halldin, K. Varnäs, L. Farde, 2020, Neuropharmacology.

Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

C. Halldin, V. Pike, L. Farde, 2019, EJNMMI Research.

Use of Dibutyl[14C]formamide as a Formylating Reagent in the Vilsmeier–Haack Reaction and Synthesis of a 14C‐Labeled Novel Phosphodiesterase‐4 (PDE‐4) Inhibitor

D. Dean, D. Melillo, M. Braun, 2005 .

Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators

Andrew S. Felts, C. Lindsley, Hyekyung P. Cho, 2018, Molecular Pharmacology.

Synthesis of di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate in unlabelled and C-13 labelled forms for use as a biomarker of drug induced phospholipidosis.

C. Elmore, H. Andersson, M. Hickey, 2019, Journal of labelled compounds & radiopharmaceuticals.

[3H]Chiba‐1001(methyl‐SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha‐7 receptor in rodent brain

Chi-Ming Lee, C. Elmore, V. Chhajlani, 2012, Synapse.

Abstracts of the 25th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2016.

P. Rayner, L. Carroll, E. Aboagye, 2017 .

Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

S. Kitson, B. Cornelissen, K. Brindle, 2018, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of [13C5] and [carbonyl‐14C]‐5‐chlorofuran‐2‐carboxylic acid

C. Elmore, P. Dorff, M. Powell, 2011 .

D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]‐MNPA, [3H]‐(+)‐PHNO, and [3H]‐raclopride

L. Mrzljak, C. Elmore, J. Malmquist, 2010, Synapse.

Pre-clinical validation of a novel alpha-7 nicotinic receptor radiotracer, [3H]AZ11637326: Target localization, biodistribution and ligand occupancy in the rat brain

C. Elmore, R. Bialecki, Emily B. Einstein, 2011, Neuropharmacology.

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.

R. A. Thompson, Richard A. Thompson, C. Elmore, 2012, Chemical research in toxicology.

PET Tracers To Study Clinically Relevant Hepatic Transporters.

M. Zanda, C. Elmore, A. Testa, 2015, Molecular pharmaceutics.

Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors.

C. Halldin, S. Zoghbi, J. Liow, 2019, Nuclear medicine and biology.

4,4,16‐Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation

M. Zanda, J. Llop, L. Kingston, 2020, ChemMedChem.

An integrated strategy for in vivo metabolite profiling using high-resolution mass spectrometry based data processing techniques.

C. Elmore, Minli Zhang, K. Vishwanathan, 2013, Analytica chimica acta.

Microsoft Word-58424088-file00.docx

Alison J. Foster, J. G. Kenna, C. Elmore, 2014 .

The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates

Yiyun Huang, R. Carson, J. Ropchan, 2017, Molecular imaging.

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

T. Pieber, H. Sourij, C. Magnes, 2022, International journal of molecular sciences.

Metabolism And Excretion of the Dipeptidyl Peptidase 4 Inhibitor [ 14 C ] Sitagliptin in Humans

W. Zeng, S. Xu, G. Herman, 2007 .

Metabolism And Excretion of the Dipeptidyl Peptidase 4 Inhibitor [14C]Sitagliptin in Humans

W. Zeng, S. Xu, G. Herman, 2007, Drug Metabolism and Disposition.

Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error.

C. Elmore, D. Hesk, W. Lockley, 2016, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.

C. Elmore, M. A. Hayes, G. Grönberg, 2017, Journal of labelled compounds & radiopharmaceuticals.

Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011

Y. Li, S. Kitson, S. Baldwin, 2012 .

Synthesis of triphenylsilyl[14C2]acetylene for use in a Sonogashira reaction

C. Elmore, P. Dorff, 2011 .

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

T. Cantat, L. Kingston, C. Elmore, 2020, Angewandte Chemie.

Rapid and Efficient Synthesis of 11 C-Labeled Benzimidazolones Using [11 C]Carbon Dioxide

C. Halldin, C. Elmore, M. Schou, 2019, ChemistrySelect.

[11C]AZ10419096 - a full antagonist PET radioligand for imaging brain 5-HT1B receptors.

C. Halldin, V. Pike, L. Farde, 2017, Nuclear medicine and biology.

Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325

R. Lewis, C. Elmore, Chungang Gu, 2018, Journal of labelled compounds & radiopharmaceuticals.

In vitro and in vivo metabolism of a selective δ-opioid receptor agonist

Diansong Zhou, S. Grimm, K. Bui, 2011 .

[N-methyl-3H3]AZ10419369 Binding to the 5-HT1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy

L. Mrzljak, C. Elmore, M. E. Pierson, 2009, Journal of Pharmacology and Experimental Therapeutics.

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

E. Chiarparin, Sepideh Heydarkhan‐Hagvall, C. Elmore, 2022, Journal of the American Chemical Society.

Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.

Alan A. Wilson, S. Houle, Z. Daskalakis, 2012, Bioorganic & medicinal chemistry.

New trends and applications in carboxylation for isotope chemistry

C. Elmore, R. Bragg, M. Artelsmair, 2018, Journal of labelled compounds & radiopharmaceuticals.

The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors.

R. Lewis, L. Kingston, C. Elmore, 2020, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of [(3) H] and [(2) H6 ]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP).

C. Elmore, G. Grönberg, C. Ericsson, 2016, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of a 14C‐labeled FPTase inhibitor via a Pd‐catalyzed cyanation with Zn(14CN)2 and via bromo[14C]acetic acid

M. Braun, C. Elmore, J. Ho, 2008 .

Deuterated active pharmaceutical ingredients: A science-based proposal for synthesis, analysis, and control. Part 1: Framing the problem.

Scott A. Miller, T. Raglione, C. Elmore, 2019, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of three alpha 7 agonists in labeled form.

J. Hall, C. Elmore, S. Landvatter, 2014, Journal of labelled compounds & radiopharmaceuticals.

Subcutaneous administration of AZD0466, a dendrimer-based Bcl-2/Bcl-xL inhibitor increases lymphatic exposure and survival in B-cell lymphoma.

A. Johnston, C. Porter, L. Kingston, 2022, Journal of Controlled Release.

Quantification of magic angle spinning dynamic nuclear polarization NMR spectra.

E. Chiarparin, C. Elmore, L. Emsley, 2021, Journal of magnetic resonance.

Isotope chemistry; a useful tool in the drug discovery arsenal.

C. Elmore, R. Bragg, 2015, Bioorganic & medicinal chemistry letters.

Disposition of the Dipeptidyl Peptidase 4 Inhibitor Sitagliptin in Rats and Dogs

David Q. Liu, S. Xu, M. Beconi, 2007, Drug Metabolism and Disposition.

The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors.

L. Kingston, C. Elmore, M. Hickey, 2017, Journal of labelled compounds & radiopharmaceuticals.

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Jian Yu, P. Schroeder, Christopher A. Hurley, 2013, ACS medicinal chemistry letters.

Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

L. Kingston, C. Elmore, M. Schou, 2019, The Journal of organic chemistry.

Visible‐Light Enabled Late‐Stage, Room‐Temperature Aminocarbonylation of Aryl Iodides with Labeled Carbon Monoxide

C. Elmore, T. Skrydstrup, M. Sardana, 2022, ChemistrySelect.

14Carbon monoxide made simple – novel approach to the generation, utilization, and scrubbing of 14carbon monoxide

G. Stenhagen, C. Elmore, T. Skrydstrup, 2012 .

Meta-substituent effects on organoiridium-catalyzed ortho-hydrogen isotope exchange

C. Elmore, J. R. Heys, 2009 .

Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation.

T. Cantat, P. Thuéry, C. Elmore, 2021, Journal of the American Chemical Society.

Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin-11(10H)-one, and dibenzo[b,f][1,4]oxazepin-11(10H)-one in C-14 labeled form by [14C]carbonylation

C. Elmore, J. R. Heys, P. Dorff, 2010 .

A convenient method for [14C] carbonylation reactions

D. Dean, D. Melillo, C. Elmore, 2000 .

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

L. Kingston, C. Elmore, T. Skrydstrup, 2020, Angewandte Chemie.

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation.

L. Kingston, C. Elmore, T. Skrydstrup, 2020, Angewandte Chemie.

The synthesis and use of [14C]carbon monoxide in Pd‐catalyzed carbonylation reactions

C. Elmore, 2010 .

Isotope labelling by reduction of nitriles: Application to the synthesis of isotopologues of tolmetin and celecoxib.

C. Elmore, N. Bushby, M. Hickey, 2017, Journal of labelled compounds & radiopharmaceuticals.

Investigation of isotopic exchange reactions using N‐heterocyclic iridium (I) complexes

C. Elmore, J. R. Heys, P. Dorff, 2007 .

The syntheses of [14C] and [13C2,15N3]aprepitant

D. Dean, C. Elmore, D. Mellilo, 2004 .

Synthesis, 3H‐labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2

A. Varrone, L. Kingston, C. Elmore, 2019, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of the NK3 receptor antagonist AZD2624 in C‐14‐, H‐3‐ and C‐13‐labeled forms

J. Hall, C. Elmore, P. Dorff, 2011 .

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

T. Darwish, Venkata R. Krishnamurthy, H. Pichler, 2021, ACS nano.

Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists

R. A. Thompson, Alison J. Foster, J. G. Kenna, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A Photochemical Strategy for Carbon Isotope Exchange with CO2

C. Elmore, F. Taran, D. Audisio, 2020 .

Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate

D. Dean, D. Melillo, C. Elmore, 2002 .

Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct

Diansong Zhou, S. Grimm, C. Elmore, 2012, Drug Metabolism and Disposition.

The synthesis of tritium, carbon-14 and stable isotope labelled selective estrogen receptor degraders.

Hai-Ying Ji, L. Kingston, C. Elmore, 2016, Journal of labelled compounds & radiopharmaceuticals.

Chapter 25 The Use of Isotopically Labeled Compounds in Drug Discovery

C. Elmore, 2009 .

Contribution of Artifacts to N-Methylated Piperazine Cyanide Adduct Formation In Vitro from N-Alkyl Piperazine Analogs

C. Elmore, Minli Zhang, K. Vishwanathan, 2013, Drug Metabolism and Disposition.

Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders

J. Llop, P. Aguiar, L. Kingston, 2023, Biomedicines.

Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

D. Dawson, M. Zanda, C. Elmore, 2018, Contrast media & molecular imaging.

Subcutaneous administration of AZD0466, a dendrimer-based Bcl-2/Bcl-xL inhibitor increases lymphatic exposure and survival in B-cell lymphoma.

A. Johnston, C. Porter, L. Kingston, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging

C. Elmore, M. Schou, F. Besson, 2022, Pharmaceuticals.

Synthesis of a delta opioid agonist in [2H6], [2H4], [11C], and [14C] labeled forms

C. Halldin, J. Hall, C. Elmore, 2011 .

In vitro binding of a radio‐labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5

C. Elmore, B. Brockel, R. Hastings, 2013, Synapse.

Synthesis of two non-peptidyl GnRH receptor antagonists via [14C]carbonylation

R. DeVita, D. Dean, D. Melillo, 2003 .

Exploring the enzyme‐catalyzed synthesis of isotope labeled cyclopropanes

C. Elmore, M. A. Hayes, Sylvia T M Wenker, 2022, Journal of labelled compounds & radiopharmaceuticals.

Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein

A. Varrone, M. Higuchi, C. Elmore, 2020, Brain Research.

Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters.

M. Zanda, C. Elmore, A. Testa, 2017, Bioorganic & medicinal chemistry.

Use of fluorous and solid-phase electrophiles as scavengers for excess amine in the preparation of sulfur-35 labelled radioligands

D. Dean, D. Melillo, C. Elmore, 2005 .

Development of a 18F-labeled PET radioligand for imaging 5-HT1B receptors: [18F]AZ10419096.

C. Halldin, V. Pike, R. Arakawa, 2019, Nuclear medicine and biology.

Development of a PET radioligand for the central 5-HT1B receptor: radiosynthesis and characterization in cynomolgus monkeys of eight radiolabeled compounds.

B. Gulyás, C. Halldin, L. Farde, 2011, Nuclear medicine and biology.

Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance

Mark A. Smith, R. Lewis, J. Hall, 2018, Drug Metabolism and Disposition.

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Clay W Scott, Magnus J. Johansson, Jennifer R. Krumrine, 2011, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor

Diansong Zhou, S. Grimm, K. Bui, 2011, Drug Metabolism and Disposition.

Stereochemistry of the methyl→methylene elimination in the enzyme-catalysed cyclization of geranyl diphosphate to (4S)-limonene

R. Croteau, P. Williams, C. Elmore, 1997 .

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

T. Baillie, Wei Tang, D. Dean, 2001, Chemical research in toxicology.

Absence of direct effects on the dopamine D2 receptor by mGluR2/3‐selective receptor agonists LY 354,740 and LY 379,268

C. Elmore, Hongyan Liu, P. Dorff, 2011, Synapse.

Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors.

C. Halldin, S. Zoghbi, J. Liow, 2019, Nuclear Medicine and Biology.

Syntheses of AZ12320927 labeled with H-3, C-14, and H-2

C. Elmore, M. Powell, J. Heys, 2008 .

Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein

A. Varrone, M. Higuchi, C. Elmore, 2020, Brain Research.

[¹²⁵I]YP20: a novel radioligand specific for the extracellular domain of the CRF₁ receptor.

R. Bostwick, C. Elmore, Clay Scott, 2010, European journal of pharmacology.

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.

A. Varrone, A. Takano, Jörgen Ådén, 2018, ACS chemical neuroscience.